CN117137866A - 含有地夸磷索及阳离子性聚合物的眼科用组合物 - Google Patents

含有地夸磷索及阳离子性聚合物的眼科用组合物 Download PDF

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Publication number
CN117137866A
CN117137866A CN202311151214.4A CN202311151214A CN117137866A CN 117137866 A CN117137866 A CN 117137866A CN 202311151214 A CN202311151214 A CN 202311151214A CN 117137866 A CN117137866 A CN 117137866A
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CN
China
Prior art keywords
ophthalmic composition
cationic
composition according
polyvinylpyrrolidone
eye
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Pending
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CN202311151214.4A
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English (en)
Chinese (zh)
Inventor
高桥恭平
浅田博之
神村明日香
森岛健司
桃川雄介
远藤健一
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Santen Pharmaceutical Co Ltd
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Santen Pharmaceutical Co Ltd
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Publication of CN117137866A publication Critical patent/CN117137866A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN202311151214.4A 2018-02-28 2019-02-27 含有地夸磷索及阳离子性聚合物的眼科用组合物 Pending CN117137866A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2018035578 2018-02-28
JP2018-035578 2018-02-28
CN201980015357.8A CN111757742B (zh) 2018-02-28 2019-02-27 含有地夸磷索及阳离子性聚合物的眼科用组合物
PCT/JP2019/007542 WO2019168023A1 (ja) 2018-02-28 2019-02-27 ジクアホソルおよびカチオン性ポリマーを含有する眼科用組成物

Related Parent Applications (1)

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CN201980015357.8A Division CN111757742B (zh) 2018-02-28 2019-02-27 含有地夸磷索及阳离子性聚合物的眼科用组合物

Publications (1)

Publication Number Publication Date
CN117137866A true CN117137866A (zh) 2023-12-01

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CN202311151214.4A Pending CN117137866A (zh) 2018-02-28 2019-02-27 含有地夸磷索及阳离子性聚合物的眼科用组合物
CN201980015357.8A Active CN111757742B (zh) 2018-02-28 2019-02-27 含有地夸磷索及阳离子性聚合物的眼科用组合物

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US (1) US20210000844A1 (enExample)
EP (1) EP3760207A4 (enExample)
JP (4) JP6716800B2 (enExample)
KR (3) KR102472773B1 (enExample)
CN (2) CN117137866A (enExample)
BR (1) BR112020017661A2 (enExample)
CA (1) CA3091700A1 (enExample)
EA (1) EA202092030A1 (enExample)
MX (2) MX2020008925A (enExample)
PH (1) PH12020551313B1 (enExample)
SG (1) SG11202007977RA (enExample)
TW (3) TWI833406B (enExample)
UA (1) UA129517C2 (enExample)
WO (1) WO2019168023A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI833406B (zh) * 2018-02-28 2024-02-21 日商參天製藥股份有限公司 含有迪夸弗索（Ｄｉｑｕａｆｏｓｏｌ）及陽離子性聚合物之眼科用組合物
TWI833913B (zh) * 2019-02-27 2024-03-01 日商參天製藥股份有限公司 含有迪夸弗索(diquafosol)或其鹽、乙烯系高分子及纖維素系高分子之眼科用組合物
KR20240049646A (ko) * 2019-08-27 2024-04-16 산텐 세이야꾸 가부시키가이샤 디쿠아포솔 또는 그 염 및 폴리비닐피롤리돈을 함유하는 수성 안과용 조성물
KR102365008B1 (ko) * 2020-06-23 2022-02-23 주식회사태준제약 디쿠아포솔을 포함하는 점안 조성물
JP7230169B2 (ja) * 2020-12-25 2023-02-28 参天製薬株式会社 ジクアホソルまたはその塩、銀塩およびイオン性等張化剤を含有する水性点眼液
CN113712910A (zh) * 2021-08-05 2021-11-30 广州市桐晖药业有限公司 一种滴眼液及其制备方法
KR102794468B1 (ko) 2022-04-04 2025-04-14 서울대학교산학협력단 감미 억제용 조성물 및 식품의 감미 억제 방법
KR20250038935A (ko) * 2023-09-13 2025-03-20 루다큐어 주식회사 8-옥소-2'-데옥시구아노신 또는 이의 약학적으로 허용가능한 염을 포함하는 수용액 형태의 점안제
KR20250160050A (ko) 2024-05-03 2025-11-11 삼천당제약주식회사 물리화학적 특성이 개선된 안구건조증 예방 또는 치료용 약학 조성물
CN119970633A (zh) * 2025-03-26 2025-05-13 苏州乐珠制药有限公司 一种地夸磷索钠滴眼液及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104203254A (zh) * 2012-03-26 2014-12-10 参天制药株式会社 含有地夸磷索的滴眼液

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01294620A (ja) 1988-05-19 1989-11-28 Kissei Pharmaceut Co Ltd 水溶液製剤およびその製造方法
US5358706A (en) * 1992-09-30 1994-10-25 Union Carbide Chemicals & Plastics Technology Corporation Muco-adhesive polymers
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
JP3155689B2 (ja) * 1995-08-10 2001-04-16 昭和薬品化工株式会社 消炎点眼剤
US5900407A (en) * 1997-02-06 1999-05-04 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with uridine triphosphates and related compounds
KR20010013797A (ko) 1997-07-25 2001-02-26 인스파이어 파마슈티컬스 인코퍼레이티드 디(우리딘 5'-테트라포스페이트) 염 및 그의 제조방법과용도
JP2001294620A (ja) 2000-04-11 2001-10-23 Showa Denko Kk プラスチックレンズ材料、該材料の製造方法、プラスチックレンズ用組成物、該組成物を硬化してなるプラスチックレンズ、及び該プラスチックレンズの製造方法
AU6064301A (en) * 2000-05-30 2001-12-11 Santen Pharmaceutical Co Ltd Ectocornea extension promoters
KR101389300B1 (ko) * 2005-02-14 2014-04-25 존슨 앤드 존슨 비젼 케어, 인코포레이티드 안과용 렌즈의 제조방법, 안과용 장치 및 콘택트 렌즈
JP4515960B2 (ja) 2005-05-19 2010-08-04 株式会社資生堂 整髪料洗浄剤及びその使用方法
KR100870104B1 (ko) * 2005-11-28 2008-11-26 주식회사 머젠스 안구건조증 치료 및 예방용 조성물
KR20150115959A (ko) * 2007-10-12 2015-10-14 레솔빅스 파마슈티칼즈, 인코퍼레이티드 안과 질환의 치료를 위한 옥실리핀 화합물
BRPI0909797A2 (pt) * 2008-03-07 2017-08-22 Sun Pharma Advanced Res Co Ltd Composição oftálmica
JP2012149057A (ja) * 2010-12-28 2012-08-09 Santen Pharmaceut Co Ltd ジクアホソル含有点眼液およびその製造方法、不溶性析出物発生の抑制方法
ES2747808T3 (es) * 2014-05-07 2020-03-11 Croma Pharma Ges M B H Solución oftálmica acuosa y método para tratar el síndrome del ojo seco
WO2015190483A1 (ja) * 2014-06-10 2015-12-17 ロート製薬株式会社 眼科用水性組成物
SG11201705138QA (en) * 2014-12-25 2017-07-28 Santen Pharmaceutical Co Ltd Aqueous ophthalmic solution
KR101587385B1 (ko) 2015-07-29 2016-01-21 국제약품공업주식회사 사이클로스포린 함유 무자극성의 안약조성물 및 편리한 제조방법
WO2017033967A1 (ja) * 2015-08-24 2017-03-02 参天製薬株式会社 眼科用フィルム製剤
LT3266446T (lt) * 2016-07-07 2019-01-25 Laboratorios Salvat, S.A. Oftalmologinė kompozicija, apimanti ricinos aliejų ir vidutinio grandinės ilgio trigliceridą
CN106772747B (zh) * 2016-12-26 2022-10-18 深圳市光科全息技术有限公司 一种光学膜及其制作方法
MY196565A (en) * 2017-04-25 2023-04-19 Wakamoto Pharma Co Ltd Thermogelling Artificial Tears
JP6582029B2 (ja) * 2017-10-03 2019-09-25 株式会社メニコン 眼科用組成液及びその使用方法
TWI833406B (zh) * 2018-02-28 2024-02-21 日商參天製藥股份有限公司 含有迪夸弗索（Ｄｉｑｕａｆｏｓｏｌ）及陽離子性聚合物之眼科用組合物
CN108853016A (zh) * 2018-09-26 2018-11-23 广州大光制药有限公司 一种地夸磷索钠滴眼液及其制备方法
TWI833913B (zh) * 2019-02-27 2024-03-01 日商參天製藥股份有限公司 含有迪夸弗索(diquafosol)或其鹽、乙烯系高分子及纖維素系高分子之眼科用組合物
KR20240049646A (ko) * 2019-08-27 2024-04-16 산텐 세이야꾸 가부시키가이샤 디쿠아포솔 또는 그 염 및 폴리비닐피롤리돈을 함유하는 수성 안과용 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104203254A (zh) * 2012-03-26 2014-12-10 参天制药株式会社 含有地夸磷索的滴眼液

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MOSHE EHRENBERG ET AL.: "Combining Sodium Hyaluronate and Polyvinylpyrrolidone Therapies for the Rabbit Cornea: A New Approach to Relief of the Human Dry Eye Syndrome", 《CURRENT EYE RESEARCH》, vol. 40, no. 9, 20 October 2014 (2014-10-20), pages 1 - 10 *
危军等: "壳聚糖及其衍生物在眼部给药系统中的研究进展", 中国医药工业杂志, vol. 42, no. 3, 31 March 2011 (2011-03-31), pages 222 - 228 *
段辉主编: "眼科临床药物手册", 28 February 2007, 辽宁科学技术出版社, pages: 2 *

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KR20250053220A (ko) 2025-04-21
JP6716800B2 (ja) 2020-07-01
US20210000844A1 (en) 2021-01-07
TWI898399B (zh) 2025-09-21
JP7297718B2 (ja) 2023-06-26
EP3760207A1 (en) 2021-01-06
MX2020008925A (es) 2020-10-01
TW202306572A (zh) 2023-02-16
TWI833406B (zh) 2024-02-21
EA202092030A1 (ru) 2020-11-16
WO2019168023A1 (ja) 2019-09-06
JP2024045506A (ja) 2024-04-02
JPWO2019168023A1 (ja) 2020-05-28
CN111757742A (zh) 2020-10-09
TW202000212A (zh) 2020-01-01
JP7472202B2 (ja) 2024-04-22
BR112020017661A2 (pt) 2020-12-22
MX2022014791A (es) 2023-01-16
TW202423451A (zh) 2024-06-16
KR102472773B1 (ko) 2022-11-30
SG11202007977RA (en) 2020-09-29
KR20200127002A (ko) 2020-11-09
PH12020551313B1 (en) 2024-02-28
KR20220163519A (ko) 2022-12-09
JP2020138980A (ja) 2020-09-03
CN111757742B (zh) 2023-09-26
TWI781296B (zh) 2022-10-21
KR102796051B1 (ko) 2025-04-14
PH12020551313A1 (en) 2021-09-06
CA3091700A1 (en) 2019-09-06
UA129517C2 (uk) 2025-05-21
EP3760207A4 (en) 2023-10-04
JP2022136152A (ja) 2022-09-15

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