TWI222366B - Tablet which can be divided exactly - Google Patents
Tablet which can be divided exactly Download PDFInfo
- Publication number
- TWI222366B TWI222366B TW088114183A TW88114183A TWI222366B TW I222366 B TWI222366 B TW I222366B TW 088114183 A TW088114183 A TW 088114183A TW 88114183 A TW88114183 A TW 88114183A TW I222366 B TWI222366 B TW I222366B
- Authority
- TW
- Taiwan
- Prior art keywords
- tablet
- curved end
- lower curved
- parallel
- year
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Packages (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
1222366 五、發明說明（1) 本發明係關於一種可精確分開之藥片。 事實上所有含有藥效作用物質的藥片，皆可藉由形成一 或多個的刻度，而以人工的方式分為所需要的適當大小及 形狀，。然而，現今已知的藥片，若不是僅可以單一方向 分開’如此對於較年長的患者通常會造成某些問題，便是 其所分開的兩個半片的藥片，不能具有相同份量的作用物 貝。根據歐洲藥品委貝會9 6屆會議報告（e u r ο p e a η Pharmacopoeia Commission， Report 96th MsGting)
案，當該完整藥片的作用物質含量超過250mg時，在兩個 藥片半片中該作用物質的含量差異，不應該超過10%的重 量百分比，而當該完整藥片的作用物質含量低於250mg 時，在兩個藥片半片中該作用物質的含量差異，不應該超 過1 5%的重量百分比。因此，根據π德國藥品'1第十版 (German pharmacopoeia, l〇th Edition) ’ 依據作用物質 所需要的量及該藥片之尺寸’在每個個別的藥片中，該作 用物質含量與所需之量有5到1 0 %的差異’所以區分藥片的 供藥方式可能會因為作用物質供給藥量的變化而導致某些 問題。
現在揭示一種藥片，其町以兩個方向分開，且當其分開 為兩個半片時，該兩半片大致上含有相同量的作用物質。 本發明說明一種藥片，具有兩端面及一圓周面，其中該 藥片的兩個相對端面： a)整個皆非平面，且相互間以至少大致平行的方式配
O:\60\60052.PTD 第4頁 1222366 五、發明說明（2) 置，以及 % b)每個該端面於該頂部及底部側皆具有刻度，該刻度位 於該藥片之中央，其相互平行且上下重疊。 該藥片的兩個相對端面相互間最好平行或者大致上平行 地配置，該藥片的兩個半片形成1 3 0到1 7 7。的角度。對於 較小的藥片，此一角度最好接近1 3 0。，同時對於較大之藥 片而言，該角度可以大至1 7 7。。當對該頂部或底部側施加 壓力時，在任何情況下皆足以使該藥片正確的裂開。該相 對之端面最好互相平行。相對上對較大的藥片而言，如果 需要增加該藥片的體積而不致影響破裂的特性時，該底部 端面（參考圖3 )所形成之角度可以略小（亦即，到達 2 5°，最好是1 5°)。 該刻度之深度大致上為該藥片與該刻度處之厚度的5到 1 0%。對於該刻度之外形並沒有特殊的需求。 於該藥片之該邊緣，該頂部或底部侧，最好於其兩側， 提供一斜角（=結晶面，斜面）是較佳的方式，如此可以增 加壓向該藥片時所作用的衝擊負載。如果該藥片於該頂部 及底部側具有一斜角，則這些斜角最好互相補償至大約 9 0〇。 該藥片通常為圓形，但亦可為橢圓形（例如長橢圓形）或 多邊形（例如矩形或正方形），而在多邊形的情況中其具有 圓形的邊角。如果用於口服供藥，該藥片之直徑必須至少 4 mm 至14 mm 〇 此種新型的藥片具有下列的優點：
1222366 五、發明說明（4) 具有該斜角5之頂部端面。
第7頁
Claims (1)
1222366
案號88114183 "Μ年厶月 日 六、申請專利範圍 1 . 一種凹面藥片，具有一上彎曲端面、一下彎曲端面 及一圓周面，其中： a) .該上、下彎曲端面係非為平面，而且各該上、下 彎曲端面形成有一刻痕以將藥片分開為兩藥片半片，各藥 片半片之上及下彎曲端面係互相平行；以及 b) .該凹面藥片之上、下彎曲端面各設有一刻痕，位 於藥片之中央且互相平行，二新月形斜角形成於上及/或 下彎曲端面之刻痕兩側之邊緣。 2. 根據申請專利範圍第1項之凹面藥片，其該由刻痕所 分開之藥片半片在下彎曲端面形成角度範圍1 3 0 °至1 77 ° 之夾角。
O:\60\60052-930621.ptc 第8頁
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19837684A DE19837684A1 (de) | 1998-08-19 | 1998-08-19 | Exakt teilbare Tablette |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TWI222366B true TWI222366B (en) | 2004-10-21 |
Family
ID=7878069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW088114183A TWI222366B (en) | 1998-08-19 | 1999-08-19 | Tablet which can be divided exactly |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6692765B1 (zh) |
| EP (1) | EP1105103B1 (zh) |
| CN (1) | CN1155371C (zh) |
| AT (1) | ATE243505T1 (zh) |
| AU (1) | AU763894B2 (zh) |
| BR (1) | BR9914610A (zh) |
| CA (1) | CA2341005C (zh) |
| CZ (1) | CZ302617B6 (zh) |
| DE (2) | DE19837684A1 (zh) |
| DK (1) | DK1105103T3 (zh) |
| ES (1) | ES2203172T3 (zh) |
| HK (1) | HK1040618B (zh) |
| HU (1) | HU230457B1 (zh) |
| IL (2) | IL141092A0 (zh) |
| NO (1) | NO318249B1 (zh) |
| PT (1) | PT1105103E (zh) |
| TW (1) | TWI222366B (zh) |
| WO (1) | WO2000010535A2 (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19849434A1 (de) * | 1998-10-27 | 2000-05-04 | Isis Pharma Gmbh | Teilbare Tablette |
| WO2001000176A1 (en) * | 1999-06-23 | 2001-01-04 | Eu Pharma Ltd. | Divisible tablets |
| JP5049517B2 (ja) * | 2006-06-09 | 2012-10-17 | 高田製薬株式会社 | 分割錠剤 |
| US7985419B1 (en) | 2006-12-22 | 2011-07-26 | Watson Laboratories, Inc. | Divisible tablet and associated methods |
| USD669573S1 (en) * | 2010-12-15 | 2012-10-23 | Otsuka Pharmaceutical Co., Ltd. | Tablet |
| DE102016119675A1 (de) | 2016-10-14 | 2018-04-19 | Ritter Pharma-Technik Gmbh | Tablette mit Bruchwinkel und senkrecht zur Pressrichtung eingebrachter Teilungskerbe |
| USD941457S1 (en) * | 2020-04-07 | 2022-01-18 | Nutramax Laboratories, Inc. | Dietary supplement |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1200790B (de) * | 1961-12-06 | 1965-09-16 | Thomas L Cooper | Zerlegbare Tablette |
| BE632692A (zh) * | 1963-05-28 | |||
| US3336200A (en) | 1963-05-28 | 1967-08-15 | Warner Lambert Pharmaceutical | Tablet structure |
| USD202467S (en) * | 1963-10-07 | 1965-10-05 | Jacques Guilmot | Pharmaceutical tablets |
| USD201497S (en) * | 1964-09-28 | 1965-06-29 | Warner Lambert Co | Tablet |
| US4258027A (en) * | 1979-03-26 | 1981-03-24 | Mead Johnson & Company | Multi-fractionable tablet structure |
| GB8514089D0 (en) * | 1985-06-04 | 1985-07-10 | Sandoz Ltd | Pharmaceutical tablet |
| JPH07179333A (ja) * | 1993-12-21 | 1995-07-18 | Kikusui Seisakusho:Kk | 錠 剤 |
| USD383535S (en) * | 1996-04-24 | 1997-09-09 | Schering Corporation | Tablet |
-
1998
- 1998-08-19 DE DE19837684A patent/DE19837684A1/de not_active Withdrawn
-
1999
- 1999-08-11 AU AU55151/99A patent/AU763894B2/en not_active Expired
- 1999-08-11 IL IL14109299A patent/IL141092A0/xx active IP Right Grant
- 1999-08-11 AT AT99941596T patent/ATE243505T1/de active
- 1999-08-11 CZ CZ20010632A patent/CZ302617B6/cs not_active IP Right Cessation
- 1999-08-11 DK DK99941596T patent/DK1105103T3/da active
- 1999-08-11 PT PT99941596T patent/PT1105103E/pt unknown
- 1999-08-11 BR BR9914610-0A patent/BR9914610A/pt not_active Application Discontinuation
- 1999-08-11 ES ES99941596T patent/ES2203172T3/es not_active Expired - Lifetime
- 1999-08-11 CA CA002341005A patent/CA2341005C/en not_active Expired - Lifetime
- 1999-08-11 HU HU0103163A patent/HU230457B1/hu unknown
- 1999-08-11 DE DE59906114T patent/DE59906114D1/de not_active Expired - Lifetime
- 1999-08-11 CN CNB998098167A patent/CN1155371C/zh not_active Expired - Lifetime
- 1999-08-11 US US09/762,399 patent/US6692765B1/en not_active Expired - Lifetime
- 1999-08-11 EP EP99941596A patent/EP1105103B1/de not_active Revoked
- 1999-08-11 WO PCT/EP1999/005905 patent/WO2000010535A2/de active IP Right Grant
- 1999-08-19 TW TW088114183A patent/TWI222366B/zh not_active IP Right Cessation
-
2001
- 2001-01-25 IL IL141092A patent/IL141092A/en not_active IP Right Cessation
- 2001-02-16 NO NO20010785A patent/NO318249B1/no not_active IP Right Cessation
-
2002
- 2002-03-18 HK HK02102067.2A patent/HK1040618B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1105103A2 (de) | 2001-06-13 |
| WO2000010535A3 (de) | 2000-06-02 |
| HUP0103163A2 (hu) | 2001-12-28 |
| HK1040618B (zh) | 2005-04-08 |
| DE19837684A1 (de) | 2000-02-24 |
| HU230457B1 (hu) | 2016-07-28 |
| AU5515199A (en) | 2000-03-14 |
| NO318249B1 (no) | 2005-02-21 |
| IL141092A (en) | 2007-03-08 |
| WO2000010535A2 (de) | 2000-03-02 |
| DK1105103T3 (da) | 2003-10-20 |
| IL141092A0 (en) | 2002-02-10 |
| AU763894B2 (en) | 2003-07-31 |
| ES2203172T3 (es) | 2004-04-01 |
| HUP0103163A3 (en) | 2006-07-28 |
| DE59906114D1 (de) | 2003-07-31 |
| CN1313761A (zh) | 2001-09-19 |
| PT1105103E (pt) | 2003-11-28 |
| EP1105103B1 (de) | 2003-06-25 |
| NO20010785D0 (no) | 2001-02-16 |
| NO20010785L (no) | 2001-02-16 |
| HK1040618A1 (en) | 2002-06-21 |
| BR9914610A (pt) | 2001-07-03 |
| CA2341005A1 (en) | 2000-03-02 |
| ATE243505T1 (de) | 2003-07-15 |
| CN1155371C (zh) | 2004-06-30 |
| US6692765B1 (en) | 2004-02-17 |
| CA2341005C (en) | 2008-09-23 |
| CZ302617B6 (cs) | 2011-08-03 |
| CZ2001632A3 (cs) | 2001-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Expiration of patent term of an invention patent |