CN110167934B - 作为αV整联蛋白抑制剂的含有环丁烷和含有氮杂环丁烷的单环和螺环化合物 - Google Patents

作为αV整联蛋白抑制剂的含有环丁烷和含有氮杂环丁烷的单环和螺环化合物 Download PDF

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CN110167934B
CN110167934B CN201780082145.2A CN201780082145A CN110167934B CN 110167934 B CN110167934 B CN 110167934B CN 201780082145 A CN201780082145 A CN 201780082145A CN 110167934 B CN110167934 B CN 110167934B
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tetrahydro
propionic acid
naphthyridin
ethyl
azetidin
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CN110167934A (zh
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P·德维尔塔尔
F·摩尔
G·赵
S·N·皮尼亚泽克
K·塞尔瓦库马
S·达努苏
M·潘达
L·R·马尔钦
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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CN201780082145.2A 2016-11-08 2017-11-07 作为αV整联蛋白抑制剂的含有环丁烷和含有氮杂环丁烷的单环和螺环化合物 Active CN110167934B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662418859P 2016-11-08 2016-11-08
US62/418,859 2016-11-08
PCT/US2017/060383 WO2018089355A1 (en) 2016-11-08 2017-11-07 Cyclobutane- and azetidine-containing mono and spirocyclic compounds as alpha v integrin inhibitors

Publications (2)

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CN110167934A CN110167934A (zh) 2019-08-23
CN110167934B true CN110167934B (zh) 2022-06-10

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US (2) US11014922B2 (https=)
EP (1) EP3538526B1 (https=)
JP (1) JP7264810B2 (https=)
KR (1) KR102506324B1 (https=)
CN (1) CN110167934B (https=)
AR (1) AR110139A1 (https=)
AU (1) AU2017359025A1 (https=)
BR (1) BR112019009129A2 (https=)
CA (1) CA3042710A1 (https=)
EA (1) EA201991127A1 (https=)
ES (1) ES2984394T3 (https=)
IL (1) IL266470A (https=)
MA (1) MA46744A (https=)
MX (1) MX377359B (https=)
TW (1) TW201819378A (https=)
WO (1) WO2018089355A1 (https=)

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CN110177787A (zh) 2016-12-29 2019-08-27 圣路易斯大学 整合素拮抗剂
MA52117A (fr) 2017-02-28 2022-04-06 Morphic Therapeutic Inc Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
MA47697A (fr) 2017-02-28 2020-01-08 Morphic Therapeutic Inc Inhibiteurs de l'(alpha-v)(bêta-6) intégrine
TWI841573B (zh) * 2018-06-27 2024-05-11 美商普萊恩醫療公司 具有未分支連接子之胺基酸化合物及使用方法
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WO2020047207A1 (en) 2018-08-29 2020-03-05 Morphic Therapeutics, Inc. Inhibitors of (alpha-v)(beta-6) integrin
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WO2020047208A1 (en) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
TW202028179A (zh) 2018-10-08 2020-08-01 美商普萊恩醫療公司 胺基酸化合物及使用方法
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GB202010626D0 (en) * 2020-07-10 2020-08-26 Univ Nottingham Compound
WO2022022364A1 (zh) * 2020-07-29 2022-02-03 清药同创(北京)药物研发中心有限公司 一种吡咯烷类整合素调节剂及其用途
CR20230472A (es) * 2021-03-10 2024-03-21 Dice Molecules Sv Inc Inhibidores de integrina alpha v beta 6 y alpha v beta 1 y sus usos
IL308063A (en) * 2021-04-30 2023-12-01 Pliant Therapeutics Inc Expanded dosage regimens for integrin inhibitors
US20250171417A1 (en) 2021-08-11 2025-05-29 Xizang Haisco Pharmaceutical Co., Ltd. Heterocyclic derivative, and composition and pharmaceutical use thereof
EP4504187A4 (en) * 2022-04-01 2026-04-08 Praxis Prec Medicines Inc T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING AN AZASPIRONONANE CORE AND THEIR METHODS OF USE
CN119300826A (zh) * 2022-04-01 2025-01-10 普拉西斯精密医药公司 包含氮杂螺庚烷核的t型钙通道调节剂和其使用方法
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WO2016046230A1 (en) * 2014-09-26 2016-03-31 Glaxosmithkline Intellectual Property Development Limited Naphthyridine derivatives as alpha v beta 6 integrin antagonists for the treatment of e.g. fibrotic diseases
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US5760029A (en) * 1996-03-15 1998-06-02 The Dupont Merck Pharmaceutical Company Spirocycle integrin inhibitors
WO1999026945A1 (en) * 1997-11-26 1999-06-03 Du Pont Pharmaceuticals Company 1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES AS αvβ3 ANTAGONISTS
CN1589145A (zh) * 1999-06-02 2005-03-02 麦克公司 αv整联蛋白受体拮抗剂
WO2016046230A1 (en) * 2014-09-26 2016-03-31 Glaxosmithkline Intellectual Property Development Limited Naphthyridine derivatives as alpha v beta 6 integrin antagonists for the treatment of e.g. fibrotic diseases
WO2016134223A2 (en) * 2015-02-19 2016-08-25 Scifluor Life Sciences, Inc. Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof

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MX2019005306A (es) 2019-08-12
US11014922B2 (en) 2021-05-25
AR110139A1 (es) 2019-02-27
KR20190076032A (ko) 2019-07-01
MX377359B (es) 2025-03-10
TW201819378A (zh) 2018-06-01
US20190270741A1 (en) 2019-09-05
CN110167934A (zh) 2019-08-23
MA46744A (fr) 2019-09-18
JP7264810B2 (ja) 2023-04-25
EP3538526A1 (en) 2019-09-18
AU2017359025A1 (en) 2019-06-20
CA3042710A1 (en) 2018-05-17
EA201991127A1 (ru) 2019-10-31
US11639353B2 (en) 2023-05-02
EP3538526B1 (en) 2024-04-10
US20210246136A1 (en) 2021-08-12
IL266470A (en) 2019-07-31
ES2984394T3 (es) 2024-10-29
WO2018089355A1 (en) 2018-05-17
BR112019009129A2 (pt) 2019-07-16
KR102506324B1 (ko) 2023-03-03

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