TW476755B - 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor - Google Patents
4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor Download PDFInfo
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- TW476755B TW476755B TW087121577A TW87121577A TW476755B TW 476755 B TW476755 B TW 476755B TW 087121577 A TW087121577 A TW 087121577A TW 87121577 A TW87121577 A TW 87121577A TW 476755 B TW476755 B TW 476755B
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- ch2ch3
- propyl
- ethyl
- nc3h7
- och3
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/58—Nitrogen atoms attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
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- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6879497P | 1997-12-24 | 1997-12-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW476755B true TW476755B (en) | 2002-02-21 |
Family
ID=22084747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW087121577A TW476755B (en) | 1997-12-24 | 1999-02-11 | 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1049676B1 (enExample) |
| JP (1) | JP4754068B2 (enExample) |
| AT (1) | ATE306472T1 (enExample) |
| AU (1) | AU2009799A (enExample) |
| CA (1) | CA2316341A1 (enExample) |
| DE (1) | DE69831876T2 (enExample) |
| DK (1) | DK1049676T3 (enExample) |
| ES (1) | ES2251121T3 (enExample) |
| TW (1) | TW476755B (enExample) |
| WO (1) | WO1999033806A1 (enExample) |
| ZA (1) | ZA9811842B (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| US6974825B1 (en) | 1996-12-20 | 2005-12-13 | Astrazeneca Canada Inc. | Compounds with analgesic effect |
| CA2683097A1 (en) * | 1998-03-10 | 1999-09-16 | Research Triangle Institute | Novel opiate compounds, methods of making and methods of use |
| US6900228B1 (en) | 1998-03-10 | 2005-05-31 | Research Triangle Institute | Opiate compounds, methods of making and methods of use |
| US6677332B1 (en) | 1999-05-25 | 2004-01-13 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
| WO2000071518A2 (en) * | 1999-05-25 | 2000-11-30 | Sepracor, Inc. | Heterocyclic analgesic compounds and their use |
| US7361666B2 (en) | 1999-05-25 | 2008-04-22 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
| US6635661B2 (en) | 2000-05-25 | 2003-10-21 | Sepracor Inc. | Heterocyclic analgesic compounds and methods of use thereof |
| SE9904674D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904675D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904673D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| US6306876B1 (en) | 1999-12-22 | 2001-10-23 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives |
| SE0001209D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0001208D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| WO2001092226A1 (en) | 2000-05-25 | 2001-12-06 | Sepracor, Inc. | Heterocyclic analgesic compounds and method of use thereof |
| WO2002048122A2 (en) * | 2000-12-14 | 2002-06-20 | Ortho-Mcneil Pharmaceutical, Inc. | Benzamidine derivatives |
| NZ525982A (en) | 2000-12-15 | 2005-09-30 | Astrazeneca Ab | New process for the preparation of diaryl-4-amino-piperidinyl compounds |
| US6699890B2 (en) * | 2000-12-22 | 2004-03-02 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| US7153871B2 (en) | 2001-01-22 | 2006-12-26 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs |
| US7205320B2 (en) | 2001-01-22 | 2007-04-17 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| MXPA03007261A (es) * | 2001-02-14 | 2006-03-09 | Abbott Lab | Moduladores del receptor de glucocorticoides. |
| SE0101769D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101771D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101770D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| EP1395567B1 (en) | 2001-05-18 | 2009-01-14 | AstraZeneca AB | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders |
| SE0101765D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101768D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101766D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101773D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0103313D0 (sv) | 2001-10-03 | 2001-10-03 | Astrazeneca Ab | Novel compounds |
| HRP20050083A2 (en) | 2002-07-19 | 2005-08-31 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs |
| ES2323688T3 (es) | 2002-07-19 | 2009-07-23 | Memory Pharmaceuticals Corporation | Compuestos de 4-aminobenzofurano como inhibidores de fosfodiesterasa 4. |
| WO2004035541A1 (en) * | 2002-10-15 | 2004-04-29 | Janssen Pharmaceutica, N.V. | Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators |
| ATE387443T1 (de) * | 2002-10-15 | 2008-03-15 | Janssen Pharmaceutica Nv | Substituierte aminochinuclidin verbindungen und deren verwendung als delta-opioid rezeptor liganden |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| EP1569908B1 (en) | 2002-11-19 | 2010-09-15 | Memory Pharmaceuticals Corporation | Pyridine n-oxide compounds as phosphodiesterase 4 inhibitors |
| ATE377589T1 (de) | 2003-03-07 | 2007-11-15 | Lilly Co Eli | 6-substituierte nikotinamidderivate als opioidrezeptorantagonisten |
| JP4810423B2 (ja) | 2003-06-27 | 2011-11-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 三環式デルタオピオイド調節剤 |
| CA2549009A1 (en) * | 2003-12-12 | 2005-07-07 | Eli Lilly And Company | Opioid receptor antagonists |
| CA2557794A1 (en) * | 2004-03-15 | 2005-10-06 | Eli Lilly And Company | Opioid receptor antagonists |
| HRP20120343T1 (hr) | 2004-08-02 | 2012-05-31 | Astrazeneca Ab | Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba |
| WO2007030089A1 (en) | 2004-08-05 | 2007-03-15 | Janssen Pharmaceutica N.V. | Tricyclic delta- opioid modulators |
| SE0402485D0 (sv) | 2004-10-13 | 2004-10-13 | Astrazeneca Ab | Polymorph of N,N-Diethyl-4-(3-Fluorophenyl-Piperidin-4-Ylidene-Methyl)-Benzamide Hydrochloride salt |
| BRPI0518563A2 (pt) | 2004-12-22 | 2008-11-25 | Janssen Pharmaceutica Nv | moduladores de delta-opiàide tricÍclicos |
| WO2006069277A1 (en) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | TRICYCLIC δ-OPIOID MODULATORS |
| JP2008526878A (ja) * | 2005-01-06 | 2008-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 三環式δ−オピオイド調節剤 |
| CN101243079A (zh) | 2005-06-16 | 2008-08-13 | 詹森药业有限公司 | 三环阿片调节剂 |
| JP2007099761A (ja) * | 2005-09-08 | 2007-04-19 | Mitsui Chemicals Inc | アミド誘導体ならびにその殺虫剤としての使用方法 |
| MY148880A (en) | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
| WO2011053706A1 (en) * | 2009-10-30 | 2011-05-05 | Janssen Pharmaceutica Nv | 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators |
| CN113979997A (zh) * | 2021-11-12 | 2022-01-28 | 中国科学院昆明植物研究所 | N,n-(4-哌啶基、芳基)-3-氨基苯酚类衍生物及其药物组合物和其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5019583A (en) * | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| IT1275433B (it) * | 1995-05-19 | 1997-08-07 | Smithkline Beecham Farma | Derivati di diarildiammine |
| IT1277597B1 (it) * | 1995-09-15 | 1997-11-11 | Smithkline Beecham Spa | Derivati di diarilalchenilammina |
| SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE9604786D0 (sv) * | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
-
1998
- 1998-12-23 DK DK98964871T patent/DK1049676T3/da active
- 1998-12-23 AU AU20097/99A patent/AU2009799A/en not_active Abandoned
- 1998-12-23 DE DE69831876T patent/DE69831876T2/de not_active Expired - Lifetime
- 1998-12-23 AT AT98964871T patent/ATE306472T1/de active
- 1998-12-23 WO PCT/US1998/027350 patent/WO1999033806A1/en not_active Ceased
- 1998-12-23 JP JP2000526490A patent/JP4754068B2/ja not_active Expired - Lifetime
- 1998-12-23 EP EP98964871A patent/EP1049676B1/en not_active Expired - Lifetime
- 1998-12-23 ES ES98964871T patent/ES2251121T3/es not_active Expired - Lifetime
- 1998-12-23 CA CA002316341A patent/CA2316341A1/en not_active Abandoned
- 1998-12-23 ZA ZA9811842A patent/ZA9811842B/xx unknown
-
1999
- 1999-02-11 TW TW087121577A patent/TW476755B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69831876D1 (de) | 2006-02-23 |
| EP1049676A1 (en) | 2000-11-08 |
| DK1049676T3 (da) | 2006-01-16 |
| ZA9811842B (en) | 2000-06-23 |
| EP1049676B1 (en) | 2005-10-12 |
| AU2009799A (en) | 1999-07-19 |
| DE69831876T2 (de) | 2006-07-27 |
| CA2316341A1 (en) | 1999-07-08 |
| JP2001527068A (ja) | 2001-12-25 |
| ES2251121T3 (es) | 2006-04-16 |
| JP4754068B2 (ja) | 2011-08-24 |
| ATE306472T1 (de) | 2005-10-15 |
| WO1999033806A1 (en) | 1999-07-08 |
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| GD4A | Issue of patent certificate for granted invention patent | ||
| MM4A | Annulment or lapse of patent due to non-payment of fees |