KR102472773B1 - 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 - Google Patents

디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 Download PDF

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KR102472773B1
KR102472773B1 KR1020207027473A KR20207027473A KR102472773B1 KR 102472773 B1 KR102472773 B1 KR 102472773B1 KR 1020207027473 A KR1020207027473 A KR 1020207027473A KR 20207027473 A KR20207027473 A KR 20207027473A KR 102472773 B1 KR102472773 B1 KR 102472773B1
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cationic
diquafosol
ophthalmic composition
eye
copolymer
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KR20200127002A (ko
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교헤이 다카하시
히로유키 아사다
아스카 가미무라
겐지 모리시마
유스케 모모카와
겐이치 엔도
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산텐 세이야꾸 가부시키가이샤
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1020207027473A 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 Active KR102472773B1 (ko)

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KR1020227041383A KR102796051B1 (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물

Applications Claiming Priority (3)

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JP2018035578 2018-02-28
JPJP-P-2018-035578 2018-02-28
PCT/JP2019/007542 WO2019168023A1 (ja) 2018-02-28 2019-02-27 ジクアホソルおよびカチオン性ポリマーを含有する眼科用組成物

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KR102472773B1 true KR102472773B1 (ko) 2022-11-30

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KR1020227041383A Active KR102796051B1 (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물
KR1020257011738A Pending KR20250053220A (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물

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KR1020257011738A Pending KR20250053220A (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물

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US (1) US20210000844A1 (enExample)
EP (1) EP3760207A4 (enExample)
JP (4) JP6716800B2 (enExample)
KR (3) KR102472773B1 (enExample)
CN (2) CN117137866A (enExample)
BR (1) BR112020017661A2 (enExample)
CA (1) CA3091700A1 (enExample)
EA (1) EA202092030A1 (enExample)
MX (2) MX2020008925A (enExample)
PH (1) PH12020551313B1 (enExample)
SG (1) SG11202007977RA (enExample)
TW (3) TWI833406B (enExample)
UA (1) UA129517C2 (enExample)
WO (1) WO2019168023A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230143117A (ko) 2022-04-04 2023-10-11 서울대학교산학협력단 감미 억제용 조성물 및 식품의 감미 억제 방법
WO2025058129A1 (en) * 2023-09-13 2025-03-20 Rudacure Corporation Eye drop formulations in the form of an aqueous solution comprising 8-oxo-2'-deoxyguanosine or a pharmaceutically acceptable salt thereof
KR20250160050A (ko) 2024-05-03 2025-11-11 삼천당제약주식회사 물리화학적 특성이 개선된 안구건조증 예방 또는 치료용 약학 조성물

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TWI833406B (zh) * 2018-02-28 2024-02-21 日商參天製藥股份有限公司 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
TWI833913B (zh) * 2019-02-27 2024-03-01 日商參天製藥股份有限公司 含有迪夸弗索(diquafosol)或其鹽、乙烯系高分子及纖維素系高分子之眼科用組合物
KR20240049646A (ko) * 2019-08-27 2024-04-16 산텐 세이야꾸 가부시키가이샤 디쿠아포솔 또는 그 염 및 폴리비닐피롤리돈을 함유하는 수성 안과용 조성물
KR102365008B1 (ko) * 2020-06-23 2022-02-23 주식회사태준제약 디쿠아포솔을 포함하는 점안 조성물
JP7230169B2 (ja) * 2020-12-25 2023-02-28 参天製薬株式会社 ジクアホソルまたはその塩、銀塩およびイオン性等張化剤を含有する水性点眼液
CN113712910A (zh) * 2021-08-05 2021-11-30 广州市桐晖药业有限公司 一种滴眼液及其制备方法
CN119970633A (zh) * 2025-03-26 2025-05-13 苏州乐珠制药有限公司 一种地夸磷索钠滴眼液及其制备方法

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* Cited by examiner, † Cited by third party
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WO1998034593A1 (en) * 1997-02-06 1998-08-13 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with purinergic receptor agonists
WO2017018760A1 (ko) 2015-07-29 2017-02-02 국제약품주식회사 사이클로스포린 함유 무자극성의 안약조성물 및 편리한 제조방법

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230143117A (ko) 2022-04-04 2023-10-11 서울대학교산학협력단 감미 억제용 조성물 및 식품의 감미 억제 방법
WO2025058129A1 (en) * 2023-09-13 2025-03-20 Rudacure Corporation Eye drop formulations in the form of an aqueous solution comprising 8-oxo-2'-deoxyguanosine or a pharmaceutically acceptable salt thereof
KR20250160050A (ko) 2024-05-03 2025-11-11 삼천당제약주식회사 물리화학적 특성이 개선된 안구건조증 예방 또는 치료용 약학 조성물

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KR20250053220A (ko) 2025-04-21
JP6716800B2 (ja) 2020-07-01
US20210000844A1 (en) 2021-01-07
TWI898399B (zh) 2025-09-21
JP7297718B2 (ja) 2023-06-26
EP3760207A1 (en) 2021-01-06
MX2020008925A (es) 2020-10-01
TW202306572A (zh) 2023-02-16
CN117137866A (zh) 2023-12-01
TWI833406B (zh) 2024-02-21
EA202092030A1 (ru) 2020-11-16
WO2019168023A1 (ja) 2019-09-06
JP2024045506A (ja) 2024-04-02
JPWO2019168023A1 (ja) 2020-05-28
CN111757742A (zh) 2020-10-09
TW202000212A (zh) 2020-01-01
JP7472202B2 (ja) 2024-04-22
BR112020017661A2 (pt) 2020-12-22
MX2022014791A (es) 2023-01-16
TW202423451A (zh) 2024-06-16
SG11202007977RA (en) 2020-09-29
KR20200127002A (ko) 2020-11-09
PH12020551313B1 (en) 2024-02-28
KR20220163519A (ko) 2022-12-09
JP2020138980A (ja) 2020-09-03
CN111757742B (zh) 2023-09-26
TWI781296B (zh) 2022-10-21
KR102796051B1 (ko) 2025-04-14
PH12020551313A1 (en) 2021-09-06
CA3091700A1 (en) 2019-09-06
UA129517C2 (uk) 2025-05-21
EP3760207A4 (en) 2023-10-04
JP2022136152A (ja) 2022-09-15

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