MX2022013417A - Inhibidores de fosfatidilinositol 3 cinasa (pi3k) alfa y metodos de uso de los mismos. - Google Patents

Inhibidores de fosfatidilinositol 3 cinasa (pi3k) alfa y metodos de uso de los mismos.

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Publication number
MX2022013417A
MX2022013417A MX2022013417A MX2022013417A MX2022013417A MX 2022013417 A MX2022013417 A MX 2022013417A MX 2022013417 A MX2022013417 A MX 2022013417A MX 2022013417 A MX2022013417 A MX 2022013417A MX 2022013417 A MX2022013417 A MX 2022013417A
Authority
MX
Mexico
Prior art keywords
pi3k
methods
inhibitors
compounds
compositions
Prior art date
Application number
MX2022013417A
Other languages
English (en)
Inventor
Claudio Sturino
Michael Paul Deninno
Andre Lescarbeau
Lucian V Dipietro
Naresh Vemula
Yue Pan
Alexander M Taylor
Alessandro Boezio
Hakan Gunaydin
Yong Tang
Thomas H Mclean
Qi Wang
Kelley C Shortsleeves
W Patrick Walters
Elaine B Krueger
Fabrizio Giordanetto
Mary M Mader
Ravi Kurukulasuriya
Cary Griffin Fridrich
Levi Charles Thomas Pierce
Kevin David Raynor
Hanmo Zhang
Yakov Pechersky
Bren-Jordan Atienza
Megan Bertrand-Laperle
Andrew J Burnie
Fei Chen
Sampada Chitale
Shorena Gelozia
Jean-Benoit Giguere
Elodie Landagaray
Alexandre Larivee
Thomas Lepitre
Gaetan Maertens
Johanne Outin
Mohan Pal
Kashif Tanveer
Rakesh Thorat
Yves Bousquet
Lauriers Antoine Jobin-Des
Jessica Lee
Tarek Mohamed
Original Assignee
Relay Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Relay Therapeutics Inc filed Critical Relay Therapeutics Inc
Publication of MX2022013417A publication Critical patent/MX2022013417A/es

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    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R25/00—Deaf-aid sets, i.e. electro-acoustic or electro-mechanical hearing aids; Electric tinnitus maskers providing an auditory perception
    • H04R25/55—Deaf-aid sets, i.e. electro-acoustic or electro-mechanical hearing aids; Electric tinnitus maskers providing an auditory perception using an external connection, either wireless or wired
    • H04R25/554—Deaf-aid sets, i.e. electro-acoustic or electro-mechanical hearing aids; Electric tinnitus maskers providing an auditory perception using an external connection, either wireless or wired using a wireless connection, e.g. between microphone and amplifier or using Tcoils
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    • A61B5/0026—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the transmission medium
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    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

La presente invención se refiere a nuevos compuestos y composiciones farmacéuticas de los mismos, y a métodos para inhibir la actividad de las enzimas PI3Ka con los compuestos y composiciones de la invención. La presente invención además se refiere, pero no se limita, a métodos para tratar trastornos asociados con la señalización de PI3Ka con los compuestos y composiciones de la invención.
MX2022013417A 2020-04-29 2021-04-29 Inhibidores de fosfatidilinositol 3 cinasa (pi3k) alfa y metodos de uso de los mismos. MX2022013417A (es)

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PCT/US2021/029882 WO2021222556A1 (en) 2020-04-29 2021-04-29 PI3K-α INHIBITORS AND METHODS OF USE THEREOF

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TW202334136A (zh) * 2021-11-03 2023-09-01 美商傳達治療有限公司 PI3Kα抑制劑及其製造與使用方法
WO2023098880A1 (zh) * 2021-12-02 2023-06-08 上海翰森生物医药科技有限公司 稠环类衍生物调节剂、其制备方法和应用
WO2024013736A1 (en) * 2022-07-12 2024-01-18 Adama Makhteshim Ltd. Process for preparing substituted benzamides
WO2024030863A1 (en) 2022-08-05 2024-02-08 Scorpion Therapeutics, Inc. Pi3k-alpha inhibitors for the treatment of cancer
TW202413348A (zh) 2022-08-11 2024-04-01 美商傳達治療有限公司 Ｃｄｋ抑制劑及其製備及使用方法
WO2024051784A1 (zh) * 2022-09-09 2024-03-14 上海璎黎药业有限公司 一种含氮杂环化合物、其药物组合物及应用
WO2024055992A1 (zh) * 2022-09-14 2024-03-21 南京再明医药有限公司 三环化合物及其应用
WO2024097721A1 (en) 2022-11-02 2024-05-10 Petra Pharma Corporation Targeting allosteric and orthosteric pockets of phosphoinositide 3-kinase (pi3k) for the treatment of disease
WO2024094163A1 (zh) * 2022-11-03 2024-05-10 上海翰森生物医药科技有限公司 多环并环衍生物、其制备方法和应用
WO2024151930A1 (en) * 2023-01-13 2024-07-18 Relay Therapeutics, Inc. Pi3k inhibitors and methods of making and using the same
WO2024153238A1 (zh) * 2023-01-20 2024-07-25 南京再明医药有限公司 四环化合物及其应用

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WO2011067365A1 (en) 2009-12-03 2011-06-09 Glaxo Group Limited Benzpyrazole derivatives as inhibitors of p13 kinases
NZ600954A (en) 2009-12-22 2013-11-29 Isoindolinone inhibitors of phosphatidylinositol 3-kinase
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