AU2021263914A1 - PI3K-α inhibitors and methods of use thereof - Google Patents

PI3K-α inhibitors and methods of use thereof Download PDF

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Publication number
AU2021263914A1
AU2021263914A1 AU2021263914A AU2021263914A AU2021263914A1 AU 2021263914 A1 AU2021263914 A1 AU 2021263914A1 AU 2021263914 A AU2021263914 A AU 2021263914A AU 2021263914 A AU2021263914 A AU 2021263914A AU 2021263914 A1 AU2021263914 A1 AU 2021263914A1
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Australia
Prior art keywords
nitrogen
sulfur
oxygen
independently selected
substituted
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AU2021263914A
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Inventor
Bren-Jordan ATIENZA
Megan Bertrand-Laperle
Alessandro Boezio
Yves BOUSQUET
Andrew J. BURNIE
Fei Chen
Sampada CHITALE
Michael Paul Deninno
Lucian V. Dipietro
Cary Griffin FRIDRICH
Shorena GELOZIA
Jean-Benoit GIGUERE
Fabrizio Giordanetto
Hakan GUNAYDIN
Antoine JOBIN-DES LAURIERS
Elaine B. Krueger
Ravi Kurukulasuriya
Elodie LANDAGARAY
Alexandre Larivee
Jessica Lee
Thomas LEPITRE
Andre Lescarbeau
Mary M. Mader
Gaetan MAERTENS
Thomas H. MCLEAN
Tarek Mohamed
Johanne OUTIN
Mohan PAL
Yue Pan
Yakov PECHERSKY
Levi Charles Thomas Pierce
Kevin David RAYNOR
Kelley C. SHORTSLEEVES
Claudio Sturino
Yong Tang
Kashif TANVEER
Alexander M. Taylor
Rakesh THORAT
Naresh Vemula
W. Patrick Walters
Qi Wang
Hanmo ZHANG
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DE Shaw Research LLC
Relay Therapeutics Inc
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DE Shaw Research LLC
Relay Therapeutics Inc
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Publication of AU2021263914A1 publication Critical patent/AU2021263914A1/en
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    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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