CL2009000725A1 - Compuestos derivados de heterociclos con uniones puente sustituidos, moduladores de receptores adrenergicos, de serotonina, de dopamina y de histaminas; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento del trastorno cognitivo y trastorno psicotico. - Google Patents
Compuestos derivados de heterociclos con uniones puente sustituidos, moduladores de receptores adrenergicos, de serotonina, de dopamina y de histaminas; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento del trastorno cognitivo y trastorno psicotico.Info
- Publication number
- CL2009000725A1 CL2009000725A1 CL2009000725A CL2009000725A CL2009000725A1 CL 2009000725 A1 CL2009000725 A1 CL 2009000725A1 CL 2009000725 A CL2009000725 A CL 2009000725A CL 2009000725 A CL2009000725 A CL 2009000725A CL 2009000725 A1 CL2009000725 A1 CL 2009000725A1
- Authority
- CL
- Chile
- Prior art keywords
- disorder
- treatment
- adrenergic
- serotonin
- dopamine
- Prior art date
Links
- 208000028017 Psychotic disease Diseases 0.000 title abstract 2
- 208000010877 cognitive disease Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 title 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 title 1
- 108060003345 Adrenergic Receptor Proteins 0.000 title 1
- 102000017910 Adrenergic receptor Human genes 0.000 title 1
- 102000015554 Dopamine receptor Human genes 0.000 title 1
- 108050004812 Dopamine receptor Proteins 0.000 title 1
- 102000000543 Histamine Receptors Human genes 0.000 title 1
- 108010002059 Histamine Receptors Proteins 0.000 title 1
- 230000001800 adrenalinergic effect Effects 0.000 title 1
- 229960003638 dopamine Drugs 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 229940076279 serotonin Drugs 0.000 title 1
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102220480121 H/ACA ribonucleoprotein complex subunit DKC1_R10A_mutation Human genes 0.000 abstract 1
- -1 INDOL HETEROCYCLIC COMPOUNDS Chemical class 0.000 abstract 1
- 230000005540 biological transmission Effects 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3905808P | 2008-03-24 | 2008-03-24 | |
| US14505809P | 2009-01-15 | 2009-01-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2009000725A1 true CL2009000725A1 (es) | 2009-05-29 |
Family
ID=40651664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2009000725A CL2009000725A1 (es) | 2008-03-24 | 2009-03-24 | Compuestos derivados de heterociclos con uniones puente sustituidos, moduladores de receptores adrenergicos, de serotonina, de dopamina y de histaminas; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento del trastorno cognitivo y trastorno psicotico. |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US8546381B2 (enExample) |
| EP (1) | EP2274307B1 (enExample) |
| JP (2) | JP5586577B2 (enExample) |
| CN (1) | CN102046625B (enExample) |
| AR (1) | AR071284A1 (enExample) |
| AU (1) | AU2009228401B2 (enExample) |
| BR (1) | BRPI0906245A2 (enExample) |
| CA (1) | CA2718790A1 (enExample) |
| CL (1) | CL2009000725A1 (enExample) |
| PE (1) | PE20091820A1 (enExample) |
| TW (1) | TWI450900B (enExample) |
| WO (1) | WO2009120720A1 (enExample) |
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| RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
| RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| EP2280968A2 (en) | 2008-03-24 | 2011-02-09 | Medivation Technologies, Inc. | Pyrido [3, 4-b]indoles and methods of use |
| WO2009120720A1 (en) | 2008-03-24 | 2009-10-01 | Medivation Technologies,Inc. | Bridged heterocyclic compounds and methods of use |
| TW201018694A (en) * | 2008-09-29 | 2010-05-16 | Abbott Lab | Indole and indoline derivatives and methods of use thereof |
| US9625475B2 (en) | 2008-09-29 | 2017-04-18 | Abbvie Inc. | Indole and indoline derivatives and methods of use thereof |
| CA2742320A1 (en) | 2008-10-31 | 2010-05-06 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles containing rigid moieties |
| AU2009308708B2 (en) * | 2008-10-31 | 2015-11-19 | Medivation Technologies, Inc. | Azepino [4, 5-b] indoles and methods of use |
| BRPI1008020A2 (pt) * | 2009-02-11 | 2016-03-15 | Sunovion Pharmaceuticals Inc | antagonistas e agonistas inversos h3 da histamina e métodos de uso dos mesmos |
| AU2010282990B2 (en) | 2009-04-29 | 2015-11-05 | Medivation Technologies, Inc. | Pyrido [4, 3-b] indoles and methods of use |
| EP2424364A4 (en) | 2009-04-29 | 2012-12-19 | Medivation Technologies Inc | PYRIDO [4.3-B] INDOLES AND METHODS OF USE |
| EP2475664A2 (en) * | 2009-09-11 | 2012-07-18 | Sunovion Pharmaceuticals Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
| JP5779183B2 (ja) | 2009-09-23 | 2015-09-16 | メディベイション テクノロジーズ， インコーポレイテッド | ピリド［４，３−ｂ］インドールおよび使用方法 |
| AU2010298168B2 (en) | 2009-09-23 | 2015-11-19 | Medivation Technologies, Inc. | Pyrido(3,4-b)indoles and methods of use |
| AU2010298169B2 (en) * | 2009-09-23 | 2015-10-29 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
| WO2011044134A1 (en) | 2009-10-05 | 2011-04-14 | Albany Molecular Research, Inc. | Epiminocycloalkyl(b)indole derivatives as serotonin sub-type 6 (5-ht6) modulators and uses thereof |
| CN104592233A (zh) * | 2009-12-17 | 2015-05-06 | Abbvie公司 | 用于治疗神经变性和神经精神紊乱的桥头胺环稠合吲哚和二氢吲哚 |
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| WO2011103433A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
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| US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
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| IN2013MN01699A (enExample) | 2011-02-18 | 2015-06-12 | Medivation Technologies Inc | |
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| RU2490268C2 (ru) * | 2011-11-10 | 2013-08-20 | Федеральное Государственное Бюджетное Учреждение Науки Институт Физиологически Активных Веществ Российской Академии Наук (Ифав Ран) | ХЛОРГИДРАТЫ ФТОРСОДЕРЖАЩИХ ЗАМЕЩЕННЫХ 5-[2-(ПИРИД-3-ИЛ)-ЭТИЛ]-2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛОВ, В КАЧЕСТВЕ СРЕДСТВ СНИЖЕНИЯ НЕКОНТРОЛИРУЕМОЙ АГРЕГАЦИИ БЕЛКОВ В НЕРВНОЙ СИСТЕМЕ, ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ИХ ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
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-
2009
- 2009-03-24 WO PCT/US2009/038142 patent/WO2009120720A1/en not_active Ceased
- 2009-03-24 TW TW098109566A patent/TWI450900B/zh not_active IP Right Cessation
- 2009-03-24 CL CL2009000725A patent/CL2009000725A1/es unknown
- 2009-03-24 EP EP09725176.3A patent/EP2274307B1/en not_active Not-in-force
- 2009-03-24 CA CA2718790A patent/CA2718790A1/en not_active Abandoned
- 2009-03-24 US US12/410,425 patent/US8546381B2/en not_active Expired - Fee Related
- 2009-03-24 BR BRPI0906245-9A patent/BRPI0906245A2/pt not_active IP Right Cessation
- 2009-03-24 JP JP2011501990A patent/JP5586577B2/ja not_active Expired - Fee Related
- 2009-03-24 PE PE2009000436A patent/PE20091820A1/es not_active Application Discontinuation
- 2009-03-24 CN CN200980118777.5A patent/CN102046625B/zh not_active Expired - Fee Related
- 2009-03-24 AU AU2009228401A patent/AU2009228401B2/en not_active Ceased
- 2009-03-25 AR ARP090101068A patent/AR071284A1/es unknown
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2013
- 2013-03-07 US US13/789,606 patent/US9034869B2/en not_active Expired - Fee Related
- 2013-03-08 US US13/791,832 patent/US8999977B2/en not_active Expired - Fee Related
- 2013-09-20 US US14/033,234 patent/US9051314B2/en not_active Expired - Fee Related
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2014
- 2014-03-11 JP JP2014047700A patent/JP2014111655A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AR071284A1 (es) | 2010-06-09 |
| CN102046625A (zh) | 2011-05-04 |
| US9034869B2 (en) | 2015-05-19 |
| US8999977B2 (en) | 2015-04-07 |
| JP5586577B2 (ja) | 2014-09-10 |
| US20100099667A1 (en) | 2010-04-22 |
| AU2009228401A1 (en) | 2009-10-01 |
| US20130190303A1 (en) | 2013-07-25 |
| JP2014111655A (ja) | 2014-06-19 |
| AU2009228401B2 (en) | 2014-10-30 |
| CN102046625B (zh) | 2015-04-08 |
| CA2718790A1 (en) | 2009-10-01 |
| US8546381B2 (en) | 2013-10-01 |
| TW201000483A (en) | 2010-01-01 |
| WO2009120720A1 (en) | 2009-10-01 |
| HK1157751A1 (en) | 2012-07-06 |
| JP2011515483A (ja) | 2011-05-19 |
| BRPI0906245A2 (pt) | 2015-06-30 |
| US20130184269A1 (en) | 2013-07-18 |
| US20140024643A1 (en) | 2014-01-23 |
| HK1153196A1 (en) | 2012-03-23 |
| EP2274307B1 (en) | 2015-07-29 |
| EP2274307A1 (en) | 2011-01-19 |
| PE20091820A1 (es) | 2009-12-10 |
| US9051314B2 (en) | 2015-06-09 |
| TWI450900B (zh) | 2014-09-01 |
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