TWI346660B - - Google Patents
Info
- Publication number
- TWI346660B TWI346660B TW094122578A TW94122578A TWI346660B TW I346660 B TWI346660 B TW I346660B TW 094122578 A TW094122578 A TW 094122578A TW 94122578 A TW94122578 A TW 94122578A TW I346660 B TWI346660 B TW I346660B
- Authority
- TW
- Taiwan
- Prior art keywords
- dihydropyridin
- cyanophenyl
- pyridyl
- phenyl
- production processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004198709 | 2004-07-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200606144A TW200606144A (en) | 2006-02-16 |
| TWI346660B true TWI346660B (zh) | 2011-08-11 |
Family
ID=35782900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094122578A TW200606144A (en) | 2004-07-06 | 2005-07-04 | Crystal of 1,2-dihydropyridine compound |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8304548B2 (zh) |
| EP (3) | EP2586771A3 (zh) |
| JP (3) | JPWO2006004107A1 (zh) |
| KR (2) | KR101187218B1 (zh) |
| CN (7) | CN104402807A (zh) |
| AT (1) | ATE547405T1 (zh) |
| AU (2) | AU2005258378B2 (zh) |
| BR (1) | BRPI0510254B8 (zh) |
| CA (2) | CA2570177C (zh) |
| CY (1) | CY1114313T1 (zh) |
| DK (1) | DK1764361T3 (zh) |
| ES (1) | ES2404697T3 (zh) |
| HK (2) | HK1102127A1 (zh) |
| HR (1) | HRP20130363T1 (zh) |
| IL (2) | IL180024A (zh) |
| JO (1) | JO2832B1 (zh) |
| ME (1) | ME01520B (zh) |
| MX (1) | MXPA06014458A (zh) |
| MY (1) | MY148809A (zh) |
| NO (1) | NO339101B1 (zh) |
| NZ (1) | NZ550720A (zh) |
| PL (2) | PL1772450T3 (zh) |
| PT (1) | PT1764361E (zh) |
| RS (1) | RS52752B (zh) |
| RU (1) | RU2323930C1 (zh) |
| SI (2) | SI1764361T1 (zh) |
| TW (1) | TW200606144A (zh) |
| WO (2) | WO2006004100A1 (zh) |
| ZA (1) | ZA200609274B (zh) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2545813C (en) | 2003-11-14 | 2011-01-04 | Shanghai Genomics, Inc. | The derivatives of pyridone and use thereof |
| RS51822B (en) * | 2005-04-04 | 2012-02-29 | Eisai R. &D. Management Co. Ltd. | DIHYDROPYRIDINE COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES AND Dementia |
| JP2008544743A (ja) | 2005-05-10 | 2008-12-11 | インターミューン インコーポレイテッド | ストレス活性化蛋白質キナーゼ系をモジュレートするためのピリドン誘導体 |
| EP1970370A4 (en) * | 2005-12-21 | 2010-11-10 | Eisai R&D Man Co Ltd | AMORPHOUS FORM OF 1,2-DIHYDROPYRIDINE COMPOUND |
| WO2007072868A1 (ja) * | 2005-12-21 | 2007-06-28 | Eisai R & D Management Co., Ltd. | １，２－ジヒドロピリジン化合物の結晶（ｉｖ型） |
| WO2007126060A1 (ja) | 2006-04-28 | 2007-11-08 | Eisai R & D Management Co., Ltd | １，２－ジヒドロピリジン化合物の塩 |
| EA016054B1 (ru) | 2006-06-16 | 2012-01-30 | Х. Лундбекк А/С | Кристаллические формы 4-[2-(4-метилфенилсульфанил)фенил] пиперидина с объединенным ингибированием повторного поглощения серотонина и норадреналина для лечения невропатической боли |
| JP2010520154A (ja) * | 2007-03-05 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経変性疾患のためのａｍｐａレセプターアンタゴニストおよびｎｍｄａレセプターアンタゴニスト |
| EP2132155A4 (en) * | 2007-03-29 | 2010-05-05 | Agency Science Tech & Res | PROCESS FOR PRODUCING OPTICALLY ACTIVE CYANOHYDRIN DERIVATIVE |
| EP2148673A1 (en) * | 2007-04-26 | 2010-02-03 | Eisai R&D Management Co., Ltd. | Cinnamide compounds for dementia |
| CA2690110A1 (en) * | 2007-07-13 | 2009-01-22 | Eisai R&D Management Co., Ltd. | Ampa receptor antagonists for neuropathic pain |
| EP2164487A1 (en) * | 2007-07-13 | 2010-03-24 | Eisai R&D Management Co., Ltd. | Ampa receptor antagonists and zonisamide for neuropathic pain |
| JP2010533127A (ja) * | 2007-07-13 | 2010-10-21 | コミッサリア ア レネルジー アトミーク エ オ ゼネルジ ザルタナテイヴ | 神経因性疼痛のためのａｍｐａ受容体アンタゴニストおよびアルドースレダクターゼ阻害剤 |
| WO2009054544A1 (en) * | 2007-10-26 | 2009-04-30 | Eisai R & D Management Co., Ltd. | Ampa receptor antagonists for parkinson's disease and movement disorders |
| JP5627574B2 (ja) | 2008-06-03 | 2014-11-19 | インターミューン， インコーポレイテッド | 炎症性および線維性疾患を治療するための化合物および方法 |
| SG10201400957UA (en) | 2009-03-25 | 2014-09-26 | Abbott Lab | Antiviral Compounds And Uses Thereof |
| ITMI20111952A1 (it) | 2011-10-27 | 2013-04-28 | Italiana Sint Spa | Procedimento per la prepazione di 2-metossi-5-(piridin-2-il)piridina, un intermedio del perampanel |
| WO2013102897A1 (en) * | 2012-01-03 | 2013-07-11 | Mapi Pharma Ltd. | Polymorphs of perampanel |
| ITMI20121390A1 (it) | 2012-08-06 | 2014-02-07 | F I S Fabbrica Italiana Sint P A | Procedimento per la preparazione di acido 2-cianofenilboronico e suoi esteri, intermedi del perampanel o di e2040 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EA031384B1 (ru) | 2013-07-25 | 2018-12-28 | Тева Фармасьютикалз Интернэшнл Гмбх | Улучшенные способы получения перампанеля |
| CN104649962A (zh) * | 2013-11-25 | 2015-05-27 | 天津市汉康医药生物技术有限公司 | 吡仑帕奈倍半水合物化合物 |
| CN103664756A (zh) * | 2013-11-26 | 2014-03-26 | 苏州晶云药物科技有限公司 | 吡仑帕奈新晶型a及其制备方法 |
| CN104706604A (zh) * | 2013-12-12 | 2015-06-17 | 北京星昊医药股份有限公司 | 一种吡仑帕奈冻干口崩片及其制备方法 |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| CN105085382B (zh) * | 2014-05-14 | 2019-10-18 | 江苏豪森药业集团有限公司 | 吡仑帕奈异构体晶型及其制备方法和用途 |
| CN103980188B (zh) * | 2014-05-30 | 2016-01-27 | 浙江永宁药业股份有限公司 | 一种吡仑帕奈的合成方法及其中间体和中间体的合成方法 |
| EP3259262A4 (en) | 2015-02-17 | 2018-08-01 | Mapi Pharma Limited | Process and intermediates for the preparation of perampanel |
| WO2016147104A1 (en) * | 2015-03-14 | 2016-09-22 | Intas Pharmaceuticals Ltd. | Novel process for the preparation of perampanel and its intermediates thereof |
| WO2016172333A1 (en) * | 2015-04-21 | 2016-10-27 | Teva Pharmaceuticals International Gmbh | A solid state form of perampanel |
| CN105287411A (zh) * | 2015-09-22 | 2016-02-03 | 美吉斯制药（厦门）有限公司 | 一种吡仑帕奈分散片及其制备方法 |
| CN105906557A (zh) * | 2016-03-30 | 2016-08-31 | 北京万全德众医药生物技术有限公司 | 2-甲氧基-5-（吡啶-2-基）吡啶的一种合成方法 |
| CN106389367B (zh) * | 2016-11-16 | 2020-12-18 | 杭州朱养心药业有限公司 | 吡仑帕奈包衣片剂药物组合物 |
| CN110028442B (zh) * | 2018-01-11 | 2020-07-17 | 新发药业有限公司 | 一种吡仑帕奈的简便制备方法 |
| SG11202007200YA (en) | 2018-03-20 | 2020-08-28 | Eisai R&D Man Co Ltd | Epilepsy treatment agent |
| EP3560934A1 (en) | 2018-04-26 | 2019-10-30 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of pure 2-cyanophenylboronic acid and esters thereof, intermediates of perampanel or of e2040 |
| AU2019395288A1 (en) * | 2018-12-14 | 2021-09-23 | Eisai R&D Management Co., Ltd. | Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds |
| KR102392825B1 (ko) | 2020-02-18 | 2022-04-29 | 명인제약주식회사 | 2-(2-옥소-1-페닐-5-피리딘-2-일피리딘-3-일)벤조니트릴과 ｌ-말릭산의 공결정 화합물 및 이의 제조 방법 |
| WO2021240540A1 (en) | 2020-05-26 | 2021-12-02 | Celagenex Research (India) Pvt. Ltd. | Novel synergistic nutritional compositions for treating seizures and chronic inflammatory diseases |
| GR1010285B (el) * | 2021-05-31 | 2022-08-24 | Elpen Αε Φαρμακευτικη Βιομηχανια, | Στερεες φαρμακοτεχνικες μορφες περαμπανελης |
| CN115745876A (zh) * | 2022-11-01 | 2023-03-07 | 南京海纳医药科技股份有限公司 | 一种吡仑帕奈的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5283761A (en) | 1976-01-01 | 1977-07-12 | Yamanouchi Pharmaceut Co Ltd | Novel pyridone derivative |
| JPS5531072A (en) | 1979-07-30 | 1980-03-05 | Rikagaku Kenkyusho | Preparation of 2-pyridone compound |
| IL109397A0 (en) | 1993-04-28 | 1994-07-31 | Schering Ag | Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| HU219777B (hu) | 1993-07-02 | 2001-07-30 | Gyógyszerkutató Intézet Kft. | Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására |
| ATE209644T1 (de) | 1994-09-27 | 2001-12-15 | Yamanouchi Pharma Co Ltd | 1,2,3,4-tetrahydroquinoxalindion derivate und ihre verwendung als glutamat rezeptor antagonisten |
| CN1188401C (zh) | 1995-04-27 | 2005-02-09 | 三菱制药株式会社 | 杂环类酰胺化合物及其医药用途 |
| AU1050597A (en) | 1995-11-15 | 1997-06-05 | California Institute Of Technology | Synthesis of zeolites by hydrothermal reaction of zeolite p1 |
| DE19604920A1 (de) | 1996-02-01 | 1997-08-07 | Schering Ag | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
| US5891871A (en) | 1996-03-21 | 1999-04-06 | Cocensys, Inc. | Substituted 2,3-benzodiazepin-4-ones and the use thereof |
| HU9600871D0 (en) | 1996-04-04 | 1996-05-28 | Gyogyszerkutato Intezet | New 2,3-benzodiazepine derivatives |
| JP3241388B2 (ja) | 1996-05-15 | 2001-12-25 | ファイザー・インク | 新規２，３二置換―４（３ｈ）―キナゾリノン |
| DE19643037A1 (de) | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| AU744028B2 (en) | 1997-02-28 | 2002-02-14 | Pfizer Products Inc. | Atropisomers of 3-aryl-4(3H)-quinazolinones and their use as ampa-receptor antagonists |
| GB9708945D0 (en) | 1997-05-01 | 1997-06-25 | Merck Sharp & Dohme | Therapeutic agents |
| GB9711753D0 (en) | 1997-06-06 | 1997-08-06 | Merck Sharp & Dohme | Therapeutic agents |
| JP4321737B2 (ja) | 1997-12-17 | 2009-08-26 | 塩野義製薬株式会社 | 新規ピリジン化合物 |
| JP2002519373A (ja) | 1998-07-02 | 2002-07-02 | エーザイ株式会社 | 製薬組成物及びそれらの使用 |
| DE19835918A1 (de) | 1998-08-07 | 2000-02-10 | Dresden Arzneimittel | Neue antikonvulsiv wirkende 4-Amino-1-aryl-pyridin-2-one und Verfahren zu deren Herstellung |
| KR100850728B1 (ko) * | 2000-06-12 | 2008-08-06 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 1,2-디하이드로피리딘 화합물, 그의 제조 방법 및 그의 용도 |
| GB0129260D0 (en) * | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| JP4208512B2 (ja) | 2002-07-23 | 2009-01-14 | 株式会社クラレ | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
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2005
- 2005-06-03 MY MYPI20052537A patent/MY148809A/en unknown
- 2005-07-04 TW TW094122578A patent/TW200606144A/zh unknown
- 2005-07-04 JO JO200597A patent/JO2832B1/en active
- 2005-07-05 CN CN201410561671.5A patent/CN104402807A/zh active Pending
- 2005-07-05 PL PL05758231T patent/PL1772450T3/pl unknown
- 2005-07-05 NZ NZ550720A patent/NZ550720A/en unknown
- 2005-07-05 CN CN201110261753.4A patent/CN102382047B/zh active Active
- 2005-07-05 WO PCT/JP2005/012364 patent/WO2006004100A1/ja not_active Application Discontinuation
- 2005-07-05 KR KR1020067027447A patent/KR101187218B1/ko active Protection Beyond IP Right Term
- 2005-07-05 EP EP13152837.4A patent/EP2586771A3/en not_active Withdrawn
- 2005-07-05 CN CN2005800115659A patent/CN1942443B/zh active Active
- 2005-07-05 CN CN2009101385759A patent/CN101544599B/zh active Active
- 2005-07-05 RS RS20130164A patent/RS52752B/en unknown
- 2005-07-05 EP EP05758231A patent/EP1772450B1/en active Active
- 2005-07-05 ME MEP-2013-40A patent/ME01520B/me unknown
- 2005-07-05 BR BRPI0510254A patent/BRPI0510254B8/pt active IP Right Grant
- 2005-07-05 DK DK05758232.2T patent/DK1764361T3/da active
- 2005-07-05 CN CN2010102462261A patent/CN101914057B/zh active Active
- 2005-07-05 MX MXPA06014458A patent/MXPA06014458A/es active IP Right Grant
- 2005-07-05 RU RU2007104342/04A patent/RU2323930C1/ru active Protection Beyond IP Right Term
- 2005-07-05 JP JP2006528904A patent/JPWO2006004107A1/ja active Pending
- 2005-07-05 KR KR1020067020395A patent/KR100939743B1/ko active Protection Beyond IP Right Term
- 2005-07-05 EP EP05758232A patent/EP1764361B1/en active Active
- 2005-07-05 PT PT57582322T patent/PT1764361E/pt unknown
- 2005-07-05 SI SI200531716T patent/SI1764361T1/sl unknown
- 2005-07-05 SI SI200531518T patent/SI1772450T1/sl unknown
- 2005-07-05 PL PL05758232T patent/PL1764361T3/pl unknown
- 2005-07-05 CA CA2570177A patent/CA2570177C/en active Active
- 2005-07-05 WO PCT/JP2005/012388 patent/WO2006004107A1/ja active Application Filing
- 2005-07-05 CA CA002561829A patent/CA2561829C/en active Active
- 2005-07-05 AU AU2005258378A patent/AU2005258378B2/en active Active
- 2005-07-05 CN CN201410561673.4A patent/CN104402808A/zh active Pending
- 2005-07-05 CN CNA2005800230712A patent/CN1984890A/zh active Pending
- 2005-07-05 JP JP2006528897A patent/JP5030206B2/ja active Active
- 2005-07-05 AT AT05758231T patent/ATE547405T1/de active
- 2005-07-05 AU AU2005258385A patent/AU2005258385B2/en active Active
- 2005-07-05 ES ES05758232T patent/ES2404697T3/es active Active
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2006
- 2006-11-07 ZA ZA200609274A patent/ZA200609274B/en unknown
- 2006-12-12 IL IL180024A patent/IL180024A/en active IP Right Grant
- 2006-12-13 NO NO20065754A patent/NO339101B1/no unknown
- 2006-12-18 IL IL180151A patent/IL180151A/en active IP Right Grant
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2007
- 2007-01-04 US US11/649,299 patent/US8304548B2/en active Active
- 2007-09-18 HK HK07110127.8A patent/HK1102127A1/xx unknown
- 2007-09-20 HK HK07110255.2A patent/HK1104999A1/xx unknown
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2010
- 2010-08-27 US US12/870,507 patent/US8772497B2/en active Active
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2011
- 2011-10-12 JP JP2011224926A patent/JP5419944B2/ja active Active
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2013
- 2013-04-25 HR HRP20130363TT patent/HRP20130363T1/hr unknown
- 2013-04-29 CY CY20131100350T patent/CY1114313T1/el unknown
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2014
- 2014-01-27 US US14/165,365 patent/US9045426B2/en active Active
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