TW442460B - Azolyl piperazinyl phenyl oxazolidinone antimicrobials - Google Patents
Azolyl piperazinyl phenyl oxazolidinone antimicrobials Download PDFInfo
- Publication number
- TW442460B TW442460B TW086102075A TW86102075A TW442460B TW 442460 B TW442460 B TW 442460B TW 086102075 A TW086102075 A TW 086102075A TW 86102075 A TW86102075 A TW 86102075A TW 442460 B TW442460 B TW 442460B
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- Taiwan
- Prior art keywords
- methyl
- phenyl
- oxo
- fluoro
- patent application
- Prior art date
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- 239000004599 antimicrobial Substances 0.000 title description 3
- UBNIPSDNVLNRMR-UHFFFAOYSA-N 3-phenyl-4-piperazin-1-yl-4-(1h-pyrrol-2-yl)-1,3-oxazolidin-2-one Chemical compound O=C1OCC(C=2NC=CC=2)(N2CCNCC2)N1C1=CC=CC=C1 UBNIPSDNVLNRMR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 43
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 33
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 33
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 12
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 239000001301 oxygen Substances 0.000 claims abstract description 5
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 5
- 208000015181 infectious disease Diseases 0.000 claims abstract description 3
- 230000000813 microbial effect Effects 0.000 claims abstract description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 53
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 52
- -1 4,5-dihydro-2-pyrazolyl Chemical group 0.000 claims description 45
- OQLZINXFSUDMHM-UHFFFAOYSA-N Acetamidine Chemical compound CC(N)=N OQLZINXFSUDMHM-UHFFFAOYSA-N 0.000 claims description 37
- 239000001257 hydrogen Substances 0.000 claims description 31
- 230000002079 cooperative effect Effects 0.000 claims description 29
- 239000011737 fluorine Substances 0.000 claims description 28
- 239000007789 gas Substances 0.000 claims description 23
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims description 17
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 claims description 16
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 8
- 235000015170 shellfish Nutrition 0.000 claims description 8
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- 125000000217 alkyl group Chemical group 0.000 claims description 7
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
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- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 3
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- OFLXLNCGODUUOT-UHFFFAOYSA-N acetohydrazide Chemical compound C\C(O)=N\N OFLXLNCGODUUOT-UHFFFAOYSA-N 0.000 claims 2
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- PCTMTFRHKVHKIS-BMFZQQSSSA-N (1s,3r,4e,6e,8e,10e,12e,14e,16e,18s,19r,20r,21s,25r,27r,30r,31r,33s,35r,37s,38r)-3-[(2r,3s,4s,5s,6r)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10 Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2.O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 PCTMTFRHKVHKIS-BMFZQQSSSA-N 0.000 claims 1
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- OQLKNTOKMBVBKV-UHFFFAOYSA-N hexamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 OQLKNTOKMBVBKV-UHFFFAOYSA-N 0.000 claims 1
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- 238000003754 machining Methods 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 10
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- 125000000623 heterocyclic group Chemical group 0.000 abstract description 4
- 229910052717 sulfur Inorganic materials 0.000 abstract description 4
- 239000011593 sulfur Substances 0.000 abstract description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 3
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- 150000001721 carbon Chemical group 0.000 abstract description 2
- HHRFWSALGNYPHA-UHFFFAOYSA-N [N].C1CNCCN1 Chemical group [N].C1CNCCN1 HHRFWSALGNYPHA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003943 azolyl group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
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- 239000007858 starting material Substances 0.000 description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 19
- 125000001153 fluoro group Chemical group F* 0.000 description 18
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 18
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- 235000021419 vinegar Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 229910001845 yogo sapphire Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1231696P | 1996-02-26 | 1996-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW442460B true TW442460B (en) | 2001-06-23 |
Family
ID=21754387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW086102075A TW442460B (en) | 1996-02-26 | 1997-02-21 | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5736545A (Direct) |
| EP (1) | EP0883611B1 (Direct) |
| JP (1) | JP2000505084A (Direct) |
| KR (1) | KR19990087238A (Direct) |
| CN (1) | CN1082952C (Direct) |
| AT (1) | ATE221521T1 (Direct) |
| AU (1) | AU703831B2 (Direct) |
| DE (1) | DE69714418T2 (Direct) |
| DK (1) | DK0883611T3 (Direct) |
| ES (1) | ES2180945T3 (Direct) |
| ID (1) | ID18467A (Direct) |
| MY (1) | MY116093A (Direct) |
| NZ (1) | NZ331011A (Direct) |
| PE (1) | PE55898A1 (Direct) |
| PT (1) | PT883611E (Direct) |
| TW (1) | TW442460B (Direct) |
| WO (1) | WO1997030981A1 (Direct) |
| ZA (1) | ZA971287B (Direct) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| KR20010021645A (ko) * | 1997-07-11 | 2001-03-15 | 로렌스 티. 마이젠헬더 | 티아디아졸릴 및 옥사디아졸릴 페닐 옥사졸리디논 항균제 |
| GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| CN1288462A (zh) * | 1998-01-23 | 2001-03-21 | 法玛西雅厄普约翰美国公司 | 噁唑烷酮组合库、组合物和制备方法 |
| KR20010052615A (ko) * | 1998-06-05 | 2001-06-25 | 다비드 에 질레스 | 옥사졸리디논 유도체, 이것의 제조 방법 및 이것을함유하는 약학 조성물 |
| US6689372B1 (en) * | 1998-08-04 | 2004-02-10 | Ciba Specialty Chemicals Corporation | Microbicidal active substances |
| EP1147422A1 (en) | 1999-01-27 | 2001-10-24 | Pharmacia & Upjohn Company | Assays for modulators of "elongation factor p" activity |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| PE20010851A1 (es) * | 1999-12-14 | 2001-08-17 | Upjohn Co | Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| WO2003008389A1 (en) * | 2001-07-16 | 2003-01-30 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as potential antimicrobials |
| HUP0302918A2 (hu) * | 2000-07-17 | 2003-12-29 | Ranbaxy Laboratories Limited | Mikrobaellenes oxazolidinonszármazékok és a vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
| AU2002360238B2 (en) * | 2001-04-17 | 2007-11-15 | Kyorin Pharmaceutical Co., Ltd. | Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof |
| US20050209248A1 (en) * | 2002-05-15 | 2005-09-22 | Biswajit Das | Plymorphic forms of phenyl oxazolidinone derivatives |
| WO2004014392A1 (en) * | 2002-07-29 | 2004-02-19 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| DE60304360T2 (de) | 2002-08-12 | 2006-11-16 | Pharmacia & Upjohn Co. Llc, Kalamazoo | N-aryl-2-oxazolidinone und deren derivate |
| WO2004026848A1 (en) * | 2002-09-20 | 2004-04-01 | Lupin Limited | Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents |
| AR042086A1 (es) | 2002-11-21 | 2005-06-08 | Upjohn Co | N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos |
| US20070185132A1 (en) * | 2003-07-02 | 2007-08-09 | Yasumichi Fukuda | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo |
| AU2004256086B2 (en) * | 2003-07-02 | 2007-12-06 | Kyorin Pharmaceutical Co., Ltd. | Oxazolidinone antibiotics and derivatives thereof |
| AU2004256084B2 (en) * | 2003-07-02 | 2007-10-18 | Kyorin Pharmaceutical Co., Ltd. | Oxazolidinone antibiotics and derivatives thereof |
| WO2005005398A2 (en) * | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof |
| WO2005051933A1 (en) * | 2003-11-28 | 2005-06-09 | Ranbaxy Laboratories Limited | An improved process for the synthesis of 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, a key intermediate for oxazolidinone antimicrobials and compounds prepared thereby |
| WO2005082899A1 (en) * | 2004-01-28 | 2005-09-09 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| JP4789934B2 (ja) * | 2004-05-24 | 2011-10-12 | アムジエン・インコーポレーテツド | １型１１−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害剤 |
| US8686011B2 (en) | 2004-05-24 | 2014-04-01 | Amgen Inc. | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 |
| WO2006035283A1 (en) * | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2006043121A1 (en) * | 2004-10-20 | 2006-04-27 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2006051408A1 (en) * | 2004-11-11 | 2006-05-18 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| US20090018123A1 (en) * | 2005-06-20 | 2009-01-15 | Milind D Sindkhedkar | Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation |
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| CN100406455C (zh) * | 2006-02-20 | 2008-07-30 | 中国科学院上海药物研究所 | 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途 |
| JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| KR20100016498A (ko) * | 2007-04-23 | 2010-02-12 | 얀센 파마슈티카 엔.브이. | 속해리성 도파민 2 수용체 길항제로서의 피리딘 유도체 |
| CN101663292A (zh) * | 2007-04-23 | 2010-03-03 | 詹森药业有限公司 | 作为快速解离的多巴胺2受体拮抗剂的4-烷氧基哒嗪衍生物 |
| MX2009011416A (es) * | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida. |
| US7666864B2 (en) * | 2008-03-26 | 2010-02-23 | Global Alliance For Tb Drug Development | Bicyclic nitroimidazole-substituted phenyl oxazolidinones |
| BRPI0915834A2 (pt) * | 2008-07-03 | 2015-11-03 | Janssen Pharmaceutica Nv | 6-(1-piperazinil)-piridazinas substituídas como antagonistas do receptor de 5-ht6 |
| AU2009275887B2 (en) * | 2008-07-31 | 2013-06-20 | Janssen Pharmaceutica Nv | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists |
| WO2011152442A1 (ja) * | 2010-06-03 | 2011-12-08 | 塩野義製薬株式会社 | 2－クロロ－6－フルオロベンゾオキサゾールの製造方法 |
| CN102079730B (zh) * | 2010-09-06 | 2013-10-16 | 贵州大学 | 一类含2,5-取代杂环基砜类衍生物及其合成方法和应用 |
| CN103450173B (zh) * | 2013-09-07 | 2015-06-03 | 吉首大学 | 吡咯酮-苯基-噁唑烷酮型化合物及其制法和用途 |
| CN103709119B (zh) * | 2013-12-04 | 2015-05-20 | 上海应用技术学院 | 一种制备5-氨基噻唑-4-甲酰胺的方法 |
| CN104202835A (zh) * | 2014-09-03 | 2014-12-10 | 苏州微站通信科技有限公司 | Ue进入静默期时让基站及时释放时频资源的方法 |
| ES2968678T3 (es) | 2018-04-27 | 2024-05-13 | Univ Osaka | Inhibidores del canal TRPC3 o TRPC6 |
| WO2020163689A1 (en) | 2019-02-08 | 2020-08-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | 20-hete formation inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US4977173A (en) * | 1987-10-21 | 1990-12-11 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents |
| US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| US5652238A (en) * | 1993-11-22 | 1997-07-29 | Pharmacia & Upjohn Company | Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones |
-
1997
- 1997-01-31 MY MYPI97000373A patent/MY116093A/en unknown
- 1997-02-14 ZA ZA971287A patent/ZA971287B/xx unknown
- 1997-02-18 AT AT97907574T patent/ATE221521T1/de not_active IP Right Cessation
- 1997-02-18 CN CN97191516A patent/CN1082952C/zh not_active Expired - Fee Related
- 1997-02-18 DE DE69714418T patent/DE69714418T2/de not_active Expired - Fee Related
- 1997-02-18 ES ES97907574T patent/ES2180945T3/es not_active Expired - Lifetime
- 1997-02-18 KR KR1019980706639A patent/KR19990087238A/ko not_active Abandoned
- 1997-02-18 EP EP97907574A patent/EP0883611B1/en not_active Expired - Lifetime
- 1997-02-18 JP JP9530192A patent/JP2000505084A/ja not_active Withdrawn
- 1997-02-18 AU AU19547/97A patent/AU703831B2/en not_active Ceased
- 1997-02-18 DK DK97907574T patent/DK0883611T3/da active
- 1997-02-18 NZ NZ331011A patent/NZ331011A/xx unknown
- 1997-02-18 PT PT97907574T patent/PT883611E/pt unknown
- 1997-02-18 WO PCT/US1997/001970 patent/WO1997030981A1/en not_active Ceased
- 1997-02-18 PE PE1997000112A patent/PE55898A1/es not_active Application Discontinuation
- 1997-02-20 US US08/803,469 patent/US5736545A/en not_active Expired - Fee Related
- 1997-02-21 TW TW086102075A patent/TW442460B/zh not_active IP Right Cessation
- 1997-02-24 ID IDP970548A patent/ID18467A/id unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE221521T1 (de) | 2002-08-15 |
| DE69714418T2 (de) | 2003-01-16 |
| US5736545A (en) | 1998-04-07 |
| MY116093A (en) | 2003-11-28 |
| ES2180945T3 (es) | 2003-02-16 |
| NZ331011A (en) | 2000-04-28 |
| ZA971287B (en) | 1998-08-14 |
| AU703831B2 (en) | 1999-04-01 |
| PE55898A1 (es) | 1998-09-16 |
| HK1017033A1 (en) | 1999-11-12 |
| DK0883611T3 (da) | 2002-12-02 |
| KR19990087238A (ko) | 1999-12-15 |
| JP2000505084A (ja) | 2000-04-25 |
| CN1206410A (zh) | 1999-01-27 |
| EP0883611B1 (en) | 2002-07-31 |
| CN1082952C (zh) | 2002-04-17 |
| AU1954797A (en) | 1997-09-10 |
| DE69714418D1 (de) | 2002-09-05 |
| WO1997030981A1 (en) | 1997-08-28 |
| ID18467A (id) | 1998-04-09 |
| PT883611E (pt) | 2002-12-31 |
| EP0883611A1 (en) | 1998-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GD4A | Issue of patent certificate for granted invention patent | ||
| MM4A | Annulment or lapse of patent due to non-payment of fees |