TWI450900B - 橋聯雜環化合物及使用方法 - Google Patents
橋聯雜環化合物及使用方法 Download PDFInfo
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- TWI450900B TWI450900B TW098109566A TW98109566A TWI450900B TW I450900 B TWI450900 B TW I450900B TW 098109566 A TW098109566 A TW 098109566A TW 98109566 A TW98109566 A TW 98109566A TW I450900 B TWI450900 B TW I450900B
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- substituted
- unsubstituted
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- alkyl
- alkoxy
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| RU2544856C2 (ru) * | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
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| US9625475B2 (en) | 2008-09-29 | 2017-04-18 | Abbvie Inc. | Indole and indoline derivatives and methods of use thereof |
| US8907097B2 (en) * | 2008-10-31 | 2014-12-09 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles containing rigid moieties |
| US8569287B2 (en) | 2008-10-31 | 2013-10-29 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
| JP2012517471A (ja) | 2009-02-11 | 2012-08-02 | スノビオン プハルマセウトイカルス インコーポレイテッド | ヒスタミンh3インバースアゴニスト及びアンタゴニスト、並びにその使用方法 |
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| WO2011019417A1 (en) | 2009-04-29 | 2011-02-17 | Medivation Technologies, Inc. | Pyrido [4, 3-b] indoles and methods of use |
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| CN102711466A (zh) * | 2009-09-23 | 2012-10-03 | 梅迪维新技术公司 | 桥连杂环化合物及其使用方法 |
| JP5791612B2 (ja) | 2009-09-23 | 2015-10-07 | メディベイション テクノロジーズ, インコーポレイテッド | ピリド[3,4−b]インドールおよび使用方法 |
| US8859561B2 (en) | 2009-09-23 | 2014-10-14 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles and methods of use |
| US8575186B2 (en) | 2009-10-05 | 2013-11-05 | Albany Molecular Research, Inc. | Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof |
| US8778959B2 (en) | 2009-12-17 | 2014-07-15 | Abbvie Inc. | AZA-bridged ring-fused indoles and indolines |
| JP5734999B2 (ja) * | 2009-12-17 | 2015-06-17 | アッヴィ・インコーポレイテッド | 神経変性および神経精神医学的障害の治療に有用な架橋アミン環縮合インドールおよびインドリン |
| US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
| WO2011103485A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| WO2011103433A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| WO2011103430A1 (en) | 2010-02-19 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| US9067949B2 (en) | 2011-01-19 | 2015-06-30 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
| WO2012112964A2 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE |
| US20140303144A1 (en) | 2011-02-18 | 2014-10-09 | Medivation Technologies, Inc. | Compounds and methods of treating hypertension |
| AU2012254158B2 (en) | 2011-02-18 | 2016-02-04 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
| US20140155384A1 (en) | 2011-02-18 | 2014-06-05 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
| RU2490268C2 (ru) * | 2011-11-10 | 2013-08-20 | Федеральное Государственное Бюджетное Учреждение Науки Институт Физиологически Активных Веществ Российской Академии Наук (Ифав Ран) | ХЛОРГИДРАТЫ ФТОРСОДЕРЖАЩИХ ЗАМЕЩЕННЫХ 5-[2-(ПИРИД-3-ИЛ)-ЭТИЛ]-2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛОВ, В КАЧЕСТВЕ СРЕДСТВ СНИЖЕНИЯ НЕКОНТРОЛИРУЕМОЙ АГРЕГАЦИИ БЕЛКОВ В НЕРВНОЙ СИСТЕМЕ, ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ИХ ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| JP6653573B2 (ja) | 2012-05-22 | 2020-02-26 | トラスティーズ・オブ・ダートマウス・カレッジ | シクロアルカニル[b]インドール、シクロアルカニル[b]ベンゾフラン、シクロアルカニル[b]ベンゾチオフェンを合成するための方法、化合物および使用の方法 |
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| CL2009000725A1 (es) | 2009-05-29 |
| US20140024643A1 (en) | 2014-01-23 |
| US8999977B2 (en) | 2015-04-07 |
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| US8546381B2 (en) | 2013-10-01 |
| HK1153196A1 (en) | 2012-03-23 |
| US20130190303A1 (en) | 2013-07-25 |
| JP2014111655A (ja) | 2014-06-19 |
| AU2009228401B2 (en) | 2014-10-30 |
| US20100099667A1 (en) | 2010-04-22 |
| HK1157751A1 (en) | 2012-07-06 |
| US9051314B2 (en) | 2015-06-09 |
| TW201000483A (en) | 2010-01-01 |
| US20130184269A1 (en) | 2013-07-18 |
| JP2011515483A (ja) | 2011-05-19 |
| WO2009120720A1 (en) | 2009-10-01 |
| JP5586577B2 (ja) | 2014-09-10 |
| CA2718790A1 (en) | 2009-10-01 |
| EP2274307B1 (en) | 2015-07-29 |
| PE20091820A1 (es) | 2009-12-10 |
| AU2009228401A1 (en) | 2009-10-01 |
| US9034869B2 (en) | 2015-05-19 |
| AR071284A1 (es) | 2010-06-09 |
| EP2274307A1 (en) | 2011-01-19 |
| CN102046625A (zh) | 2011-05-04 |
| CN102046625B (zh) | 2015-04-08 |
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