WO2010147917A1 - Disubstituted phthalazine hedgehog pathway antagonists - Google Patents

Disubstituted phthalazine hedgehog pathway antagonists

Info

Publication number
WO2010147917A1
WO2010147917A1 PCT/US2010/038568 US2010038568W WO2010147917A1 WO 2010147917 A1 WO2010147917 A1 WO 2010147917A1 US 2010038568 W US2010038568 W US 2010038568W WO 2010147917 A1 WO2010147917 A1 WO 2010147917A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
cancer
methyl
yl
compound
cell
Prior art date
Application number
PCT/US2010/038568
Other languages
English (en)
French (fr)
Inventor
Philip Arthur Hipskind
Bharvin Kumar Patel
Wilson (Nee Takakuwa), Takako
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
PCT/US2010/038568 2009-06-19 2010-06-15 Disubstituted phthalazine hedgehog pathway antagonists WO2010147917A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US21862809 true 2009-06-19 2009-06-19
US61/218,628 2009-06-19

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN 201080027189 CN102459233B (zh) 2009-06-19 2010-06-15 二取代的酞嗪hedgehog途径拮抗剂
KR20117030157A KR101389165B1 (ko) 2009-06-19 2010-06-15 이치환된 프탈라진 헤지호그 (hedgehog) 경로 길항제
CA 2764542 CA2764542C (en) 2009-06-19 2010-06-15 Disubstituted phthalazine hedgehog pathway antagonists
JP2012516178A JP5596139B2 (ja) 2009-06-19 2010-06-15 二置換フタラジンヘッジホッグ経路アンタゴニスト
EP20100726756 EP2443104B1 (en) 2009-06-19 2010-06-15 Disubstituted phthalazine hedgehog pathway antagonists
DK10726756T DK2443104T3 (da) 2009-06-19 2010-06-15 Disubstituerede phthalazin-hedgehog-sti-antagonister
ES10726756T ES2409054T3 (es) 2009-06-19 2010-06-15 Antagonistas de la vía Hedgehog de ftalazina disubstituida

Publications (1)

Publication Number Publication Date
WO2010147917A1 true true WO2010147917A1 (en) 2010-12-23

Family

ID=42332981

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/038568 WO2010147917A1 (en) 2009-06-19 2010-06-15 Disubstituted phthalazine hedgehog pathway antagonists

Country Status (9)

Country Link
US (2) US8273742B2 (e)
EP (1) EP2443104B1 (e)
JP (1) JP5596139B2 (e)
KR (1) KR101389165B1 (e)
CN (1) CN102459233B (e)
CA (1) CA2764542C (e)
DK (1) DK2443104T3 (e)
ES (1) ES2409054T3 (e)
WO (1) WO2010147917A1 (e)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012127441A1 (en) 2011-03-23 2012-09-27 Semorex Technologies Ltd. Treatment of proliferative disorders with a chemiluminescent agent
WO2014191737A1 (en) * 2013-05-28 2014-12-04 Redx Pharma Limited Heterocyclic compounds as hedgehog signaling pathway inhibitors
WO2015001348A1 (en) * 2013-07-03 2015-01-08 Redx Pharma Limited Pyridazine derivatives as hedgehog pathway inhibitors
US9000023B2 (en) 2009-06-19 2015-04-07 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
WO2017157825A1 (en) 2016-03-15 2017-09-21 F. Hoffmann-La Roche Ag Combinations of lsd1 inhibitors for use in the treatment of solid tumors

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7981892B2 (en) * 2008-04-29 2011-07-19 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
JP2012507535A (ja) * 2008-11-03 2012-03-29 イーライ リリー アンド カンパニー 二置換フタラジンヘッジホッグ経路アンタゴニスト
CA2743483C (en) 2008-11-17 2014-03-11 Eli Lilly And Company Tetrasubstituted pyridazine hedgehog pathway antagonists
KR101335770B1 (ko) * 2008-11-17 2013-12-12 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
US9814703B2 (en) 2013-11-14 2017-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of BMP signaling
CN105017140B (zh) * 2014-04-28 2017-12-29 复旦大学 邻氨基苯甲酰胺化合物及其制备方法和用途
CN105985321A (zh) * 2015-02-11 2016-10-05 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985319A (zh) * 2015-02-11 2016-10-05 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320A (zh) * 2015-02-11 2016-10-05 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN106279114A (zh) * 2016-08-04 2017-01-04 东南大学 一种Taladegib的合成方法

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Publication number Priority date Publication date Assignee Title
WO2003088970A2 (en) * 2002-04-22 2003-10-30 Johns Hopkins University School Of Medicine Modulators of hedgehog signaling pathways, compositions and uses related thereto
WO2005033288A2 (en) 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
WO2008110611A1 (en) 2007-03-15 2008-09-18 Novartis Ag Organic compounds and their uses
WO2009002469A1 (en) 2007-06-25 2008-12-31 Amgen Inc. Phthalazine compounds, compositions and methods of use
WO2009134574A2 (en) * 2008-04-29 2009-11-05 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists

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JPS5538351B2 (e) * 1977-06-03 1980-10-03
CA2237273C (en) 1996-01-15 2009-01-13 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
JP5067986B2 (ja) 1998-04-09 2012-11-07 ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用
CA2376210A1 (en) 1999-06-08 2000-12-14 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
WO2003011219A3 (en) * 2001-07-27 2004-09-23 Curis Inc Mediators of hedgehog signaling pathways, compositions and uses related thereto
WO2004020599A3 (en) 2002-08-29 2006-12-28 Curis Inc Hedgehog antagonists, methods and uses related thereto
WO2005080378A1 (ja) 2004-02-24 2005-09-01 Mitsubishi Pharma Corporation 縮合ピリダジン誘導体
CN1984904A (zh) 2004-05-08 2007-06-20 神经能质公司 3-芳基-5,6-二取代哒嗪
CA2579002C (en) 2004-09-02 2012-11-27 Genentech, Inc. Pyridyl inhibitors of hedgehog signalling
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
ES2392157T3 (es) 2007-09-07 2012-12-05 Amgen Inc. Piridazinas anilladas para el tratamiento de tumores dirigidos por señalización Hedgehog inapropiada
JP5620821B2 (ja) * 2007-12-13 2014-11-05 シエナ ビオテク ソシエタ ペル アチオニSiena Biotech S.P.A. ヘッジホッグ経路拮抗薬およびその治療用途
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
CA2732101C (en) * 2008-08-04 2013-09-17 Amgen Inc. Aurora kinase modulators and methods of use
JP2012507535A (ja) 2008-11-03 2012-03-29 イーライ リリー アンド カンパニー 二置換フタラジンヘッジホッグ経路アンタゴニスト
CA2743483C (en) 2008-11-17 2014-03-11 Eli Lilly And Company Tetrasubstituted pyridazine hedgehog pathway antagonists
KR101335770B1 (ko) 2008-11-17 2013-12-12 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
JP5596139B2 (ja) 2009-06-19 2014-09-24 イーライ リリー アンド カンパニー 二置換フタラジンヘッジホッグ経路アンタゴニスト

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003088970A2 (en) * 2002-04-22 2003-10-30 Johns Hopkins University School Of Medicine Modulators of hedgehog signaling pathways, compositions and uses related thereto
WO2005033288A2 (en) 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
WO2008110611A1 (en) 2007-03-15 2008-09-18 Novartis Ag Organic compounds and their uses
WO2009002469A1 (en) 2007-06-25 2008-12-31 Amgen Inc. Phthalazine compounds, compositions and methods of use
WO2009134574A2 (en) * 2008-04-29 2009-11-05 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
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CAN. J. CHEM., vol. 43, 1965, pages 2708
S.M. BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, January 1977 (1977-01-01)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9000023B2 (en) 2009-06-19 2015-04-07 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
WO2012127441A1 (en) 2011-03-23 2012-09-27 Semorex Technologies Ltd. Treatment of proliferative disorders with a chemiluminescent agent
US9464079B2 (en) 2011-03-23 2016-10-11 Semorex Technologies Ltd. Treatment of proliferative disorders with a chemiluminescent agent
WO2014191736A1 (en) * 2013-05-28 2014-12-04 Redx Pharma Limited Heterocyclic compounds as hedgehog signaling pathway inhibitors
US20160113928A1 (en) * 2013-05-28 2016-04-28 Redx Pharma Plc Heterocyclic compounds as hedgehog signaling pathway inhibitors
WO2014191737A1 (en) * 2013-05-28 2014-12-04 Redx Pharma Limited Heterocyclic compounds as hedgehog signaling pathway inhibitors
US9579319B2 (en) 2013-05-28 2017-02-28 Redx Pharma Plc Heterocyclic compounds as hedgehog signaling pathway inhibitors
WO2015001348A1 (en) * 2013-07-03 2015-01-08 Redx Pharma Limited Pyridazine derivatives as hedgehog pathway inhibitors
GB2528298A (en) * 2014-07-16 2016-01-20 Redx Pharma Plc Compounds
WO2017157825A1 (en) 2016-03-15 2017-09-21 F. Hoffmann-La Roche Ag Combinations of lsd1 inhibitors for use in the treatment of solid tumors

Also Published As

Publication number Publication date Type
US8273742B2 (en) 2012-09-25 grant
EP2443104B1 (en) 2013-04-17 grant
KR101389165B1 (ko) 2014-04-24 grant
JP2012530705A (ja) 2012-12-06 application
EP2443104A1 (en) 2012-04-25 application
US9000023B2 (en) 2015-04-07 grant
US20100324048A1 (en) 2010-12-23 application
CN102459233A (zh) 2012-05-16 application
CA2764542A1 (en) 2010-12-23 application
ES2409054T3 (es) 2013-06-24 grant
US20120316174A1 (en) 2012-12-13 application
DK2443104T3 (da) 2013-05-06 grant
CA2764542C (en) 2013-09-10 grant
KR20120024783A (ko) 2012-03-14 application
JP5596139B2 (ja) 2014-09-24 grant
CN102459233B (zh) 2014-07-02 grant

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