JP5666140B2 - （−）−ｏ−デスメチルベンラファキシンを含む固形物およびそれらの使用 - Google Patents
（−）−ｏ−デスメチルベンラファキシンを含む固形物およびそれらの使用 Download PDFInfo
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- JP5666140B2 JP5666140B2 JP2009550930A JP2009550930A JP5666140B2 JP 5666140 B2 JP5666140 B2 JP 5666140B2 JP 2009550930 A JP2009550930 A JP 2009550930A JP 2009550930 A JP2009550930 A JP 2009550930A JP 5666140 B2 JP5666140 B2 JP 5666140B2
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- desmethylvenlafaxine
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- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
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- 230000008736 traumatic injury Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- HFFLGKNGCAIQMO-UHFFFAOYSA-N trichloroacetaldehyde Chemical compound ClC(Cl)(Cl)C=O HFFLGKNGCAIQMO-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- 210000003462 vein Anatomy 0.000 description 1
- 229960002416 venlafaxine hydrochloride Drugs 0.000 description 1
- 238000002460 vibrational spectroscopy Methods 0.000 description 1
- 238000001845 vibrational spectrum Methods 0.000 description 1
- NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 239000008136 water-miscible vehicle Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90295007P | 2007-02-21 | 2007-02-21 | |
| US60/902,950 | 2007-02-21 | ||
| PCT/US2008/002379 WO2008103461A2 (en) | 2007-02-21 | 2008-02-21 | Solid forms comprising (-) o-desmethylvenlafaxine and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010519300A JP2010519300A (ja) | 2010-06-03 |
| JP2010519300A5 JP2010519300A5 (enExample) | 2011-04-07 |
| JP5666140B2 true JP5666140B2 (ja) | 2015-02-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009550930A Expired - Fee Related JP5666140B2 (ja) | 2007-02-21 | 2008-02-21 | （−）−ｏ−デスメチルベンラファキシンを含む固形物およびそれらの使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20090005457A1 (enExample) |
| EP (2) | EP2114863B1 (enExample) |
| JP (1) | JP5666140B2 (enExample) |
| KR (1) | KR101528326B1 (enExample) |
| CN (1) | CN101663263A (enExample) |
| AR (1) | AR065431A1 (enExample) |
| AU (1) | AU2008218997B2 (enExample) |
| BR (1) | BRPI0807604A2 (enExample) |
| CA (1) | CA2678599C (enExample) |
| ES (1) | ES2609264T3 (enExample) |
| IL (1) | IL200514A (enExample) |
| MX (1) | MX2009008705A (enExample) |
| NZ (2) | NZ579137A (enExample) |
| RU (1) | RU2477269C2 (enExample) |
| SG (1) | SG175611A1 (enExample) |
| TW (1) | TWI446903B (enExample) |
| WO (1) | WO2008103461A2 (enExample) |
| ZA (1) | ZA200905698B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100015923A (ko) * | 2007-04-09 | 2010-02-12 | 세프라코 아이엔시. | 수면관련 호흡 장애를 치료하는 방법들 및 수면관련 호흡 장애 치료용 조성물들 |
| CZ2008756A3 (cs) * | 2008-11-27 | 2010-03-24 | Zentiva, A. S. | Zpusob prípravy desvenlafaxinu a jeho solí |
| CZ302145B6 (cs) * | 2009-07-15 | 2010-11-10 | Zentiva, K. S. | Zpusob prípravy desvenlafaxinu a jeho solí |
| CN102249936B (zh) * | 2010-05-19 | 2014-09-17 | 江苏豪森医药集团有限公司 | O-去甲基文拉法辛盐酸盐的水合物及其制备方法 |
| CA2773948A1 (en) * | 2011-04-12 | 2012-10-12 | Geo. Pfau's Sons Company, Inc. | Method for rendering animal materials |
| CN103772220A (zh) * | 2013-12-03 | 2014-05-07 | 镇江圣安医药有限公司 | 1-[2-二甲基氨基-1-（4-甲氧基苯基）乙基]环己醇的新型衍生物及其应用 |
| CN105348119B (zh) * | 2015-11-04 | 2017-09-15 | 江苏豪森药业集团有限公司 | 晶状的文拉法辛代谢物及其制备方法 |
| WO2018146529A1 (en) * | 2017-02-09 | 2018-08-16 | R L Finechem Private Limited | A process for preparation of1-[2-(dimethylamino)-1-(4-hydroxyphenyl) ethyl]-cyclohexanol and salts thereof |
| CN109771380A (zh) * | 2017-11-10 | 2019-05-21 | 连云港恒运药业有限公司 | 去甲文拉法辛盐酸盐药物组合物及其制备方法 |
| JP7315256B2 (ja) | 2018-12-05 | 2023-07-26 | ヘッジホッグ，インコーポレイテッド | エンドセリン受容体ａ活性調節抗体 |
| WO2021243351A2 (en) * | 2020-05-26 | 2021-12-02 | Mars, Incorporated | Process for preparing pet food and pet food obtainable thereby |
| CN116199590B (zh) * | 2022-12-26 | 2024-12-24 | 湖北美林药业有限公司 | 一种盐酸多巴酚丁胺及其注射剂 |
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| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4535186A (en) | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5213738A (en) | 1990-05-15 | 1993-05-25 | L. Perrigo Company | Method for making a capsule-shaped tablet |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| US6342533B1 (en) | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
| AU5738700A (en) * | 1999-06-15 | 2001-01-02 | American Home Products Corporation | Enantiomers of o-desmethyl venlafaxine |
| BR0207157A (pt) * | 2001-02-12 | 2004-02-17 | Wyeth Corp | Sal de succinato de o-desmetil-venlafaxina |
| IL162255A0 (en) * | 2001-12-05 | 2005-11-20 | Wyeth Corp | Novel crystalline polymorph of venlafaxine hydrochloride and methods for the preparation thereof |
| NZ537142A (en) | 2002-06-10 | 2008-01-31 | Wyeth Corp | Novel formate salt of O-desmethyl-venlafaxine |
| JP2009500420A (ja) * | 2005-07-06 | 2009-01-08 | セプラコア インコーポレーテッド | エスゾピクロン及びｏ−デスメチルベンラファキシンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法 |
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2008
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- 2008-02-21 CA CA2678599A patent/CA2678599C/en active Active
- 2008-02-21 NZ NZ579137A patent/NZ579137A/en not_active IP Right Cessation
- 2008-02-21 ZA ZA200905698A patent/ZA200905698B/xx unknown
- 2008-02-21 CN CN200880012483A patent/CN101663263A/zh active Pending
- 2008-02-21 TW TW097106132A patent/TWI446903B/zh not_active IP Right Cessation
- 2008-02-21 NZ NZ599480A patent/NZ599480A/xx not_active IP Right Cessation
- 2008-02-21 AU AU2008218997A patent/AU2008218997B2/en not_active Ceased
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- 2008-02-21 SG SG2011074085A patent/SG175611A1/en unknown
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- 2008-02-21 AR ARP080100726A patent/AR065431A1/es not_active Application Discontinuation
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- 2008-02-21 RU RU2009135016/04A patent/RU2477269C2/ru active
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- 2008-02-21 JP JP2009550930A patent/JP5666140B2/ja not_active Expired - Fee Related
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20090113904A (ko) | 2009-11-02 |
| TW200901955A (en) | 2009-01-16 |
| JP2010519300A (ja) | 2010-06-03 |
| KR101528326B1 (ko) | 2015-06-11 |
| IL200514A (en) | 2013-12-31 |
| RU2477269C2 (ru) | 2013-03-10 |
| NZ579137A (en) | 2012-05-25 |
| EP2500337A3 (en) | 2012-12-26 |
| SG175611A1 (en) | 2011-11-28 |
| RU2009135016A (ru) | 2011-03-27 |
| US20160355457A1 (en) | 2016-12-08 |
| CA2678599A1 (en) | 2008-08-28 |
| US20090005457A1 (en) | 2009-01-01 |
| EP2500337A2 (en) | 2012-09-19 |
| MX2009008705A (es) | 2009-09-10 |
| AR065431A1 (es) | 2009-06-10 |
| CN101663263A (zh) | 2010-03-03 |
| BRPI0807604A2 (pt) | 2014-07-22 |
| ZA200905698B (en) | 2010-10-27 |
| AU2008218997A1 (en) | 2008-08-28 |
| WO2008103461A2 (en) | 2008-08-28 |
| TWI446903B (zh) | 2014-08-01 |
| CA2678599C (en) | 2015-11-10 |
| EP2114863A2 (en) | 2009-11-11 |
| ES2609264T3 (es) | 2017-04-19 |
| IL200514A0 (en) | 2010-04-29 |
| AU2008218997B2 (en) | 2013-06-20 |
| EP2114863B1 (en) | 2016-10-05 |
| WO2008103461A3 (en) | 2008-11-13 |
| NZ599480A (en) | 2013-10-25 |
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