TW202208354A - ＰＩ３Ｋα抑制劑及其使用方法 - Google Patents

ＰＩ３Ｋα抑制劑及其使用方法 Download PDF

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Publication number
TW202208354A
TW202208354A TW110115674A TW110115674A TW202208354A TW 202208354 A TW202208354 A TW 202208354A TW 110115674 A TW110115674 A TW 110115674A TW 110115674 A TW110115674 A TW 110115674A TW 202208354 A TW202208354 A TW 202208354A
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Taiwan
Prior art keywords
nitrogen
sulfur
oxygen
independently selected
partially unsaturated
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TW110115674A
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English (en)
Chinese (zh)
Inventor
亞歷山卓 波席歐
路西恩 Ｖ 迪彼埃特羅
凱瑞 葛莉芬 弗里德里奇
哈坎 谷奈丁
拉維 克魯克拉斯里亞
安德烈 蘭斯卡比
瑪莉 Ｍ 麥德
湯瑪士 Ｈ 麥林
李維 查理斯 湯瑪士 皮爾斯
凱文 大衛 雷諾
凱利 Ｃ 秀特李維斯
湧 湯
亞歷山大 Ｍ 泰勒
Ｗ 派翠克 華特斯
瀚墨 張
法比奇 佐丹尼多
雅寇 沛切司基
大可 王
布蘭 喬登 阿田札
拉伯勒 梅根 博傳
安德魯 Ｊ 伯尼
菲 陳
山帕達 奇塔勒
索倫娜 葛洛茲雅
琴 貝諾 基貴雷
依洛迪 蘭妲嘉雷
愛麗珊德雷 拉里維
湯瑪士 勒皮崔
蓋譚 梅坦斯
喬漢 澳汀
莫漢 柏
克勞蒂歐 司圖利諾
卡西夫 譚維爾
萊克什 索拉
納萊什 維木拉
依蘭 Ｂ 奎傑
潘越
麥寇 保羅 丹尼諾
依芙斯 包斯奎
德斯 勞里爾斯 安托尼 喬彬
碧瑩 李
塔雷 穆罕默德
Original Assignee
美商傳達治療有限公司
美商Ｄ Ｅ 蕭爾研究有限公司
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Application filed by 美商傳達治療有限公司, 美商Ｄ Ｅ 蕭爾研究有限公司 filed Critical 美商傳達治療有限公司
Publication of TW202208354A publication Critical patent/TW202208354A/zh

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    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; ELECTRIC HEARING AIDS; PUBLIC ADDRESS SYSTEMS
    • H04R25/00—Electric hearing aids
    • H04R25/55—Electric hearing aids using an external connection, either wireless or wired
    • H04R25/554—Electric hearing aids using an external connection, either wireless or wired using a wireless connection, e.g. between microphone and amplifier or using Tcoils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0026—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the transmission medium
    • A—HUMAN NECESSITIES
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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