TWI309645B - Pyrazoles - Google Patents
Pyrazoles Download PDFInfo
- Publication number
- TWI309645B TWI309645B TW095111719A TW95111719A TWI309645B TW I309645 B TWI309645 B TW I309645B TW 095111719 A TW095111719 A TW 095111719A TW 95111719 A TW95111719 A TW 95111719A TW I309645 B TWI309645 B TW I309645B
- Authority
- TW
- Taiwan
- Prior art keywords
- methyl
- phenyl
- octahydro
- methanone
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66836705P | 2005-04-05 | 2005-04-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200643013A TW200643013A (en) | 2006-12-16 |
| TWI309645B true TWI309645B (en) | 2009-05-11 |
Family
ID=36514279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095111719A TWI309645B (en) | 2005-04-05 | 2006-04-03 | Pyrazoles |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7345058B2 (de) |
| EP (1) | EP1928840B1 (de) |
| JP (1) | JP4880671B2 (de) |
| KR (1) | KR100931411B1 (de) |
| CN (1) | CN101155783B (de) |
| AR (1) | AR053203A1 (de) |
| AT (1) | ATE519744T1 (de) |
| AU (1) | AU2006232660B2 (de) |
| BR (1) | BRPI0610459A2 (de) |
| CA (1) | CA2602781C (de) |
| DK (1) | DK1928840T3 (de) |
| ES (1) | ES2369389T3 (de) |
| IL (1) | IL186118A0 (de) |
| MX (1) | MX2007012212A (de) |
| NO (1) | NO20074872L (de) |
| PL (1) | PL1928840T3 (de) |
| PT (1) | PT1928840E (de) |
| RU (1) | RU2381217C2 (de) |
| TW (1) | TWI309645B (de) |
| WO (1) | WO2006106052A1 (de) |
| ZA (1) | ZA200708419B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102659659B (zh) * | 2005-11-21 | 2014-07-23 | 盐野义制药株式会社 | 具有I型11β羟基类固醇脱氢酶抑制活性的杂环化合物 |
| WO2007107470A2 (en) * | 2006-03-22 | 2007-09-27 | F. Hoffmann-La Roche Ag | Pyrazoles as 11-beta-hsd-1 |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP2051977A2 (de) * | 2006-07-20 | 2009-04-29 | Amgen Inc. | SUBSTITUIERTE AROMATISCHE AZOL-HETEROCYCLEN ALS LLbeta-HSD-1-HEMMER |
| TW200827346A (en) * | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| TW200836719A (en) * | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
| CA2682727C (en) * | 2007-04-02 | 2016-03-22 | Banyu Pharmaceutical Co., Ltd. | Indoledione derivative |
| CA2689659C (en) * | 2007-05-18 | 2012-10-23 | Shionogi And Co., Ltd. | Nitrogen-containing heterocyclic derivative having 11.beta.-hydroxysteroid dehydrogenase type 1 inhibitory activity |
| EP2178845B1 (de) | 2007-07-17 | 2013-06-19 | F. Hoffmann-La Roche AG | Inhibitoren von 11b-hydroxysteroiddehydrogenase |
| FR2924931B1 (fr) * | 2007-12-12 | 2010-01-15 | Oreal | Utilisations de derives 1-°(1h-pyrazol-4-y!heterocycliques pour stimuler ou induire la pousse des fibres keratiniques et/ou freiner leur chute ; nouveaux composes ; compositions les contenant. |
| AU2009211215B2 (en) * | 2008-02-04 | 2011-11-03 | Astrazeneca Ab | Novel crystalline forms of 4- [4- (2-adamantylcarbam0yl) -5-tert-butyl-pyrazol-1-yl] benzoic acid |
| CN102300851A (zh) * | 2009-01-30 | 2011-12-28 | 阿斯利康(瑞典)有限公司 | 制备含羧基的吡唑酰氨基化合物597的新方法 |
| AR078887A1 (es) * | 2009-11-06 | 2011-12-07 | Boehringer Ingelheim Int | Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen. |
| WO2013189904A1 (en) | 2012-06-20 | 2013-12-27 | F. Hoffmann-La Roche Ag | Pyranopyridone inhibitors of tankyrase |
| ES2869172T3 (es) * | 2013-11-25 | 2021-10-25 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoides de azadecalina condensada con octahidro |
| US9273254B2 (en) * | 2013-12-20 | 2016-03-01 | Ecolab Usa Inc. | Amino acetals and ketals as hydrogen sulfide and mercaptan scavengers |
| CN103772282B (zh) * | 2014-02-26 | 2015-09-23 | 上海毕得医药科技有限公司 | 一种3-叔丁基-1h-吡唑-4-甲醛的制备方法 |
| US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| WO2020172501A1 (en) | 2019-02-22 | 2020-08-27 | Corcept Therapeutics Incorporated | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
| CA3158745A1 (en) | 2019-12-11 | 2021-06-17 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| IL298151A (en) * | 2020-05-27 | 2023-01-01 | Corcept Therapeutics Inc | Concomitant Administration of a Recorrelating Glucocorticoid Receptor Modulator and Cyp2c8 Substrates |
| CN114560811B (zh) * | 2022-03-11 | 2023-09-01 | 上海立森印迹医药技术有限公司 | 1,3,5-三取代-吡唑-4羧酸衍生物及其制备方法和应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO760996L (de) * | 1975-03-25 | 1976-09-28 | Byk Gulden Lomberg Chem Fab | |
| US4620865A (en) | 1983-11-07 | 1986-11-04 | Eli Lilly And Company | Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides |
| JPH0768220B2 (ja) * | 1986-04-24 | 1995-07-26 | 三井東圧化学株式会社 | 新規ピラゾ−ル誘導体、その製造法およびそれらを含有する農園芸用殺菌剤 |
| US4792565A (en) * | 1986-04-24 | 1988-12-20 | Mitsui Toatsu Chemicals, Inc. | Pyrazolecarbonylamine derivatives and agricultural and horticultural fungicides containing said compounds |
| IL91418A (en) | 1988-09-01 | 1997-11-20 | Rhone Poulenc Agrochimie | (hetero) cyclic amide derivatives, process for their preparation and fungicidal compositions containing them |
| MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| JP2002003410A (ja) | 2000-06-27 | 2002-01-09 | Fuji Photo Film Co Ltd | 芳香族ハロゲン化物の製造方法。 |
| EP1337508A1 (de) | 2000-11-28 | 2003-08-27 | Pfizer Products Inc. | Verfahren zur herstellung eines natrium-wasserstoff-austauschers typ 1 inhibitor |
| GB0107383D0 (en) | 2001-03-23 | 2001-05-16 | Univ Edinburgh | Lipid profile modulation |
| EP1461327A1 (de) | 2001-11-22 | 2004-09-29 | Biovitrum Ab | Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1 |
| BR0214344A (pt) | 2001-11-22 | 2004-09-14 | Biovitrum Ab | Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1 |
| ATE469136T1 (de) | 2001-11-22 | 2010-06-15 | Biovitrum Ab | Inhibitoren von 11-beta- hydroxysteroiddehydrogenase typ 1 |
| EP1456181A1 (de) | 2001-12-19 | 2004-09-15 | Pfizer Products Inc. | Verfahren zur herstellung von typ-1 natrium-wasserstoff-austauscher (oder nhe-1)- inhibitoren |
| WO2003059267A2 (en) | 2001-12-21 | 2003-07-24 | Rhode Island Hospital | SELECTIVE 11β-HSD INHIBITORS AND METHODS FOR USE THEREOF |
| WO2003065983A2 (en) | 2002-02-01 | 2003-08-14 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
| AU2003219934A1 (en) | 2002-03-06 | 2003-09-22 | Merck And Co., Inc. | Method of treatment or prevention of obesity |
| AR040241A1 (es) | 2002-06-10 | 2005-03-23 | Merck & Co Inc | Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia |
| MXPA05001009A (es) | 2002-07-27 | 2005-05-16 | Astrazeneca Ab | Cetonas. |
| US20050256159A1 (en) | 2002-10-11 | 2005-11-17 | Astrazeneca Ab | 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors |
| WO2004041264A1 (en) | 2002-11-07 | 2004-05-21 | Astrazeneca Ab | 2-oxo-ethanesulfonamide derivates |
| US20040122033A1 (en) | 2002-12-10 | 2004-06-24 | Nargund Ravi P. | Combination therapy for the treatment of obesity |
| JO2397B1 (en) | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
| TW200503994A (en) | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| WO2004089416A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent |
| WO2004089415A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST |
| JP4629657B2 (ja) | 2003-04-11 | 2011-02-09 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型化活性化合物 |
| WO2004089471A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | NEW PYRAZOLO[1,5-a] PYRIMIDINES DERIVATIVES AND PHARMACEUTICAL USE THEREOF |
| EP1631558A1 (de) | 2003-05-21 | 2006-03-08 | Biovitrum Ab | Inhibitoren von 11-beta-hydroxy-steroiddehydrogenase typ i |
| CA2526712A1 (en) | 2003-05-29 | 2004-12-09 | Merck & Co., Inc. | Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1 |
| SE0301886D0 (sv) | 2003-06-25 | 2003-06-25 | Biovitrum Ab | New use V |
| SE0301883D0 (sv) | 2003-06-25 | 2003-06-25 | Biovitrum Ab | New use II |
| CN1832741A (zh) * | 2003-08-07 | 2006-09-13 | 默克公司 | 作为11－β－羟甾类脱氢酶－1抑制剂的吡唑甲酰胺类 |
| WO2005037199A2 (en) * | 2003-10-10 | 2005-04-28 | Bristol-Myers Squibb Company | Pyrazole derivatives as cannabinoid receptor modulators |
-
2006
- 2006-03-27 ES ES06725326T patent/ES2369389T3/es active Active
- 2006-03-27 CA CA2602781A patent/CA2602781C/en not_active Expired - Fee Related
- 2006-03-27 KR KR1020077022649A patent/KR100931411B1/ko not_active IP Right Cessation
- 2006-03-27 MX MX2007012212A patent/MX2007012212A/es active IP Right Grant
- 2006-03-27 DK DK06725326.0T patent/DK1928840T3/da active
- 2006-03-27 BR BRPI0610459-2A patent/BRPI0610459A2/pt not_active IP Right Cessation
- 2006-03-27 AT AT06725326T patent/ATE519744T1/de active
- 2006-03-27 PT PT06725326T patent/PT1928840E/pt unknown
- 2006-03-27 WO PCT/EP2006/061057 patent/WO2006106052A1/en active Application Filing
- 2006-03-27 RU RU2007140737/04A patent/RU2381217C2/ru not_active IP Right Cessation
- 2006-03-27 PL PL06725326T patent/PL1928840T3/pl unknown
- 2006-03-27 AU AU2006232660A patent/AU2006232660B2/en not_active Ceased
- 2006-03-27 EP EP06725326A patent/EP1928840B1/de not_active Not-in-force
- 2006-03-27 CN CN2006800111775A patent/CN101155783B/zh not_active Expired - Fee Related
- 2006-03-27 JP JP2008504736A patent/JP4880671B2/ja not_active Expired - Fee Related
- 2006-03-31 US US11/395,763 patent/US7345058B2/en not_active Expired - Fee Related
- 2006-04-03 AR ARP060101312A patent/AR053203A1/es unknown
- 2006-04-03 TW TW095111719A patent/TWI309645B/zh not_active IP Right Cessation
-
2007
- 2007-09-20 IL IL186118A patent/IL186118A0/en unknown
- 2007-09-25 NO NO20074872A patent/NO20074872L/no not_active Application Discontinuation
- 2007-10-02 ZA ZA200708419A patent/ZA200708419B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100931411B1 (ko) | 2009-12-10 |
| ZA200708419B (en) | 2008-11-26 |
| IL186118A0 (en) | 2008-01-20 |
| AR053203A1 (es) | 2007-04-25 |
| US7345058B2 (en) | 2008-03-18 |
| RU2381217C2 (ru) | 2010-02-10 |
| EP1928840B1 (de) | 2011-08-10 |
| CN101155783A (zh) | 2008-04-02 |
| KR20070108937A (ko) | 2007-11-13 |
| WO2006106052A1 (en) | 2006-10-12 |
| TW200643013A (en) | 2006-12-16 |
| MX2007012212A (es) | 2007-12-07 |
| AU2006232660B2 (en) | 2010-03-25 |
| AU2006232660A1 (en) | 2006-10-12 |
| CA2602781C (en) | 2011-02-08 |
| ATE519744T1 (de) | 2011-08-15 |
| NO20074872L (no) | 2007-10-30 |
| US20060223852A1 (en) | 2006-10-05 |
| JP2008534647A (ja) | 2008-08-28 |
| DK1928840T3 (da) | 2011-09-12 |
| BRPI0610459A2 (pt) | 2010-06-22 |
| CA2602781A1 (en) | 2006-10-12 |
| RU2007140737A (ru) | 2009-05-20 |
| PT1928840E (pt) | 2011-10-03 |
| EP1928840A1 (de) | 2008-06-11 |
| ES2369389T3 (es) | 2011-11-30 |
| PL1928840T3 (pl) | 2012-01-31 |
| CN101155783B (zh) | 2012-01-04 |
| JP4880671B2 (ja) | 2012-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI309645B (en) | Pyrazoles | |
| Kumar et al. | Biological activities of pyrazoline derivatives-A recent development | |
| TW200806651A (en) | Pyrazoles as 11-beta-HSD-1 | |
| TW200913992A (en) | Inhibitors of 11β-hydroxysteroid dehydrogenase | |
| US7354938B2 (en) | Pyrazole compounds and uses related thereto | |
| TWI329638B (en) | Benzimidazole derivatives | |
| TWI262792B (en) | Compositions for treating female sexual dysfunction | |
| TWI321563B (en) | Compounds useful in therapy | |
| TW200911756A (en) | Novel compounds | |
| TW201036961A (en) | Benzofuranyl derivatives | |
| CN102791701B (zh) | 作为二肽基肽酶iv(dpp-iv)抑制剂的3-(3-氨基哌啶-1-基)-5-氧代-1,2,4-三嗪衍生物 | |
| TW200808771A (en) | Novel compounds II | |
| TW201020235A (en) | Indazole or 4,5,6,7-tetrahydro-indazole derivatives | |
| JP2008519083A (ja) | アミノキナゾリン化合物 | |
| KR20020058074A (ko) | 소염진통제로서의 헤테로시클로-알킬술포닐 피라졸 유도체 | |
| WO2007121687A1 (fr) | Dérivés du 4-méthyl-1h-diaryl pyrazole et leur utilisation comme médicaments | |
| TW201014831A (en) | New benzimidazole derivatives | |
| AU2002330120B2 (en) | Methods of increasing endogenous testosterone levels | |
| JP2011518213A (ja) | １，３−ジヒドロ−２Ｈ−ピロロ［３，２−ｂ］ピリジン−２−オン誘導体、この調製、およびこの治療用途 | |
| EP2181990B1 (de) | Piperidinderivate | |
| TWI274751B (en) | Acyloxypyrrolidine derivatives, preparation thereof and application thereof in therapeutics | |
| TW201204710A (en) | Novel indazole derivative or salt thereof and production intermediate thereof, and antioxidant using same | |
| TWI322688B (en) | Pyrazole compounds and antidiabetics comprising the pyrazole compounds | |
| CN104936957A (zh) | 二肽基肽酶抑制剂 | |
| WO2013056067A1 (en) | Compounds for use in the treatment of basal cell carcinoma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |