MX2021013146A - Inhibidores de receptores del factor de crecimiento de fibroblastos (fgfr) y metodos de uso de los mismos. - Google Patents
Inhibidores de receptores del factor de crecimiento de fibroblastos (fgfr) y metodos de uso de los mismos.Info
- Publication number
- MX2021013146A MX2021013146A MX2021013146A MX2021013146A MX2021013146A MX 2021013146 A MX2021013146 A MX 2021013146A MX 2021013146 A MX2021013146 A MX 2021013146A MX 2021013146 A MX2021013146 A MX 2021013146A MX 2021013146 A MX2021013146 A MX 2021013146A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compounds
- compositions
- fgfr inhibitors
- fgfr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a nuevos compuestos y composiciones farmacéuticas de los mismos, y a métodos para inhibir la actividad de las enzimas FGFR con los compuestos y composiciones de la invención. La presente invención además se refiere, pero no se limita, a métodos para tratar trastornos asociados con la señalización de FGFR con los compuestos y composiciones de la invención.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962846991P | 2019-05-13 | 2019-05-13 | |
US202062993957P | 2020-03-24 | 2020-03-24 | |
US202063011469P | 2020-04-17 | 2020-04-17 | |
PCT/US2020/032474 WO2020231990A1 (en) | 2019-05-13 | 2020-05-12 | Fgfr inhibitors and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021013146A true MX2021013146A (es) | 2022-01-24 |
Family
ID=73289291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021013146A MX2021013146A (es) | 2019-05-13 | 2020-05-12 | Inhibidores de receptores del factor de crecimiento de fibroblastos (fgfr) y metodos de uso de los mismos. |
Country Status (15)
Country | Link |
---|---|
US (2) | US20230104574A1 (es) |
EP (2) | EP3968999B1 (es) |
JP (1) | JP2022533570A (es) |
KR (1) | KR20220007889A (es) |
CN (1) | CN114126620A (es) |
AU (1) | AU2020274083A1 (es) |
BR (1) | BR112021022457A2 (es) |
CA (1) | CA3137458A1 (es) |
CL (1) | CL2021002882A1 (es) |
IL (1) | IL287940A (es) |
MX (1) | MX2021013146A (es) |
PE (1) | PE20220573A1 (es) |
SG (1) | SG11202111327XA (es) |
TW (1) | TW202108141A (es) |
WO (1) | WO2020231990A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20220573A1 (es) | 2019-05-13 | 2022-04-20 | Relay Therapeutics Inc | Inhibidores de fgfr y metodos de uso de los mismos |
TW202233625A (zh) * | 2020-11-18 | 2022-09-01 | 美商傳達治療有限公司 | Fgfr抑制劑及其製造及使用方法 |
CN115160319B (zh) * | 2021-04-01 | 2023-12-26 | 西安新通药物研究股份有限公司 | 含1,3-苯并二氧戊环结构的化合物及其制备方法与用途 |
CN117222640A (zh) * | 2021-04-03 | 2023-12-12 | 先声再明医药有限公司 | 作为fgfr抑制剂的杂环化合物及其应用 |
WO2023011581A1 (zh) * | 2021-08-04 | 2023-02-09 | 江苏恒瑞医药股份有限公司 | 含氮杂环化合物、其制备方法及其在医药上的应用 |
CA3231948A1 (en) * | 2021-09-23 | 2023-03-30 | Jingyu Hu | Fgfr inhibitors and methods of use thereof |
WO2023104035A1 (zh) * | 2021-12-06 | 2023-06-15 | 英矽智能科技(上海)有限公司 | 取代的单环或双环杂环化合物,其制法与医药上的用途 |
WO2023151560A1 (en) * | 2022-02-08 | 2023-08-17 | Etern Biopharma (Shanghai) Co., Ltd. | Bicyclic heteroaryl compounds and uses thereof |
CN116903628A (zh) * | 2022-04-20 | 2023-10-20 | 深圳福沃药业有限公司 | Fgfr2抑制剂及使用方法 |
TW202400175A (zh) * | 2022-05-10 | 2024-01-01 | 美商傳達治療有限公司 | PI3Kα抑制劑及其使用方法 |
TW202404957A (zh) * | 2022-06-29 | 2024-02-01 | 大陸商上海翰森生物醫藥科技有限公司 | 雜環類衍生物抑制劑、其製備方法和應用 |
WO2024002157A1 (en) * | 2022-06-29 | 2024-01-04 | Insilico Medicine Ip Limited | Inhibitors of fgfr2 and fgfr3 and uses thereof |
CN117402161A (zh) * | 2022-07-06 | 2024-01-16 | 上海科恩泰生物医药科技有限公司 | 一种具有fgfr抑制作用的亚砜亚胺类化合物、包含其的药物组合物及其用途 |
WO2024083111A1 (zh) * | 2022-10-18 | 2024-04-25 | 首药控股(北京)股份有限公司 | 一种新型杂环化合物 |
CN115594682B (zh) * | 2022-10-26 | 2024-03-15 | 苏州浦合医药科技有限公司 | Fgfr2抑制剂 |
WO2024109799A1 (zh) * | 2022-11-22 | 2024-05-30 | 西藏海思科制药有限公司 | 一种嘧啶衍生物及其在医药上的应用 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2224435C (en) * | 1995-07-06 | 2008-08-05 | Novartis Ag | Pyrrolopyrimidines and processes for the preparation thereof |
AU720429B2 (en) * | 1996-08-23 | 2000-06-01 | Novartis Ag | Substituted pyrrolopyrimidines and processes for their preparation |
JP2001516353A (ja) * | 1997-03-19 | 2001-09-25 | ビーエーエスエフ アクチェンゲゼルシャフト | ピロロ[2,3d]ピリミジンおよびチロシンキナーゼ阻害剤としてのこれらの使用 |
AUPQ441499A0 (en) * | 1999-12-02 | 2000-01-06 | Fujisawa Pharmaceutical Co., Ltd. | Novel compound |
GB0031080D0 (en) * | 2000-12-20 | 2001-01-31 | Novartis Ag | Organic compounds |
AUPR548601A0 (en) * | 2001-06-06 | 2001-06-28 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyrazinecompound and pharmaceutical use thereof |
US7323469B2 (en) * | 2001-08-07 | 2008-01-29 | Novartis Ag | 7H-pyrrolo[2,3-d]pyrimidine derivatives |
TW200509938A (en) * | 2003-08-26 | 2005-03-16 | Teijin Pharma Ltd | Pyrrolopyrimidine thion derivatives |
UY28931A1 (es) * | 2004-06-03 | 2005-12-30 | Bayer Pharmaceuticals Corp | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis |
US7358250B2 (en) | 2004-06-29 | 2008-04-15 | Amgen Inc. | Pyrrolo[2,3-d]pyrimidines that modulate ACK1 activity |
AU2005260077A1 (en) * | 2004-06-29 | 2006-01-12 | Amgen Inc. | Furanopyrimidines |
DE102005061170A1 (de) * | 2005-12-21 | 2007-07-05 | Bayer Healthcare Ag | Neue, acyclisch substituierte Furopyrimidin-Derivate und ihre Verwendung |
WO2010126960A1 (en) * | 2009-04-29 | 2010-11-04 | Locus Pharmaceuticals, Inc. | Pyrrolotriazine compounds |
CN102286048A (zh) * | 2011-06-24 | 2011-12-21 | 吉林大学 | 4-氨基-6-(3-(3-溴苯基)苯基)-5-氰基-7-(β-L-呋喃木糖)吡咯并[2, 3-d]嘧啶、同类衍生物及用于制备抗肿瘤药物 |
WO2013078254A1 (en) | 2011-11-22 | 2013-05-30 | Array Biopharma Inc. | Bicyclic heteroaryl derivatives as kinase inhibitors |
EP2788000B1 (en) | 2011-12-06 | 2018-05-30 | Merck Sharp & Dohme Corp. | Pyrrolopyrimidines as janus kinase inhibitors |
JP5355825B1 (ja) * | 2012-01-19 | 2013-11-27 | 大鵬薬品工業株式会社 | 3,5−二置換ベンゼンアルキニル化合物及びその塩 |
JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
DK3269370T3 (da) * | 2016-02-23 | 2020-04-06 | Taiho Pharmaceutical Co Ltd | Hidtil ukendt kondenseret pyrimidinforbindelse eller salt deraf |
US20190192522A1 (en) * | 2016-09-08 | 2019-06-27 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor 4 in combination with cyclin-dependent kinase inhibitors |
US11529347B2 (en) | 2016-09-22 | 2022-12-20 | Relay Therapeutics, Inc. | SHP2 phosphatase inhibitors and methods of use thereof |
SG11201906209SA (en) | 2017-01-23 | 2019-08-27 | Revolution Medicines Inc | Bicyclic compounds as allosteric shp2 inhibitors |
MX2019011330A (es) | 2017-03-23 | 2020-02-05 | Jacobio Pharmaceuticals Co Ltd | Derivados heterocíclicos novedosos útiles como inhibidores de sph2. |
PE20220573A1 (es) | 2019-05-13 | 2022-04-20 | Relay Therapeutics Inc | Inhibidores de fgfr y metodos de uso de los mismos |
TW202233625A (zh) | 2020-11-18 | 2022-09-01 | 美商傳達治療有限公司 | Fgfr抑制劑及其製造及使用方法 |
-
2020
- 2020-05-12 PE PE2021001878A patent/PE20220573A1/es unknown
- 2020-05-12 JP JP2021566480A patent/JP2022533570A/ja active Pending
- 2020-05-12 AU AU2020274083A patent/AU2020274083A1/en active Pending
- 2020-05-12 CN CN202080035916.4A patent/CN114126620A/zh active Pending
- 2020-05-12 KR KR1020217040628A patent/KR20220007889A/ko unknown
- 2020-05-12 EP EP20805444.5A patent/EP3968999B1/en active Active
- 2020-05-12 US US17/595,257 patent/US20230104574A1/en active Pending
- 2020-05-12 MX MX2021013146A patent/MX2021013146A/es unknown
- 2020-05-12 CA CA3137458A patent/CA3137458A1/en active Pending
- 2020-05-12 WO PCT/US2020/032474 patent/WO2020231990A1/en unknown
- 2020-05-12 SG SG11202111327XA patent/SG11202111327XA/en unknown
- 2020-05-12 EP EP23210430.7A patent/EP4306529A3/en active Pending
- 2020-05-12 BR BR112021022457A patent/BR112021022457A2/pt unknown
- 2020-05-13 TW TW109115853A patent/TW202108141A/zh unknown
-
2021
- 2021-11-03 CL CL2021002882A patent/CL2021002882A1/es unknown
- 2021-11-09 IL IL287940A patent/IL287940A/en unknown
-
2023
- 2023-01-31 US US18/162,127 patent/US11780845B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
PE20220573A1 (es) | 2022-04-20 |
CN114126620A (zh) | 2022-03-01 |
EP4306529A3 (en) | 2024-04-10 |
EP3968999A4 (en) | 2022-08-03 |
US20230104574A1 (en) | 2023-04-06 |
EP3968999B1 (en) | 2023-12-27 |
SG11202111327XA (en) | 2021-11-29 |
US20230192709A1 (en) | 2023-06-22 |
AU2020274083A1 (en) | 2021-11-18 |
TW202108141A (zh) | 2021-03-01 |
US11780845B2 (en) | 2023-10-10 |
CL2021002882A1 (es) | 2022-10-07 |
EP4306529A2 (en) | 2024-01-17 |
IL287940A (en) | 2022-01-01 |
KR20220007889A (ko) | 2022-01-19 |
BR112021022457A2 (pt) | 2022-03-22 |
CA3137458A1 (en) | 2020-11-19 |
EP3968999A1 (en) | 2022-03-23 |
WO2020231990A1 (en) | 2020-11-19 |
JP2022533570A (ja) | 2022-07-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2021013146A (es) | Inhibidores de receptores del factor de crecimiento de fibroblastos (fgfr) y metodos de uso de los mismos. | |
MX2023009086A (es) | Inhibidores de cinasas dependientes de ciclinas (cdk) y metodos de uso de estos. | |
MX2022013417A (es) | Inhibidores de fosfatidilinositol 3 cinasa (pi3k) alfa y metodos de uso de los mismos. | |
MX2023001917A (es) | Inhibidores de la fosfatasa shp2 y metodos para su uso. | |
PH12020550881A1 (en) | Substituted bicyclic heterocyclic compounds as prmt5 inhibitors | |
EA202091709A1 (ru) | Ингибиторы днк-пк | |
TW201613875A (en) | EGFR inhibitors, their preparation and their use thereof | |
CR20220169A (es) | Heterociclos bicíclicos como inhibidores de fgfr | |
PH12017500829A1 (en) | 2-amino-3,5-difluoro-3,6-dimethyl-6-phenyl-3,4,5,6-tetrahydropyridines as bace1 inhibitors for treating alzheimer's disease | |
MX2022007376A (es) | Fluoroalqull-oxadiazoles y sus usos. | |
EA201990904A1 (ru) | 1,3-дизамещенные производные циклобутана или азетидина в качестве ингибиторов гемопоэтической простагландин-d-синтазы | |
MX2020002487A (es) | Derivados de piperidina como inhibidores de hdac1/2. | |
MX2021010916A (es) | Inhibidores rad51. | |
EA202091708A1 (ru) | Ингибиторы днк-пк | |
MX2021016049A (es) | Metodos de uso de inhibidores de rad51 para el tratamiento de cancer de pancreas. | |
MX2022002946A (es) | Inhibidores de cdk y su uso como productos farmaceuticos. | |
CA3082254A1 (en) | Heterocyclic compounds as kinase inhibitors | |
MX2021001565A (es) | Inhibidores tipo indol y azaindol de enzimas peptidil arginina deiminasas (pad). | |
AU2020258568A8 (en) | CD73 inhibitors | |
MX2020012900A (es) | Potentes inhibidores de d-aminoacido oxidasa (daao) y sus usos. | |
MX2017009600A (es) | Derivados de 2-fenil-3h-imidazo[4,5-b]piridina utiles como inhibidores de actividad de receptor huerfano similar a tirosina cinasa (ror1) de tirosina cinasa de mamifero. | |
MX2023008968A (es) | Inhibidores de cdk2 y metodos de uso de los mismos. | |
AR126447A1 (es) | INHIBIDORES DE PI3Ka Y MÉTODOS DE USO DE LOS MISMOS | |
MX2022006750A (es) | Inhibidores de masp-2 y metodos de uso. | |
WO2023220131A3 (en) | PI3Kα INHIBITORS AND METHODS OF USE THEREOF |