CN116261562A - PI3K-α抑制剂和其使用方法 - Google Patents

PI3K-α抑制剂和其使用方法 Download PDF

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Publication number
CN116261562A
CN116261562A CN202180043509.2A CN202180043509A CN116261562A CN 116261562 A CN116261562 A CN 116261562A CN 202180043509 A CN202180043509 A CN 202180043509A CN 116261562 A CN116261562 A CN 116261562A
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CN
China
Prior art keywords
nitrogen
independently selected
oxygen
sulfur
partially unsaturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN202180043509.2A
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English (en)
Chinese (zh)
Inventor
A·博齐奥
L·V·迪彼得罗
C·G·弗里德里希
H·居纳伊登
R·库鲁库拉苏里亚
A·莱斯卡尔博
M·M·梅德
T·H·麦克莱恩
L·C·T·皮尔斯
K·D·雷纳
K·C·肖特斯里弗斯
汤涌
A·M·泰勒
W·P·沃尔特斯
张瀚墨
F·焦尔达内途
Y·佩歇尔斯凯
Q·王
B-J·阿蒂恩萨
M·伯特兰德-拉佩尔勒
A·J·比尔尼
陈菲
S·奇塔莱
S·盖洛齐亚
J-B·吉格尔
E·兰达加雷
A·拉里维
T·勒皮特
G·梅尔滕斯
J·乌坦
M·帕尔
C·斯图里诺
K·坦韦尔
R·索拉特
N·韦穆拉
E·B·克鲁格
潘越
M·P·德尼诺
Y·布斯凯
A·乔宾-德斯·洛里耶
J·李
T·穆罕默德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Communication Therapy Ltd
DE Shaw Research LLC
Original Assignee
Communication Therapy Ltd
DE Shaw Research LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Communication Therapy Ltd, DE Shaw Research LLC filed Critical Communication Therapy Ltd
Priority to CN202510407046.3A priority Critical patent/CN120247911B/zh
Publication of CN116261562A publication Critical patent/CN116261562A/zh
Pending legal-status Critical Current

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    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; ELECTRIC HEARING AIDS; PUBLIC ADDRESS SYSTEMS
    • H04R25/00—Electric hearing aids
    • H04R25/55—Electric hearing aids using an external connection, either wireless or wired
    • H04R25/554—Electric hearing aids using an external connection, either wireless or wired using a wireless connection, e.g. between microphone and amplifier or using Tcoils
    • C—CHEMISTRY; METALLURGY
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0026—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the transmission medium
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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