AU2018260495B2 - 6-6 Fused Bicyclic Heteroaryl Compounds and their use as LATS inhibitors - Google Patents

6-6 Fused Bicyclic Heteroaryl Compounds and their use as LATS inhibitors Download PDF

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Publication number
AU2018260495B2
AU2018260495B2 AU2018260495A AU2018260495A AU2018260495B2 AU 2018260495 B2 AU2018260495 B2 AU 2018260495B2 AU 2018260495 A AU2018260495 A AU 2018260495A AU 2018260495 A AU2018260495 A AU 2018260495A AU 2018260495 B2 AU2018260495 B2 AU 2018260495B2
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pyrimidin
pyrido
pyridin
amine
methyl
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AU2018260495A1 (en
Inventor
Dirk Behnke
Frada BERENSHTEYN
Xueshi Hao
Timothy Hoffman
Qihui Jin
Arnaud Lacoste
Cameron Lee
Jun Liu
Yahu LIU
Juergen Klaus Maibaum
Tingting Mo
Jianfeng Pan
Xin Qu
Jan TCHORZ
Yun Feng Xie
Shanshan YAN
Yefen Zou
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Novartis AG
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Novartis AG
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Priority to AU2021286281A priority Critical patent/AU2021286281A1/en
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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AU2018260495A 2017-04-28 2018-04-26 6-6 Fused Bicyclic Heteroaryl Compounds and their use as LATS inhibitors Ceased AU2018260495B2 (en)

Priority Applications (1)

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AU2021286281A AU2021286281A1 (en) 2017-04-28 2021-12-14 6-6 Fused Bicyclic Heteroaryl Compounds and their use as LATS inhibitors

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201762491475P 2017-04-28 2017-04-28
US201762491526P 2017-04-28 2017-04-28
US201762491573P 2017-04-28 2017-04-28
US201762491484P 2017-04-28 2017-04-28
US62/491,573 2017-04-28
US62/491,484 2017-04-28
US62/491,526 2017-04-28
US62/491,475 2017-04-28
US201862650232P 2018-03-29 2018-03-29
US62/650,232 2018-03-29
PCT/IB2018/052919 WO2018198077A2 (en) 2017-04-28 2018-04-26 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors

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AU2018260495A1 AU2018260495A1 (en) 2019-10-17
AU2018260495B2 true AU2018260495B2 (en) 2021-09-16

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AU2021286281A Abandoned AU2021286281A1 (en) 2017-04-28 2021-12-14 6-6 Fused Bicyclic Heteroaryl Compounds and their use as LATS inhibitors

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EP (1) EP3615537B1 (enExample)
JP (2) JP7247102B2 (enExample)
KR (1) KR20190142776A (enExample)
CN (3) CN114703144A (enExample)
AU (2) AU2018260495B2 (enExample)
BR (1) BR112019022512A2 (enExample)
CA (1) CA3056906A1 (enExample)
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PL3813800T3 (pl) 2018-06-29 2025-08-18 Incyte Corporation Formulacje inhibitora axl/mer
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WO2020158841A1 (ja) 2019-01-30 2020-08-06 日産化学株式会社 ヒドラジド化合物及びキナーゼ阻害剤
CN112707905B (zh) * 2019-10-25 2024-07-02 武汉誉祥医药科技有限公司 一种三并杂环化合物及其制备方法和用途
GB201915829D0 (en) * 2019-10-31 2019-12-18 Cancer Research Tech Ltd Compounds, compositions and therapeutic uses thereof
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JP7759877B2 (ja) * 2019-11-27 2025-10-24 ジェネンテック， インコーポレイテッド 治療用化合物
CN115515579B (zh) * 2020-02-05 2025-09-30 洛克菲勒大学 吡咯并[2,3-b]吡啶-3-甲酰胺组合物和改善听力损失的方法
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CN111443068B (zh) * 2020-03-06 2023-06-27 天津大学 具有多重刺激响应特性的纯有机室温磷光材料及筛选方法和应用
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JP7738165B2 (ja) * 2021-08-23 2025-09-11 イー・エム・デイー・ミリポア・コーポレイシヨン 電気泳動ゲルの光重合システム及び方法
CN115974868B (zh) * 2022-11-07 2024-04-12 安徽理工大学 一种尿嘧啶衍生物的合成方法及其抗肺纤维化方面的潜在应用
WO2024211621A1 (en) * 2023-04-04 2024-10-10 Children's Hospital Los Angeles Lats kinase inhibitor to treat retinal degeneration
CN119462609A (zh) * 2024-10-25 2025-02-18 烟台皓元生物医药科技有限公司 一种lats抑制剂vt02956的制备方法

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