MX363727B - Nuevos derivados de pirazol. - Google Patents

Nuevos derivados de pirazol.

Info

Publication number
MX363727B
MX363727B MX2015011534A MX2015011534A MX363727B MX 363727 B MX363727 B MX 363727B MX 2015011534 A MX2015011534 A MX 2015011534A MX 2015011534 A MX2015011534 A MX 2015011534A MX 363727 B MX363727 B MX 363727B
Authority
MX
Mexico
Prior art keywords
pyrazol derivatives
novel
novel pyrazol
derivatives
compound
Prior art date
Application number
MX2015011534A
Other languages
English (en)
Other versions
MX2015011534A (es
Inventor
Schulz-Gasch Tanja
Nettekoven Matthias
Rogers-Evans Mark
Grether Uwe
Kimbara Atsushi
Roever Stephan
Ricklin Fabienne
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2015011534A publication Critical patent/MX2015011534A/es
Publication of MX363727B publication Critical patent/MX363727B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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    • A61P27/06—Antiglaucoma agents or miotics
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    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
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  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)

Abstract

La invención se refiere a un compuesto de la fórmula (I): (ver Fórmula) en la que de A1 a A3 y de R1 a R3 tienen los significados definidos en la descripción y en las reivindicaciones. El compuesto de la fórmula (I) puede utilizarse como medicamento.
MX2015011534A 2013-03-07 2014-03-04 Nuevos derivados de pirazol. MX363727B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13158233 2013-03-07
PCT/EP2014/054107 WO2014135507A1 (en) 2013-03-07 2014-03-04 Novel pyrazol derivatives

Publications (2)

Publication Number Publication Date
MX2015011534A MX2015011534A (es) 2016-02-05
MX363727B true MX363727B (es) 2019-04-01

Family

ID=47827068

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015011534A MX363727B (es) 2013-03-07 2014-03-04 Nuevos derivados de pirazol.

Country Status (35)

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US (2) US9512132B2 (es)
EP (1) EP2964646B1 (es)
JP (2) JP6514119B2 (es)
KR (2) KR102369407B1 (es)
CN (1) CN105143220B (es)
AR (1) AR094978A1 (es)
AU (1) AU2014224784B2 (es)
BR (1) BR112015020795B1 (es)
CA (1) CA2897513C (es)
CL (1) CL2015002387A1 (es)
CR (1) CR20150447A (es)
CY (1) CY1118950T1 (es)
DK (1) DK2964646T3 (es)
EA (1) EA027935B1 (es)
ES (1) ES2629751T3 (es)
HK (1) HK1213258A1 (es)
HR (1) HRP20170919T1 (es)
HU (1) HUE034831T2 (es)
IL (1) IL240327B (es)
LT (1) LT2964646T (es)
MA (1) MA38403A1 (es)
MX (1) MX363727B (es)
MY (1) MY176797A (es)
NZ (1) NZ710052A (es)
PE (1) PE20151539A1 (es)
PH (1) PH12015501843A1 (es)
PL (1) PL2964646T3 (es)
PT (1) PT2964646T (es)
RS (1) RS56148B1 (es)
SG (1) SG11201507168XA (es)
SI (1) SI2964646T1 (es)
TW (1) TWI609866B (es)
UA (1) UA118666C2 (es)
WO (1) WO2014135507A1 (es)
ZA (1) ZA201505073B (es)

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PT3483163T (pt) 2013-09-06 2021-08-24 Hoffmann La Roche Novos derivados de triazolo[4,5-d]pirimidina como antagonistas de receptor cb2
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CN109311895B (zh) 2016-06-23 2021-06-18 豪夫迈·罗氏有限公司 新型[1,2,3]三唑并[4,5-d]嘧啶衍生物
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TWI609866B (zh) 2018-01-01
BR112015020795A2 (pt) 2017-07-18
CL2015002387A1 (es) 2016-03-04
CA2897513C (en) 2021-03-16
EA027935B1 (ru) 2017-09-29
CA2897513A1 (en) 2014-09-12
PL2964646T3 (pl) 2017-09-29
PH12015501843B1 (en) 2015-12-07
EA201591624A1 (ru) 2016-01-29
US20150376192A1 (en) 2015-12-31
TW201506023A (zh) 2015-02-16
BR112015020795B1 (pt) 2022-08-16
JP2016510054A (ja) 2016-04-04
MX2015011534A (es) 2016-02-05
JP6514119B2 (ja) 2019-05-15
ZA201505073B (en) 2016-07-27
KR20150126355A (ko) 2015-11-11
US9694012B2 (en) 2017-07-04
WO2014135507A1 (en) 2014-09-12
KR102369407B1 (ko) 2022-03-02
HK1213258A1 (zh) 2016-06-30
AR094978A1 (es) 2015-09-09
AU2014224784A1 (en) 2015-07-23
IL240327A0 (en) 2015-09-24
SI2964646T1 (sl) 2017-08-31
CN105143220B (zh) 2018-06-22
EP2964646B1 (en) 2017-04-19
RS56148B1 (sr) 2017-11-30
ES2629751T3 (es) 2017-08-14
HRP20170919T1 (hr) 2017-09-22
LT2964646T (lt) 2017-07-10
KR20210019578A (ko) 2021-02-22
EP2964646A1 (en) 2016-01-13
JP2019055986A (ja) 2019-04-11
MY176797A (en) 2020-08-21
UA118666C2 (uk) 2019-02-25
PH12015501843A1 (en) 2015-12-07
PT2964646T (pt) 2017-06-29
PE20151539A1 (es) 2015-10-28
SG11201507168XA (en) 2015-10-29
US9512132B2 (en) 2016-12-06
CR20150447A (es) 2015-10-08
HUE034831T2 (en) 2018-03-28
DK2964646T3 (en) 2017-07-10
NZ710052A (en) 2020-09-25
IL240327B (en) 2019-01-31
KR102217297B1 (ko) 2021-02-22
CY1118950T1 (el) 2018-01-10
CN105143220A (zh) 2015-12-09
MA38403A1 (fr) 2017-11-30
AU2014224784B2 (en) 2018-03-08
US20170035769A1 (en) 2017-02-09

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