TWI446903B - 含(-)-o-去甲基泛拉弗辛(venlafaxine)之固體形式及其用途 - Google Patents
含(-)-o-去甲基泛拉弗辛(venlafaxine)之固體形式及其用途 Download PDFInfo
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- TWI446903B TWI446903B TW097106132A TW97106132A TWI446903B TW I446903 B TWI446903 B TW I446903B TW 097106132 A TW097106132 A TW 097106132A TW 97106132 A TW97106132 A TW 97106132A TW I446903 B TWI446903 B TW I446903B
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- hydrochloride
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- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
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| KR20100015923A (ko) * | 2007-04-09 | 2010-02-12 | 세프라코 아이엔시. | 수면관련 호흡 장애를 치료하는 방법들 및 수면관련 호흡 장애 치료용 조성물들 |
| CZ2008756A3 (cs) * | 2008-11-27 | 2010-03-24 | Zentiva, A. S. | Zpusob prípravy desvenlafaxinu a jeho solí |
| CZ302145B6 (cs) * | 2009-07-15 | 2010-11-10 | Zentiva, K. S. | Zpusob prípravy desvenlafaxinu a jeho solí |
| CN102249936B (zh) * | 2010-05-19 | 2014-09-17 | 江苏豪森医药集团有限公司 | O-去甲基文拉法辛盐酸盐的水合物及其制备方法 |
| CA2773948A1 (en) * | 2011-04-12 | 2012-10-12 | Geo. Pfau's Sons Company, Inc. | Method for rendering animal materials |
| CN103772220A (zh) * | 2013-12-03 | 2014-05-07 | 镇江圣安医药有限公司 | 1-[2-二甲基氨基-1-(4-甲氧基苯基)乙基]环己醇的新型衍生物及其应用 |
| CN105348119B (zh) * | 2015-11-04 | 2017-09-15 | 江苏豪森药业集团有限公司 | 晶状的文拉法辛代谢物及其制备方法 |
| WO2018146529A1 (en) * | 2017-02-09 | 2018-08-16 | R L Finechem Private Limited | A process for preparation of1-[2-(dimethylamino)-1-(4-hydroxyphenyl) ethyl]-cyclohexanol and salts thereof |
| CN109771380A (zh) * | 2017-11-10 | 2019-05-21 | 连云港恒运药业有限公司 | 去甲文拉法辛盐酸盐药物组合物及其制备方法 |
| JP7315256B2 (ja) | 2018-12-05 | 2023-07-26 | ヘッジホッグ,インコーポレイテッド | エンドセリン受容体a活性調節抗体 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000076955A1 (en) * | 1999-06-15 | 2000-12-21 | American Home Products Corporation | Enantiomers of o-desmethyl venlafaxine |
| US6342533B1 (en) * | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
| WO2007005961A2 (en) * | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
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| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4535186A (en) | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5213738A (en) | 1990-05-15 | 1993-05-25 | L. Perrigo Company | Method for making a capsule-shaped tablet |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| BR0207157A (pt) * | 2001-02-12 | 2004-02-17 | Wyeth Corp | Sal de succinato de o-desmetil-venlafaxina |
| IL162255A0 (en) * | 2001-12-05 | 2005-11-20 | Wyeth Corp | Novel crystalline polymorph of venlafaxine hydrochloride and methods for the preparation thereof |
| NZ537142A (en) | 2002-06-10 | 2008-01-31 | Wyeth Corp | Novel formate salt of O-desmethyl-venlafaxine |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6342533B1 (en) * | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
| US20060199860A1 (en) * | 1998-12-01 | 2006-09-07 | Jerussi Thomas P | Salts of (-)-O-desmethylvenlafaxine |
| WO2000076955A1 (en) * | 1999-06-15 | 2000-12-21 | American Home Products Corporation | Enantiomers of o-desmethyl venlafaxine |
| WO2007005961A2 (en) * | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
Also Published As
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| KR20090113904A (ko) | 2009-11-02 |
| TW200901955A (en) | 2009-01-16 |
| JP2010519300A (ja) | 2010-06-03 |
| KR101528326B1 (ko) | 2015-06-11 |
| IL200514A (en) | 2013-12-31 |
| RU2477269C2 (ru) | 2013-03-10 |
| NZ579137A (en) | 2012-05-25 |
| EP2500337A3 (en) | 2012-12-26 |
| SG175611A1 (en) | 2011-11-28 |
| RU2009135016A (ru) | 2011-03-27 |
| US20160355457A1 (en) | 2016-12-08 |
| CA2678599A1 (en) | 2008-08-28 |
| US20090005457A1 (en) | 2009-01-01 |
| EP2500337A2 (en) | 2012-09-19 |
| MX2009008705A (es) | 2009-09-10 |
| AR065431A1 (es) | 2009-06-10 |
| CN101663263A (zh) | 2010-03-03 |
| BRPI0807604A2 (pt) | 2014-07-22 |
| ZA200905698B (en) | 2010-10-27 |
| AU2008218997A1 (en) | 2008-08-28 |
| WO2008103461A2 (en) | 2008-08-28 |
| JP5666140B2 (ja) | 2015-02-12 |
| CA2678599C (en) | 2015-11-10 |
| EP2114863A2 (en) | 2009-11-11 |
| ES2609264T3 (es) | 2017-04-19 |
| IL200514A0 (en) | 2010-04-29 |
| AU2008218997B2 (en) | 2013-06-20 |
| EP2114863B1 (en) | 2016-10-05 |
| WO2008103461A3 (en) | 2008-11-13 |
| NZ599480A (en) | 2013-10-25 |
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