CN1090478C - 制剂 - Google Patents
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Abstract
本发明公开了一种稳定的冷水分散的富含花生四烯酸的微生物产生的油的粉状制剂，该制剂含有作为基体组分的鱼凝胶和作为抗氧剂的生育酚、抗坏血酸酯或者抗坏血酯和生育酚的混合物及制备该制剂的方法。
Description
本发明涉及新的、稳定的，冷水分散的微生物产生的油的粉制剂，该制剂在下文中称SCO(单细胞油)，其中富含花生四烯酸，该酸在下文中称AA，以及生产该制剂的方法。
冷水分散的脂溶性物质的制剂在人类营养学领域扮演一个重要角色。这样的制剂通常以乳剂或干粉的形式出售，这是由于脂溶性活性成分不溶于水以及它们具有明显或不明显的不稳定性并不易处理。在这类制剂中，活性成分，即脂溶性物质通常通过以基体组分的形式被包封。该基体组分特别是对于活性成分的保护或其稳定性，对于需要的最终制剂的最佳吸收及水分散性负有责任。
根据本发明，现已发现，当鱼凝胶用作保护胶体并加入抗氧剂时可制备上述易于稳定及易于处理的SCO制剂。所用的抗氧剂为：
a)对于油相：生育酚，抗坏血酸酯或抗坏血酸酯和生育酚的混合物，抗坏血酸酯中优选抗坏血酸棕榈酸酯；
b)对于水相：抗坏血酸碱金属或碱土金属盐，优选抗坏血酸钠。
从厂商Norland Product Inc.，695 Joyce Kilmer Ave.，NewBrunswick，N.J.，USA得到的商品名称为“Norland HiPure FishGelatin”的凝胶是特别优选的鱼凝胶。
任何生育酸都可用于本发明，生育酚的例子有α-生育酚，γ-生育酚或天然生育酚的混合物。优选方案中使用天然生育酚的混合物。
抗坏血酸棕榈酸酯和生育酚的优选用量比为1∶5到1∶25，特别是1∶5，加入SCO中的总量优选每百分份1200-5250份，特别是1200-2000份，最优选每百分份1200份。抗坏血酸棕棕酸酯和生育酚既可混合加入也可单独加入。当单独使用生育酚时，总量优选每百万份1000-5000份，特别是1000-2000，最优选每百万份约100份。
本发明的制剂原则上可通过制备SCO和鱼凝胶的含水乳剂并将其转化成干粉而制得。该制备方法为本发明的另一发明目的。
一般说来，首先将鱼凝胶和非强制性加入的辅助剂溶于水，通过强力搅拌可使其加速。如果需要可在水相中加入抗氧剂，例如抗坏血酸钠。
常用的辅助剂为，例如，单-和双-糖类；糖醇；淀粉衍生物，例如麦芽糖糊清；乳蛋白，例如酪蛋白酸钠；以及植物蛋白，例如大豆蛋白，土豆蛋白和麦蛋白。另外，现已发现室温或升高的温度有利于鱼蛋白溶解，适合的温度范围为20℃到90℃，优选50℃到70℃。所谓基体以这种方式获得。然后，将由抗氧剂稳定的SCO在这种基体中乳化，最好通过在大气压或最高至1000bar(100MPa)，优选300-500bar(30-50MPa)的压力下均化进行，或者，也可使用超声波或类似技术。压力和温度不是该步骤的关键参数，该步骤可在约室温到约70℃，特别是约60℃到70℃的温度，以及大气压下容易地进行。
最终产物中SCO与其他组分(鱼凝胶，糖等)的重量比通常为约20∶80到约80∶20，在用于提供补充消耗的使用形式中精确的比例取决于AA的各个生物学需要，取决于最终制剂均一性和充分分配的需要。
将由成分而定通常含有约20到约80重量百分比SCO的上述制备的乳剂转化成干燥的步骤可通过，例如，喷雾干燥法，二次分散法或淀粉收集法实现。在一方法中，将乳剂液滴喷到淀粉床中，随后干燥。需要时，可将喷雾的乳剂用水稀释。
总之，本发明的制剂具有良好的冷水分散性和流动性。
本发明制剂可被用于人类营养物，特别是婴儿食品。
本发明将由下面的实施例说明。
实施例1
将48.5g鱼凝胶和48.5结晶糖置于600ml玻璃烧杯中。然后，加入80ml去离子水并在50℃下用盘式搅拌机(mincer disc)(1000r/min)搅拌下使该混合物成为溶液。随后，将已由1000ppm天然生育酚和200ppm抗坏血酸棕榈酸酯混合物稳定的含50％ AA的60g SCO在该基体中乳化并搅拌15分钟(在乳化及随后的搅拌过程中，盘式搅拌机的速度为4800r/min)。这时，该乳剂的内相的平均粒径约为200nm。然后，将该乳剂用90ml去离子水稀释并加热至65℃。然后将1kg用硅酸流化的淀粉置于实验室喷雾罐中并冷却到约5℃。接着用旋转喷嘴将乳剂喷入其中。然后将用淀粉包封的以上得到的颗粒从过量淀粉中筛出并使用压缩空气在室温下干燥。于是得到约190g其中AA含量为17.4％的干粉。
实施例2
将44.2g干燥的鱼凝胶，44.2g结晶糖和8.6g抗坏血酸钠置于600ml玻璃烧杯中。以下按与实施例1相似的方法进行。
中间相的平均粒径为180nm。大约得到190g AA含量为17％的干粉。
Claims (12)
1.通过干燥一种乳剂而得到的稳定的水分散的干粉状组合物，该组合物包含：
(a)微生物产生的油，该油包含(i)花生四烯酸和(ii)选自生育酚和抗坏血酸酯或其混合物的第一种抗氧剂，
其中，所述油被乳化于一种含水基体中，该基体包含鱼凝胶，鱼凝胶的存在量足以使所述油分散于水中，以及
(b)选自抗坏血酸的碱金属盐和抗坏血酸的碱土金属盐的用于水相的第二种抗氧剂。
2.根据权利要求1的制剂，它含有作为抗氧剂的生育酚或者抗坏血酸棕榈酸酯和生育酚的混合物。
3.根据权利要求1或2的制剂，它含有比例为1∶5至1∶25的抗坏血酸棕榈酸酯和生育酚。
4.根据权利要求1或2的制剂，它含有比例为1∶5的抗坏血酸棕榈酸酯和生育酚。
5.根据权利要求1或2的制剂，其中抗坏血酸棕榈酸酯和生育酚的总量为每百万份1200～5250份。
6.根据权利要求5的制剂，其中抗坏血酸棕榈酸酯和生育酚的总量为每百万份1200-2000份。
7.根据权利要求5的制剂，其中抗坏血酸棕榈酸酯和生育酚的总量为每百万份1200份。
8.根据权利要求1或2的制剂，其中生育酚是天然生育酚的混合物。
9.根据权利要求1或2的制剂，其中所述抗坏血酸的碱金属盐是抗坏血酸钠。
10.根据权利要求1或2的制剂，它另外含有一种辅助剂。
11.一种制备稳定的水分散的干粉状组合物的方法，所述组合物包含：(A)微生物产生的油，该油包含(i)花生四烯酸和(ii)选自生育酚和抗坏血酸酯或其混合物的第一种抗氧剂，其中，所述油被乳化于一种含水基体中，该基体包含鱼凝胶，鱼凝胶的存在量足以使所述油分散于水中，以及(B)选自抗坏血酸的碱金属盐和抗坏血酸的碱土金属盐的用于水相的第二种抗氧剂；
该方法包括下列步骤：
(a)将鱼凝胶以及第二种抗氧剂溶于水而形成一种含水基体；
(b)将所述微生物产生的油乳化于步骤(a)的含水基体中而形成一种乳剂；和
(c)通过喷雾干燥将步骤(b)的乳剂转化成粉末。
12.根据权利要求11的方法，其中在将所述鱼凝胶溶于水时它另外含有一种辅助剂。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2741/96 | 1996-11-06 | ||
| CH274196 | 1996-11-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1181238A CN1181238A (zh) | 1998-05-13 |
| CN1090478C true CN1090478C (zh) | 2002-09-11 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97122432A Expired - Fee Related CN1090478C (zh) | 1996-11-06 | 1997-11-05 | 制剂 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6071963A (zh) |
| EP (1) | EP0841010B1 (zh) |
| JP (1) | JP3051093B2 (zh) |
| KR (1) | KR19980042093A (zh) |
| CN (1) | CN1090478C (zh) |
| AT (1) | ATE219891T1 (zh) |
| AU (1) | AU688720B1 (zh) |
| BR (1) | BR9705425A (zh) |
| CA (1) | CA2220178C (zh) |
| DE (1) | DE59707636D1 (zh) |
| DK (1) | DK0841010T3 (zh) |
| ES (1) | ES2178735T3 (zh) |
| NO (1) | NO315071B1 (zh) |
| NZ (1) | NZ329105A (zh) |
| TW (1) | TW414695B (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9908014D0 (en) * | 1999-04-08 | 1999-06-02 | Scherer Corp R P | Pharmaceutical compositions |
| ATE292455T1 (de) * | 1999-12-09 | 2005-04-15 | Dsm Ip Assets Bv | Fettlösliche vitamine enthaltende zusammensetzungen |
| WO2005110123A1 (en) * | 2003-04-25 | 2005-11-24 | Abbott Laboratories | Stable nutritional powder containing ascorbyl palmitate |
| US7332178B2 (en) | 2003-04-25 | 2008-02-19 | Abbott Laboratories | Stable nutritional powder containing ascorbyl palmitate |
| US7110827B2 (en) * | 2003-04-25 | 2006-09-19 | Medtronic, Inc. | Electrical connectors for medical lead having weld-less wiring connection |
| CA2538886A1 (en) * | 2003-09-26 | 2005-04-07 | Nestec S.A. | Nutritional composition with unsaturated fatty acids and trace elements |
| US20100055281A1 (en) * | 2006-04-07 | 2010-03-04 | Ocean Nutrition Canada Limited | Emulsions and Microcapsules With Substances Having Low Interfacial Tension, Methods of Making and Using Thereof |
| KR20100095437A (ko) * | 2007-11-07 | 2010-08-30 | 아스트라제네카 아베 | 아스코르브산 유도체를 포함하는 건조 분말 제제 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2513517A1 (fr) * | 1981-09-30 | 1983-04-01 | Chevalier Jacques | Nouvelles compositions a usage pharmaceutique, dietetique et cosmetologique rendues gastro-resistantes, riches en acides gras essentiels polyinsatures et leur procede de preparation |
| JPS6037934A (ja) * | 1983-08-10 | 1985-02-27 | Kosumosu Shokuhin:Kk | 可溶性マイクロカプセル油 |
| DE3603000A1 (de) * | 1986-01-31 | 1987-08-06 | Milupa Ag | Neue polyensaeure-reiche fettmischung und deren verwendung bei der herstellung von saeuglingsnahrungen |
| JPH0734752B2 (ja) * | 1986-03-31 | 1995-04-19 | サントリー株式会社 | アラキドン酸及びこれを含有する脂質の製造方法 |
| JPS63102688A (ja) * | 1986-10-17 | 1988-05-07 | Nippon Oil & Fats Co Ltd | 微生物によるアラキドン酸含有油脂の製造方法 |
| JPH01304892A (ja) * | 1988-02-03 | 1989-12-08 | Suntory Ltd | 高度不飽和脂肪酸強化油脂の製造方法 |
| MC2034A1 (fr) * | 1988-06-23 | 1990-05-30 | Hoffmann La Roche | Preparations |
| JP2710344B2 (ja) * | 1988-07-13 | 1998-02-10 | サントリー株式会社 | 高度不飽和脂肪酸及びこれを含有する脂質の製造方法 |
| JP2730081B2 (ja) * | 1988-09-24 | 1998-03-25 | 日本油脂株式会社 | 微生物によるアラキドン酸含有油脂の製造方法 |
| JPH03161448A (ja) * | 1989-11-20 | 1991-07-11 | Asahi Chem Ind Co Ltd | 油脂含有組成物 |
| JPH03263499A (ja) * | 1990-03-13 | 1991-11-22 | Asahi Denka Kogyo Kk | 粉末油脂 |
| JP3027858B2 (ja) * | 1991-01-30 | 2000-04-04 | 日本油脂株式会社 | 高度不飽和脂肪酸含有組成物の製造方法 |
| JPH06172782A (ja) * | 1992-12-10 | 1994-06-21 | Ikeda Shiyokuken Kk | 高度不飽和脂肪酸含有油脂粉末 |
| US5603952A (en) * | 1994-12-30 | 1997-02-18 | Tastemaker | Method of encapsulating food or flavor particles using warm water fish gelatin, and capsules produced therefrom |
| AUPN137895A0 (en) * | 1995-02-27 | 1995-03-16 | Clover Corporation Pty Ltd | Composition and method |
-
1997
- 1997-10-07 US US08/946,480 patent/US6071963A/en not_active Expired - Lifetime
- 1997-10-31 AT AT97119013T patent/ATE219891T1/de not_active IP Right Cessation
- 1997-10-31 DK DK97119013T patent/DK0841010T3/da active
- 1997-10-31 DE DE59707636T patent/DE59707636D1/de not_active Expired - Lifetime
- 1997-10-31 ES ES97119013T patent/ES2178735T3/es not_active Expired - Lifetime
- 1997-10-31 EP EP97119013A patent/EP0841010B1/de not_active Expired - Lifetime
- 1997-11-04 TW TW086116341A patent/TW414695B/zh not_active IP Right Cessation
- 1997-11-04 NZ NZ329105A patent/NZ329105A/xx unknown
- 1997-11-04 NO NO19975074A patent/NO315071B1/no not_active IP Right Cessation
- 1997-11-04 JP JP9301478A patent/JP3051093B2/ja not_active Expired - Fee Related
- 1997-11-04 AU AU44337/97A patent/AU688720B1/en not_active Ceased
- 1997-11-04 CA CA002220178A patent/CA2220178C/en not_active Expired - Fee Related
- 1997-11-05 KR KR1019970058136A patent/KR19980042093A/ko active Search and Examination
- 1997-11-05 CN CN97122432A patent/CN1090478C/zh not_active Expired - Fee Related
- 1997-11-05 BR BR9705425-9A patent/BR9705425A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0841010B1 (de) | 2002-07-03 |
| NO975074D0 (no) | 1997-11-04 |
| BR9705425A (pt) | 1999-12-07 |
| DE59707636D1 (de) | 2002-08-08 |
| EP0841010A1 (de) | 1998-05-13 |
| DK0841010T3 (da) | 2002-10-28 |
| JP3051093B2 (ja) | 2000-06-12 |
| TW414695B (en) | 2000-12-11 |
| NO975074L (no) | 1998-05-07 |
| ES2178735T3 (es) | 2003-01-01 |
| ATE219891T1 (de) | 2002-07-15 |
| CA2220178A1 (en) | 1998-05-06 |
| KR19980042093A (ko) | 1998-08-17 |
| NO315071B1 (no) | 2003-07-07 |
| CN1181238A (zh) | 1998-05-13 |
| NZ329105A (en) | 1998-10-28 |
| JPH10139673A (ja) | 1998-05-26 |
| CA2220178C (en) | 2001-10-30 |
| AU688720B1 (en) | 1998-03-12 |
| US6071963A (en) | 2000-06-06 |
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