TW202600146A - 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物 - Google Patents

含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物

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Publication number
TW202600146A
TW202600146A TW114131509A TW114131509A TW202600146A TW 202600146 A TW202600146 A TW 202600146A TW 114131509 A TW114131509 A TW 114131509A TW 114131509 A TW114131509 A TW 114131509A TW 202600146 A TW202600146 A TW 202600146A
Authority
TW
Taiwan
Prior art keywords
cationic
polyglucosamine
eye drops
ophthalmic composition
ophthalmic
Prior art date
Application number
TW114131509A
Other languages
English (en)
Chinese (zh)
Inventor
髙橋恭平
浅田博之
神村明日香
森島健司
桃川雄介
遠藤健一
Original Assignee
日商參天製藥股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日商參天製藥股份有限公司 filed Critical 日商參天製藥股份有限公司
Publication of TW202600146A publication Critical patent/TW202600146A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
TW114131509A 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物 TW202600146A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018-035578 2018-02-28
JP2018035578 2018-02-28

Publications (1)

Publication Number Publication Date
TW202600146A true TW202600146A (zh) 2026-01-01

Family

ID=67806273

Family Applications (4)

Application Number Title Priority Date Filing Date
TW114131509A TW202600146A (zh) 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
TW113102160A TWI898399B (zh) 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
TW108106730A TWI781296B (zh) 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
TW111140996A TWI833406B (zh) 2018-02-28 2019-02-27 含有迪夸弗索（Ｄｉｑｕａｆｏｓｏｌ）及陽離子性聚合物之眼科用組合物

Family Applications After (3)

Application Number Title Priority Date Filing Date
TW113102160A TWI898399B (zh) 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
TW108106730A TWI781296B (zh) 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
TW111140996A TWI833406B (zh) 2018-02-28 2019-02-27 含有迪夸弗索（Ｄｉｑｕａｆｏｓｏｌ）及陽離子性聚合物之眼科用組合物

Country Status (14)

Country Link
US (1) US20210000844A1 (enExample)
EP (1) EP3760207A4 (enExample)
JP (5) JP6716800B2 (enExample)
KR (3) KR20250053220A (enExample)
CN (2) CN117137866A (enExample)
BR (1) BR112020017661A2 (enExample)
CA (1) CA3091700A1 (enExample)
EA (1) EA202092030A1 (enExample)
MX (2) MX2020008925A (enExample)
PH (1) PH12020551313B1 (enExample)
SG (1) SG11202007977RA (enExample)
TW (4) TW202600146A (enExample)
UA (1) UA129517C2 (enExample)
WO (1) WO2019168023A1 (enExample)

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WO2020175525A1 (ja) * 2019-02-27 2020-09-03 参天製薬株式会社 ジクアホソルまたはその塩、ビニル系高分子およびセルロース系高分子を含有する眼科用組成物
JP6966667B2 (ja) * 2019-08-27 2021-11-17 参天製薬株式会社 ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物
KR102365008B1 (ko) * 2020-06-23 2022-02-23 주식회사태준제약 디쿠아포솔을 포함하는 점안 조성물
JP7230169B2 (ja) * 2020-12-25 2023-02-28 参天製薬株式会社 ジクアホソルまたはその塩、銀塩およびイオン性等張化剤を含有する水性点眼液
CN113712910A (zh) * 2021-08-05 2021-11-30 广州市桐晖药业有限公司 一种滴眼液及其制备方法
WO2023054669A1 (ja) * 2021-09-30 2023-04-06 ロート製薬株式会社 眼科組成物
KR102794468B1 (ko) 2022-04-04 2025-04-14 서울대학교산학협력단 감미 억제용 조성물 및 식품의 감미 억제 방법
JP2024043685A (ja) * 2022-09-20 2024-04-02 参天製薬株式会社 ジクアホソルまたはその塩を含有する眼科用組成物のｐＨの低下を抑制する方法
KR20250038935A (ko) * 2023-09-13 2025-03-20 루다큐어 주식회사 8-옥소-2'-데옥시구아노신 또는 이의 약학적으로 허용가능한 염을 포함하는 수용액 형태의 점안제
KR20250160050A (ko) 2024-05-03 2025-11-11 삼천당제약주식회사 물리화학적 특성이 개선된 안구건조증 예방 또는 치료용 약학 조성물
CN119970633A (zh) * 2025-03-26 2025-05-13 苏州乐珠制药有限公司 一种地夸磷索钠滴眼液及其制备方法

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SG11202007977RA (en) * 2018-02-28 2020-09-29 Santen Pharmaceutical Co Ltd Ophthalmic composition comprising diquafosol and cationic polymer
CN108853016A (zh) * 2018-09-26 2018-11-23 广州大光制药有限公司 一种地夸磷索钠滴眼液及其制备方法
WO2020175525A1 (ja) * 2019-02-27 2020-09-03 参天製薬株式会社 ジクアホソルまたはその塩、ビニル系高分子およびセルロース系高分子を含有する眼科用組成物
JP6966667B2 (ja) * 2019-08-27 2021-11-17 参天製薬株式会社 ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物

Also Published As

Publication number Publication date
KR20220163519A (ko) 2022-12-09
CA3091700A1 (en) 2019-09-06
US20210000844A1 (en) 2021-01-07
JP2020138980A (ja) 2020-09-03
SG11202007977RA (en) 2020-09-29
JPWO2019168023A1 (ja) 2020-05-28
JP7796782B2 (ja) 2026-01-09
JP6716800B2 (ja) 2020-07-01
TWI781296B (zh) 2022-10-21
EA202092030A1 (ru) 2020-11-16
TW202423451A (zh) 2024-06-16
MX2020008925A (es) 2020-10-01
JP2026034664A (ja) 2026-02-27
UA129517C2 (uk) 2025-05-21
TWI833406B (zh) 2024-02-21
EP3760207A1 (en) 2021-01-06
CN111757742A (zh) 2020-10-09
PH12020551313B1 (en) 2024-02-28
MX2022014791A (es) 2023-01-16
TWI898399B (zh) 2025-09-21
JP7297718B2 (ja) 2023-06-26
TW202000212A (zh) 2020-01-01
JP2024045506A (ja) 2024-04-02
CN111757742B (zh) 2023-09-26
KR102796051B1 (ko) 2025-04-14
KR20200127002A (ko) 2020-11-09
PH12020551313A1 (en) 2021-09-06
JP7472202B2 (ja) 2024-04-22
TW202306572A (zh) 2023-02-16
BR112020017661A2 (pt) 2020-12-22
WO2019168023A1 (ja) 2019-09-06
CN117137866A (zh) 2023-12-01
KR102472773B1 (ko) 2022-11-30
JP2022136152A (ja) 2022-09-15
EP3760207A4 (en) 2023-10-04
KR20250053220A (ko) 2025-04-21

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