TW201843140A - 6-6稠合雙環雜芳基化合物及其作為lats抑制劑之用途 - Google Patents
6-6稠合雙環雜芳基化合物及其作為lats抑制劑之用途 Download PDFInfo
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- TW201843140A TW201843140A TW107114216A TW107114216A TW201843140A TW 201843140 A TW201843140 A TW 201843140A TW 107114216 A TW107114216 A TW 107114216A TW 107114216 A TW107114216 A TW 107114216A TW 201843140 A TW201843140 A TW 201843140A
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- Prior art keywords
- pyridin
- pyrido
- pyrimidin
- amine
- alkyl
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| MX2022013518A (es) * | 2020-04-28 | 2023-02-01 | Global Blood Therapeutics Inc | Pirimidinas cicloalquiladas como inhibidores de la ferroportina. |
| CN112305126A (zh) * | 2020-11-02 | 2021-02-02 | 宁夏贝利特生物科技有限公司 | 一种硝酸胍含量的测定方法 |
| JP7738165B2 (ja) * | 2021-08-23 | 2025-09-11 | イー・エム・デイー・ミリポア・コーポレイシヨン | 電気泳動ゲルの光重合システム及び方法 |
| CN115974868B (zh) * | 2022-11-07 | 2024-04-12 | 安徽理工大学 | 一种尿嘧啶衍生物的合成方法及其抗肺纤维化方面的潜在应用 |
| WO2024211621A1 (en) * | 2023-04-04 | 2024-10-10 | Children's Hospital Los Angeles | Lats kinase inhibitor to treat retinal degeneration |
| CN119462609A (zh) * | 2024-10-25 | 2025-02-18 | 烟台皓元生物医药科技有限公司 | 一种lats抑制剂vt02956的制备方法 |
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| WO2004065392A1 (en) | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
| KR20070113252A (ko) * | 2005-02-25 | 2007-11-28 | 쿠도스 파마슈티칼스 리미티드 | 2,4-디아미노-피리도피리미딘 유도체 및 이의 mTOR억제제로서의 용도 |
| MX2009010696A (es) * | 2007-04-06 | 2009-10-20 | Novartis Ag | Derivados de 2,6-naftiridina como moduladores de cinasa de proteina. |
| KR20110046514A (ko) | 2008-07-31 | 2011-05-04 | 제넨테크, 인크. | 피리미딘 화합물, 조성물 및 사용 방법 |
| US20110319409A1 (en) * | 2010-06-23 | 2011-12-29 | Cox Christopher D | 7-aza-quinazoline pde10 inhibitors |
| WO2013012087A1 (ja) * | 2011-07-15 | 2013-01-24 | 国立大学法人大阪大学 | 角膜内皮細胞の調製方法 |
| KR20140074964A (ko) | 2011-09-27 | 2014-06-18 | 에프. 호프만-라 로슈 아게 | 피라졸-4-일-헤테로사이클릴-카복사마이드 화합물 및 사용 방법 |
| NZ706857A (en) * | 2012-09-28 | 2018-05-25 | Ignyta Inc | Azaquinazoline inhibitors of atypical protein kinase c |
| BR112016013201B1 (pt) * | 2013-12-12 | 2023-01-31 | The Broad Institute, Inc. | Uso de uma composição compreendendo um sistema crispr-cas no tratamento de uma doença genética ocular |
| TWI675836B (zh) * | 2014-03-25 | 2019-11-01 | 美商伊格尼塔公司 | 非典型蛋白質激酶c之氮雜喹唑啉抑制劑 |
| EP3197557A1 (en) | 2014-09-24 | 2017-08-02 | Friedrich Miescher Institute for Biomedical Research | Lats and breast cancer |
| MA43512A (fr) * | 2015-08-03 | 2018-11-07 | Bristol Myers Squibb Co | Composés hétérocycliques utiles en tant que modulateurs du tnf alpha |
| CA2996513A1 (en) | 2015-08-25 | 2018-03-02 | President And Fellows Of Harvard College | Methods and compositions relating to the diagnosis and treatment of cancer |
| JOP20190257A1 (ar) | 2017-04-28 | 2019-10-28 | Novartis Ag | مركبات أريل غير متجانسة ثنائية الحلقة مندمجة 6-6 واستخدامها كمثبطات lats |
| UY38427A (es) * | 2018-10-26 | 2020-05-29 | Novartis Ag | Métodos y composiciones para terapia con células oculares |
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