MY142404A - A process for the preparation of racemic citalopram diol and/or s- or r- citalopram diols and the use of such diols for the preparation of racemic citalopram, ricitalopram and/or s-citalopram - Google Patents
A process for the preparation of racemic citalopram diol and/or s- or r- citalopram diols and the use of such diols for the preparation of racemic citalopram, ricitalopram and/or s-citalopramInfo
- Publication number
- MY142404A MY142404A MYPI20034948A MYPI20034948A MY142404A MY 142404 A MY142404 A MY 142404A MY PI20034948 A MYPI20034948 A MY PI20034948A MY PI20034948 A MYPI20034948 A MY PI20034948A MY 142404 A MY142404 A MY 142404A
- Authority
- MY
- Malaysia
- Prior art keywords
- diol
- acid addition
- free base
- addition salt
- citalopram
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
THE PRESENT INVENTION RELATES TO A PROCESS FOR THE PREPARATION OF CERAMIC DIOL FREE BASE AND/OR ACID ADDITION SALT AND/OR R- OR S-DIOL FREE BASE AND/OR ACID ADDITION SALT COMPRISING A SEPARATION OF AN INITIAL NON-CERAMIC MIXTURE OF R-AND S-DIOL FREE BASE AND/OR ACID ADDITION SALT WITH MORE THAN 50OF ONE OF THE ENANTIOMERS INTO A FRACTION BEING ENRICHED WITH S-DIOL OF R-DIOL FREE BASE AND/OR ACID ADDITION SALT AND A FRACTION COMPRISING RS-DIOL FREE BASE AND/OR ACID ADDITION SALT WHEREIN THE RATIO OF R-DIOL:S-DIOL IS EQUAL TO 1:1 THAN IN THE INITIAL MIXTURE OF R- AND S-DIOL CHARACTERIZED IN THAT @i) RS-DIOL FREE BASE AND/OR ACID ADDITION SALT IS PRECIPITATED FROM A SOLUTION OF THE INITIAL NON-RACEMIC MIXTURE OF R- AND S-DIOL FREE BASE AND/OR ACID ADDITION SALT; OR @ R- OR S-DIOL FREE BASE AND/OR ACID ADDITION SALT IS DISSOLVED INTO A @ SOLVENT FROM THE INITIAL NON-RACEMIC MIXTURE OF R- AND S-DIOL FREE BASE AND/OR ACID ADDITION SALT IN SAID SOLVENT, LEAVING A RESIDUE COMPRISING RS-DIOL FREE BASE AND/OR ACID ADDITION SALT;@ii) THE RESIDUE/PRECIPITATE FORMED IS SEPARATED FROM THE FINAL SOLUTION PHASE;@iia) IF THE RESIDUE/PRECIPITATE IS CRYSTALLINE IT IS OPTIONALLE RECRYSTALLISED ONE OR MORE TIMES TO FORM RACEMIC DIOL;@iib) IF THE RESIDUE/PRECIPITATE IS NOT CRYSTALLINE, STEPS i) AND ii) ARE OPTIONALLY REPREATED UNTIL A CRYSTALLINE RESIDUE/PRECIPITATE IS OBTAINED AND THE CRYSTALLINE RESIDUE/PRECIPITATE IS OPTIONALLY RECRYSTALLINE ONE OR MORE TIMES TO FORM RECEMIC DIOL;@iii) THE FINAL SOLUTION PHASE IS OPTIONALLY SUBJECTED TO FURTHER PURIFICATION AND S-DIOL OR R-DIOL FREE BASE AND/OR ACID ADDITION SALT IS ISOLATED FROM THE FINAL SOLUTION PHASE;@THE FREE BASES OF THE DIOLS OBTAINED ARE OPTIONALLY CONVERTED TO ACID ADDITION SALTS THEREOF OR ACID ADDITION SALTS OF THE DIOLS OBTAINED ARE OPTIONALLY CONVERTED TO OTHER ACID ADDITION SALTS OR ACID ADDITION SALTS OF THE DIOLS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200202004 | 2002-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
MY142404A true MY142404A (en) | 2010-11-30 |
Family
ID=35423357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI20034948A MY142404A (en) | 2002-12-23 | 2003-12-22 | A process for the preparation of racemic citalopram diol and/or s- or r- citalopram diols and the use of such diols for the preparation of racemic citalopram, ricitalopram and/or s-citalopram |
Country Status (17)
Country | Link |
---|---|
KR (1) | KR101076640B1 (en) |
CN (1) | CN100334071C (en) |
AR (1) | AR042655A1 (en) |
BR (1) | BR0317629A (en) |
DK (1) | DK1581483T3 (en) |
EA (1) | EA009061B1 (en) |
ES (1) | ES2385975T3 (en) |
ME (1) | MEP5708A (en) |
MY (1) | MY142404A (en) |
PE (1) | PE20050065A1 (en) |
PT (1) | PT1581483E (en) |
RS (1) | RS52152B (en) |
SI (1) | SI1581483T1 (en) |
TW (1) | TWI331605B (en) |
UA (1) | UA84859C2 (en) |
UY (1) | UY28146A1 (en) |
ZA (1) | ZA200504715B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA95199U (en) | 2014-07-09 | 2014-12-10 | PRECISION DISPOSER WITH ACCURATE DOSAGE FOR Bulk Products | |
CN110590602B (en) * | 2019-09-25 | 2022-04-05 | 浙江海森药业股份有限公司 | Resolution refining method of racemic citalopram diol |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
AR034612A1 (en) * | 2001-06-25 | 2004-03-03 | Lundbeck & Co As H | PROCESS FOR THE PREPARATION OF RACEMIC CITALOPRAM AND / OR OF THE S- OR R-CITALOPRAM THROUGH THE SEPARATION OF A MIXING OF R- AND S-CITALOPRAM |
-
2003
- 2003-12-18 RS YU20050488A patent/RS52152B/en unknown
- 2003-12-18 DK DK03767476.9T patent/DK1581483T3/en active
- 2003-12-18 BR BR0317629-0A patent/BR0317629A/en not_active Application Discontinuation
- 2003-12-18 EA EA200501042A patent/EA009061B1/en not_active IP Right Cessation
- 2003-12-18 KR KR1020057011898A patent/KR101076640B1/en not_active IP Right Cessation
- 2003-12-18 ES ES03767476T patent/ES2385975T3/en not_active Expired - Lifetime
- 2003-12-18 PT PT03767476T patent/PT1581483E/en unknown
- 2003-12-18 SI SI200332174T patent/SI1581483T1/en unknown
- 2003-12-18 TW TW092135925A patent/TWI331605B/en not_active IP Right Cessation
- 2003-12-18 UA UAA200506921A patent/UA84859C2/en unknown
- 2003-12-18 CN CNB200380107283XA patent/CN100334071C/en not_active Expired - Lifetime
- 2003-12-18 ME MEP-57/08A patent/MEP5708A/en unknown
- 2003-12-22 MY MYPI20034948A patent/MY142404A/en unknown
- 2003-12-22 UY UY28146A patent/UY28146A1/en not_active Application Discontinuation
- 2003-12-22 AR ARP030104781A patent/AR042655A1/en unknown
-
2004
- 2004-01-05 PE PE2004000033A patent/PE20050065A1/en not_active Application Discontinuation
-
2005
- 2005-06-09 ZA ZA200504715A patent/ZA200504715B/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW200512202A (en) | 2005-04-01 |
KR20050093801A (en) | 2005-09-23 |
DK1581483T3 (en) | 2012-07-23 |
UY28146A1 (en) | 2004-07-30 |
EA009061B1 (en) | 2007-10-26 |
UA84859C2 (en) | 2008-12-10 |
CN1729164A (en) | 2006-02-01 |
ME00034B (en) | 2010-02-10 |
KR101076640B1 (en) | 2011-10-27 |
BR0317629A (en) | 2005-11-29 |
PT1581483E (en) | 2012-07-24 |
MEP5708A (en) | 2010-02-10 |
EA200501042A1 (en) | 2005-12-29 |
AR042655A1 (en) | 2005-06-29 |
CN100334071C (en) | 2007-08-29 |
RS52152B (en) | 2012-08-31 |
SI1581483T1 (en) | 2012-09-28 |
ES2385975T3 (en) | 2012-08-06 |
TWI331605B (en) | 2010-10-11 |
RS20050488A (en) | 2007-06-04 |
PE20050065A1 (en) | 2005-02-18 |
ZA200504715B (en) | 2006-08-30 |
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