JP5699129B2 - 造血器新生物および白血病の治療のためのベンゾジアゼピン誘導体 - Google Patents
造血器新生物および白血病の治療のためのベンゾジアゼピン誘導体 Download PDFInfo
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- JP5699129B2 JP5699129B2 JP2012506078A JP2012506078A JP5699129B2 JP 5699129 B2 JP5699129 B2 JP 5699129B2 JP 2012506078 A JP2012506078 A JP 2012506078A JP 2012506078 A JP2012506078 A JP 2012506078A JP 5699129 B2 JP5699129 B2 JP 5699129B2
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- Epidemiology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
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| US16909409P | 2009-04-14 | 2009-04-14 | |
| US61/169,094 | 2009-04-14 | ||
| PCT/US2010/030315 WO2010120614A1 (en) | 2009-04-14 | 2010-04-08 | Benzodiazepine derivative for the treatment of hematopoietic neoplasm and leukemia |
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| Publication Number | Publication Date |
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| JP2012524089A JP2012524089A (ja) | 2012-10-11 |
| JP2012524089A5 JP2012524089A5 (OSRAM) | 2013-05-30 |
| JP5699129B2 true JP5699129B2 (ja) | 2015-04-08 |
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| JP2012506078A Expired - Fee Related JP5699129B2 (ja) | 2009-04-14 | 2010-04-08 | 造血器新生物および白血病の治療のためのベンゾジアゼピン誘導体 |
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| JP (1) | JP5699129B2 (OSRAM) |
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| UA (1) | UA103792C2 (OSRAM) |
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| SG175207A1 (en) | 2009-04-14 | 2011-11-28 | Lilly Co Eli | Benzodiazepine derivative for the treatment of hematopoietic neoplasm and leukemia |
| US9446048B2 (en) | 2011-03-17 | 2016-09-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for treating leukemia and disorders mediated by CBFβ and RUNX1 proteins |
| US10292937B2 (en) | 2011-03-23 | 2019-05-21 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| US9498447B2 (en) | 2011-03-23 | 2016-11-22 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9119809B2 (en) | 2011-03-23 | 2015-09-01 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US11241391B2 (en) | 2011-03-23 | 2022-02-08 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9603809B2 (en) | 2011-03-23 | 2017-03-28 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| US10905652B2 (en) | 2011-03-23 | 2021-02-02 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| TW201417817A (zh) * | 2012-09-25 | 2014-05-16 | Daiichi Sankyo Co Ltd | Ｇｓｋ３抑制劑與抗ｄｒ５抗體之組合 |
| CN102887896B (zh) * | 2012-10-26 | 2015-11-18 | 南京工业大学 | 一种2-（咪唑并[1,2-a]吡啶-3-基）乙腈的制备方法 |
| CA2892927A1 (en) * | 2012-12-10 | 2014-06-19 | Centogene Ag | Use of maleimide derivatives for preventing and treating leukemia |
| JP6534098B2 (ja) * | 2014-09-12 | 2019-06-26 | 国立大学法人 鹿児島大学 | 成人ｔ細胞白血病治療薬 |
| CN104945436B (zh) * | 2015-07-09 | 2017-02-08 | 山东罗欣药业集团股份有限公司 | 一种米诺膦酸的制备方法 |
| KR101694063B1 (ko) | 2015-10-12 | 2017-01-17 | 전남대학교병원 | Ｂｉｏ 화합물을 함유하는 심혈관질환의 치료용 조성물 |
| US11071720B2 (en) | 2016-11-03 | 2021-07-27 | Ucl Business Ltd | Cancer therapy |
| EP3920885A1 (en) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
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| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| CN1312154C (zh) * | 2002-03-05 | 2007-04-25 | 伊莱利利公司 | 作为激酶抑制剂的嘌呤衍生物 |
| TWI428132B (zh) * | 2007-07-02 | 2014-03-01 | Lilly Co Eli | 癌症化療效果之強化 |
| AU2008333215B2 (en) | 2007-12-05 | 2013-06-13 | Johannes Gutenberg-Universitat Mainz | Use of 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives in leukemia management |
| SG175207A1 (en) * | 2009-04-14 | 2011-11-28 | Lilly Co Eli | Benzodiazepine derivative for the treatment of hematopoietic neoplasm and leukemia |
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- 2010-04-08 WO PCT/US2010/030315 patent/WO2010120614A1/en not_active Ceased
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- 2010-04-08 EA EA201171243A patent/EA018933B1/ru not_active IP Right Cessation
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Also Published As
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| WO2010120614A1 (en) | 2010-10-21 |
| CN102395372A (zh) | 2012-03-28 |
| EP2419106A1 (en) | 2012-02-22 |
| US8802668B2 (en) | 2014-08-12 |
| NZ595413A (en) | 2013-05-31 |
| AU2010236747A1 (en) | 2011-10-06 |
| IL215107A0 (en) | 2011-12-29 |
| CA2758473C (en) | 2013-12-17 |
| BRPI1013774A2 (pt) | 2016-04-05 |
| SG175207A1 (en) | 2011-11-28 |
| EA201171243A1 (ru) | 2012-03-30 |
| MA33184B1 (fr) | 2012-04-02 |
| TW201105328A (en) | 2011-02-16 |
| DOP2011000312A (es) | 2011-10-31 |
| MY157218A (en) | 2016-05-13 |
| KR20120004447A (ko) | 2012-01-12 |
| CL2011002531A1 (es) | 2012-06-01 |
| AU2010236747B2 (en) | 2012-11-08 |
| TN2011000500A1 (en) | 2013-05-24 |
| KR101290509B1 (ko) | 2013-07-26 |
| US9044487B2 (en) | 2015-06-02 |
| CA2758473A1 (en) | 2010-10-21 |
| JP2012524089A (ja) | 2012-10-11 |
| CN102395372B (zh) | 2014-07-02 |
| UA103792C2 (uk) | 2013-11-25 |
| EA018933B1 (ru) | 2013-11-29 |
| ECSP11011403A (es) | 2011-11-30 |
| PE20120772A1 (es) | 2012-06-27 |
| US20140235621A1 (en) | 2014-08-21 |
| TWI453022B (zh) | 2014-09-21 |
| MX2011010937A (es) | 2011-11-02 |
| US20100261712A1 (en) | 2010-10-14 |
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