TWI392673B - 調控細胞內鈣離子濃度之化合物 - Google Patents

調控細胞內鈣離子濃度之化合物 Download PDF

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TWI392673B
TWI392673B TW098128758A TW98128758A TWI392673B TW I392673 B TWI392673 B TW I392673B TW 098128758 A TW098128758 A TW 098128758A TW 98128758 A TW98128758 A TW 98128758A TW I392673 B TWI392673 B TW I392673B
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Taiwan
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carbon
calcium
thiophene
carboxylic acid
compound
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TW098128758A
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Chinese (zh)
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TW201022256A (en
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Gonul Velicelebi
Kenneth A Stauderman
Jeffrey P Whitten
Yazhong Pei
Jianguo Cao
Zhijun Wang
Evan Rogers
Brian Dyck
Jonathan Grey
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Calcimedica Inc
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    • C07D491/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW098128758A 2008-08-27 2009-08-26 調控細胞內鈣離子濃度之化合物 TWI392673B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US9236408P 2008-08-27 2008-08-27
US14284609P 2009-01-06 2009-01-06
US14373909P 2009-01-09 2009-01-09
US15727409P 2009-03-04 2009-03-04
US15870209P 2009-03-09 2009-03-09
US15871009P 2009-03-09 2009-03-09

Publications (2)

Publication Number Publication Date
TW201022256A TW201022256A (en) 2010-06-16
TWI392673B true TWI392673B (zh) 2013-04-11

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US (7) US7906553B2 (https=)
EP (1) EP2321303B1 (https=)
JP (1) JP5782377B2 (https=)
KR (1) KR101724161B1 (https=)
CN (1) CN102256969A (https=)
AU (1) AU2009288245B2 (https=)
BR (1) BRPI0917719A2 (https=)
CA (1) CA2734500A1 (https=)
IL (1) IL211391B (https=)
MX (1) MX2011002149A (https=)
MY (1) MY157445A (https=)
RU (1) RU2472791C2 (https=)
TW (1) TWI392673B (https=)
WO (2) WO2010027875A2 (https=)
ZA (1) ZA201101335B (https=)

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US8263641B2 (en) 2007-09-10 2012-09-11 Calcimedica, Inc. Compounds that modulate intracellular calcium
TWI392673B (zh) * 2008-08-27 2013-04-11 Calcimedica Inc 調控細胞內鈣離子濃度之化合物
US8524763B2 (en) * 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
EP2477982A4 (en) * 2009-09-16 2013-04-03 Calcimedica Inc COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
US8993612B2 (en) 2009-10-08 2015-03-31 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
US8377970B2 (en) 2009-10-08 2013-02-19 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel
CN102574843B (zh) 2009-10-22 2015-06-17 法博太科制药有限公司 抗纤维化剂的稠环类似物
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
TWI504404B (zh) * 2010-07-22 2015-10-21 Univ Kaohsiung Medical 用於抑制結腸直腸癌細胞及子宮上皮癌細胞生長轉移之醫藥組合物
EP2609095A4 (en) * 2010-08-27 2014-06-18 Calcimedica Inc COMPOUNDS MODULATING INTRACELLULAR CALCIUM
EP2619200A4 (en) * 2010-09-22 2014-10-15 Calcimedica Inc COMPOUNDS AS MODULATORS OF INTRA CELLULAR CALCIUM
AU2011322068B2 (en) 2010-10-30 2015-11-05 Lupin Limited Oxazoline and isoxazoline derivatives as CRAC modulators
CA2871270A1 (en) 2012-05-02 2013-11-07 Lupin Limited Substituted pyridine compounds as crac modulators
WO2013164773A1 (en) 2012-05-02 2013-11-07 Lupin Limited Substituted pyrazole compounds as crac modulators
CN104395326B (zh) * 2012-08-20 2017-04-05 玛耐科股份有限公司 二取代硼酸衍生物的制造方法和新型二取代硼酸衍生物
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
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WO2014203217A1 (en) 2013-06-21 2014-12-24 Lupin Limited Substituted heterocyclic compounds as crac modulators
WO2014207648A1 (en) 2013-06-24 2014-12-31 Lupin Limited Chromane and chromene derivatives and their use as crac modulators
MX388871B (es) 2014-06-27 2025-03-20 Nogra Pharma Ltd Moduladores del receptor arilo y metodos para elaborar y usar los mismos.
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TWI735416B (zh) 2014-10-06 2021-08-11 美商維泰克斯製藥公司 囊腫纖維化症跨膜傳導調節蛋白之調節劑
EP3778595B1 (en) 2015-02-27 2021-08-25 Calcimedica, Inc. Pancreatitis treatment
CA2995094A1 (en) 2015-08-07 2017-02-16 Calcimedica, Inc. Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury
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TW201022256A (en) 2010-06-16
WO2010027875A3 (en) 2010-06-10
US8383670B2 (en) 2013-02-26
US20130231344A1 (en) 2013-09-05
US20130245025A1 (en) 2013-09-19
EP2321303B1 (en) 2019-11-27
AU2009288245B2 (en) 2012-12-20
BRPI0917719A2 (pt) 2019-11-19

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