KR20250053220A - 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 - Google Patents

디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 Download PDF

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Publication number
KR20250053220A
KR20250053220A KR1020257011738A KR20257011738A KR20250053220A KR 20250053220 A KR20250053220 A KR 20250053220A KR 1020257011738 A KR1020257011738 A KR 1020257011738A KR 20257011738 A KR20257011738 A KR 20257011738A KR 20250053220 A KR20250053220 A KR 20250053220A
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KR
South Korea
Prior art keywords
ophthalmic composition
cationic
polyvinylpyrrolidone
diquafosol
salt
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Pending
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KR1020257011738A
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English (en)
Korean (ko)
Inventor
교헤이 다카하시
히로유키 아사다
아스카 가미무라
겐지 모리시마
유스케 모모카와
겐이치 엔도
Original Assignee
산텐 세이야꾸 가부시키가이샤
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Publication of KR20250053220A publication Critical patent/KR20250053220A/ko
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1020257011738A 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 Pending KR20250053220A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JPJP-P-2018-035578 2018-02-28
JP2018035578 2018-02-28
PCT/JP2019/007542 WO2019168023A1 (ja) 2018-02-28 2019-02-27 ジクアホソルおよびカチオン性ポリマーを含有する眼科用組成物
KR1020227041383A KR102796051B1 (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020227041383A Division KR102796051B1 (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물

Publications (1)

Publication Number Publication Date
KR20250053220A true KR20250053220A (ko) 2025-04-21

Family

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Family Applications (3)

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KR1020257011738A Pending KR20250053220A (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물
KR1020207027473A Active KR102472773B1 (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물
KR1020227041383A Active KR102796051B1 (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물

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KR1020227041383A Active KR102796051B1 (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물

Country Status (14)

Country Link
US (1) US20210000844A1 (enExample)
EP (1) EP3760207A4 (enExample)
JP (5) JP6716800B2 (enExample)
KR (3) KR20250053220A (enExample)
CN (2) CN117137866A (enExample)
BR (1) BR112020017661A2 (enExample)
CA (1) CA3091700A1 (enExample)
EA (1) EA202092030A1 (enExample)
MX (2) MX2020008925A (enExample)
PH (1) PH12020551313B1 (enExample)
SG (1) SG11202007977RA (enExample)
TW (4) TW202600146A (enExample)
UA (1) UA129517C2 (enExample)
WO (1) WO2019168023A1 (enExample)

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WO2020175525A1 (ja) * 2019-02-27 2020-09-03 参天製薬株式会社 ジクアホソルまたはその塩、ビニル系高分子およびセルロース系高分子を含有する眼科用組成物
JP6966667B2 (ja) * 2019-08-27 2021-11-17 参天製薬株式会社 ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物
KR102365008B1 (ko) * 2020-06-23 2022-02-23 주식회사태준제약 디쿠아포솔을 포함하는 점안 조성물
JP7230169B2 (ja) * 2020-12-25 2023-02-28 参天製薬株式会社 ジクアホソルまたはその塩、銀塩およびイオン性等張化剤を含有する水性点眼液
CN113712910A (zh) * 2021-08-05 2021-11-30 广州市桐晖药业有限公司 一种滴眼液及其制备方法
WO2023054669A1 (ja) * 2021-09-30 2023-04-06 ロート製薬株式会社 眼科組成物
KR102794468B1 (ko) 2022-04-04 2025-04-14 서울대학교산학협력단 감미 억제용 조성물 및 식품의 감미 억제 방법
JP2024043685A (ja) * 2022-09-20 2024-04-02 参天製薬株式会社 ジクアホソルまたはその塩を含有する眼科用組成物のｐＨの低下を抑制する方法
KR20250038935A (ko) * 2023-09-13 2025-03-20 루다큐어 주식회사 8-옥소-2'-데옥시구아노신 또는 이의 약학적으로 허용가능한 염을 포함하는 수용액 형태의 점안제
KR20250160050A (ko) 2024-05-03 2025-11-11 삼천당제약주식회사 물리화학적 특성이 개선된 안구건조증 예방 또는 치료용 약학 조성물
CN119970633A (zh) * 2025-03-26 2025-05-13 苏州乐珠制药有限公司 一种地夸磷索钠滴眼液及其制备方法

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CN108853016A (zh) * 2018-09-26 2018-11-23 广州大光制药有限公司 一种地夸磷索钠滴眼液及其制备方法
WO2020175525A1 (ja) * 2019-02-27 2020-09-03 参天製薬株式会社 ジクアホソルまたはその塩、ビニル系高分子およびセルロース系高分子を含有する眼科用組成物
JP6966667B2 (ja) * 2019-08-27 2021-11-17 参天製薬株式会社 ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物

Also Published As

Publication number Publication date
KR20220163519A (ko) 2022-12-09
CA3091700A1 (en) 2019-09-06
US20210000844A1 (en) 2021-01-07
JP2020138980A (ja) 2020-09-03
SG11202007977RA (en) 2020-09-29
JPWO2019168023A1 (ja) 2020-05-28
JP7796782B2 (ja) 2026-01-09
JP6716800B2 (ja) 2020-07-01
TWI781296B (zh) 2022-10-21
EA202092030A1 (ru) 2020-11-16
TW202423451A (zh) 2024-06-16
MX2020008925A (es) 2020-10-01
JP2026034664A (ja) 2026-02-27
UA129517C2 (uk) 2025-05-21
TWI833406B (zh) 2024-02-21
EP3760207A1 (en) 2021-01-06
CN111757742A (zh) 2020-10-09
PH12020551313B1 (en) 2024-02-28
MX2022014791A (es) 2023-01-16
TWI898399B (zh) 2025-09-21
TW202600146A (zh) 2026-01-01
JP7297718B2 (ja) 2023-06-26
TW202000212A (zh) 2020-01-01
JP2024045506A (ja) 2024-04-02
CN111757742B (zh) 2023-09-26
KR102796051B1 (ko) 2025-04-14
KR20200127002A (ko) 2020-11-09
PH12020551313A1 (en) 2021-09-06
JP7472202B2 (ja) 2024-04-22
TW202306572A (zh) 2023-02-16
BR112020017661A2 (pt) 2020-12-22
WO2019168023A1 (ja) 2019-09-06
CN117137866A (zh) 2023-12-01
KR102472773B1 (ko) 2022-11-30
JP2022136152A (ja) 2022-09-15
EP3760207A4 (en) 2023-10-04

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