TW414695B - Preparations - Google Patents
Preparations Download PDFInfo
- Publication number
- TW414695B TW414695B TW086116341A TW86116341A TW414695B TW 414695 B TW414695 B TW 414695B TW 086116341 A TW086116341 A TW 086116341A TW 86116341 A TW86116341 A TW 86116341A TW 414695 B TW414695 B TW 414695B
- Authority
- TW
- Taiwan
- Prior art keywords
- tocopherol
- patent application
- item
- scope
- ascorbate
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 37
- 239000011732 tocopherol Substances 0.000 claims abstract description 34
- 229930003799 tocopherol Natural products 0.000 claims abstract description 33
- 229960001295 tocopherol Drugs 0.000 claims abstract description 27
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 26
- 235000010384 tocopherol Nutrition 0.000 claims abstract description 26
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 26
- 239000000203 mixture Substances 0.000 claims abstract description 24
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 20
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 20
- 229920000159 gelatin Polymers 0.000 claims abstract description 14
- 235000019322 gelatine Nutrition 0.000 claims abstract description 14
- 241000251468 Actinopterygii Species 0.000 claims abstract description 12
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 12
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 12
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims abstract description 12
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 10
- 239000011159 matrix material Substances 0.000 claims abstract description 9
- 229940114079 arachidonic acid Drugs 0.000 claims abstract description 6
- 235000021342 arachidonic acid Nutrition 0.000 claims abstract description 6
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 6
- -1 ascorbic acid ester Chemical class 0.000 claims abstract 3
- 229940072107 ascorbate Drugs 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 108010010803 Gelatin Proteins 0.000 claims description 13
- 239000008273 gelatin Substances 0.000 claims description 13
- 235000011852 gelatine desserts Nutrition 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 239000000839 emulsion Substances 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 8
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 8
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 8
- 235000019149 tocopherols Nutrition 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 230000002079 cooperative effect Effects 0.000 claims description 4
- 235000010378 sodium ascorbate Nutrition 0.000 claims description 4
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 4
- 229960005055 sodium ascorbate Drugs 0.000 claims description 4
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 3
- 150000001342 alkaline earth metals Chemical class 0.000 claims description 3
- 239000008346 aqueous phase Substances 0.000 claims description 3
- 230000000813 microbial effect Effects 0.000 claims description 3
- 238000004945 emulsification Methods 0.000 claims description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 125000002640 tocopherol group Chemical class 0.000 claims 4
- 244000005700 microbiome Species 0.000 claims 3
- PCTMTFRHKVHKIS-BMFZQQSSSA-N (1s,3r,4e,6e,8e,10e,12e,14e,16e,18s,19r,20r,21s,25r,27r,30r,31r,33s,35r,37s,38r)-3-[(2r,3s,4s,5s,6r)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10 Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2.O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 PCTMTFRHKVHKIS-BMFZQQSSSA-N 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 239000000306 component Substances 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 230000001850 reproductive effect Effects 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 235000012149 noodles Nutrition 0.000 claims 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 1
- 239000000779 smoke Substances 0.000 claims 1
- 235000021419 vinegar Nutrition 0.000 claims 1
- 239000000052 vinegar Substances 0.000 claims 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- 239000012071 phase Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 235000000346 sugar Nutrition 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 102000011632 Caseins Human genes 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 241000519695 Ilex integra Species 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 108010064851 Plant Proteins Proteins 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 238000004091 panning Methods 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229940080237 sodium caseinate Drugs 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L35/00—Food or foodstuffs not provided for in groups A23L5/00 – A23L33/00; Preparation or treatment thereof
- A23L35/10—Emulsified foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/70—Vitamins
- A23V2250/712—Vitamin E
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Pediatric Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fats And Perfumes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Edible Oils And Fats (AREA)
- Fodder In General (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Cosmetics (AREA)
Description
414695 A7 ____ B7 五、發明説明_( 1 ) 經濟部中央棹準局負工消費合作社印製 本發明係關於新穎的、安定的、溶於冷水的由微生物製 的油製成的粉狀製劑，此後稱爲SCO(Single Cell Oil，單細 胞油），富含花生四烯酸，此後稱作AA，以及其製法。 脂溶液物質的溶於冷水的製劑在人營養上扮演重要角 色。此類製劑一般是以乳液或乾粉的形式在商業上流通， 因爲脂溶性活性成分不溶於水，以及其或多或少的顯著的 不安定性和難以搬運0在此類製劑中一般是以基質成分包 封活性成分，即脂溶性物質。基質成分主要用以保護活性 成分使其安定，使終製劑易於吸收並在需要時使終製劑分 散於水内。 根據本發明，現已發現特別安定的及易於搬運的SCO製 劑，可用魚明膠作爲保護膠體及加抗氧化劑製成。所用的 抗氧化劑是： a) 供油相使用者：生育酚，抗壞血酸酯或抗壞血酸酯與 生育酚的混合物，抗壞血酸酯以棕櫚酸抗壞血酸酯爲佳； b) 供水相使用者：抗壞血酸酯或鹼土金屬鹽，較佳是抗 壞血酸鋼。 可以商品名"Norland HiPure Fish Gelatin"由 Norland PtOducts Inc.，695 Joyce Kilmer Ave.，Ne,w Brunswick，N. J· USA購得的明膠是特佳的魚明膠。 本發明可使用任何生育酚，此等生育酚的例是生育 驗，泠-生育酚或天然生育酚的混合物。於較佳具體實施例 中是使用然生育酚的混合物。 棕櫚酸抗壞血酸酯及生育酚較佳是以1 : 5至1 ·· 25，特別 _ -4- 本紙張狀適用巾關家轉（CNS ) Α刪§ ( 21GX297公釐) 一 c請先聞讀背面之注意事項再填寫本頁) 裝· r _j 订 A7 B7 414695 五、發明説明（2 是1 : 5的比値使用，加入SCO内的總量較佳是1200-5250 ppm，特別是1200-2000，尤佳是12〇〇 ppm。棕櫚酸抗壞血 酸酯及生育酚可以混合物加入，也可個別加入。在單獨使用生 育酚時，總量較佳是100-5000 ρριη，特別是1000-2000，尤佳 是約 1000 ppm。 根據本發明的製劑原則上可將SCO及魚明膠製成水性乳 液再將此乳液轉化成乾粉製備。此一製法代表本發明的又 一方面。 通常是’先將魚明膠，視需要也加佐劑，溶於水内，此 種溶解可以強烈攪拌加速。如有需要，也可於此水相内加 抗氧化劑如抗壞血酸鈉。 一般的佐劑是’例如’單—及雙糖；糖醇；澱粉衍生 物，例如麥芽糖糊精；牛奶蛋白質，例如酪蛋白酸鈉；及 植物蛋白質，例如大豆蛋白質，馬鈐薯蛋白質，及小麥蛋 白質。此外，現已發現魚明膠之溶解較佳是於室溫或高溫 造行，特別是20°C至90°C，尤佳是50°C至7(TC。所謂基質 即运樣製得。然後將以抗氧化劑安定的SC〇於此基質内乳 化，較佳是於大氣壓或加壓至1000巴（100毫帕斯卡），較佳 疋300-500巴（3 0-50毫帕斯卡）均質化，或此用超音波技術 均質化。於此工序中，壓力及溫度並非極重要參數，一般 了於主m·至約70 C ’特別是約6〇°C至7〇eC，在大氣壓下輕 易計進行。 終產物中SCO與其他成分（魚明膠，糖等）的比値一般是 約2 0 : 8 0至8 0 : 2 0，正確的比値視A A的生物需求及視終 -5 ⑽尺度適用準（⑽)Α4^τ^297公瘦- I^ τ------- - :Μ (V.- {請先閱讀背面之注意事項再填寫本頁) 、ΤΓ 經濟部中央標準局員工消費合作社印製 A7 B7 4146&5 五、發明説明'(3 ) 製劑的施用形式的均質性及細分佈性而異。 这樣製成的乳液’一般含約2 0至約8 0重量百分比的 SCO，視各成分而異，之轉化成乾粉可藉，例如，喷霧乾 燥，雙为散法，或澱粉截流（Starch catch)法進行。後一法 是將噴霧小滴截於澱粉床上然後乾燥。需要時可將要噴霧 的乳液用水稀釋。 . 一般而s，根據本發明的製劑具良好水分散性及良好可 流性。 根據本發明的製劑可用於人類營養，特別是新生免的營 養。 以下實例説明本發明。 實例1 將48.5克，乾魚明膠及48 5克結晶糖置於6〇〇毫升玻璃燒瓶 内。然後加8 0毫升去離子水，此混合物於5〇τ在用攪盤攪 拌（1000轉/分鐘）下成爲溶液。此時，將6〇克含5〇% ΑΑ及 .以用1000 ppm天然生育酚與200.ppm棕櫚酸抗壞血酸酯安定 過的SCO乳化於此基質内並攪拌15分鐘（在乳化期間及隨後 的揽拌期間，授盤速度爲4800轉/分鐘）^此後’乳液内相 的平均顆粒大小爲約200毫微米。然後用9 〇毫升去離子水 將乳液稀釋，加熱至65eC。將1公斤以矽酸液化的澱粉置 於實驗室噴霧槽内，並冷至約5°C。用旋轉噴嘴將乳液嘴 入其中。然後將這樣以澱粉包封的顆粒由過多的澱粉中篩 出，用壓縮氣於室溫乾燥。製得19〇克乾粉，AA含量 17.4% » 本紙張尺度賴中關家鮮（⑽）鑛^ ( 21GX297公f 414695 A7 B7 五、發明説明'(4 ) 實例2 將44·2克乾魚明膠，44 2克結晶糖及8 6克抗壞血酸鈉 於600毫升燒瓶内。其後之加工以類似實例1方法進行/
内相平均顆粒大小爲1S〇毫微米。製得約19〇克乾粉 含量爲17%。 c ，AA „ ------ΓΤ 裂.ι· .. :\ V、 〈許先閎磧背面之注意事項再填寫本頁) •?7- d 經濟部中央標準局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐）
Claims (1)
- H7a 修if 號專利申請案 利範園修正本(88年10月) ABCD βΧ 烟請委員明示*本衆修正後是否變更原實質内容· 經濟部智慧財產局員工消費合作社印製 六、申請專利範圍 1，一種微生物產製油之安定的 '冷水可分散的粉狀製劑， 其富含花生四婦酸，該製劑含作為基質成分的魚明膠， 及作為油相之第一抗氧化劑的生育酚、抗壞血酸酯或抗 壞血酸酯與生育酚的混合物，以及作為水相之第二抗氧 化劑，其係選.自由抗壞血酸之驗金屬塩或鹼土金屬塩所 组成組群。 2. 根據申請專利範圍第1項之製劑，其含生育酚或棕櫚酸抗 壞血酸酯與生育酚的混合物作為第—抗氧化劍。 3. 根據申請專利範圍第1或2項之製劑，其含栋櫚酸抗壞血 酸酯與生育酚的比為1 : 5至1 : 2 5，特別是i : 5。 4·根據申請專利範圍第3項之製劑，其中棕櫚酸抗壞血酸酯 與生育酚的總量為1200-5250 ppm 5. 根據申請專利範圍第4項之製劑，其中棕櫚酸抗壞血酸醋 與生育齡·的總量為1200-2000 ppm，特別是1200 ppm。 6. 根據申請專利範圍第1項之製劑，其中生育酚是天然生育 酚的混合物。 7‘根據申請專利範圍第1項之製劑，其包含抗壞血酸鈉作為 第二抗氧化劑及/或佐劑》 8· —種製備根據申請專利範圍第I項之富含花生四烯酸的微 生物產製油之安定的、冷水可分散的粉狀製劑之方法， 此方法包括： a) 將魚明膠及抗壞血麵及/炎佐劑溶於水， b) 將以生育酚、抗壞血酸酯或抗壞血酸酯與生育酚的 混合物安定的微生物產製油於水性基質内乳化，及 本紙張尺度適用中國國家榇準（CNSj A4規格（2丨OX297公釐） H7a 修if 號專利申請案 利範園修正本(88年10月) ABCD βΧ 烟請委員明示*本衆修正後是否變更原實質内容· 經濟部智慧財產局員工消費合作社印製 六、申請專利範圍 1，一種微生物產製油之安定的 '冷水可分散的粉狀製劑， 其富含花生四婦酸，該製劑含作為基質成分的魚明膠， 及作為油相之第一抗氧化劑的生育酚、抗壞血酸酯或抗 壞血酸酯與生育酚的混合物，以及作為水相之第二抗氧 化劑，其係選.自由抗壞血酸之驗金屬塩或鹼土金屬塩所 组成組群。 2. 根據申請專利範圍第1項之製劑，其含生育酚或棕櫚酸抗 壞血酸酯與生育酚的混合物作為第—抗氧化劍。 3. 根據申請專利範圍第1或2項之製劑，其含栋櫚酸抗壞血 酸酯與生育酚的比為1 : 5至1 : 2 5，特別是i : 5。 4·根據申請專利範圍第3項之製劑，其中棕櫚酸抗壞血酸酯 與生育酚的總量為1200-5250 ppm 5. 根據申請專利範圍第4項之製劑，其中棕櫚酸抗壞血酸醋 與生育齡·的總量為1200-2000 ppm，特別是1200 ppm。 6. 根據申請專利範圍第1項之製劑，其中生育酚是天然生育 酚的混合物。 7‘根據申請專利範圍第1項之製劑，其包含抗壞血酸鈉作為 第二抗氧化劑及/或佐劑》 8· —種製備根據申請專利範圍第I項之富含花生四烯酸的微 生物產製油之安定的、冷水可分散的粉狀製劑之方法， 此方法包括： a) 將魚明膠及抗壞血麵及/炎佐劑溶於水， b) 將以生育酚、抗壞血酸酯或抗壞血酸酯與生育酚的 混合物安定的微生物產製油於水性基質内乳化，及 本紙張尺度適用中國國家榇準（CNSj A4規格（2丨OX297公釐） 414G95 A8 B8 C8 D8 六、申請專利範圍 C)將如此製得的乳液轉化成乾粉。9.根據申請專利範圍第8項之方法，其中b)步驟製得的乳液 是以一般的喷霧乾燥、雙分散法或澱粉截流法轉化成乾 粉。 請 先 閱 讀 背 之 注 意. 事丨 項 再广 % 本 頁 裝 訂 經濟部智慧財產局員工消費合作社印製本紙張尺度適用中國國家標準（CNS-) A4規格（210 X 297公釐）
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH274196 | 1996-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW414695B true TW414695B (en) | 2000-12-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW086116341A TW414695B (en) | 1996-11-06 | 1997-11-04 | Preparations |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6071963A (zh) |
| EP (1) | EP0841010B1 (zh) |
| JP (1) | JP3051093B2 (zh) |
| KR (1) | KR19980042093A (zh) |
| CN (1) | CN1090478C (zh) |
| AT (1) | ATE219891T1 (zh) |
| AU (1) | AU688720B1 (zh) |
| BR (1) | BR9705425A (zh) |
| CA (1) | CA2220178C (zh) |
| DE (1) | DE59707636D1 (zh) |
| DK (1) | DK0841010T3 (zh) |
| ES (1) | ES2178735T3 (zh) |
| NO (1) | NO315071B1 (zh) |
| NZ (1) | NZ329105A (zh) |
| TW (1) | TW414695B (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9908014D0 (en) * | 1999-04-08 | 1999-06-02 | Scherer Corp R P | Pharmaceutical compositions |
| ATE292455T1 (de) * | 1999-12-09 | 2005-04-15 | Dsm Ip Assets Bv | Fettlösliche vitamine enthaltende zusammensetzungen |
| US7332178B2 (en) | 2003-04-25 | 2008-02-19 | Abbott Laboratories | Stable nutritional powder containing ascorbyl palmitate |
| WO2005110123A1 (en) * | 2003-04-25 | 2005-11-24 | Abbott Laboratories | Stable nutritional powder containing ascorbyl palmitate |
| US7110827B2 (en) * | 2003-04-25 | 2006-09-19 | Medtronic, Inc. | Electrical connectors for medical lead having weld-less wiring connection |
| MXPA06003228A (es) * | 2003-09-26 | 2006-06-08 | Nestec Sa | Composicion nutricional con acidos grasos insaturados y elementos en trazas. |
| NZ572529A (en) * | 2006-04-07 | 2010-11-26 | Ocean Nutrition Canada Ltd | Emulsions and microcapsules with substances having low interfacial tension, methods of making and using thereof |
| KR20100095437A (ko) * | 2007-11-07 | 2010-08-30 | 아스트라제네카 아베 | 아스코르브산 유도체를 포함하는 건조 분말 제제 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2513517A1 (fr) * | 1981-09-30 | 1983-04-01 | Chevalier Jacques | Nouvelles compositions a usage pharmaceutique, dietetique et cosmetologique rendues gastro-resistantes, riches en acides gras essentiels polyinsatures et leur procede de preparation |
| JPS6037934A (ja) * | 1983-08-10 | 1985-02-27 | Kosumosu Shokuhin:Kk | 可溶性マイクロカプセル油 |
| DE3603000A1 (de) * | 1986-01-31 | 1987-08-06 | Milupa Ag | Neue polyensaeure-reiche fettmischung und deren verwendung bei der herstellung von saeuglingsnahrungen |
| JPH0734752B2 (ja) * | 1986-03-31 | 1995-04-19 | サントリー株式会社 | アラキドン酸及びこれを含有する脂質の製造方法 |
| JPS63102688A (ja) * | 1986-10-17 | 1988-05-07 | Nippon Oil & Fats Co Ltd | 微生物によるアラキドン酸含有油脂の製造方法 |
| JPH01304892A (ja) * | 1988-02-03 | 1989-12-08 | Suntory Ltd | 高度不飽和脂肪酸強化油脂の製造方法 |
| MC2034A1 (fr) * | 1988-06-23 | 1990-05-30 | Hoffmann La Roche | Preparations |
| JP2710344B2 (ja) * | 1988-07-13 | 1998-02-10 | サントリー株式会社 | 高度不飽和脂肪酸及びこれを含有する脂質の製造方法 |
| JP2730081B2 (ja) * | 1988-09-24 | 1998-03-25 | 日本油脂株式会社 | 微生物によるアラキドン酸含有油脂の製造方法 |
| JPH03161448A (ja) * | 1989-11-20 | 1991-07-11 | Asahi Chem Ind Co Ltd | 油脂含有組成物 |
| JPH03263499A (ja) * | 1990-03-13 | 1991-11-22 | Asahi Denka Kogyo Kk | 粉末油脂 |
| JP3027858B2 (ja) * | 1991-01-30 | 2000-04-04 | 日本油脂株式会社 | 高度不飽和脂肪酸含有組成物の製造方法 |
| JPH06172782A (ja) * | 1992-12-10 | 1994-06-21 | Ikeda Shiyokuken Kk | 高度不飽和脂肪酸含有油脂粉末 |
| US5603952A (en) * | 1994-12-30 | 1997-02-18 | Tastemaker | Method of encapsulating food or flavor particles using warm water fish gelatin, and capsules produced therefrom |
| AUPN137895A0 (en) * | 1995-02-27 | 1995-03-16 | Clover Corporation Pty Ltd | Composition and method |
-
1997
- 1997-10-07 US US08/946,480 patent/US6071963A/en not_active Expired - Lifetime
- 1997-10-31 EP EP97119013A patent/EP0841010B1/de not_active Expired - Lifetime
- 1997-10-31 AT AT97119013T patent/ATE219891T1/de not_active IP Right Cessation
- 1997-10-31 ES ES97119013T patent/ES2178735T3/es not_active Expired - Lifetime
- 1997-10-31 DK DK97119013T patent/DK0841010T3/da active
- 1997-10-31 DE DE59707636T patent/DE59707636D1/de not_active Expired - Lifetime
- 1997-11-04 NO NO19975074A patent/NO315071B1/no not_active IP Right Cessation
- 1997-11-04 JP JP9301478A patent/JP3051093B2/ja not_active Expired - Fee Related
- 1997-11-04 AU AU44337/97A patent/AU688720B1/en not_active Ceased
- 1997-11-04 NZ NZ329105A patent/NZ329105A/xx unknown
- 1997-11-04 TW TW086116341A patent/TW414695B/zh not_active IP Right Cessation
- 1997-11-04 CA CA002220178A patent/CA2220178C/en not_active Expired - Fee Related
- 1997-11-05 KR KR1019970058136A patent/KR19980042093A/ko active Search and Examination
- 1997-11-05 BR BR9705425-9A patent/BR9705425A/pt not_active Application Discontinuation
- 1997-11-05 CN CN97122432A patent/CN1090478C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ329105A (en) | 1998-10-28 |
| CA2220178C (en) | 2001-10-30 |
| NO975074L (no) | 1998-05-07 |
| NO315071B1 (no) | 2003-07-07 |
| ATE219891T1 (de) | 2002-07-15 |
| CA2220178A1 (en) | 1998-05-06 |
| DK0841010T3 (da) | 2002-10-28 |
| JP3051093B2 (ja) | 2000-06-12 |
| CN1090478C (zh) | 2002-09-11 |
| KR19980042093A (ko) | 1998-08-17 |
| ES2178735T3 (es) | 2003-01-01 |
| AU688720B1 (en) | 1998-03-12 |
| DE59707636D1 (de) | 2002-08-08 |
| CN1181238A (zh) | 1998-05-13 |
| JPH10139673A (ja) | 1998-05-26 |
| US6071963A (en) | 2000-06-06 |
| NO975074D0 (no) | 1997-11-04 |
| EP0841010A1 (de) | 1998-05-13 |
| EP0841010B1 (de) | 2002-07-03 |
| BR9705425A (pt) | 1999-12-07 |
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