TWI385165B - 經二取代之呔猬狀途徑拮抗劑 - Google Patents

經二取代之呔猬狀途徑拮抗劑 Download PDF

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Publication number
TWI385165B
TWI385165B TW099119158A TW99119158A TWI385165B TW I385165 B TWI385165 B TW I385165B TW 099119158 A TW099119158 A TW 099119158A TW 99119158 A TW99119158 A TW 99119158A TW I385165 B TWI385165 B TW I385165B
Authority
TW
Taiwan
Prior art keywords
cancer
methyl
pharmaceutically acceptable
acceptable salt
compound
Prior art date
Application number
TW099119158A
Other languages
English (en)
Chinese (zh)
Other versions
TW201113268A (en
Inventor
Philip Arthur Hipskind
Bharvin Kumar Patel
Takako Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of TW201113268A publication Critical patent/TW201113268A/zh
Application granted granted Critical
Publication of TWI385165B publication Critical patent/TWI385165B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
TW099119158A 2009-06-19 2010-06-11 經二取代之呔猬狀途徑拮抗劑 TWI385165B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21862809P 2009-06-19 2009-06-19

Publications (2)

Publication Number Publication Date
TW201113268A TW201113268A (en) 2011-04-16
TWI385165B true TWI385165B (zh) 2013-02-11

Family

ID=42332981

Family Applications (1)

Application Number Title Priority Date Filing Date
TW099119158A TWI385165B (zh) 2009-06-19 2010-06-11 經二取代之呔猬狀途徑拮抗劑

Country Status (36)

Country Link
US (2) US8273742B2 (e)
EP (1) EP2443104B1 (e)
JP (1) JP5596139B2 (e)
KR (1) KR101389165B1 (e)
CN (1) CN102459233B (e)
AR (1) AR077014A1 (e)
AU (1) AU2010260244B2 (e)
BR (1) BRPI1011601A2 (e)
CA (1) CA2764542C (e)
CL (1) CL2011003147A1 (e)
CO (1) CO6480932A2 (e)
CR (1) CR20110658A (e)
DK (1) DK2443104T3 (e)
DO (1) DOP2011000386A (e)
EA (1) EA019059B1 (e)
EC (1) ECSP11011541A (e)
ES (1) ES2409054T3 (e)
HK (1) HK1164872A1 (e)
HN (1) HN2011003139A (e)
HR (1) HRP20130408T1 (e)
IL (1) IL216599A (e)
JO (1) JO2931B1 (e)
MA (1) MA33363B1 (e)
MX (1) MX2011014029A (e)
MY (1) MY156667A (e)
NZ (1) NZ596882A (e)
PE (1) PE20121050A1 (e)
PL (1) PL2443104T3 (e)
PT (1) PT2443104E (e)
SG (1) SG177289A1 (e)
SI (1) SI2443104T1 (e)
TN (1) TN2011000627A1 (e)
TW (1) TWI385165B (e)
UA (1) UA106755C2 (e)
WO (1) WO2010147917A1 (e)
ZA (1) ZA201108587B (e)

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EA201071248A1 (ru) * 2008-04-29 2011-06-30 Эли Лилли Энд Компани Дизамещенные фталазиновые антагонисты пути hedgehog
BRPI0921437A2 (pt) * 2008-11-03 2018-10-30 Lilly Co Eli antagonistas da via do hedgehog á base de fitalazina dissubstituída
MX2011005177A (es) 2008-11-17 2011-05-30 Lilly Co Eli Antagonistas de la trayectoria hedgehog de piridazinas tetrasustituidas.
EP2358703B1 (en) * 2008-11-17 2013-12-25 Eli Lilly and Company Tetrasubstituted pyridazines hedgehog pathway antagonists
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
US9464079B2 (en) 2011-03-23 2016-10-11 Semorex Technologies Ltd. Treatment of proliferative disorders with a chemiluminescent agent
GB201309508D0 (en) * 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
GB201311953D0 (en) * 2013-07-03 2013-08-14 Redx Pharma Ltd Compounds
WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling
CN105017140B (zh) * 2014-04-28 2017-12-29 复旦大学 邻氨基苯甲酰胺化合物及其制备方法和用途
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
BR112017026103B1 (pt) 2015-06-04 2023-10-03 Sol-Gel Technologies Ltd Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos
WO2016196879A1 (en) * 2015-06-05 2016-12-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer
SG11201807965YA (en) 2016-03-15 2018-10-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors
CN106279114B (zh) * 2016-08-04 2019-01-29 东南大学 一种Taladegib的合成方法
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
CN106831718B (zh) * 2016-12-30 2019-05-07 上海科技大学 平滑受体配体及其应用
JP7323457B2 (ja) 2017-05-18 2023-08-08 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 肥満細胞疾患の処置のための方法及び医薬組成物
EP4173639A4 (en) 2020-06-26 2024-03-13 Raqualia Pharma Inc METHOD FOR SELECTING A CANCER PATIENT WITH EFFECT OF COMBINATION THERAPY WITH RETINOID AND CANCER TREATMENT
JP2023546536A (ja) * 2020-10-13 2023-11-02 エンデバー バイオメディシンズ， インコーポレイテッド 線維症を処置する方法

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TW200848414A (en) * 2007-03-15 2008-12-16 Novartis Ag Organic compounds and their uses
US20090048259A1 (en) * 2007-06-25 2009-02-19 Amgen Inc. Phthalazine compounds, compositions and methods of use

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NZ326354A (en) 1996-01-15 1999-05-28 Janssen Pharmaceutica Nv 3-(substituted-1-piperazinyl)-6-(substituted-1,2,4-thiadiazol-5 -yl)-pyridazine derivatives and medicaments
JP5067986B2 (ja) 1998-04-09 2012-11-07 ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用
JP2003501395A (ja) 1999-06-08 2003-01-14 ローランティス・リミテッド 治療的使用
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ATE404200T1 (de) * 2002-04-22 2008-08-15 Univ Johns Hopkins Med Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
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EA201071248A1 (ru) * 2008-04-29 2011-06-30 Эли Лилли Энд Компани Дизамещенные фталазиновые антагонисты пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
ES2433469T3 (es) * 2008-08-04 2013-12-11 Amgen Inc. Moduladores de la aurora cinasa y métodos de uso
BRPI0921437A2 (pt) 2008-11-03 2018-10-30 Lilly Co Eli antagonistas da via do hedgehog á base de fitalazina dissubstituída
EP2358703B1 (en) 2008-11-17 2013-12-25 Eli Lilly and Company Tetrasubstituted pyridazines hedgehog pathway antagonists
MX2011005177A (es) 2008-11-17 2011-05-30 Lilly Co Eli Antagonistas de la trayectoria hedgehog de piridazinas tetrasustituidas.
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2008028689A1 (en) * 2006-09-07 2008-03-13 Bayer Schering Pharma Aktiengesellschaft N-(1-phthalazin-1-ylpiperidin-4-yl)amides as ep2 receptor modulators
TW200848414A (en) * 2007-03-15 2008-12-16 Novartis Ag Organic compounds and their uses
US20090048259A1 (en) * 2007-06-25 2009-02-19 Amgen Inc. Phthalazine compounds, compositions and methods of use

Also Published As

Publication number Publication date
HK1164872A1 (en) 2012-09-28
CO6480932A2 (es) 2012-07-16
JO2931B1 (en) 2015-09-15
PE20121050A1 (es) 2012-08-09
IL216599A (en) 2015-09-24
CN102459233B (zh) 2014-07-02
TW201113268A (en) 2011-04-16
CA2764542C (en) 2013-09-10
US20120316174A1 (en) 2012-12-13
CN102459233A (zh) 2012-05-16
EA019059B1 (ru) 2013-12-30
PL2443104T3 (pl) 2013-08-30
CR20110658A (es) 2012-02-20
IL216599A0 (en) 2012-03-01
AR077014A1 (es) 2011-07-27
PT2443104E (pt) 2013-05-07
US20100324048A1 (en) 2010-12-23
ZA201108587B (en) 2013-05-29
HN2011003139A (es) 2013-07-29
BRPI1011601A2 (pt) 2016-03-22
DK2443104T3 (da) 2013-05-06
SI2443104T1 (sl) 2013-07-31
UA106755C2 (uk) 2014-10-10
TN2011000627A1 (en) 2013-05-24
DOP2011000386A (es) 2012-02-29
MX2011014029A (es) 2012-02-21
JP2012530705A (ja) 2012-12-06
HRP20130408T1 (en) 2013-06-30
ECSP11011541A (es) 2012-01-31
KR101389165B1 (ko) 2014-04-24
WO2010147917A1 (en) 2010-12-23
MA33363B1 (fr) 2012-06-01
AU2010260244A1 (en) 2012-01-19
CA2764542A1 (en) 2010-12-23
EP2443104B1 (en) 2013-04-17
MY156667A (en) 2016-03-15
NZ596882A (en) 2013-08-30
SG177289A1 (en) 2012-02-28
EP2443104A1 (en) 2012-04-25
JP5596139B2 (ja) 2014-09-24
ES2409054T3 (es) 2013-06-24
CL2011003147A1 (es) 2012-07-20
US8273742B2 (en) 2012-09-25
EA201270049A1 (ru) 2012-05-30
AU2010260244B2 (en) 2013-09-05
US9000023B2 (en) 2015-04-07
KR20120024783A (ko) 2012-03-14

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