TWI349663B - - Google Patents

Info

Publication number
TWI349663B
TWI349663B TW093126889A TW93126889A TWI349663B TW I349663 B TWI349663 B TW I349663B TW 093126889 A TW093126889 A TW 093126889A TW 93126889 A TW93126889 A TW 93126889A TW I349663 B TWI349663 B TW I349663B
Authority
TW
Taiwan
Prior art keywords
diffraction
cyanobenzenesulfonamide
indol
cyano
methyl
Prior art date
Application number
TW093126889A
Other languages
English (en)
Other versions
TW200514770A (en
Inventor
Keiko Takahashi
Kenji Hayashi
Taichi Abe
Takao Omae
Takashi Kato
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of TW200514770A publication Critical patent/TW200514770A/zh
Application granted granted Critical
Publication of TWI349663B publication Critical patent/TWI349663B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW093126889A 2003-09-10 2004-09-06 Crystal of sulfonamide-containing indole compound and process for producing the same TW200514770A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003318953 2003-09-10

Publications (2)

Publication Number Publication Date
TW200514770A TW200514770A (en) 2005-05-01
TWI349663B true TWI349663B (zh) 2011-10-01

Family

ID=34308544

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093126889A TW200514770A (en) 2003-09-10 2004-09-06 Crystal of sulfonamide-containing indole compound and process for producing the same

Country Status (25)

Country Link
US (2) US7754894B2 (zh)
EP (1) EP1666463B1 (zh)
JP (1) JP4435090B2 (zh)
KR (1) KR20060120644A (zh)
CN (2) CN101165049A (zh)
AT (1) ATE486849T1 (zh)
AU (1) AU2004272400B2 (zh)
BR (1) BRPI0414314A (zh)
CA (1) CA2536995C (zh)
CY (1) CY1110975T1 (zh)
DE (1) DE602004029907D1 (zh)
DK (1) DK1666463T3 (zh)
ES (1) ES2354286T3 (zh)
HK (1) HK1092796A1 (zh)
HR (1) HRP20100631T1 (zh)
IL (2) IL174059A0 (zh)
MX (1) MXPA06002732A (zh)
NO (1) NO335256B1 (zh)
NZ (1) NZ546111A (zh)
PL (1) PL1666463T3 (zh)
PT (1) PT1666463E (zh)
RU (1) RU2336269C2 (zh)
SI (1) SI1666463T1 (zh)
TW (1) TW200514770A (zh)
WO (1) WO2005026118A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004029907D1 (de) * 2003-09-10 2010-12-16 Eisai R&D Man Co Ltd Kristall einer sulfonamidhaltigen indolverbindung und verfahren zu dessen herstellung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3868534B2 (ja) * 1996-05-24 2007-01-17 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド誘導体の製造法および中間体
JP2000247949A (ja) * 1999-02-26 2000-09-12 Eisai Co Ltd スルホンアミド含有インドール化合物
JP4039856B2 (ja) * 2000-02-03 2008-01-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 インテグリン発現阻害剤
TWI283575B (en) * 2000-10-31 2007-07-11 Eisai Co Ltd Medicinal compositions for concomitant use as anticancer agent
DE602004029907D1 (de) * 2003-09-10 2010-12-16 Eisai R&D Man Co Ltd Kristall einer sulfonamidhaltigen indolverbindung und verfahren zu dessen herstellung

Also Published As

Publication number Publication date
EP1666463A4 (en) 2007-12-12
JPWO2005026118A1 (ja) 2007-11-08
AU2004272400A1 (en) 2005-03-24
SI1666463T1 (sl) 2011-02-28
MXPA06002732A (es) 2006-06-05
PT1666463E (pt) 2011-01-17
PL1666463T3 (pl) 2011-04-29
BRPI0414314A (pt) 2006-10-31
IL196569A0 (en) 2011-07-31
ATE486849T1 (de) 2010-11-15
CY1110975T1 (el) 2015-06-11
NZ546111A (en) 2008-11-28
KR20060120644A (ko) 2006-11-27
ES2354286T3 (es) 2011-03-11
US20090247768A1 (en) 2009-10-01
US20070082941A1 (en) 2007-04-12
HK1092796A1 (en) 2007-02-16
DK1666463T3 (da) 2010-12-20
CA2536995A1 (en) 2005-03-24
CN100406440C (zh) 2008-07-30
DE602004029907D1 (de) 2010-12-16
US7754894B2 (en) 2010-07-13
WO2005026118A1 (ja) 2005-03-24
CA2536995C (en) 2013-12-17
IL174059A0 (en) 2006-08-01
EP1666463B1 (en) 2010-11-03
HRP20100631T1 (hr) 2010-12-31
NO335256B1 (no) 2014-10-27
CN101165049A (zh) 2008-04-23
NO20061545L (no) 2006-06-09
AU2004272400B2 (en) 2010-03-04
RU2336269C2 (ru) 2008-10-20
CN1849305A (zh) 2006-10-18
EP1666463A1 (en) 2006-06-07
RU2006111454A (ru) 2006-08-27
TW200514770A (en) 2005-05-01
JP4435090B2 (ja) 2010-03-17

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees