TW202532647A - 甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關疾病之使用方法 - Google Patents
甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關疾病之使用方法Info
- Publication number
- TW202532647A TW202532647A TW114112856A TW114112856A TW202532647A TW 202532647 A TW202532647 A TW 202532647A TW 114112856 A TW114112856 A TW 114112856A TW 114112856 A TW114112856 A TW 114112856A TW 202532647 A TW202532647 A TW 202532647A
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- nucleotides
- double
- rnai agent
- stranded rnai
- ttr
- Prior art date
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199563P | 2015-07-31 | 2015-07-31 | |
| US62/199,563 | 2015-07-31 | ||
| US201662287518P | 2016-01-27 | 2016-01-27 | |
| US62/287,518 | 2016-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202532647A true TW202532647A (zh) | 2025-08-16 |
Family
ID=56682264
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW114112856A TW202532647A (zh) | 2015-07-31 | 2016-07-29 | 甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關疾病之使用方法 |
| TW112123223A TWI883468B (zh) | 2015-07-31 | 2016-07-29 | 甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關疾病之使用方法 |
| TW105124065A TWI727963B (zh) | 2015-07-31 | 2016-07-29 | 甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關疾病之使用方法 |
| TW110113415A TWI807302B (zh) | 2015-07-31 | 2016-07-29 | 甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關疾病之使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW112123223A TWI883468B (zh) | 2015-07-31 | 2016-07-29 | 甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關疾病之使用方法 |
| TW105124065A TWI727963B (zh) | 2015-07-31 | 2016-07-29 | 甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關疾病之使用方法 |
| TW110113415A TWI807302B (zh) | 2015-07-31 | 2016-07-29 | 甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關疾病之使用方法 |
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| PT2937418T (pt) | 2008-10-20 | 2018-01-23 | Alnylam Pharmaceuticals Inc | Composições e métodos de inibição da expressão de transtirretina |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| IN2012DN00720A (enExample) | 2009-07-06 | 2015-06-19 | Ontorii Inc | |
| MX343559B (es) | 2010-04-29 | 2016-11-10 | Ionis Pharmaceuticals Inc | Modulacion de la expresion de transtiretina. |
| WO2012039448A1 (ja) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
| MX347361B (es) | 2011-07-19 | 2017-04-12 | Wave Life Sciences Ltd | Metodos para la sintesis de acidos nucleicos funcionalizados. |
| PE20142362A1 (es) | 2011-11-18 | 2015-01-30 | Alnylam Pharmaceuticals Inc | Agentes de iarn, composiciones y metodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr) |
| DK3366775T4 (da) * | 2011-11-18 | 2025-10-27 | Alnylam Pharmaceuticals Inc | Modificerede rnai-midler |
| EP2872147B1 (en) | 2012-07-13 | 2022-12-21 | Wave Life Sciences Ltd. | Method for making chiral oligonucleotides |
| EP2872485B1 (en) | 2012-07-13 | 2020-12-16 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| CN106068325B (zh) | 2014-01-16 | 2021-07-09 | 波涛生命科学有限公司 | 手性设计 |
| ES2842300T3 (es) | 2015-07-31 | 2021-07-13 | Alnylam Pharmaceuticals Inc | Composiciones de ARNi de transtiretina (TTR) y métodos para su uso para el tratamiento o la prevención de enfermedades asociadas con TTR |
| JOP20210043A1 (ar) * | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| EP3555292A1 (en) * | 2016-12-16 | 2019-10-23 | Alnylam Pharmaceuticals, Inc. | Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions |
| US11806360B2 (en) | 2017-09-19 | 2023-11-07 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating transthyretin (TTR) mediated amyloidosis |
| AU2018374219C1 (en) * | 2017-12-01 | 2023-05-11 | Suzhou Ribo Life Science Co., Ltd. | Double-stranded oligonucleotide, composition and conjugate comprising double-stranded oligonucleotide, preparation method therefor and use thereof |
| CA3114396A1 (en) | 2018-09-28 | 2020-04-02 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases |
| EP4022062A1 (en) | 2019-08-30 | 2022-07-06 | Alnylam Pharmaceuticals, Inc. | Neurofilament light chain (nfl) as a biomarker for transthyretin amyloidosis polyneuropathy |
| AU2021232029A1 (en) * | 2020-03-06 | 2022-10-06 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of transthyretin (TTR) |
| EP4237005A4 (en) * | 2020-10-28 | 2024-10-09 | Novo Nordisk A/S | ANTI-TRANSTHYRETIN ANTIBODIES AND METHODS OF USE THEREOF |
| US20240182892A1 (en) * | 2021-03-24 | 2024-06-06 | Atalanta Therapeutics, Inc. | Double-stranded sirna having patterned chemical modifications |
| EP4351541A2 (en) | 2021-06-08 | 2024-04-17 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating or preventing stargardt's disease and/or retinal binding protein 4 (rbp4)-associated disorders |
| AR126675A1 (es) | 2021-08-03 | 2023-11-01 | Alnylam Pharmaceuticals Inc | COMPOSICIONES DE ARNi CONTRA LA TRANSTIRRETINA (TTR) Y SUS MÉTODOS DE USO |
| EP4634385A2 (en) * | 2022-12-16 | 2025-10-22 | Amgen Inc. | Rnai constructs for inhibiting ttr expression and methods of use thereof |
| TW202530408A (zh) | 2023-09-29 | 2025-08-01 | 美商英西特羅公司 | 用於治療非酒精性脂肪肝病的組合物與方法 |
| WO2025077916A1 (zh) * | 2023-10-13 | 2025-04-17 | 北京安龙生物医药有限公司 | 靶向转甲状腺素蛋白的寡核苷酸及其用途 |
| WO2025098117A1 (zh) * | 2023-11-06 | 2025-05-15 | 成都倍特药业股份有限公司 | 一种抑制甲状腺素转运蛋白(TTR)表达的RNAi试剂、组合物及应用 |
| WO2025113470A1 (en) * | 2023-11-27 | 2025-06-05 | Shanghai Argo Biopharmaceutical Co., Ltd. | Compositions and methods for inhibiting expression of transthyretin (ttr) |
| US20250333742A1 (en) | 2024-04-25 | 2025-10-30 | Insitro, Inc. | Compositions and methods for treating metabolic dysfunction-associated steatotic liver disease |
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| WO2005121370A2 (en) | 2004-06-03 | 2005-12-22 | Isis Pharmaceuticals, Inc. | Oligomeric compounds that facilitate risc loading |
| AU2001247951A1 (en) | 2000-02-07 | 2001-08-14 | Roche Diagnostics Corporation | Novel cationic amphiphiles |
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