TW201819378A - 作為αv整合素抑制劑之含環丁烷及氮雜環丁烷之單及螺環化合物 - Google Patents

作為αv整合素抑制劑之含環丁烷及氮雜環丁烷之單及螺環化合物 Download PDF

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TW201819378A
TW201819378A TW106138359A TW106138359A TW201819378A TW 201819378 A TW201819378 A TW 201819378A TW 106138359 A TW106138359 A TW 106138359A TW 106138359 A TW106138359 A TW 106138359A TW 201819378 A TW201819378 A TW 201819378A
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tetrahydro
pyridin
propionic acid
azetidin
ethyl
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TW106138359A
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Chinese (zh)
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普拉禔克 迪瓦絲夏爾
余芳
蘇珊 妮可 皮恩以賽克
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美商必治妥美雅史谷比公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
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    • A61P3/06Antihyperlipidemics
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    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW106138359A 2016-11-08 2017-11-07 作為αv整合素抑制劑之含環丁烷及氮雜環丁烷之單及螺環化合物 TW201819378A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662418859P 2016-11-08 2016-11-08
US62/418,859 2016-11-08

Publications (1)

Publication Number Publication Date
TW201819378A true TW201819378A (zh) 2018-06-01

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TW106138359A TW201819378A (zh) 2016-11-08 2017-11-07 作為αv整合素抑制劑之含環丁烷及氮雜環丁烷之單及螺環化合物

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US (2) US11014922B2 (https=)
EP (1) EP3538526B1 (https=)
JP (1) JP7264810B2 (https=)
KR (1) KR102506324B1 (https=)
CN (1) CN110167934B (https=)
AR (1) AR110139A1 (https=)
AU (1) AU2017359025A1 (https=)
BR (1) BR112019009129A2 (https=)
CA (1) CA3042710A1 (https=)
EA (1) EA201991127A1 (https=)
ES (1) ES2984394T3 (https=)
IL (1) IL266470A (https=)
MA (1) MA46744A (https=)
MX (1) MX377359B (https=)
TW (1) TW201819378A (https=)
WO (1) WO2018089355A1 (https=)

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FI3844162T3 (fi) 2018-08-29 2025-03-27 Morphic Therapeutic Inc Alfa v beeta6 -integriinin estäjiä
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CN116134028A (zh) 2020-07-07 2023-05-16 四川海思科制药有限公司 一种具有降解btk激酶的化合物及其制备方法和药学上的应用
GB202010626D0 (en) * 2020-07-10 2020-08-26 Univ Nottingham Compound
WO2022022364A1 (zh) * 2020-07-29 2022-02-03 清药同创(北京)药物研发中心有限公司 一种吡咯烷类整合素调节剂及其用途
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JP2019537605A (ja) 2019-12-26
MX2019005306A (es) 2019-08-12
US11014922B2 (en) 2021-05-25
AR110139A1 (es) 2019-02-27
KR20190076032A (ko) 2019-07-01
MX377359B (es) 2025-03-10
US20190270741A1 (en) 2019-09-05
CN110167934A (zh) 2019-08-23
MA46744A (fr) 2019-09-18
JP7264810B2 (ja) 2023-04-25
EP3538526A1 (en) 2019-09-18
AU2017359025A1 (en) 2019-06-20
CA3042710A1 (en) 2018-05-17
EA201991127A1 (ru) 2019-10-31
US11639353B2 (en) 2023-05-02
EP3538526B1 (en) 2024-04-10
US20210246136A1 (en) 2021-08-12
IL266470A (en) 2019-07-31
ES2984394T3 (es) 2024-10-29
WO2018089355A1 (en) 2018-05-17
CN110167934B (zh) 2022-06-10
BR112019009129A2 (pt) 2019-07-16
KR102506324B1 (ko) 2023-03-03

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