TWI252203B - Infusion container with multiple chambers and production method thereof - Google Patents

Infusion container with multiple chambers and production method thereof Download PDF

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Publication number
TWI252203B
TWI252203B TW92107021A TW92107021A TWI252203B TW I252203 B TWI252203 B TW I252203B TW 92107021 A TW92107021 A TW 92107021A TW 92107021 A TW92107021 A TW 92107021A TW I252203 B TWI252203 B TW I252203B
Authority
TW
Taiwan
Prior art keywords
sealing
infusion container
weak seal
strong
seal portion
Prior art date
Application number
TW92107021A
Other languages
English (en)
Other versions
TW200305531A (en
Inventor
Toshiharu Iwasaki
Masataka Kotani
Kiyokazu Ishiwatari
Katsuyuki Yoshikawa
Original Assignee
Showa Denko Plastic Product Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2003023436A external-priority patent/JP4298308B2/ja
Application filed by Showa Denko Plastic Product Co filed Critical Showa Denko Plastic Product Co
Publication of TW200305531A publication Critical patent/TW200305531A/zh
Application granted granted Critical
Publication of TWI252203B publication Critical patent/TWI252203B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/18—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using heated tools
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/76—Making non-permanent or releasable joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/21—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being formed by a single dot or dash or by several dots or dashes, i.e. spot joining or spot welding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/345—Progressively making the joint, e.g. starting from the middle
    • B29C66/3452—Making complete joints by combining partial joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/40—General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
    • B29C66/41—Joining substantially flat articles ; Making flat seams in tubular or hollow articles
    • B29C66/43—Joining a relatively small portion of the surface of said articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/731—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the intensive physical properties of the material of the parts to be joined
    • B29C66/7311—Thermal properties
    • B29C66/73115—Melting point
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/739—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/7392—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic
    • B29C66/73921—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic characterised by the materials of both parts being thermoplastics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
    • B29C66/814—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps
    • B29C66/8141—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined
    • B29C66/81433—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined being toothed, i.e. comprising several teeth or pins, or being patterned
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
    • B29C66/814—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps
    • B29C66/8141—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined
    • B29C66/81433—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined being toothed, i.e. comprising several teeth or pins, or being patterned
    • B29C66/81435—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined being toothed, i.e. comprising several teeth or pins, or being patterned comprising several parallel ridges, e.g. for crimping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
    • B29C66/832—Reciprocating joining or pressing tools
    • B29C66/8322—Joining or pressing tools reciprocating along one axis
    • B29C66/83221—Joining or pressing tools reciprocating along one axis cooperating reciprocating tools, each tool reciprocating along one axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/84—Specific machine types or machines suitable for specific applications
    • B29C66/851—Bag or container making machines
    • B29C66/8511—Bag making machines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3261—Flexible containers having several compartments
    • B65D81/3266—Flexible containers having several compartments separated by a common rupturable seal, a clip or other removable fastening device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2024—Separating means having peelable seals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/82—Testing the joint
    • B29C65/8207—Testing the joint by mechanical methods
    • B29C65/8246—Pressure tests, e.g. hydrostatic pressure tests
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53—Joining single elements to tubular articles, hollow articles or bars
    • B29C66/532—Joining single elements to the wall of tubular articles, hollow articles or bars
    • B29C66/5326—Joining single elements to the wall of tubular articles, hollow articles or bars said single elements being substantially flat
    • B29C66/53261—Enclosing tubular articles between substantially flat elements
    • B29C66/53262—Enclosing spouts between the walls of bags, e.g. of medical bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/72—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined
    • B29C66/723—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined being multi-layered
    • B29C66/7234—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined being multi-layered comprising a barrier layer
    • B29C66/72343—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined being multi-layered comprising a barrier layer for liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/731—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the intensive physical properties of the material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/735—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the extensive physical properties of the parts to be joined
    • B29C66/7352—Thickness, e.g. very thin
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Landscapes

  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Package Specialized In Special Use (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Description

1252203 (1) 玖、發明說明 【發明所屬之技術領域】 本發明是關於可分別收容複數種藥劑，使用時能容易 混合這些藥劑之複室輸液容器及其製造方法。 【先前技術】 將維他命劑等混合生理食鹽水中對患者施予注射或點 滴等，混合複數種藥劑投藥給患者。此樣混合複數種藥劑 ，時，依藥劑的種類會有預先混合就會變質的可能性。所 以使用能分別收容此種有變質可能性的複數種藥劑且在使 用當前可將這些藥劑混合之複室輸液容器。此類的複室輸 液容器其本體由聚烯等的熱可塑性樹脂薄膜所形成。 由此種熱可塑性樹脂薄膜所形成之複室輸液容器，混 合複數種藥劑之前的階段則是藥劑室與藥劑室的交界部位 以液密加以密封，不過混合複數種藥劑之際，此交界部位 必須容易剝離又可開通，才能使藥劑迅速混合。因而，此 交界部位的形成方法已多有硏究。 例如，在日本專利文件1 :特開平2-467 1號公報或日 本專利文件2 :特開2000- 1 4746號公報中，記載爲了形成 容易剝離的交界部位，施予粘合的部位用特定的材料來形 成之技術。另外，在日本專利文件3 :特開平1卜1 69432號 公報中，記載將具剝離性塗劑塗在交界部位的內面，使其 容易剝離之方法。 此外，在日本專利文件4 :特開平8-243 1 4號公報中， (2) 1252203 記載當密封此交界部位之際所使用之加熱密封片，將形成 有特定形狀的密封緣之2片密封片後使用，在精密控制密 封緣的位置下夾持薄膜，而將交界部位的剝離強度設在適 度的範圍內之技術。 【發明內容】 不過日本專利文件1 :特開平2-467 1號公報和日本專 利文件2 :特開2000- 1 4746號公報中所記載的技術，會有 爲了形成容易剝離的交界部位，不得不將該部位設爲多層 構成，單層薄膜則不能適用而造成薄膜的製造成本提高之 問題。另外，日本專利文件3 :特開平1卜1 69432號公報中 的技術則會有必要特定的塗劑而造成製程或製造成本增加 之問題。 此外，日本專利文件4 ··特開平8-243 1 4號公報中所記 載的方法’不必時需將薄膜設爲多層構造時而使用塗劑， 不過必須將密封此交界部位之加熱密封片的密合緣對準位 置’這些位置發生偏離，則所形成的交界部位會有每個複 室輸液容器中剝離強度的參差不齊變大。另外，加熱密封 片的間距特別窄時，此樣的對準位置特別困難，例如即使 將加熱密封溫度維持在一定溫度的情況，也會有每個複室 輸液容器中剝離強度參差不齊的情況，所以期望能安定生 產所要剝離強度的複室輸液容器。 本發明鑑於上述的問題點，其課題爲提供無關薄膜的 材質、構成等，複數個藥劑室與藥劑室的交界部位有安定 1252203 (3) 的剝離強度之複室輸液容器。另外的課題則是提供生產性 良好又能容易製造此樣的複室輸液容器之方法° 本發明者發現經由使具有熔接程度不同的複數個熔接 部來形成將複數個藥劑室隔開的弱密合部’控制這些熔接 部當中熔接強度最大的強熔接部所占有的面積就能解決上 述課題而構成本發明。然而，此處熔接強度較大是指經熔 接而被密封的部位之剝離所要的大量較大。 另外，本發明中熔接是指一邊加熱一邊壓接使其密接 ，不單是指熱可塑性樹脂薄膜熔融而完全成一體化且其交 界不明的狀態，只要能保持液體密閉性的話’也包括熱可 塑性樹脂薄膜彼此間的交界被認同的狀態。 本發明的複室輸液容器，是針對具有由熱可塑性樹脂 薄膜所形成，收容藥劑的複數個藥劑室之複室輸液容器， 其特徵爲：該複室輸液容器周緣的至少一部分用強密封部 來密封成液密，各藥劑室彼此間用可剝離的弱密封部來密 封成液密，前述弱密封部由具有熔接強度不同的複數個熔 接部所形成，這些熔接部當中熔接強度最大的強熔接部分 散分佈在於該弱密封部中，並且該占有面積未滿該弱密封 部面積的2 5 %。 本發明的複室輸液容器之製造方法，是針對用各藥劑 室彼此間可剝離之弱密封部來密合成液密的複室輸液容器 之製造方法，其特徵爲··具有從兩面側用2片的加熱密封 片來夾持被重疊的2片熱可塑性樹脂薄膜而形成具有熔接 強度不同之複數個熔接部的弱密封部之弱密封過程，該弱 -8- (4) 1252203 密封過程是使前述熔接部當中熔接強度最大且分散分布在 於前述弱密封部內之強熔接部的合計占有面積未滿該弱密 封部面積的25%。 【實施方式】 以下，詳細說明本發明。（第1實施形態） (第1實施形態例） 第1圖爲本發明之複室輸液容器1 〇的一例，也就是具 備由熱可塑性樹脂薄膜所形成，裝塡藥劑的2個藥劑室1 1 、12之複室輸液容器。此例的複室輸液容器1〇，一方的藥 劑室11連接藥劑投入部1 3，另一方的藥劑室1 2連接將藥劑 投入此藥劑室，並且在藥劑發放給患者之際從這個藥劑室 使藥劑排出之藥劑進出部1 4。 此複室輸液容器1 0中的2個藥劑室1 1、1 2用密閉液體 的弱密封部1 5來加以隔開。此弱密封部1 5使藥劑室1 1、1 2 分別裝塡藥劑後，從外方對至少一方的藥劑室1 1、1 2施加 大量就剝離來加熱密封，而成爲要用之際能迅速且容易混 合藥劑彼此間。 此外，此複室輸液容器1 0的周緣，利用即使從外方對 藥劑室1 1、1 2施加力量時也不會剝離之強密封部1 6來密閉 成液密，熱可塑性樹脂薄膜被加熱密封且牢固熔接所形成 。然而此例中，強密封部1 6在複室輸液容器1 0的周緣全周 部有形成，不過例如，以筒狀的熱可塑性樹脂薄膜作爲材 -9- (5) 1252203 料使用時，只有薄膜的長度方向兩端側（圖中，上端部及 下端部）爲強密封部1 6亦可，不一定要在周緣全周形成強 密封部1 6亦可。 然後，此例中複室輸液容器1 〇的弱密封部1 5，詳情於 後述’經由用特定的密封緣形成在密封面的2片加熱密合 片從其兩面側夾持被重疊的2片熱可塑性樹脂薄膜而被形 成，如第2圖的擴大平面圖中其中一部分所示，具有熔接 強度的3個熔接部，即是具有強熔接部1 5 a及中熔接部1 5 b 及弱熔接部1 5 c。 這些熔接部當中熔接強度最大的強融接部15a大致形 成爲正方形，大致均等地分散分布在於弱密合部1 5中。另 外’弱密封部1 5中熔接強度最低的弱熔接部1 5c，形成爲 比強熔接部1 5 a還大的大致正方形，大致均等地分散分布 在於弱密合部15中。具有強熔接部15a與弱熔接部15c之間 的熔接強度之中熔接部1 5 b，大致形成爲長方形，相同地 大致均等地分散分布在於弱密合部1 5中。另外，強熔接部 15a、中熔接部15b、弱熔接部15c當中，強熔接部15a的厚 度最薄，弱熔接部15c的厚度最厚。 進而，這些3個熔接部當中熔接強度最大的強熔接部 15a ’形成爲其占有面積未滿弱密合部15全體面積的25%。 因而，弱密封部1 5的剝離強度被適度控制，開通此弱 密封部1 5之際所要的力量也成爲適度，即是開通強度也成 爲適度，通常時液密把時在藥劑室1 1、1 2間，此外從外方 藥劑室1 1、1 2施加力量時形成爲容易剝離又能開通。 -10- 1252203 (6) 此外弱密封部15中各強熔接部15a的合計占有面積爲 25 %以上，則開通強度過大，必要時無法容易地將弱密封 部15剝離。另外，若未滿0.01 %則開通強度大小，會有因 衝擊等就剝離的可能性。所以理想的是各強熔接部丨5a的 合計占有面積爲0.01〜25%，更加理想的是〇.〇1〜15%，再更 加理想的是0.0 5〜1 0 %。 另外，此例的複室輸液容器1 0中各強溶接部i 5 a，以 符合下述式（1)來分布所接近之各強熔接部1 5 a間的平均間 _’（即是平均間隔A )、及所接近之各強熔接部1 5 a間的平 均距離，（即是平均距離B)。 B<2A......... (1) 此處，所接近之強熔接部1 5 a間的距離，如第3圖中的 圖號B !所例示，係指所接近之強熔接部1 5 a的重心間距離 ，平均距離B則是這些距離的平均。另外，所接近之熔接 部1 5 a間的間隔，如圖號a i所例示，係指聯結所接近之強 熔接部1 5 a的重心間之線上，一方強熔接部丨5 a的末端與另 一方強熔接部1 5a的末端之距離，平均間隔a則是這些間隔 的平均。 此樣符合式（1)來分布強熔接部i 5 a，就能更確實且容 易地控制弱密封部1 5的開通強度。進而，平均距離b爲 1mm以’理想的是i.5mm以上，更理想的是2mm以上，則 能更加確實且容易地控制弱密封部丨5的開通強度。另外， -11 - (7) 1252203 理想平均距離B的上限爲i 〇 m m，更理想的是5 m m。此外， B 2 2A，則開通強度過大，會有即使須要時對藥劑室11、 1 2施加力量仍無法容易地開通弱密封部丨5的情況。 然而’此例中，各強熔接部1 5 a爲一邊約〇 . 2 m m的大致 正方面（面積0.04m2)之面，平均間隔A爲1.8mm，平均距離 爲2mm，而強熔接部的合計丨5用面積爲1 %。另外，各強熔 接部1 5 a爲追種面時，該各面積爲1 m m 2以下較爲理想，若 爲0.5 m m2以下則更理想。 依據此複室輸液容器1 〇，因弱密封部1 5中各強熔接部 1 5 a的合計占有面積未滿2 5 %，所以弱密封部1 5的剝離強度 被適度控制，其結果開通強度也成爲適度。所以所使用的 熱可塑性樹脂薄膜例如爲具有結晶性的聚烯樹脂等的單層 薄膜，即使剝離強度較難控制時，仍能控制所形成弱密封 部1 5的剝離強度，其結果是開通強度能容易具確定地成爲 適當的範圍。然而，開通強度的測定方法於後述的實施例 中作說明。 即是具有結晶性的聚烯樹脂薄膜加熱密封時，通常以 這個樹脂熔點附近的溫度進行密封，不過在於熔點附點， 由於結晶熔觸急遽行進，因而會有只要加熱密封溫度若平 變動就變動所形成弱密封部15的剝離強度之情形。此樣變 動剝離強度，則會有因各個複室輸液容器1 〇中弱密封部1 5 的開通強度出現參差不齊所以無法生產具有安定性能的複 室輸液容器之可能性。不過若是控制強熔接部1 5 a的面積 ，熱可塑性樹脂使用具有結晶性的單層薄膜，以該熔點附 -12- (8) 1252203 近的溫度來加以密封，且即使加熱密封溫度若干變動時也 能將弱密封部1 5的剝離強度參差不齊抑制在最小限度，就 能安定生產一定開通強度的複室輸液容器1 0。 用於此例的複室輸液容器1 〇之熱可塑性樹脂薄膜，由 於低價且透明性、柔軟性都優良，所以聚烯樹脂較爲理想 ，例如列舉有高度聚乙烯、中密度聚乙烯、高壓法低密度 聚乙烯、低密度聚乙烯、直鏈狀低密度聚乙烯、乙烯·醋 酸乙烯共聚物等的聚乙烯類樹脂；乙烯-丁二烯共聚物等 的聚烯類彈性橡膠；聚丙烯、乙烯-丙烯不規則共聚物、 α -聚烯-丙烯不規則共聚物等的聚丙烯類樹脂或這些的混 合物。另外，依據此複室輸液容器1 9，如上述，因不必要 爲了形成弱密封部1 5而特別選用特定的樹脂，所以若爲用 於醫療領域的熱可塑性樹脂薄膜則使用上述並沒有特限定 ，也能使用由氯乙烯、乙烯酯酸乙烯共聚物、聚醚硕、環 狀聚烯、環狀聚烯共聚物、氫化苯乙烯乙烯丁二烯共聚物 等的苯乙烯類彈性橡膠、這些樹脂的混合物以及這些與上 述聚烯類樹脂的混合物所形成之薄膜。另外，這些的樹脂 若爲提升耐熱性作爲目的則一部分交聯也可以。 進而，所使用的熱可塑性樹脂薄膜爲由一種薄膜所形 成的單層薄膜或層疊複數種薄膜的形態之多層薄膜皆可。 單層薄膜時，因透明性、柔軟性優良所以爲直鏈狀低密度 聚乙烯、乙烯丁二烯不規則共聚物、乙烯丁二烯異分子共 聚物、聚丙烯類樹脂與苯乙烯類彈性橡膠的混合物等的薄 膜較理想。多層薄膜時，以複室輸液容器的外側，可以列 -13- 1252203 (9) 舉有高密度聚乙烯/直鏈狀低密度聚乙烯、中密度聚乙烯/ 低密度聚乙烯/高密度聚乙烯、高密度聚乙烯/低密度聚乙 烯/高密度聚乙烯等的材質。 另外，多層薄膜由內層能容易剝離之樹脂組成物所構 成亦可。 進而，薄膜的製造方法並沒有特別限定，列舉有T模 、水冷吸塑成形、噴吹成形、層壓成形等的製造方法。從 透明性的觀點則T模成形、水冷吹塑成形較爲理想。 另外，熱可塑性樹脂薄膜使用厚度5〜1 000 // m，最好 是50〜500# m程度。 此複室輸溢容器1 0的弱密封部1 5經由使用如第4圖所 示的密封線20a、21a形成在密封面之2片加熱密封片20、 2 1，而從兩面側夾持被重疊的2片熱可塑性樹脂薄膜就能 形成。然而，此處被重疊的2片熱可塑性樹脂薄膜使用重 疊2片薄膜狀的材質所形成的薄膜亦可，使用預定形成爲 筒狀的薄膜亦可。另外，加上2片的熱可塑性樹脂薄膜， 在弱密封部插入新的薄膜後加以密封亦可。 第4圖的2片加熱密封片20、21，如第5圖中擴大表示 ，密封緣20a、21a，以寬度W爲0.2mm的複數根凸條相互 平行隔有2mm的距離形成在密封面，使一方的加熱密封片 20之凸條的密封緣20a與另一方的加熱密封片21之凸條的 密封緣21a呈90°交互來配置2條的加熱密封片20、21，夾 持被重疊的2片熱可塑性樹脂薄膜。 其結果：從熱可塑性樹脂薄膜的兩面側分別接觸密封 -14- (10) 1252203 緣20a、21a，被壓接的部位厚度較薄，而形成爲已牢固熔 接之強密封部1 5 a，從兩面側都未接觸加熱密封片2 0、2 1 的密封緣20a、2 1 a之部位，藉由熱傳導等被間接加熱，而 形成爲弱熔接之弱熔接部1 5 c。另外，只有接觸任何一方 加熱密封片20、21的密封緣20a、21a之部位形成爲具有強 熔接部15a與弱熔接部15c之間的熔接強度之中間熔接部 15b ° 所以密封緣的寬度W或距離P，依情況預先適度調整 後述的緣角度等，使用從熱可塑性樹脂薄膜的兩面側分別 接觸密封緣20a、21 a而被壓接之部位的合計面積爲未滿弱 密封部1 5全體的25 %之加熱密封片20、2 1，就能容易地形 成具有一定開通強度之弱密封部1 5。 另外，依據此方法，即使加熱密封溫度比最適溫度變 動1 °C程度時，仍得到只在弱密封部1 5的開通速度爲1 〇〇0N 以下，更理想爲7 5 ON以下的範圍內變動。即是開通強度上 升率爲1 000N/°C以下，最好是7 5 0NTC以下。開通強度實 用上300〜2000N程度較爲理想，300〜1 500N則更理想，不過 依據此方法，即使加熱密封溫度若偏離，也形成爲開通強 度容易函蓋在這個範圍內。然而，加熱密封溫度依所使用 的熱可塑性樹脂薄膜適度作決定即可。另外，大致成平行 所形成之複數個凸條的密封緣20a、21a寬度W爲1mm以下較 爲理想，更理想的是0.5mm以下，距離P則設成1mm以上。 另外，依據此方法，因只要使用密封緣20a、21 a的寬 度W或距離p依情況調整緣角度之加熱密封片20、2 1來使所 -15- 1252203 (11) 形成強熔接部1 5 a的合計占有面積未滿弱密封部1 5 a面積的 2 5 %，就能形成所要開通強度的弱密封部1 5，所以形成弱 密封部1 5之弱密封過程及將複室輸液容器1 〇的周緣密封成液 密之強密封過程也能同時進行。 即是使用能同時夾形成有強密封部1 6之複室輸液容器1 〇 的周緣及形成有弱密封部15之複室輸液容器10的中央部之模 型的加熱密封片（未圖示），形成弱密封部15的部位之密封緣 20a、21a，如上述，設爲強熔接部i5a的合計占有面積未滿 25%之密封緣；此外，形成強密封部16的部位之密封緣，由 於設爲即使對藥劑室11、1 2施加力量也不會剝離，所以只用 加熱密封條夾持熱可塑性樹脂薄膜的1次操作，就能同時形 成弱密封部15及強密封部16。 然而，在形成弱密封部1 5之加熱密封片中所形成之密封 緣的緣角度α ，如第5圖所示般爲1 20度以下較理想。超過 1 20度則會有強熔接部1 5的面積控制困難的可能性。更理想 爲90度以下，再更加理想爲60度以下。 此方式所製造之複室輸液容器10的弱密封部15，如同在 第6(a)、6(b)圖中分別槪略表示沿著第3圖的I-厂線及ΙΙ-ΙΙ / 線之剖面圖，經由加熱密封片20、21的密封緣20a、21 a與熱 可塑性樹脂薄膜接觸就形成爲形成有凹凸的狀態。此例的情 況，沿著已接觸之密封緣的形狀，寬度約0.2mm或更寬若干 ，相互間的距離約2mm成平行的凹條22a分別形成在弱密封 部1 5的兩面。然後，此凹條22a當中，一部分爲從熱可塑性 樹脂薄膜的兩面側壓接密封緣2 〇 a、2 1 a所形成之強熔接部 -16- (12) 1252203 20a、2 1 a，其餘的部分爲只從熱可塑性樹脂薄膜的一側接觸 密封緣20a、21a之中熔接部15b。 此方式所形成之凹條22a，與密封緣20a、21 a的寬度W或 距離p相對應來決定，不過理想的是所圖示的寬度w/約爲 1mm以下而距離p /約爲1mm以上。然而，寬度W —具有與寬 度W相同或大若干的傾向，距離p /則與距離p幾乎相同。 然而，此例中的凹條22a，面對複室輸液容器1〇的長度 方向形成有45 °C的角度。此角度沒有特別限制，不過若爲 3 0〜60 °的範圍較爲理想。第2圖中，箭頭方向爲複室輸液容 器10的長度方向。 另外，此例則強密封部1 5a幾乎均等分散在於弱密封部 15中，不過只要強密封部15a的合計占有面積未滿弱密封部 1 5的25 %，即使其分布狀態爲弱密封部1 5的寬度方向，即是 爲第1圖中的左右方向一定程度不同亦可。例如，寬度方向 的中央部附近緊密分布強熔接部15a，寬度方向的兩端部附 近則粗略分布，或是相反地，寬度方向的中央部附近粗略分 布強熔接部1 5a，寬度方向的兩端部附近則緊密分布皆可（未 圖示）。 此樣形成爲弱密封部15的寬度方向強熔接部15a的分布 狀態有所不同，就能達到所期望剝離、開通此弱密封部1 5之 際的狀態，或不慎使複室輸液容器1 0掉落，即使力量加諸在 弱密封部1 5的寬度方向之端部也不會開通等，可以作種種的 調整。此樣爲使寬度方向強熔接部15a的分布狀態有所不同 ’使用依照此布來形成密封面的密封緣之加熱密封片即可。 -17- (13) 1252203 (第2實施形態） 第7圖爲表示本發明第2實施形態的複室輸液容器1 〇之弱 密封部1 5。 此例中的弱密封部1 5也是用密封面形成有特定的密封緣 的2片加熱密封片，從其兩面側夾持被重疊的2片熱可塑性樹 脂薄膜而被形成，具有熔接強度不同的2個熔接部，即是具 有強熔接部1 5 a及弱熔接部1 5 c。 其中熔接強度較大的強熔接部1 5a形成爲大致正方形及 線狀，線狀的強熔接部1 5a相互間大致成平行以等間隔配置 ，大致正方形的強熔接部1 5a分散分布在這些之間。熔接強 度較低的弱熔接部15c則是弱密封15中除了強熔接部15a以外 的全部。 然後，此例中也是2個熔接部當中剝離強度較大的強熔 接部15a形成爲其合計占有面積未滿弱密封部15全體面積的 25%，適度控制弱密封部15的開通強度即可。 另外，此例中也是分散分布在於弱密封部1 5中之各強熔 接部15a依照所接近強熔接部15a間的平均間隔A及平均距離 B符合上述式（1)的關係加以分布，進而平均距離B理想爲 1mm以上，更理想爲1.5mm以上，特別理想爲2mm以上，就 能非常確實且容易控制弱密封部1 5的開通強度。 然而，此例的情況，所接近大致正方形彼此間的間隔A ^ 及距離1，與第1實施形態的情況相同，如同第8圖。此外， 線狀的強熔接部1 5a及與此接近的大致成正方形等之面狀的 強熔接部15a之兩者間的距離B2爲從面狀強熔接部15a的重心 -18- 1252203 (14) 往線狀的強熔接部1 5a畫垂線，該垂線上線狀強熔接部1 5a之 寬度方向的中心點與前述重心的長度。另外，間隔A2爲此垂 線上一方強熔接部1 5 a的末端與另一方強熔接部1 5 a的末端之 距離。然後將這些距離平均，就能求得平均間隔A及平均距 離。 另外，強熔接部15A爲線狀及面狀時，面的面積爲1mm2 以下，線的寬度爲1 mm以下較理想。另外，若爲面狀時，其 形狀並不侷限於大致成略正方形，若爲其他的多角形或圓形 等亦可。 此複室輸液容器1 0的弱密封部1 5，使用如同第9圖的密 封緣23a、24a形成在密封面之2片加熱密封片23、24，從兩 側面夾持被重疊的2片熱可塑性薄膜就能形。 第9圖的2片加熱密封片23、24當中，一方的加熱密封片 23具有如同第1實施形態束所使用的在密封面形成有相互或 平行的複數個凸條之密封緣23a，另一方加熱密封片24具有 由等間隔呈格子狀分布之多數個大致成正方形的凸面所形成 之密封緣24a。然後，使一方加熱密封片23上之凸條的密封 緣23a與另一方加熱密封片24上的凸面24a相互偏離來夾持熱 可塑性樹脂薄膜。 其結果：從熱可塑性樹脂薄膜的任何一方的面側接觸密 封緣23a、24a而被壓接的部位成爲牢固熔接的強熔接部15a ，兩面側都不接觸加熱密封片23、24的密封緣23a、24a之部 位成爲以熱傳導等間接加熱而被稍加熔接之弱熔接部1 5c。 此處，預先依照各密封緣2.3a，24a的寬度或距離，情況 -19- (15) 1252203 ，適當調整緣角度，適當使用從熱可塑性樹脂薄膜的任何一 方的兩側接觸密封緣23a、24a而被壓接之部位的合計面積未 滿弱密封部15全體面積的25%之加熱密封片23、24，就能容 易且安定地形成一定開通強度的弱密封部1 5。使用此加熱密 封片23、24時，大致成平行所形成之複數個凸條的密封緣 23a寬度理想爲1mm以下，距離爲1mm以上。另外由凸面所形 成之密封凸緣24a的面積爲1mm2以下較理想。 此方式所形成此例的複室輸液容器10的弱密封部15a， 如同第10圖中表示沿著第8圖的Ill-Ill線之斷面圖，形成爲 加熱密封片23、24的密封緣23A、24A接觸到熱可塑性樹脂 薄膜而形成有凹部的狀態。此例的情況，在弱密封部15的兩 面具有凹部，具體上在一方的面形成有凹條22a。形成有此 凹條22a及凹面的部位都是強熔接部15a。 此方式所形成的凹條22a，與所使用的加熱密封條所具 有之密封緣的寬度或距離相對應，寬度與密封緣的寬度相同 或大若干，距離則與密封緣的距離幾乎相同。此方式所形成 的凹條22a最好是寬度爲1mm以下且相互間的距離爲1mm以上 。另外，凹面22b與由凸面所形成之密封緣的面積幾乎相同 爲1mm2以下較理想。 然而，此樣由強熔接部15a及弱熔接部15c所形成之弱密 封部15的形成，除了使用上述的方法，此外也能使用耐熱性 比所使用的熱可塑性樹脂薄膜更優良且形成有與所形成之強 熔接部1 5a相對應的孔之薄膜製的模型之方法。即是藉由此 模型將熱可塑性樹脂薄膜加熱，與孔對應之部位成爲強熔接 •20- (16) 1252203 部1 5 a ’其餘的部位成爲弱熔接部。 (第3實施形態） 第1 1圖爲表示本發明第3實施形態的複室輸液容器1 〇中 的弱密封部1 5。 此例中的弱密封部1 5也是用2片的加熱密封片從其兩面 側夾持被重疊的2片熱可塑性樹脂薄膜而被形成，具有強熔 接部15a及弱熔接部15c。 其中強熔接部較高的強熔接部1 5a形成爲大致成正方形 ，熔接強度較低的弱熔接部15c則是弱密封部15c中除了強熔 接部15a以外的全部。 然後’此例中也是強熔接部1 5a形成爲其合計占有面積 未滿弱密封部1 5全體面積的25 %，其結果：弱密封部1 5的開 通強度被適度控制。 此複室輸液容器1 0的弱密封部1 5用具有第9圖中圖號24 所示由等間隔呈格子狀分布之多數大致成正方形的凸面所形 成的密封緣24a之加熱密封片、及具備未形成有加熱緣的平 面狀密封面（未圖示）之加熱密封片，從兩面側夾持被重疊的 2片熱可塑性樹脂薄膜就可以形成，利用由凸面所形成的密 封緣24a及平面狀的密封面來夾持而被壓接之部位成爲牢固 熔接之強熔接部1 5a。從一方的面側只接觸加熱密封片的平 面狀密封面之部位成爲稍加熔接之弱熔接部1 5 c。 此情況也是使此方式所形成之強熔接部1 5 a的合計占有 面積未滿弱密封部全體面積的25%來選用加熱密封片’就能 -21 - (17) 1252203 容易地形成具有一定剝離強度之弱密封部1 5。使用此加熱密 封片時，也是由凸面所形成之密封緣24a的面積設爲1mm2以 下較理想。 經此方式所形成此例的複室輸液容器1 0之弱密封部1 5， 如同第12圖中表示沿著第11圖的IV-IV /線之剖面圖，加熱 密封片的密封緣接觸到熱可塑性樹脂薄膜，而成爲只在一方 的面形戊凹部，具體上形成凹面22b的狀態。此例的情況， 此部位都是強熔接部15a。 經此方式所形成之凹面22b，當利用具有由面積爲1mm2 以下的凸面所形成的密封緣24a之加熱密封片24所形成時， 其面積也幾乎是1mm2以下。 然而，形成此例的弱密封部1 5時，首先用具備未形成' 有密封緣的平面狀密封面（未圖示）之加熱密封片來將形成弱 密封部1 5的全體部位密封，之後用具有圖號24所示由等間隔 呈格子狀分布之多數個大致成正方形的凸面所形成的密封緣 24a之加熱密封片來將形成弱密封部1 5的全體部位加熱之方 法，也能形成強熔接部15a及弱熔接部15c。 此第1〜第3實施形態例的複室輸液容器10中，特別是弱 密封部1 5具有強熔接強度不同的複數個熔接部所形成，這些 熔接部當中熔接強度最大的強熔接部1 5a分散分布在於弱密 封部1 5中，且被控制在其合計占有面積未滿弱密封部1 5面積 的25 %，所以弱密封部1 5的開通強度被適度控制，通常是液 密把持在藥劑室11、12間，此外形成爲當力量從外方加諸到 藥劑室11、1 2時能容易開通。另外，例如熱可塑性樹脂薄膜 -22- (18) 1252203 使用具有結晶性的單層薄膜，以該熔點附近的溫度加以密封 ，且即使加熱密封溫度若干變動時，仍將弱密封部1 5之開通 強度的參差不齊抑制在最小限度，而能穩定生產一定性能的 複室輸液容器1 0。 (實施例1) 以下，以實施例來具體說明本發明。（實施例1) 利用水冷吹塑法，作成由直線狀低密度聚乙烯（MFR : 2g/10 分（190°C )、密度 0.9 25g/cm3、JISK67 60)所形成之厚度 300// m的薄膜。 重疊2片的薄膜，用2片的加熱密封片從兩面側夾持此被 重疊的2片薄膜，而形成能剝離開通的弱密封部15及不剝離 的強密封部，製造與第1圖所示的複室輸液容器10相同形態 的複室輸液容器。然而，弱密封部15以10mm長度形成在複 室輸液容器1 〇的長度方向的中央部。另外，此時所使用的2 片加熱密封片，如第4圖所示，爲多數條略成平行形成有凸 條的密封緣之加熱密封片，而密封緣的寬度W爲0.2mm，距 離P爲2mm，緣角度α爲90 °，且弱密封部15中強熔接部15a 的合計占有面積都是4%。 另外，密封條件設爲密封壓力0.39MP、密封時間4秒’ 加熱密封溫度用1 1 8 °C、11 9 °C、1 20 °C的3種溫度來進行。即 是製造只有加熱密封溫度不同的3個複室輸液容器1 〇。 在此方式所形成的2個複室輸液容器10之藥劑室11、12 中，取代充塡藥劑改而分別充塡lOOOmL被加色的水後，利 -23- (19) 1252203 用壓縮測試器，用100mm xlOOmm的平板以速度500mm/分擠 壓藥劑室1 1、1 2的一方。測定弱密封部1 5開通之際的負荷， 此測定値則爲弱密封部1 5的開通強度。 其結果得知：此方式所形成的複室輸液容器10之弱密封 部1 5的開通強度，加熱密封溫度1 1 8 t時爲25 3N，1 1 9 t時爲 760N，120°C時爲126N ; 300〜1000N的開通強度上升率（每1°C ，開通強度的變化）只有507N/t，即使加熱密封溫度若干變 動，開通強度也沒有大幅的變化。 進而，在這些複室輸液容器10的兩者藥劑室11、12中分 別放入lOOOmL的已被加色的水後，將此載置在平坦台上， 交互用手按壓5次兩藥劑室11、1 2，全體弱密封部1 5都已剝 離（5次以內全體都已剝離者，表1中以開通性：〇表示）。 另外，已形成之複室輸液容器10的弱密封部15其凹條的 寬度W，及距離，（參照第6圖）分別爲2mm、0.4mm，上述式 (1)的平均間隔爲平均距離爲分別爲1.6mm、2mm。然而這些 的測定是用像片來進行，該像片是以倍率20倍將弱密封部1 5 攝影。 以上的結果等都顯示表1及表2中。 (實施例2) 除了所使用2個加熱密封具的密封緣寬度W爲0.2mm，距 離P爲4mm，緣角度α爲90 °，加熱密封溫度爲120°C、121°C 、1 22 t以外，其他與實施例1同樣地，製造3種的複室輸液 容器1 0，弱密封部1 5中強熔接部1 5a的合計占有面積都是 -24- 1252203 (20) 0.6%。 與實施例同樣地，評比此3種的複室輸液容器，其結果 顯示在表1與表2中。 如表2所示，得知開通強度300〜1 000N的開通強度上升率 較小’即使加熱密封溫度若干變動，開通強度也沒有大幅的 變化。另外，開通性也良好。 (比較例1) 除了所使用2片加熱密封片的密封緣寬度爲0.4mm，距 離爲1mm，綠角度α爲90 °，加熱密封溫度爲117°C及118°C 以外，其他與實施例1同樣地，製造2種的複室輸液容器1 〇。 弱密封部15中強熔接部15a的合計占有面積都是25%。 與實施例1同樣地，評比此2種的複室輸液容器，其結果 顯示在表1及表2中。 如表2所示，得知開通強度300〜1000N的開通強度上升率 較大，加熱溫度若干變化則開通溫度就大幅變化。另外，針 對開通性，弱密封部15—部分未剝離，而不是良好（表2中用 X表示）。 (比較例2) 除了所使用2個加熱密封具的密封緣寬度W都是0.2mm. ，距離P爲2mm，緣角度α爲150 °，加熱密封溫度爲1 17 t： 及1 1 8 t：以外，其他與實施例1同樣地，製造2種的複室輸液 容器1 0。弱密封部1 65中強熔接部1 5a的合計占有面積都是 -25· (21) 1252203 30%。 與實施例1同樣地，評比此2種的複室輸液容器’其結果 顯示在表1及表2中。 如表2所示，得知開通強度300〜1 000N的開通強度上升率 較大，加熱密封溫若干變動，開通強度就大幅變化。另外’ 針對開通性，弱密封部1 5 —部分未剝離，並不良好。 (實施例3) 如第9圖所示，將凸條的密封緣與凸面的密封緣（呈格子 狀均等地存在正方形的密封緣）組合後使用。然而這些密封 緣都是寬度W爲0.2 m m ’距離P爲4 in m ·緣角度（2爲9 0 。然後 ，除了加熱密封溫度爲118°C、119°C、120°C以外，其他與 實施例同樣地，製造3種的複室輸液容器10。弱密封部1 5中 強熔接部15a的合計占有面積都是8%。 與實施例1同樣地，評比此3種的複室輸液容器，其結果 顯示在表1及表2中。 如表2所示，得知開通強度300〜1000N的開通強度上升率 較小，即使密封溫度若干變化，開通強度也沒有大幅度化 。另外，開通性也良好。 然而，表1中，平均距離A!及平均距離B!，如第8圖所示 ，都是針對對凹面作測定，也就是針對強熔接部1 5間作測定 ;平均距離A2及平均距離B2都是針對凹面及凹條的強熔接部 15a間作測定。 -26- (22) 1252203 (實施例4) 2片的加熱密封片，一方爲凸面的密封緣（正方形）之第9 圖中圖號24所示形態的加熱密封片，另一方爲備有沒有密封 緣之平面狀的密封面之加熱密封片，將兩加熱密封片組合後 使用。然而，凸面的密封緣，寬度W爲0.2mm，距離P爲2mm ，緣角度爲60 °。然後，除了加熱密封溫度爲1 20 °C、1 2 1°C 、122°C以外，與實施例同樣地，製造3種的複室輸液容器10 。弱密封部15中強熔接部15a的合計占有面積都是1%。 與實施例1同樣地，評比此3種的複室輸液容器，其結果 顯示在表1及表2中。 如表2所示，得知開通強度300〜1000N的開通強度上升率 較小，即使加熱密封溫度若干變動，開通強度也沒有大幅變 化。另外，開通性也良好。 (比較例3) 2片的加熱密封片都是將具備沒有密封緣之平面狀的 密封面之加熱密封片組合後使用。然而，凸面也就是密封 緣，寬度W爲0.2 mm，距離P爲2mm，緣角度爲60°。然後 ，除了加熱密封溫度爲12(TC、121°C、122°C以外，其他與 實施例1同樣地，製造3種的複室輸液容器1 〇。弱密封部1 5中 強熔接部15a的合計與占有面積都是1%。 與實施例1同樣地，評比此3種的複室輸液容器’其結果 顯示在表1及表2中。 如表2所示，得知開通強度300〜1 000N的開通強度上升率 «27- (23) 1252203 較小’即使加熱密封溫度若干變動，開通強度也沒有大幅變 化。另外，開通性也良好。 (比較例3) 2片的加熱密封片都是將具備沒有密封緣之平面狀的 密封面之加熱密封片組合後使用。然後，除了加熱密封片 溫度爲1 1 7 °C及1 1 8 °C以外，其他與實施例1同樣地，製造2 種的複室輸液容器1 〇。弱密封部1 5中強熔接部1 5 a的合計與 占有面積都是1〇〇%。 如表2所示，得知開通強度300〜1000N的開通強度上升率 較大，加熱密封溫度若干變動則開通強度也大幅變化。另外 ，針對開通性，弱密封部1 5 —部分未剝離，並不是良好。
-28- (24)1252203 hO. •m §3 锑 < I CD T— 卜 CO 3.7(^) 1.7(A2) 00 τ~ ΙΟ Ο 0..9 1 m I CNJ 寸 4(B〇 2(B2) CM Τ— CN I S — • m ^ 1 缌祀 寸 CD d 00 τ— LO CM 另 100 馨 侧 k i 寸 d CO o CO d CM Ο ΙΟ Ο τ~ 1 x—v '〇 I CNJ 寸 寸 CM τ— CM 1 加熱密封片 -I g § § g § 150 1 CM d CM 〇 CM d CM d 寸 ο CNJ d 1 i I CM xr CM τ~ Csl 雇 實施例1 CM 變 1¾ CO 鹣 寸 Μ 比較例1 比較例2 比較例3
-29- (25)1252203 開通性 〇 〇 〇 〇 X X X 液體洩漏 〇 〇 〇 〇 〇 〇 〇 開通強度 上昇率 (N/°C ) 507 270 529 267 1230 1100 1180 侧 賴 SS 122 (°C ) 1041 900 __ X—V 5 〇 广 。一 771 633 120 (°C ) 1267 § 1379 366 鲥 II 119 (°C ) 760 850 118 (°C ) 253 321 1860 1640 1900 j 117 ! (°c ) 630 540 720 實施例1 CM 匡 ㈣ 1¾ CO 舞 1¾ 寸 1¾ 比較例1 比較例2 比較例3
-30- (26) 1252203 另外，實施例1〜4以及比較例1〜3的全部複室輸液容器！ 〇 都是在藥劑室Π、1 2內裝塡液體後’目視下弱密封部1 5未被 發現液體洩漏。 [發明效果] 如以上所說明過，本發明的複室輸液容器，因弱密封部 中強熔接部的合計占有面積未滿25 %，所以無關薄膜的材質 、構成等，形成爲複室輸液容器與藥劑室之交界部位的剝離 強度安定之複室輸液容器。另外，依據本發明的製造方法， 能容易且良好生產性地製造此種複室輸液容器。 【圖式簡單說明】 第1圖爲表示本發明複室輸液容器的一例之平面圖。 第2圖爲部分擴大第1圖中複室輸液容器的弱密封部之 平面圖。 第3圖爲部分更擴大第1圖中複室輸液容器的弱密封部 之平面圖。 第4圖爲用來形成第1圖中複室輸液容器的弱密封部所 使用之加熱密封片的斜視圖。 第5圖爲沿著第4圖的V - V /線之剖面圖。 第6 Α圖爲沿著第3圖的I -1 /線之剖面圖，第6 (Β )圖爲 沿著第3圖的IL·II /線之剖面圖。 第7圖爲部分擴大本發明其他例的複室輸液容器的弱密 封部之平面圖。 -31 - (27) 1252203 第8圖爲與第7圖同樣的平面圖。 第9圖爲用來形成第7圖中複室輸液容器的弱密封部所 使用之加熱密封片之斜視圖。 第1 〇圖爲沿著第8圖的111 -111 >線之剖面圖。 第1 1圖爲部分擴大本發明另外例的複室輸液容器的弱 密封部之平面圖。 第12圖爲沿著第1 1圖的IV-IV -線之剖面圖。
[符號說明]
1 〇 :複室輸液容器 1 1、1 2 :藥劑室 1 5 :弱密封部 1 5 a :強熔接部 1 6 :強密封部 20、21 :加熱密封片 22a :凹條 22b :凹面 223 ”24 :加熱密封片 -32-

Claims (1)

  1. (1) 1252203 拾、申請專利範圍 1 · 一種複室輸液容器，是針對具有由熱可塑性樹脂薄 膜所形成，收容藥劑的複數種藥劑室之複室輸液容器，其 特徵爲： 各藥劑室彼此間用可剝離的弱密封部來加以液密密封， 前述弱密封部具有熔接強度不同的複數個熔接部， 這些熔接部當中熔接強度最大的強熔接部是分散分布於 弱密封部中，且該合計占有面積未滿該弱密封部面積的2 5 % 〇 2 ·如申請專利範圍第1項之複室輸液容器，其中各強熔 接部係使所接近的強熔接部間之平均間隔A及平均距離B 爲符合下述式（1)來加以分布； B < 2 A .........(1) 〇 3 ·如申請專利範圍第2項之複室輸液容器，其中強熔接 部間的前述平均距離爲1.0mm以上。 4 ·如申請專利範圍第1項之複室輸液容器，其中各強熔 接部爲面積爲1mm2以下的面及/或寬度爲imm以下的線。 5 ·如申請專利範圍第1項之複室輸液容器，其中弱密封 部的至少其中一方的面具有凹部，該凹部的至少一部分爲強 熔接部。 6.如申請專利範圍第5項之複室輸液容器，其中前述凹 部由大致成平行所形成之寬度爲1 mm以下的複數個凹條及/ 或面積爲1mm2以下的複數個凹面所形成。 7 .如申請專利範圍第5項之複室輸液容器，其中弱密封 -33- (2) 1252203 部的其中一面具有凹部，另一面則形成爲平面狀。 8 .如申請專利範圍第5項之複室輸液容器，其中弱密封 部的兩面具有凹部。 9 .如申請專利範圍第1項之複室輸液容器，其中各強熔 接部的分布狀態爲在弱密合部的寬度方向上有所不同。 10.—種複室輸液容器之製造方法，是針對具有收容藥 劑之複數個藥劑室，各藥劑室彼此間用可剝離的弱密封部來 加以液密密封的複室輸液容器之製造方法，其特徵爲： 具有從兩面側利用2片加熱密封片來夾持被重疊的2片 熱可塑性樹脂薄膜，而形成具有熔接強度不同的複數個熔接 部之弱密封部之弱密封過程， 該弱密封過程係使前述熔接部當中熔接強度最大且分散 分布在前述弱密封部內之強熔接部的合計占有面積未滿該弱 密封部面積的25%。 11·如申請專利範圍第10項之複室輸液容器之製造方法 ，其中至少在一方的前述加熱密封片的密封面上形成有密封 緣。 1 2.如申請專利範圍第11項之複室輸液容器之製造方法 ，其中前述密封緣由大致成平行所形成之寬度爲1 mm以下 的複數個凸條及/或面積爲1 mm2以下的複數個凸面所形成 〇 1 3 ·如申請專利範圍第11項之複室輸液容器之製造方法 ’其中在一方的加熱密封片的密封面上形成有密封緣，另〜 方的加熱密封片的密封面上則形成爲平面狀。 -34- (3) 1252203 j 4.如申請專利範圍第11項之複室輸液容器之製造方法 .其中在兩個加熱密封片的密封面上形成密封緣。 1 5.如申請專利範圍第11項之複室輸液容器之^七方法 ，其中各密封緣間的平均距離爲1.0mm以上。 1 6.如申請專利範圍第11項之複室輸液容器之製造方法 ，其中各密封緣的緣角度爲1 20度以下。 17. 如申請專利範圍第10項之複室輸液容器之製造方法 ，其中具有從兩面側利用加熱密封片來夾持該複室輸液容器 周緣的至少一部分’閉合該周緣部保持液體密閉性之強密封 過程’ 該強密封過程和前述弱密封過程是同時進行。 18. 如申請專利範圍第1〇項之複室輸液容器之製造方法 ，其中弱密封過程是使相對於加熱密封溫度之弱密封部的開 通強度上升率爲l〇〇〇N/°C以下。 -35-
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CN1642716A (zh) 2005-07-20
EP1490207B1 (en) 2010-05-26
US7776414B2 (en) 2010-08-17
KR20050016315A (ko) 2005-02-21
PT1490207E (pt) 2010-06-25
ES2344891T3 (es) 2010-09-09
ATE468963T1 (de) 2010-06-15
KR100659650B1 (ko) 2006-12-20
US20100269972A1 (en) 2010-10-28
AU2003226480A1 (en) 2003-10-13
EP1490207A1 (en) 2004-12-29
US20050221034A1 (en) 2005-10-06
CN100344439C (zh) 2007-10-24
TW200305531A (en) 2003-11-01

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