TWI331605B - A process for the preparation of racemic citalopram diol and/or s- or r-citalopram diols and the use of such diols for the preparation of racemic citalopram, r-citalopram and/or s-citalopram - Google Patents

A process for the preparation of racemic citalopram diol and/or s- or r-citalopram diols and the use of such diols for the preparation of racemic citalopram, r-citalopram and/or s-citalopram Download PDF

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Publication number
TWI331605B
TWI331605B TW092135925A TW92135925A TWI331605B TW I331605 B TWI331605 B TW I331605B TW 092135925 A TW092135925 A TW 092135925A TW 92135925 A TW92135925 A TW 92135925A TW I331605 B TWI331605 B TW I331605B
Authority
TW
Taiwan
Prior art keywords
diol
acid addition
addition salt
free base
residue
Prior art date
Application number
TW092135925A
Other languages
English (en)
Chinese (zh)
Other versions
TW200512202A (en
Inventor
Hans Petersen
Robert Dancer
Brian Christiansen
Rikke Eva Humble
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of TW200512202A publication Critical patent/TW200512202A/zh
Application granted granted Critical
Publication of TWI331605B publication Critical patent/TWI331605B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW092135925A 2002-12-23 2003-12-18 A process for the preparation of racemic citalopram diol and/or s- or r-citalopram diols and the use of such diols for the preparation of racemic citalopram, r-citalopram and/or s-citalopram TWI331605B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200202004 2002-12-23

Publications (2)

Publication Number Publication Date
TW200512202A TW200512202A (en) 2005-04-01
TWI331605B true TWI331605B (en) 2010-10-11

Family

ID=35423357

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092135925A TWI331605B (en) 2002-12-23 2003-12-18 A process for the preparation of racemic citalopram diol and/or s- or r-citalopram diols and the use of such diols for the preparation of racemic citalopram, r-citalopram and/or s-citalopram

Country Status (17)

Country Link
KR (1) KR101076640B1 (sl)
CN (1) CN100334071C (sl)
AR (1) AR042655A1 (sl)
BR (1) BR0317629A (sl)
DK (1) DK1581483T3 (sl)
EA (1) EA009061B1 (sl)
ES (1) ES2385975T3 (sl)
ME (1) MEP5708A (sl)
MY (1) MY142404A (sl)
PE (1) PE20050065A1 (sl)
PT (1) PT1581483E (sl)
RS (1) RS52152B (sl)
SI (1) SI1581483T1 (sl)
TW (1) TWI331605B (sl)
UA (1) UA84859C2 (sl)
UY (1) UY28146A1 (sl)
ZA (1) ZA200504715B (sl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA95199U (uk) 2014-07-09 2014-12-10 Дозатор з точним дозуванням для сипучих продуктів
CN110590602B (zh) * 2019-09-25 2022-04-05 浙江海森药业股份有限公司 外消旋西酞普兰二醇的拆分精制方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram

Also Published As

Publication number Publication date
ME00034B (me) 2010-02-10
UY28146A1 (es) 2004-07-30
MY142404A (en) 2010-11-30
RS52152B (sr) 2012-08-31
DK1581483T3 (da) 2012-07-23
CN1729164A (zh) 2006-02-01
EA200501042A1 (ru) 2005-12-29
PE20050065A1 (es) 2005-02-18
KR20050093801A (ko) 2005-09-23
MEP5708A (xx) 2010-02-10
PT1581483E (pt) 2012-07-24
KR101076640B1 (ko) 2011-10-27
BR0317629A (pt) 2005-11-29
RS20050488A (en) 2007-06-04
SI1581483T1 (sl) 2012-09-28
ES2385975T3 (es) 2012-08-06
AR042655A1 (es) 2005-06-29
EA009061B1 (ru) 2007-10-26
CN100334071C (zh) 2007-08-29
TW200512202A (en) 2005-04-01
UA84859C2 (ru) 2008-12-10
ZA200504715B (en) 2006-08-30

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