TWI453022B - 造血系腫瘤之化學治療 - Google Patents

造血系腫瘤之化學治療 Download PDF

Info

Publication number
TWI453022B
TWI453022B TW099111650A TW99111650A TWI453022B TW I453022 B TWI453022 B TW I453022B TW 099111650 A TW099111650 A TW 099111650A TW 99111650 A TW99111650 A TW 99111650A TW I453022 B TWI453022 B TW I453022B
Authority
TW
Taiwan
Prior art keywords
leukemia
mll
translocation
fluoro
mixed lineage
Prior art date
Application number
TW099111650A
Other languages
English (en)
Chinese (zh)
Other versions
TW201105328A (en
Inventor
Marcio Chedid
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42174602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI453022(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of TW201105328A publication Critical patent/TW201105328A/zh
Application granted granted Critical
Publication of TWI453022B publication Critical patent/TWI453022B/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/55171,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41621,2-Diazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW099111650A 2009-04-14 2010-04-14 造血系腫瘤之化學治療 TWI453022B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16909409P 2009-04-14 2009-04-14

Publications (2)

Publication Number Publication Date
TW201105328A TW201105328A (en) 2011-02-16
TWI453022B true TWI453022B (zh) 2014-09-21

Family

ID=42174602

Family Applications (1)

Application Number Title Priority Date Filing Date
TW099111650A TWI453022B (zh) 2009-04-14 2010-04-14 造血系腫瘤之化學治療

Country Status (23)

Country Link
US (2) US8802668B2 (OSRAM)
EP (1) EP2419106A1 (OSRAM)
JP (1) JP5699129B2 (OSRAM)
KR (1) KR101290509B1 (OSRAM)
CN (1) CN102395372B (OSRAM)
AU (1) AU2010236747B2 (OSRAM)
BR (1) BRPI1013774A2 (OSRAM)
CA (1) CA2758473C (OSRAM)
CL (1) CL2011002531A1 (OSRAM)
DO (1) DOP2011000312A (OSRAM)
EA (1) EA018933B1 (OSRAM)
EC (1) ECSP11011403A (OSRAM)
IL (1) IL215107A0 (OSRAM)
MA (1) MA33184B1 (OSRAM)
MX (1) MX2011010937A (OSRAM)
MY (1) MY157218A (OSRAM)
NZ (1) NZ595413A (OSRAM)
PE (1) PE20120772A1 (OSRAM)
SG (1) SG175207A1 (OSRAM)
TN (1) TN2011000500A1 (OSRAM)
TW (1) TWI453022B (OSRAM)
UA (1) UA103792C2 (OSRAM)
WO (1) WO2010120614A1 (OSRAM)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20120772A1 (es) 2009-04-14 2012-06-27 Lilly Co Eli Derivado de benzodiazepina para el tratamiento de neoplasma hematopoyetico y leucemia
WO2012125787A1 (en) 2011-03-17 2012-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic METHODS FOR TREATING LEUKEMIA AND DISORDERS MEDIATED BY CBFβ AND RUNX1 PROTEINS
US9603809B2 (en) 2011-03-23 2017-03-28 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US9498447B2 (en) 2011-03-23 2016-11-22 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US10292937B2 (en) 2011-03-23 2019-05-21 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US10905652B2 (en) 2011-03-23 2021-02-02 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US11241391B2 (en) 2011-03-23 2022-02-08 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9119809B2 (en) 2011-03-23 2015-09-01 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
WO2014050779A1 (ja) * 2012-09-25 2014-04-03 第一三共株式会社 Gsk3阻害剤と抗dr5抗体の組み合わせ
CN102887896B (zh) * 2012-10-26 2015-11-18 南京工业大学 一种2-(咪唑并[1,2-a]吡啶-3-基)乙腈的制备方法
WO2014090398A1 (en) * 2012-12-10 2014-06-19 Centogene Ag Use of maleimide derivatives for preventing and treating leukemia
JP6534098B2 (ja) * 2014-09-12 2019-06-26 国立大学法人 鹿児島大学 成人t細胞白血病治療薬
CN104945436B (zh) * 2015-07-09 2017-02-08 山东罗欣药业集团股份有限公司 一种米诺膦酸的制备方法
KR101694063B1 (ko) 2015-10-12 2017-01-17 전남대학교병원 Bio 화합물을 함유하는 심혈관질환의 치료용 조성물
WO2018083481A1 (en) 2016-11-03 2018-05-11 Ucl Business Plc Cancer therapy
AU2020218366A1 (en) 2019-02-08 2021-09-16 Frequency Therapeutics, Inc. Valproic acid compounds and Wnt agonists for treating ear disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200911272A (en) * 2007-07-02 2009-03-16 Lilly Co Eli Potentiation of cancer chemotherapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
KR100974770B1 (ko) * 2002-03-05 2010-08-06 일라이 릴리 앤드 캄파니 키나제 억제제로서의 퓨린 유도체
ATE535241T1 (de) 2007-12-05 2011-12-15 Univ Mainz Johannes Gutenberg Verwendung von 3-(indolyl)- oder 3-(azaindolyl)-4-arylmaleimid-derivaten bei der behandlung von leukämie
PE20120772A1 (es) 2009-04-14 2012-06-27 Lilly Co Eli Derivado de benzodiazepina para el tratamiento de neoplasma hematopoyetico y leucemia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200911272A (en) * 2007-07-02 2009-03-16 Lilly Co Eli Potentiation of cancer chemotherapy

Also Published As

Publication number Publication date
CA2758473C (en) 2013-12-17
JP2012524089A (ja) 2012-10-11
US8802668B2 (en) 2014-08-12
CN102395372B (zh) 2014-07-02
MY157218A (en) 2016-05-13
ECSP11011403A (es) 2011-11-30
TW201105328A (en) 2011-02-16
CA2758473A1 (en) 2010-10-21
CL2011002531A1 (es) 2012-06-01
KR20120004447A (ko) 2012-01-12
EP2419106A1 (en) 2012-02-22
IL215107A0 (en) 2011-12-29
JP5699129B2 (ja) 2015-04-08
SG175207A1 (en) 2011-11-28
EA201171243A1 (ru) 2012-03-30
AU2010236747B2 (en) 2012-11-08
BRPI1013774A2 (pt) 2016-04-05
PE20120772A1 (es) 2012-06-27
MX2011010937A (es) 2011-11-02
AU2010236747A1 (en) 2011-10-06
MA33184B1 (fr) 2012-04-02
UA103792C2 (uk) 2013-11-25
WO2010120614A1 (en) 2010-10-21
CN102395372A (zh) 2012-03-28
TN2011000500A1 (en) 2013-05-24
US20100261712A1 (en) 2010-10-14
US9044487B2 (en) 2015-06-02
DOP2011000312A (es) 2011-10-31
EA018933B1 (ru) 2013-11-29
NZ595413A (en) 2013-05-31
US20140235621A1 (en) 2014-08-21
KR101290509B1 (ko) 2013-07-26

Similar Documents

Publication Publication Date Title
TWI453022B (zh) 造血系腫瘤之化學治療
CA3087089C (en) Fused ring compounds
CN102083314A (zh) Parp抑制剂化合物、组合物以及使用方法
ES2609296T3 (es) Análogos de triazina y su uso como agentes terapéuticos y sondas de diagnóstico
CN101981013B (zh) 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮
CN106279142A (zh) 5‑[[4‑[[吗啉‑2‑基]甲基氨基]‑5‑(三氟甲基)‑2‑吡啶基]氨基]吡嗪‑2‑腈及其治疗应用
CN110141570A (zh) 药物化合物
JP2019507779A (ja) 尿素系化合物、その製造方法及びその医薬用途
TW201902896A (zh) 治療化合物及組合物及其使用方法
ES2709003T3 (es) Compuestos de 5-(piridin-2-il-amino)-pirazina-2-carbonitrilo y su uso terapéutico
KR20140082710A (ko) 이미다조피리딘 화합물, 조성물 및 사용 방법
CN110494434B (zh) 吡唑并氯苯基化合物、其组合物及其使用方法
CN109890817B (zh) 8-(氮杂环丁烷-1-基)-[1,2,4]三唑并[1,5-a]吡啶基化合物、其组合物和应用方法
CN108473472A (zh) 作为p70s6激酶抑制剂的2-氨基喹唑啉衍生物
CN114592061A (zh) 用于ttk抑制剂化疗的预后生物标记
CN102731416A (zh) 1-(芳基甲基)-喹唑啉-2,4-二酮作为parp抑制剂及其应用
TW202535354A (zh) 可用於治療增殖性疾病或病症之化合物及組合物
JP5064795B2 (ja) サイクリン依存性キナーゼの阻害剤、組成物及びそれに関連する使用
JP4791975B2 (ja) サイクリン依存性キナーゼの阻害剤、組成物およびそれに関連する使用
Takagi et al. Different initial steps of apoptosis induced by two types of antineoplastic drugs
WO2020118753A1 (zh) 一种喹啉结构的pan-KIT激酶抑制剂及其用途
BR112019020309A2 (pt) derivados de quinoxalina e piridopirazina como inibidores de pi3k-beta
WO2024243343A2 (en) Compounds that re-activate mutant p53
CN118401527A (zh) 化合物
HK1105586A1 (en) Phthalazine derivatives as parp inhibitors

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees