TWI255713B - Method for treating meibomian gland disease - Google Patents

Method for treating meibomian gland disease

Info

Publication number
TWI255713B
TWI255713B TW088107469A TW88107469A TWI255713B TW I255713 B TWI255713 B TW I255713B TW 088107469 A TW088107469 A TW 088107469A TW 88107469 A TW88107469 A TW 88107469A TW I255713 B TWI255713 B TW I255713B
Authority
TW
Taiwan
Prior art keywords
meibomian gland
gland disease
tetracycline
treating
treating meibomian
Prior art date
Application number
TW088107469A
Other languages
English (en)
Chinese (zh)
Inventor
Stephen C Pflugfelder
Balakrishna L Lokeshwar
Marie Selzer
Original Assignee
Univ Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Miami filed Critical Univ Miami
Application granted granted Critical
Publication of TWI255713B publication Critical patent/TWI255713B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW088107469A 1998-05-08 1999-05-25 Method for treating meibomian gland disease TWI255713B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8487398P 1998-05-08 1998-05-08

Publications (1)

Publication Number Publication Date
TWI255713B true TWI255713B (en) 2006-06-01

Family

ID=22187748

Family Applications (2)

Application Number Title Priority Date Filing Date
TW088107469A TWI255713B (en) 1998-05-08 1999-05-25 Method for treating meibomian gland disease
TW094111310A TWI255714B (en) 1998-05-08 1999-05-25 Method for treating meibomian gland disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW094111310A TWI255714B (en) 1998-05-08 1999-05-25 Method for treating meibomian gland disease

Country Status (12)

Country Link
US (6) US6455583B1 (enExample)
EP (2) EP1676579B1 (enExample)
JP (1) JP4860038B2 (enExample)
AT (2) ATE319456T1 (enExample)
AU (1) AU763164B2 (enExample)
CA (1) CA2331257C (enExample)
DE (2) DE69940227D1 (enExample)
DK (2) DK1676579T3 (enExample)
ES (2) ES2260912T3 (enExample)
PT (2) PT1676579E (enExample)
TW (2) TWI255713B (enExample)
WO (1) WO1999058131A1 (enExample)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1676579T3 (da) * 1998-05-08 2009-03-16 Univ Miami Anvendelse af sub-antimikrobielle tetracykliner til behandling af okulær rosacea
US6432934B1 (en) 1998-08-06 2002-08-13 Advanced Vision Research Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
AU4684000A (en) * 1999-04-27 2000-11-10 Antibody Systems, Inc. Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders
US7211267B2 (en) * 2001-04-05 2007-05-01 Collagenex Pharmaceuticals, Inc. Methods of treating acne
JP2004525955A (ja) * 2001-04-05 2004-08-26 コッラジェネックス ファーマシューチカルス インコーポレイテッド テトラサイクリン化合物およびテトラサイクリン誘導体の制御された伝達
EP2332547A1 (en) * 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of inflammatory bowel disease
US20030073068A1 (en) * 2001-10-15 2003-04-17 Campbell Robert Edward Methods for application of tear-based biomarkers to ophthalmic product evaluation and clinical study management
WO2003088906A2 (en) * 2002-04-16 2003-10-30 Collagenex Pharmaceuticals, Inc. Methods of simultaneously treating ocular rosacea and acne rosacea
US8192749B2 (en) * 2003-04-16 2012-06-05 Galderma Laboratories Inc. Methods of simultaneously treating ocular rosacea and acne rosacea
JP2005526114A (ja) * 2002-05-06 2005-09-02 コッラジェネックス ファーマシューチカルス インコーポレイテッド 粘膜炎及び真菌感染症の同時治療方法
KR20050092429A (ko) * 2003-01-22 2005-09-21 니찌방 가부시기가이샤 안질환 치료용 경피 흡수형 제제, 그 사용, 및 안질환치료약의 눈의 국소 조직으로의 이행 방법
EP2204168B1 (en) * 2003-04-07 2015-01-14 Supernus Pharmaceuticals, Inc. Once daily formulations of tetracyclines
US6984628B2 (en) * 2003-07-15 2006-01-10 Allergan, Inc. Ophthalmic compositions comprising trefoil factor family peptides
WO2005011707A1 (en) * 2003-07-25 2005-02-10 Warner Chilcott Company, Inc. A doxycycline metal complex in a solid dosage form
WO2007024972A2 (en) * 2005-08-22 2007-03-01 Quick-Med Technologies, Inc. Non-leaching absorbent wound dressing
CN100340241C (zh) * 2004-06-28 2007-10-03 中山大学中山眼科中心 一种滴眼液及其制备方法与用途
CA2595481C (en) * 2005-01-21 2014-05-13 Warner Chilcott Company, Inc. A tetracycline metal complex in a solid dosage form
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US20080242642A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7541347B2 (en) 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US20080114423A1 (en) * 2006-05-15 2008-05-15 Grenon Stephen M Apparatus for inner eyelid treatment of meibomian gland dysfunction
US20090043365A1 (en) * 2005-07-18 2009-02-12 Kolis Scientific, Inc. Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma
WO2013003594A2 (en) 2011-06-28 2013-01-03 Tearscience, Inc. Methods and systems for treating meibomian gland dysfunction using radio-frequency energy
US7981146B2 (en) 2006-05-15 2011-07-19 Tearscience Inc. Inner eyelid treatment for treating meibomian gland dysfunction
US7981145B2 (en) 2005-07-18 2011-07-19 Tearscience Inc. Treatment of meibomian glands
US8950405B2 (en) * 2006-05-15 2015-02-10 Tearscience, Inc. Treatment of obstructive disorders of the eye or eyelid
US7981095B2 (en) * 2005-07-18 2011-07-19 Tearscience, Inc. Methods for treating meibomian gland dysfunction employing fluid jet
US20070016256A1 (en) * 2005-07-18 2007-01-18 Korb Donald R Method and apparatus for treating gland dysfunction
US8255039B2 (en) 2006-09-29 2012-08-28 Tearscience, Inc. Meibomian gland illuminating and imaging
US20070060988A1 (en) * 2005-07-18 2007-03-15 Grenon Stephen M Melting meibomian gland obstructions
US8128674B2 (en) * 2006-05-15 2012-03-06 Tearscience, Inc. System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8137390B2 (en) * 2006-05-15 2012-03-20 Tearscience, Inc. System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction
US7976573B2 (en) 2006-05-15 2011-07-12 Tearscience, Inc. Inner eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8128673B2 (en) * 2006-05-15 2012-03-06 Tearscience, Inc. System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction
US9314369B2 (en) 2006-05-15 2016-04-19 Tearscience, Inc. System for inner eyelid treatment of meibomian gland dysfunction
US7981147B2 (en) 2006-05-15 2011-07-19 Tearscience, Inc. Outer eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8007524B2 (en) * 2006-05-15 2011-08-30 Tearscience, Inc. Heat treatment and heat loss reduction for treating meibomian gland dysfunction
WO2008027069A1 (en) * 2006-08-21 2008-03-06 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction employing fluid
CN101547666B (zh) 2006-08-21 2012-06-20 眼泪科学公司 用于治疗腺体功能障碍的器械
US8249695B2 (en) 2006-09-29 2012-08-21 Tearscience, Inc. Meibomian gland imaging
ES2692434T3 (es) 2007-01-17 2018-12-03 Tearscience, Inc. Aparato de tratamiento térmico para tratar la disfunción de la glándula de Meibomio
US20080188445A1 (en) * 2007-02-02 2008-08-07 Warner Chilcott Company Inc. Tetracycline compositions for topical administration
WO2008097851A1 (en) * 2007-02-02 2008-08-14 Warner Chilcott Company, Inc. Tetracycline compositions for topical administration
WO2008106228A2 (en) * 2007-02-28 2008-09-04 Aciex Therapeutics, Inc. Methods and compositions for normalizing meibomian gland secretions
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
WO2009025763A2 (en) * 2007-08-16 2009-02-26 Schepens Eye Research Institute Therapeutic compositions for treatment of inflammation of ocular and adnexal tissues
US20090131303A1 (en) * 2007-11-16 2009-05-21 Bor-Shyue Hong Methods and compositions for treating dry eye
USD613408S1 (en) 2008-02-06 2010-04-06 Tearscience, Inc. Eye treatment head gear
USD614303S1 (en) 2008-02-06 2010-04-20 Tearscience, Inc. Eye treatment apparatus
USD617443S1 (en) 2008-02-06 2010-06-08 Tearscience, Inc. Eye treatment goggles
WO2009120881A1 (en) * 2008-03-26 2009-10-01 Eric Donnenfeld Methods for improving lid margin and tear film function and treatment of lid margin desease using tetracycline family antibiotics
JP2011527709A (ja) * 2008-07-10 2011-11-04 インスパイアー ファーマシューティカルズ，インコーポレイティド 眼瞼炎の治療方法
WO2010017310A1 (en) 2008-08-06 2010-02-11 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
WO2010085572A1 (en) * 2009-01-23 2010-07-29 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with azithromycin
EP2420180B1 (en) 2009-04-01 2019-05-22 Tearscience, Inc. Apparatus for measuring ocular tear film layer thickness(es)
USD638128S1 (en) 2009-10-06 2011-05-17 Tearscience, Inc. Ocular device design
US8721572B1 (en) 2010-06-10 2014-05-13 Eyedetec Medical, Inc. Systems, devices, kits and methods for therapy of the eye
US20120190653A1 (en) * 2011-01-20 2012-07-26 Dow Pharmaceutical Sciences, Inc. Therapeutic eye drop comprising doxycycline and a stabilizer
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
US9636355B2 (en) 2011-09-22 2017-05-02 Theo Holdings, Llc Hypertonic dextran solution and methods of treating and preventing recurrent corneal erosion
UA109359C2 (xx) * 2011-11-10 2015-08-10 Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном
US9931031B2 (en) 2012-02-21 2018-04-03 Massachusetts Eye & Ear Infirmary Meibomian gland dysfunction
WO2014005138A1 (en) * 2012-06-29 2014-01-03 Kerschensteiner Daniel A Colorimetric gelatinase assay
US10842670B2 (en) 2012-08-22 2020-11-24 Johnson & Johnson Vision Care, Inc. Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices
PT106679B (pt) * 2012-11-27 2015-03-25 Hovione Farmaciencia Sa Formulações tópicas de tetraciclinas, sua preparação e usos
EP3744391B1 (en) 2013-04-30 2023-03-01 Alcon Inc. Systems for the treatment of eye conditions
US9763827B2 (en) 2013-04-30 2017-09-19 Tear Film Innovations, Inc. Systems and methods for the treatment of eye conditions
JP6615748B2 (ja) 2013-05-03 2019-12-04 テイアサイエンス・インコーポレーテツド マイボーム腺分析のためにマイボーム腺を画像化するための眼瞼照射システムおよび方法
US10130507B2 (en) 2013-08-03 2018-11-20 Michael C. Whitehurst Dry eye treatment device
WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
WO2016079590A1 (en) 2014-11-19 2016-05-26 Dr. Reddy's Laboratories Ltd. Modified release doxycycline composition
BR112017020358A2 (pt) 2015-03-23 2018-07-17 Biopharmx Inc composição farmacêutica de tetraciclina para uso dermatológico
EP3178462A1 (de) 2015-12-07 2017-06-14 WDT-Wolz-Dental-Technik GmbH Verfahren zur herstellung eines polychrom und/oder räumlich polychrom oder eines monochrom gefärbten keramischen körpers und vorrichtung hierfür
US10974063B2 (en) 2016-06-30 2021-04-13 Alcon Inc. Light therapy for eyelash growth
WO2018044877A1 (en) 2016-08-29 2018-03-08 Renaud Nicole Kyongnan Eye mask
FR3064482B1 (fr) * 2017-04-03 2020-11-13 Horus Pharma Composition topique de doxycycline
KR20250057155A (ko) 2017-12-15 2025-04-28 타르서스 파마수티칼스, 아이엔씨. 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
CN119731152A (zh) * 2022-07-08 2025-03-28 大脑和脊髓研究所 四环素衍生物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788479A (fr) * 1971-09-06 1973-01-02 Medimpex Gyogyszerkulkereskede Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques
CA1263606A (en) * 1985-05-29 1989-12-05 Jeffrey P. Gilbard Non-toxic opthalmic preparations
IE74244B1 (en) * 1985-10-01 1997-07-16 Bimeda Res Dev Ltd A process for preparing an antibiotic composition
US4866049A (en) * 1987-08-10 1989-09-12 Spectra Pharmaceutical Services, Inc. Ophthalmic compositionn and method of using same
US5360611A (en) * 1988-10-03 1994-11-01 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation
FR2660193B1 (fr) * 1990-04-03 1994-11-04 Philippe Maincent Produit opthalmique comportant des nanocapsules, son procede de preparation et utilisation des nanocapsules.
US5340572A (en) * 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
US6015803A (en) * 1998-05-04 2000-01-18 Wirostko; Emil Antibiotic treatment of age-related macular degeneration
DK1676579T3 (da) * 1998-05-08 2009-03-16 Univ Miami Anvendelse af sub-antimikrobielle tetracykliner til behandling af okulær rosacea
US6432934B1 (en) * 1998-08-06 2002-08-13 Advanced Vision Research Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease

Also Published As

Publication number Publication date
US20030114426A1 (en) 2003-06-19
ATE418989T1 (de) 2009-01-15
DK1676579T3 (da) 2009-03-16
JP2002514602A (ja) 2002-05-21
AU763164B2 (en) 2003-07-17
DK1075265T3 (da) 2006-06-26
EP1075265A1 (en) 2001-02-14
EP1075265B1 (en) 2006-03-08
ES2260912T3 (es) 2006-11-01
EP1676579A3 (en) 2006-07-12
ES2320579T3 (es) 2009-05-25
PT1676579E (pt) 2009-03-24
TW200526232A (en) 2005-08-16
US20060154901A1 (en) 2006-07-13
US20120088739A1 (en) 2012-04-12
CA2331257A1 (en) 1999-11-18
AU3887999A (en) 1999-11-29
HK1089696A1 (en) 2006-12-08
DE69940227D1 (de) 2009-02-12
ATE319456T1 (de) 2006-03-15
EP1676579A2 (en) 2006-07-05
EP1676579B1 (en) 2008-12-31
DE69930252D1 (de) 2006-05-04
HK1034899A1 (en) 2001-11-09
US6455583B1 (en) 2002-09-24
US20080214510A1 (en) 2008-09-04
US20110039805A1 (en) 2011-02-17
DE69930252T2 (de) 2006-12-14
TWI255714B (en) 2006-06-01
JP4860038B2 (ja) 2012-01-25
PT1075265E (pt) 2006-07-31
WO1999058131A1 (en) 1999-11-18
CA2331257C (en) 2012-01-03

Similar Documents

Publication Publication Date Title
TWI255713B (en) Method for treating meibomian gland disease
EP1225168B8 (en) Prostaglandin-F-2 alpha derivative for the treatment of glaucoma or ocular hypertension
MX9702349A (es) Usos de derivado de 9-deoxi prostaglandina para tratar glaucoma.
AU3632497A (en) Use of the chelating agent clioquinol for the manufacture of a pharmaceutical composition for the treatment of alzheimer's disease
EP1514548A3 (en) Use of cloprostenol fluprostenol, and their analogues to treat glaucoma and ocular hypertension
MY137348A (en) Highly selective norepinephrine reuptake inhibitors and methods of using the same
NO972980L (no) Anvendelse av nebivolol som et anti-aterogent middel
IL142864A0 (en) Compositions and methods for producing vascular occlusion
PT998287E (pt) Utilizacao de levobupivacaina
IL124977A0 (en) Oral administration of effective amounts of forms of hyaluronic acid
BR0012696A (pt) Composição oftálmica
EP0422068A4 (en) Pharmacological treatment of ocular development
NO994165L (no) Anvendelse av deskarboetoksyloratadin for fremstilling av et medikament for behandling av urininkontinens, reisesyke og svimmelhet
AR023687A1 (es) Una composicion para el tratamiento de desordenes de la retina externa y el uso de un antagonista de glutamato para la manufactura de un medicamento parael tratamiento de desordenes de la retina externa
LV11728A (lv) Farmaceitiska kompozicija
ZA991749B (en) Pharmaceutical composition for prophylaxis and therapy of diseases associated with ocular fundus tissue cytopathy.
MXPA03005922A (es) Metodo para tratar glaucoma ib.
AU4609900A (en) Ophthalmic compositions for the treatment of visual disorders characterised by areduced contrast sensitivity
ES2106852T3 (es) Composicion oftalmica que contiene hemihidrato de timolol.
AU3581695A (en) Method and means for prevention and treatment of secondary cataract
MXPA04000980A (es) Tratamiento de hipertension ocular y glaucoma.
BR0205932A (pt) Método e composição para tratamento de hipertensão ocular e glaucoma
MX9604692A (es) Derivados de quinoxalina para el tratamiento de tinnitus.
IL146962A0 (en) Aminotetralin derivatives for the therapy of cardiovascular diseases
ATE289817T1 (de) Arzneimittelzusammenstellung zur behandlung des erhöhten augeninnendrucks oder des glaukom

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees