TWI265168B - C peptide for improved preparation of insulin and insulin analogs - Google Patents

C peptide for improved preparation of insulin and insulin analogs

Info

Publication number
TWI265168B
TWI265168B TW089120149A TW89120149A TWI265168B TW I265168 B TWI265168 B TW I265168B TW 089120149 A TW089120149 A TW 089120149A TW 89120149 A TW89120149 A TW 89120149A TW I265168 B TWI265168 B TW I265168B
Authority
TW
Taiwan
Prior art keywords
insulin
chain
amino acid
human insulin
peptide
Prior art date
Application number
TW089120149A
Other languages
English (en)
Inventor
Paul Habermann
Johann Ertl
Johannes Meiwes
Gerhard Seipke
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of TWI265168B publication Critical patent/TWI265168B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
TW089120149A 1999-10-02 2000-09-29 C peptide for improved preparation of insulin and insulin analogs TWI265168B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19947456A DE19947456A1 (de) 1999-10-02 1999-10-02 C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga

Publications (1)

Publication Number Publication Date
TWI265168B true TWI265168B (en) 2006-11-01

Family

ID=7924253

Family Applications (1)

Application Number Title Priority Date Filing Date
TW089120149A TWI265168B (en) 1999-10-02 2000-09-29 C peptide for improved preparation of insulin and insulin analogs

Country Status (25)

Country Link
US (1) US6534288B1 (zh)
EP (1) EP1222207B1 (zh)
JP (1) JP4681784B2 (zh)
KR (1) KR100823463B1 (zh)
CN (1) CN1193042C (zh)
AT (1) ATE380196T1 (zh)
AU (1) AU778369B2 (zh)
BR (2) BRPI0014464B8 (zh)
CA (1) CA2385857C (zh)
CY (1) CY1107860T1 (zh)
DE (2) DE19947456A1 (zh)
DK (1) DK1222207T3 (zh)
ES (1) ES2295054T3 (zh)
HK (1) HK1049016B (zh)
HU (1) HU228313B1 (zh)
IL (2) IL148942A0 (zh)
MX (1) MXPA02003103A (zh)
NO (1) NO329975B1 (zh)
NZ (1) NZ518066A (zh)
PL (1) PL203195B1 (zh)
PT (1) PT1222207E (zh)
SI (1) SI1222207T1 (zh)
TW (1) TWI265168B (zh)
WO (1) WO2001025278A1 (zh)
ZA (1) ZA200202520B (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US20050250676A1 (en) * 2001-11-19 2005-11-10 Aventis Pharma Deutschland Gmbh Method of activating insulin receptor substrate-2 to stimulate insulin production
US20040038864A1 (en) * 2002-06-27 2004-02-26 Per Balschmidt Use of dimethyl sulfone as isotonicity agent
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
EP1692168B1 (en) * 2003-12-03 2011-07-20 Novo Nordisk A/S Single-chain insulin
CN1663960B (zh) * 2004-03-01 2012-07-04 重庆富进生物医药有限公司 高效表达重组人胰岛素原及其类似物的新型c肽
WO2007121318A2 (en) * 2006-04-12 2007-10-25 Emisphere Technologies, Inc. Formulations for delivering insulin
CA2711752A1 (en) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
DE102008003568A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008025007A1 (de) 2008-05-24 2009-11-26 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003566A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008025008A1 (de) 2008-05-24 2009-11-26 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
PL2229407T3 (pl) * 2008-01-09 2017-06-30 Sanofi-Aventis Deutschland Gmbh Nowe pochodne insuliny o ekstremalnie spowolnionym profilu czasu działania
PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
JP5973918B2 (ja) 2009-11-13 2016-08-23 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト及びメチオニンを含む薬学的組成物
TR201809460T4 (tr) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
JP6199186B2 (ja) 2010-08-30 2017-09-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病の治療用の医薬の製造のためのａｖｅ００１０の使用
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
TWI780236B (zh) 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
MX2016008979A (es) 2014-01-09 2016-10-04 Sanofi Sa Formulaciones farmaceuticas estabilizadas de analogos de insulina y/o derivados de insulina.
BR112016015851A2 (pt) 2014-01-09 2017-08-08 Sanofi Sa Formulações farmacêuticas estabilizadas de insulina aspart
CN105899191B (zh) 2014-01-09 2020-06-16 赛诺菲 胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂
CA2970200A1 (en) 2014-12-12 2016-06-16 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH16156A (en) * 1980-03-27 1983-07-18 Lilly Co Eli Process for producing an insulin precursor
US4430266A (en) * 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
HRP940432B1 (en) * 1994-08-05 2003-10-31 Pliva Pharm & Chem Works Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin
PT821006E (pt) * 1996-07-26 2004-09-30 Aventis Pharma Gmbh Derivados de insulina com ligacao a zinco aumentada
DE19726167B4 (de) * 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung

Also Published As

Publication number Publication date
DK1222207T3 (da) 2008-03-17
PL354078A1 (en) 2003-12-15
CY1107860T1 (el) 2013-06-19
JP4681784B2 (ja) 2011-05-11
EP1222207A1 (de) 2002-07-17
HU228313B1 (en) 2013-03-28
ATE380196T1 (de) 2007-12-15
EP1222207B1 (de) 2007-12-05
HUP0202755A3 (en) 2005-01-28
DE19947456A1 (de) 2001-04-05
CA2385857C (en) 2012-05-22
KR20020047209A (ko) 2002-06-21
BR0014464A (pt) 2002-06-11
HK1049016A1 (en) 2003-04-25
JP2003511018A (ja) 2003-03-25
CN1193042C (zh) 2005-03-16
ES2295054T3 (es) 2008-04-16
NO20021335L (no) 2002-06-03
PL203195B1 (pl) 2009-09-30
HUP0202755A2 (hu) 2002-12-28
MXPA02003103A (es) 2002-09-30
NZ518066A (en) 2004-05-28
IL148942A (en) 2010-02-17
WO2001025278A1 (de) 2001-04-12
ZA200202520B (en) 2002-12-24
AU7287700A (en) 2001-05-10
NO329975B1 (no) 2011-01-31
PT1222207E (pt) 2008-02-11
US6534288B1 (en) 2003-03-18
KR100823463B1 (ko) 2008-04-21
CA2385857A1 (en) 2001-04-12
AU778369B2 (en) 2004-12-02
HK1049016B (zh) 2005-10-14
SI1222207T1 (sl) 2008-04-30
IL148942A0 (en) 2002-09-12
BRPI0014464B8 (pt) 2021-05-25
CN1377370A (zh) 2002-10-30
DE50014830D1 (de) 2008-01-17
NO20021335D0 (no) 2002-03-18
BRPI0014464B1 (pt) 2018-03-13

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