TW516965B - A cosmetic light-screening composition for protecting human skin or human hair against ultraviolet radiation and novel sunscreening agents - Google Patents
A cosmetic light-screening composition for protecting human skin or human hair against ultraviolet radiation and novel sunscreening agents Download PDFInfo
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- TW516965B TW516965B TW087116339A TW87116339A TW516965B TW 516965 B TW516965 B TW 516965B TW 087116339 A TW087116339 A TW 087116339A TW 87116339 A TW87116339 A TW 87116339A TW 516965 B TW516965 B TW 516965B
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- cosmetic composition
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 35
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 239000000516 sunscreening agent Substances 0.000 title claims description 28
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- 238000012216 screening Methods 0.000 title abstract 2
- 150000001875 compounds Chemical group 0.000 claims abstract description 36
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 9
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- 230000000475 sunscreen effect Effects 0.000 claims description 26
- 239000003795 chemical substances by application Substances 0.000 claims description 17
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- 238000010521 absorption reaction Methods 0.000 claims description 10
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- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
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- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
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- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- DCBSHORRWZKAKO-UHFFFAOYSA-N rac-1-monomyristoylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 description 1
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- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Description
516965
五、發明說明(1) 本發明係關於一種防曬化链 合物用以保護人類皮膚和人類 28 0和40 0毫微米的紫外光傷害 合物及這些化合物作為UV濾劑 已經知道日光加速皮膚老化 不欲的效果係由UV射線引發。 品組合物,此防曬化粧品組 頭髮使其免受波長介於約 之用途’組合物中含有的化 方面的用途。 ,甚至引發皮膚癌,這些所 現在發現式I化合物
I 其中, R:代,Ci-8直鏈或帶有支鏈的烷基鏈,而 R2和R3分別代表(^_8直鏈或帶有支鏈的烷基鏈,是極佳的 UV濾劑,其具有皮膚配伍性和安定性(光、熱、濕氣);它 們使得皮膚有強烈的UV保護性並因此能夠延緩皮膚老化= 特別地,這些UV濾劑也具有箸g越的光穩定性。 。 雖然式I化合物的最大吸收不在此範圍,而是在約3 2 〇至 34 0毫微米,即,介於UVA和ϋνβ射線最大吸收之間,作 疋,已經知道式I化合物有最大吸收出現於— Α波長者 (如:4-第三丁基-4,-曱氧基二琴醯基曱烷)和出現於” 波長且特別並另人訝異地提高UV-B光保護效果者(即, 要吸收製造紅斑之約2 9 0至約3 2 0毫微米的Uv — B射線者,)主 亦能夠吸收這些範圍之可用於化粧品應用 川上的唯一類型
C:\DATA\DATA29\54057.ptd
516965 五、發明說明(2) 是二苯曱綱和鄰-胺基苯曱酸旨。許多調配物不被採用 的原因如··萃出量比式I化合物少得多。 式I的烧氧基苯胺基伸曱基丙二酸酯可由⑽^^^^· 3,0 7 9,3 6 6 和 W.O.Kermack,N.E.St〇rey,】·⑶亂 Soc· 607 (1950) ;Τ· Takahashi, S· Senda, j· pharm. s〇c· Jpn·, 71, 1 1 1 2 ( 1 952 )得知。被特別提到的有甲氧基_、 乙^基-和丁氧基—苯胺基—伸曱基丙二酸乙酯。但未曾提 及这些化合物於化粧品應用上之使用,特別是未曾提及這 些化合物於皮膚保養或人類頭髮保養方面之使用。 曲UV濾劑在化粧品溶劑中的溶解度應夠大,以調配成合理 ’辰度。例如,在水含量70% ' uv_之濾劑含量6%之典型的油 於水中礼劑中,於油相中之溶解度必須高至20%。令人訝 異地,已經發現到式1化合物在許多化粧品溶劑(如:辛酸 癸,1油三酸酯、丙二醇二辛酸酯二癸酸酯、Cl^5烷基笨 曱I S曰、丙一酸一硬脂酸酯、二異丙酸己二酸酯之類)中 的溶解度高至20%。 +據此本發明之目的係關於新穎的式I化合物,包含至 H刚述式I化合物(以與至少_種叮β渡劑和至少一種 ^併用為佳)之用於化粧品用途的防曬製劑,及式I 化::為防曬劑(特別是於化粧品用途方面)之使用。 其免受紫外光傷種用以?護人類皮膚或人類頭髮使 ,α 的防曬化粧σσ組合物’其中含有處於化 说口口用途上可技成 」接又的载體中之至少一種式I化合物
C:\DATA\DATA29\54057.ptd 〜
516965 五、發明說明(3) ρ】
Η Ν, CO.R2 CO,R3 其中, R1代表Cps直鏈或帶有支鏈的烷基鏈,而 R2和R3分別代表Cil直鏈或帶有支鏈的烷基鏈。 所謂n CV8直鏈或帶有支鏈的烷基鏈”是指如甲基、乙 基、正丙基、異丙基、正丁基、第三丁基、戊基、己基、 2 -乙基己基之類。 較佳的化合物是其R2和R3分別代表曱基、乙基、戊基或 2-乙基己基者。 R1基較佳為甲基、乙基或正丁基。 因此,以下列化合物為佳·· 其R1、R2和R3是曱基(實例1 )或乙基(實例4)的化合物;或 其R1是乙基而R2和R3是曱基(實例2)或2-乙基己基(實例6) 的化合物;或 其R1是正丁基而R2和R3是曱基(實例3 )或乙基(實例5 )的化 合物。 最佳者是根據實例4的化合物,其中,R1、R2和R3是乙 基。 此防曬化粧品組合物包含0 . 1至1 0重量% (以0 . 5至5重量 %為佳)的式I化合物,特別是包含1至3重量%式1化合物。 此防曬化粧品組合物可以另包含至少一種最大吸收位於
C:\DATA\DATA29\54057.ptd 第7頁 516965 五、發明說明(4) 約3 0 0至320毫微米的UV-B濾劑及至少一種最大吸收^340 毫微米(特定言之,介於340和360毫微米之間,更特別是 位於3 5 6毫微米)的U V - A濾劑。特定言之,此u V - A -濾劑是 4-第三丁基-4’ -甲氧基二车醯曱烷。通常,此UV-Α劑可以 選自2-曱基二亨醯基曱烷、4-曱基二罕醯基甲烷、4-第三 丁基一卞醯基曱烧、2,4-一曱基二丰醯基甲烧'2,5 -二甲 基二$酿基曱烷'4, 4’-二異丙基二窄醯基曱烷、4-第三 丁基-4’:曱氧基二琴醯基曱烷、2-曱基_5 -異丙基-4,-曱 氧基一卞醯基曱烧、2_曱基-5-第三丁基_4’_曱基二亨醯 基曱烷、2, 4 -二曱基-4’-曱氧基二窄醯基曱烷和2,6一二曱 基-4-第二丁基-4 -曱氧基二卞^基〜曱烷及對笨亞二曱基 二樟腦續酸。 此UV-B濾劑是選自下列之至少—者:肉桂酸醋、二笨曱 銅、二笨基丙烯酸三嗪、樟腦衍生物、聚合型訂吸收劑 „述appllcation us 5 4〇3 9“中者) 少一者·钿、错 ^ 处斗 此1^ —B濾劑是自下列之至 J 有·錦 鐵、欽、鋅或4 士 物顏料及具烴結構或帶有至小一、別是鈦或鋅)的金屬氧化 烷結構的聚合物。 個紫外光吸收基團之矽氧 防曬化粧品組合物或式I化八私 人類頭髮使其免受紫外光傷害"。句可用以保護人類皮膚或 下列式I化合物是新穎的化合物· 2 -(4-庚氧基-笨胺基伸甲基)丙二 2 -(4-曱氧基-笨胺基伸甲 - 曰 丞)丙二酸二曱酯,
$ 8頁 C:\DATA\DATA29\54057.ptd 516965 五、發明說明(5) 2-(4 -乙氧基-笨胺基伸甲基)丙二酸二甲酯, 2 -(4_丙氧基-苯胺基伸曱基)丙二酸二曱酯’ 2-(4- 丁氧基-苯胺基伸曱基)丙二酸二曱酯, 2-(4 -戊氧基-苯胺基伸曱基)丙二酸二曱酯, 2-(4-己氧基-苯胺基伸曱基)丙二酸二曱酯, 2-(4-乙氧基-苯胺基伸甲基)丙二酸二戊酯, 2-(4-乙氧基-笨胺基伸曱基)丙二酸乙酯戊酯, 2 -(4_乙氧基-苯胺基伸曱基)丙二酸二_2-乙基己醋及 2-(4_乙氧基_苯胺基伸曱基)丙二酸乙醋2_乙基己醋。 這些中的每一者可作為UV濾、劑,特定言之,可用於前述 的化粧品用途上。此處,對下列者特別感興趣: 2-(4-乙氧基-苯胺基伸曱基)丙二酸二戊酷, 2-(4-乙氧基-笨胺基伸曱基)丙二酸乙酯戊酯, 2-(4-乙氧基-苯胺基伸曱基)丙二酸二-2-乙基己酯,和 2-(4-乙氧基-苯胺基伸甲基)丙二酸乙酯2-乙基己酯。 以式I表示的化合物(已知及新化合物)可藉由 US 3,0 7 9,3 6 6中所述的傳統方法簡便製得,其製法如下: 苯胺衍生物(Ci-q烷氧基笨胺)與經適當取代的烷氧基伸 烧基丙二酸衍生物在有或無溶劑的情況下反應。 至於可用於本發明之防曬劑之化粧品用途上可接受的載 體,可以是符合化粧品要求之任何慣用的製劑,如:乳 霜、化粧水、乳劑、膏藥、膠、溶液、喷霧、膏狀物和乳 液;請參考,如:Kosmetik,Entwi cklung, Herstellung and Anwendung Kosmetischer Mittel 編輯,Wilfried
C:\DATA\DATA29\54057.ptd 第9頁 516965 丨五、發明說明(6)
Umbach, Georg Thieme Vertrag Stuttgart - New York 1 9 8 8; Sunscreens , Development, Evu1 at i on and Regulatory Aspects, ed. N. Y. Lowe, N. A. Shaat, Marcel Decker, Inc· New York Basel, 1990 0 由於它們的親脂性,式I化合物在含油和含脂的化粧品 製劑中之摻合良好。 由於它們的親脂性,新穎的化合物符合此處所須的標 準,即,在化粧品溶劑(如:M i g 1 y ο 1 8 1 2 N (辛酸癸酸甘 油三酸酯)、Miglyol 840 (丙二醇二辛酸酯二癸酸酯)、 Finsolv TN (C12_15 烷基苯曱酸酯)、Prisorine 203 4 (丙 二酸一硬脂酸酯)或Crodamol Μ (二異丙酸己二酸酯)中 之溶解度。 | 就前述觀點,特別佳是實例4的化合物。 適當情況下,此防曬化粧品製劑可以是油、化粧水、 i 膠、固體膏和乳劑(如:乳霜、乳液或離子性或非離子性 | 親脂性脂質之有小氣泡的分散液)、氣溶膠、喷霧、泡 |沫、粉末、洗髮精、潤髮乳或漆或化粧品之類的形式。 I 用以保護人類頭髮的化粧品製劑製自至少一種式I化合 丨 |物時,此適當的製劑是洗髮精、潤髮乳、化被水膠、乳 ; 丨膠、分散k、染髮劑之類。所有這些調配物的製劑為嫻於 丨此技藝之人士所習知。 ! ; ί 嫻於此技藝之人士已經知道的溶劑可用以製備這些形 丨式,如:油、蠟、醇、多元醇。所用之較佳的物劑是脂肪丨 丨酸、酯、脂肪醇,但也可以是乙醇、異丙醇、丙二醇、甘;
C:\DATA\DATA29\54057.ptd 第10頁 516965
五、發明說明(7) ' ~〜___ —~- -— 油之類。 此化粧品調配物可以另含有輔 釋劑、軟化劑、保濕劑、表面&其他溶劑、稀 香料、油1、低碳多元醇和單劑、消泳劑、 著色劑和顏料之類。 工基知、推進劑、矽酮、 此新穎的防曬組合物或式;!化合物 此技藝之人士可以自由地由前述者n點基於嫻於 但uv-A濾劑中,最佳的訂 — A濾劑是4—特丁」υν一A,劑。 亨醯基甲烷,其特別用以與2-( 、 土—曱乳基二 二酸二乙醋併用。 乙乳基本胺基伸甲基)丙 由下列貫例揭示其他優點、特·•徵和細節。 實例1 2-(4-曱氧基—笨胺基伸曱基)丙二酸二曱西旨 於室溫攪拌的情況下,在丨2· 3克(〇·丨莫耳)對—曱氧笨胺 的50毫升乙醇溶液中,逐滴添加17· 4克(〇·丨莫耳)甲氧美 伸曱士基丙二酸二甲_的70毫升乙醇溶液。於此溫度再授^ 1小%之後,反應混合物以冰浴冷卻,自行結晶出產物。 藉過濾而分離此粗製的固體物質,以乙醇清洗,得到12 9 克標題產物,其為白色固體,熔點89-9KC · (E: 8 9 9 )。 宅来 實例2 2一(4~乙氧基-笨胺基伸曱基)丙二酸二曱醋 製程與實例1相同,但以一當量對—胺基笨乙_ 曱氧笨胺。得到1 9· 8克標題產物,其為白色固μ 1對一 巴U ,熔點是
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五、發明說明(8) 6 6 - 6 7 °C ,UV 3 28 毫米(E = 8 7 9 ) 實例3 2-(4 - 丁氧基-苯胺基伸甲基)丙二酸二甲醋 a) 2-(4-羥基-苯胺基伸乙基)丙二酸二甲酯之製備 於室溫下,在16.4克(〇.15莫耳)4_胺基酚的1〇〇毫 醇溶液中逐滴添加26.1克(0.15莫耳)甲氧基伸甲基丙二 二甲酯的70毫升乙醇溶液。再於此溫度攪拌1〇分鐘之後, 過濾分離出粗製固體物質,以乙醇清洗,得到34. 3 固體’其未經純化便使用。 b) 溫中攪拌的情況下,在7克(28毫莫耳)的2— (4—羥 基-苯胺^基伸乙基)丙二酸二甲醑、3—· 9克(28毫莫耳)碳酸 部於50毫升一甲替曱醯胺中之说合物中,逐滴添加'3克 (2 8宅莫耳)丁基碘。此反應混合物於8 〇 t加熱2 4小時。之 後,反應混合物倒入5 〇毫升水中,以乙酸乙酯萃取三次。 有機層先後以氫氧化鈉溶液(15%)和水清洗,乾燥並蒸 發’得到4· 5克標題化合物,其為白色固體,熔點46-4? C ’UV 328 宅微米(e = 685)。 實例i 2 -(4-乙氧基-笨胺基伸曱基)丙二酸二乙酯 製程與實例1相同’但以一當量對-胺基笨乙醚代替對— 曱氧笨胺,並以一當量乙氧基伸甲基丙二酸二乙酯代替曱 氧基伸曱基丙二酸二曱酯。以己烷代替乙醇,得到2 克標 題產物’其為白色固體,熔點是55-56 °C ,UV 329毫米 (E二802)。
C:\DATA\DATA29\d4057.ptd 第 12 頁 516965 五、發明說明(9) 實例5 2 -(4- 丁氧基—笨胺基伸曱基)丙二酸二乙酯 製程與實例3相同,但以一當量乙氧基伸曱基丙二酸二 乙酯代替曱氧基伸曱基丙二酸二曱酯。得到3· 1克標題產 物’其為白色固體,熔點是54-55它,uv 3 2 9毫米 (E=714) 〇 ^ 實例6 2 -(4-乙氧基—笨胺基伸甲基)_丙二酸二__2—乙基己酯和 2-(4-乙氧基~笨胺基伸甲基)_丙二酸乙酯2_乙基己酯 18.4克(60毫莫耳)2 —(4-乙氧基-苯胺基伸甲基)_丙二 酸二乙醋、430毫克異丙氧化鈦<IV)於70毫升2-乙基一己 醇中之混^物於l5(rc攪拌4小時。此反應混合物於低壓 (8 0 C 6愛巴)’辰、%§以得到黃色油。此油溶解於1 〇 〇亳升乙 馱乙8曰和5耄升水中,攪拌1 〇分鐘,以無水硫酸鎂乾燥。 成片的懸浮液經過濾及於低壓濃縮,得到2 6 · 8克黃色油, 使用己烷··乙酸乙醋(10 : n作為沖提液,以加壓層析法 分離這兩種標題產物。 得到23. 6克的2-(4-乙氧基-笨胺基伸甲基)_丙二酸二 ―2:乙基己酯,其為黃色油,UV 3 2 9毫微米(Ε = 5 6 7 )。 得到1· 8克的2-(4-乙氧基—笨胺基伸曱基)—丙二酸乙酯 和2-乙基己酯,其為黃色油,ϋν 329毫微米(£二632)。
實例J 2-U-乙氧基-笨胺基伸乙基)—丙二酸二戊酯和2_(4_乙氧 基-笨胺基伸乙基)-丙二酸乙酯戊酷
C:\DATA\DATA29\54057.ptd 第13頁 516965 五、發明說明(ίο) 其製程與實例6相同,但以正戊醇代替2-乙基-己醇。使 用己烷:乙酸乙酯(8 ·· 1)作為沖提液,以加壓層析法分離 兩種標題產物。 得到16. 6克的2-(4-乙氧基-苯胺基伸甲基)-丙二酸二戊 酯,其為黃色油,UV 329毫微米(E = 651)。 得到2. 5克的2-(4-乙氧基-苯胺基伸甲基)-丙二酸乙酯 戊酯,其為黃色油,UV 3 2 9毫微米(E = 725 )。
II C:\DATA\DATA29\540D7.ptd 第14頁 516965 五、發明說明(11) 實例8 製備製劑類型:水於油中之乳劑 成份 重量% A) 得自實例6的產物(二-2-乙基己酯) 6 丁基甲氧基二_醯基曱烷(Parsol 1789) 1.5 曱氧基丁二酸辛酯(Parsol MCX) 3 多甘油基-3-二異硬脂酸酯 5 油酸甘油酯 3 鯨蠟醇 2 礦油 10 椰子基辛酸/癸酸酯 10 經Dimethicone塗覆的二氧化鈦 2 辛基十二碳醇 2 丁基羥基曱苯 0.1 苯氧基乙醇、對-羥基苯酸曱酯、對-羥基苯酸乙酯和對羥基苯 0.6 酸丙酯及對-羥基苯酸丁酯 B) 甘油(86%) 5 苯基苯並咪唑磺酸(Parsol HS) 2 EDTA 二鈉 0.1 水 47.7 A部分和B部分分別於8 5 °C混合,之後在攪拌的情況下合 併。最後,必要時,以10%氫氧化鈉或1(3%檸檬酸將pH調整 至7。
C:\DATA\DATA29\54057.ptd 第15頁 516965 五、發明說明(12) 實例9 製備製劑類型:水於油中之乳液(軟性乳霜) 成份 重量% A) 得自實例4的產物 5 POP-POE甘油山梨糖醇脂肪酸酯 5 伸庚基壬烧 5 石蠟 9 PPG-(15)-硬脂醇和 cyclomethicone 2 石夕石 0.4 丁基羥基甲苯 广 ^ 0.1 苯氧基乙醇、對-羥基苯曱酸曱酯、對-羥基苯曱酸乙酯和對-羥 0.6 基笨曱酸丙酯及對-羥基苯甲酸丁酯 B) 氯化鈉 0.5 POE-30山梨糖醇 1.5 甘油(8 6%) 2.5 EDTA 二鈉 0.1 水 68.3 A部分和B部分分別於85 °C混合,之後在攪拌的情況下合 併。最後,必要時,以10%氫氧化鈉或10%檸檬酸將pH調整 至7。
C:\DATA\DATA29\54057.ptd 第16頁 516965 五、發明說明(13) 實例1 0 製劑類型:矽於水中之乳劑(乳液) 成份 重量% A) 得自實例5的產物 2 Cyclomethicone pentamere和經基硬脂酸#呂錤 9 Cyclomethicone 和 Dimethicone 共聚多元醇 10 Cyclomethicone 5 PPG-3肉豆蔻醚 2 經Dimethicone塗覆的二氧化鈦 2 C12-15烧基苯曱酸酯 10 丁基羥基曱苯 0.1 苯氧基乙醇、對-羥基苯甲酸曱酯、對-羥基苯甲酸乙酯和對-羥 0.6 基苯曱酸丙酯及對-羥基苯曱酸丁酯 B) 氯化鈉 0.5 醋酸生育酯 2 EDTA 二納 0.1 水 56.7 A部分和B部分分別於85°G混合,之後在攪拌的情況下合 | 併。最後,必要時,以1 0%氫氧化鈉或1 〇%擰檬酸將pH調整 至7。
第17頁 C:\DATA\DATA29\54057.ptd 516965 五、發明說明(14) 實例11 製劑類型:油於水中之乳劑 成份 重量% A) 得自實例4的產物 4 甲氧基肉桂酸辛酯(Parsol MCX) 3 丁基曱氧基二夸醯基曱烷(Parsol I789) 1.5 4-曱基笨亞甲基樟腦(Parsol 5000) 3 一肉豆蔻酸甘油酯 4 錄壤醇 一 一 1 椰子基辛酸/癸酸酯 15 肉豆蔻酸異丙酯 5 PVP-二十碳烯共聚物 2 丁基羥基曱苯 0.1 EDTA 二納 0.1 苯氧基乙醇、對-羥基苯甲酸甲酯、對-羥基苯曱酸乙酯和對-羥 0.6 基苯曱酸丙酯及對-羥基苯甲酸丁酯 B) POE-POP團聯共聚物 2 水 38.7 Carbomer 981 10 丙二醇 10 A部分和B部分分別於85 °C混合,之後在攪拌的情況下合 併。最後,必要時,以10%氫氧化鈉或10%檸檬酸將pH調整 至7。 -
C:\DATA\DATA29\54057.ptd 第18頁 516965 五、發明說明(15) 實例1 2 製劑類型:油於水中之乳劑 成份 重量% A) 得自實例4的產物 3.5 甲氧基丁二酸辛酯(Parsol MCX) 3 丁基甲氧基二醯基甲烷(Parsol 1789) 1.5 4-曱基苯亞甲基樟腦(Parsol 5000) 3 一肉豆謹酸甘油醋 4 鯨蠟醇 1 椰子基辛酸/癸酸酯 ~ — 5 肉豆蔻酸異丙酯 5 PVP-二十碳烯共聚物 1 丁基羥基曱苯 0.1 EDTA 二鈉 0.1 苯氧基乙醇、對-羥基苯曱酸曱酯、對-羥基苯甲酸乙酯和對-羥 0.6 棊苯曱酸丙酯及對-羥基苯曱酸丁酯 B) 山梨糖醇酯和蔗糖酯 4 水 48.2 Carbomer 981 10 丙二醇 10 A部分和B部分分別於85 °C混合,之後在攪拌的情況下合 併。最後,必要時,以10%氫氧化鈉或10%擰檬酸將pH調整 至7。
C:\DATA\DATA29\54057.ptd 第19頁 516965 五、發明說明(16) 實例8、11和12的乳劑在約2 8 0至40 0毫微米的整個UV範 圍内顯現寬廣的濾光活性,最大吸收出現於約3 0 0至3 6 0毫 微米處。
C:\DATA\DATA29\54057.ptd 第20頁
Claims (1)
- 516965 fJl年II月 案號| #5116339' B 六、申請專利範圍I_ 1 · 一種用以保護人類皮膚或人▲頭【言*免;受紫外光傷 害的防曬化粧品組合物,其中含有位於化粧品用途上可接 受的載體中之式I化合物其中, R1代表C^8直鏈或帶有支鏈的烷基鏈,而 R2和R3分別代表C^8直鏈或帶有支鏈的烧基鏈。 2. 根據申請專利範圍第1項之防曬化粧品組合物,其 中, R1代表甲基、乙基或正丁基,而 R2和R3分別代表甲基、乙基、丙基、2 -乙基-己基。 3. 根據申請專利範圍第2項之防曬化粧品組合物,其中 R1、R2和R3是乙基。 4. 根據申請專利範圍第1至3項中任何一項之防曬化粧品 組合物,其包含0. 1至10重量%的式I化合物。 5. 根據申請專利範圍第4項之防曬化粧品組合物,其包 含0.5至5重量%的式I化合物。 6. 根據申請專利範圍第4項之防曬化粧品組合物,其包 含1至3重量%的式I化合物。 7. 根據申請專利範圍第1至3項中任何一項之防曬化粧品O:\54\54057-911105.ptc 第22頁 516965 修正 案號 87116339 六、申請專利範圍 組合物,其另包含一或多種最大吸收位於約3 0 0至3 2 0毫微 米的UV-B濾劑及一或多種最大吸收^ 3 4 0毫微米的UV-A濾 劑。 8.根據申請專利範圍第7項之防曬化粧品組合物,其另 包含一或多種最大吸收位於約3 0 0至3 2 0毫微米的U V- Β濾劑 及一或多種最大吸收是介於3 40和3 60毫微米之間的UV-A濾 劑。 9 .根據申請專利範圍第7項之防釀化粧品組合物’其 中,UV-Α劑是2-甲基二苄醯基甲烷、4-甲基二〒醯基甲 烷、4 -第三丁基二苄醯基甲烷、2, 4-二曱基二苄醯基甲 烷、2, 5 -二甲基二苄醯基甲烷、4, 4’-二異丙基二苄醯基 甲烷、4-第三丁基-4’ -甲氧基二苄醯基甲烷、2-甲基-5 -異丙基-4’-甲氧基二〒醯基甲烷、2-甲基-5-第三丁基 -4,-甲基二苄醯基甲烷、2, 4 -二甲基-4’-甲氧基二苄醯基 甲院和2,6 -二甲基-4-第三丁基甲氧基二卞龜基甲烧 及對苯亞二甲基二樟腦磺酸中的一者。 1 0.根據申請專利範圍第9項之防曬化粧品組合物,其 中,UV_A劑是4_第三丁基-4’ -曱氧基二苄醯基甲烷。 1 1 .根據申請專利範圍第7項之防曬化粧品組合物,其 中,UV-B劑是一或多種選自下列組群所組成者:肉桂酸 酯、水揚酸酯、二苯甲酮、二苯基丙烯酸三嗪、樟腦衍生 物、聚合型UV -吸收劑或鈽、鐵、鈦、鋅或錘的金屬氧化 物顏料及具烴結構或帶有紫外光吸收基團之矽氧烷結構的 聚合物。O:\54\54057-911105.ptc 第23頁 516965 _案號 87Π6339 0丨年I (月 日_: 六、申請專利範圍 1 2.根據申請專利範圍第1 1項之防曬化粧品組合物,其 中,U V - B劑是一或多種選自下列組群所組成者:肉桂酸 酯、水楊酸酯、二苯甲酮、二苯基丙烯酸三嗪、樟腦衍生 物、聚合型U V -吸收劑鈦或鋅的金屬氧化物顏料及具烴結 構或帶有紫外光吸收基團之矽氧烷結構的聚合物。 1 3.根據申請專利範圍第9項之防曬化粧品組合物,其 中,U V - B劑是一或多種選自下列組群所組成者:肉桂酸 酯、水楊酸酯、二苯甲酮、二苯基丙烯酸三嗪、樟腦衍生 物、聚合型U V -吸收劑或鈽、鐵、鈦、鋅或錯的金屬氧化 物顏料及具烴結構或帶有紫外光吸收基團之矽氧烷結構的 聚合物。 1 4.根據申請專利範圍第1 3項之防曬化粧品組合物,其 中,U V - B劑是一或多種選自下列組群所組成者:肉桂酸 酯、水楊酸酯、二苯甲酮、二苯基丙烯酸三嗪、樟腦衍生 物、聚合型UV-吸收劑鈦或鋅的金屬氧化物顏料及具烴結 構或帶有紫外光吸收基團之矽氧烷結構的聚合物。 1 5.根據申請專利範圍第1 0項之防曬化粧品組合物,其 中,U V - B劑是一或多種選自下列組群所組成者:肉桂酸 酯、水楊酸酯、二苯甲酮、二苯基丙烯酸三嗪、樟腦衍生 物、聚合型UV-吸收劑或鈽、鐵、鈦、鋅或錘的金屬氧化 物顏料及具烴結構或帶有紫外光吸收基團之矽氧烷結構的 聚合物。 1 6.根據申請專利範圍第1 5項之防曬化粧品組合物,其 中,U V - B劑是一或多種選自下列組群所組成者:肉桂酸O:\54\54057-911105.ptc 第24頁 516965 案號 87116339 9 (年(1月 曰 修正 六、申請專利範圍 酯、水揚酸酯、二苯甲酮、二苯基丙烯酸三嗪、樟腦衍生 物、聚合型UV-吸收劑鈦或鋅的金屬氧化物顏料及具烴結 構或帶有紫外光吸收基團之矽氧烷結構的聚合物。 1 7.根據申請專利範圍第1至3項中任何一項之防曬化粧 品組合物,其係用於保護人類皮膚或人類頭髮使其免受紫 外光傷害方面。 1 8. —種化合物,選自以下組群所組成者: 2-(4 -庚氧基-苯胺基伸曱基)丙二酸二乙酯, 2 -(4_甲氧基-苯胺基伸甲基)丙二酸二甲酯, 2-(4-乙氧基-苯胺基伸甲基)丙二酸二甲酯, 2-(4-丙氧基-苯胺基伸甲基)丙二酸二甲酯, 2-(4 - 丁氧基_苯胺基伸甲基)丙二酸二甲酯, 2 -(4 -戊氧基-苯胺基伸甲基)丙二酸二甲酯, 2 -(4-己氧基-苯胺基伸甲基)丙二酸二甲酯, 2-(4-乙氧基-苯胺基伸甲基)丙二酸二戊酯, 2 -(4-乙氧基-苯胺基伸甲基)丙二酸乙酯戊酯, 2-(4-乙氧基_苯胺基伸曱基)丙二酸二-2 -乙基己酯 及 2 -(4-乙氧基-苯胺基伸甲基)丙二酸乙酯2-乙基己 酉旨0 、 ·,O:\54\54057-9ill05.ptc 第25頁
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EP97113446 | 1997-08-05 |
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TW516965B true TW516965B (en) | 2003-01-11 |
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TW087116339A TW516965B (en) | 1997-08-05 | 1998-10-01 | A cosmetic light-screening composition for protecting human skin or human hair against ultraviolet radiation and novel sunscreening agents |
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US (1) | US6069170A (zh) |
EP (1) | EP0895776B1 (zh) |
JP (1) | JPH11100318A (zh) |
KR (1) | KR100543269B1 (zh) |
CN (1) | CN1148165C (zh) |
AU (1) | AU739558B2 (zh) |
BR (1) | BR9802837A (zh) |
CA (1) | CA2244556A1 (zh) |
DE (1) | DE69815449T2 (zh) |
DK (1) | DK0895776T3 (zh) |
ES (1) | ES2198026T3 (zh) |
ID (1) | ID20678A (zh) |
NO (1) | NO312332B1 (zh) |
TW (1) | TW516965B (zh) |
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1998
- 1998-07-24 US US09/122,117 patent/US6069170A/en not_active Expired - Fee Related
- 1998-07-30 DK DK98114262T patent/DK0895776T3/da active
- 1998-07-30 ES ES98114262T patent/ES2198026T3/es not_active Expired - Lifetime
- 1998-07-30 EP EP98114262A patent/EP0895776B1/en not_active Expired - Lifetime
- 1998-07-30 CA CA002244556A patent/CA2244556A1/en not_active Abandoned
- 1998-07-30 DE DE69815449T patent/DE69815449T2/de not_active Expired - Fee Related
- 1998-08-03 CN CNB981167918A patent/CN1148165C/zh not_active Expired - Fee Related
- 1998-08-04 KR KR1019980031729A patent/KR100543269B1/ko not_active IP Right Cessation
- 1998-08-04 JP JP10219930A patent/JPH11100318A/ja active Pending
- 1998-08-04 BR BR9802837-5A patent/BR9802837A/pt not_active Application Discontinuation
- 1998-08-04 AU AU78776/98A patent/AU739558B2/en not_active Ceased
- 1998-08-04 NO NO19983581A patent/NO312332B1/no not_active IP Right Cessation
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Also Published As
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JPH11100318A (ja) | 1999-04-13 |
ES2198026T3 (es) | 2004-01-16 |
ID20678A (id) | 1999-02-11 |
CN1207290A (zh) | 1999-02-10 |
KR100543269B1 (ko) | 2006-04-21 |
CA2244556A1 (en) | 1999-02-05 |
DE69815449D1 (de) | 2003-07-17 |
NO983581D0 (no) | 1998-08-04 |
EP0895776A2 (en) | 1999-02-10 |
KR19990023356A (ko) | 1999-03-25 |
EP0895776A3 (en) | 1999-04-28 |
DK0895776T3 (da) | 2003-08-25 |
US6069170A (en) | 2000-05-30 |
NO983581L (no) | 1999-02-08 |
DE69815449T2 (de) | 2004-02-12 |
CN1148165C (zh) | 2004-05-05 |
BR9802837A (pt) | 2000-01-11 |
NO312332B1 (no) | 2002-04-29 |
EP0895776B1 (en) | 2003-06-11 |
AU739558B2 (en) | 2001-10-18 |
AU7877698A (en) | 1999-02-18 |
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