TW201625545A - 取代唑化合物及糖尿病治療藥 - Google Patents
取代唑化合物及糖尿病治療藥 Download PDFInfo
- Publication number
- TW201625545A TW201625545A TW104115166A TW104115166A TW201625545A TW 201625545 A TW201625545 A TW 201625545A TW 104115166 A TW104115166 A TW 104115166A TW 104115166 A TW104115166 A TW 104115166A TW 201625545 A TW201625545 A TW 201625545A
- Authority
- TW
- Taiwan
- Prior art keywords
- group
- compound
- ring
- mmol
- substituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014098007A JP2017119628A (ja) | 2014-05-09 | 2014-05-09 | 置換アゾール化合物及び糖尿病治療薬 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW201625545A true TW201625545A (zh) | 2016-07-16 |
Family
ID=54392622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW104115166A TW201625545A (zh) | 2014-05-09 | 2015-05-11 | 取代唑化合物及糖尿病治療藥 |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP2017119628A (ja) |
TW (1) | TW201625545A (ja) |
WO (1) | WO2015170775A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106397311A (zh) * | 2016-08-31 | 2017-02-15 | 安徽省鸿鑫生物科技有限公司 | 一种1‑[5‑(苯基甲氧基)‑2‑吡啶]‑乙酮的制备方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019068613A1 (en) | 2017-10-02 | 2019-04-11 | Boehringer Ingelheim International Gmbh | NOVEL [1,6] NAPHTHYRIDINE COMPOUNDS AND DERIVATIVES AS CDK8 / CDK19 INHIBITORS |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL374860A1 (en) * | 2002-07-09 | 2005-11-14 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
US8183381B2 (en) * | 2007-07-19 | 2012-05-22 | Metabolex Inc. | N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders |
DK2280704T3 (en) * | 2008-03-31 | 2015-06-29 | Cymabay Therapeutics Inc | Oxymethylenarylforbindelser and uses thereof |
PE20120399A1 (es) * | 2009-06-05 | 2012-04-24 | Pfizer | Derivados del l-(piperidin-4-il)-pirazol como moduladores de gpr 119 |
TWI464164B (zh) * | 2009-08-05 | 2014-12-11 | Daiichi Sankyo Co Ltd | 醯胺衍生物 |
KR101829086B1 (ko) * | 2010-10-14 | 2018-02-13 | 다이이찌 산쿄 가부시키가이샤 | 아실벤젠 유도체 |
EP2643310A1 (en) * | 2010-11-23 | 2013-10-02 | Pfizer Inc | 4- (5-cyano-pyrazol-1-yl) -piperidine derivatives as gpr 119 modulators |
JP5973440B2 (ja) * | 2011-07-29 | 2016-08-23 | 第一三共株式会社 | N−ヘテロ環置換アミド誘導体 |
SG11201404026SA (en) * | 2012-01-18 | 2014-11-27 | Daiichi Sankyo Co Ltd | Substituted phenylazole derivative |
-
2014
- 2014-05-09 JP JP2014098007A patent/JP2017119628A/ja active Pending
-
2015
- 2015-05-11 TW TW104115166A patent/TW201625545A/zh unknown
- 2015-05-11 WO PCT/JP2015/063525 patent/WO2015170775A1/ja active Application Filing
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106397311A (zh) * | 2016-08-31 | 2017-02-15 | 安徽省鸿鑫生物科技有限公司 | 一种1‑[5‑(苯基甲氧基)‑2‑吡啶]‑乙酮的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2015170775A1 (ja) | 2015-11-12 |
JP2017119628A (ja) | 2017-07-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7088983B2 (ja) | キナーゼ阻害剤としてのビアリールアミド化合物 | |
JP7017521B2 (ja) | アクチビン受容体様キナーゼの阻害剤 | |
RU2685234C1 (ru) | Конденсированные бициклические гетероароматические производные в качестве модуляторов активности tnf | |
KR102030305B1 (ko) | 키나제 억제제로서 유용한 인돌 카르복스아미드 화합물 | |
JP7440101B2 (ja) | キナーゼ阻害剤としてのヘテロ環式化合物、ヘテロ環式化合物を含む組成物、及びそれらを使用する方法 | |
JP6387086B2 (ja) | 新規ソマトスタチン受容体亜型4(sstr4)作動薬 | |
TWI382026B (zh) | 經取代的雜芳基物 | |
TW201706263A (zh) | 化合物 | |
JP2021193099A (ja) | 置換4−アザインドール及びglun2b受容体調節因子としてのそれらの使用 | |
RU2684637C1 (ru) | Производные тетрагидробензимидазола в качестве модуляторов активности tnf | |
TW201831481A (zh) | 作為Rho激酶抑制劑之酪胺酸醯胺衍生物 | |
CN112424167A (zh) | 化学化合物 | |
TW201444849A (zh) | 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途 | |
WO2019101086A1 (zh) | 卤代烯丙基胺类ssao/vap-1抑制剂及其应用 | |
AU2014315109A1 (en) | Spirocyclic compounds as tryptophan hydroxylase inhibitors | |
TWI833819B (zh) | 用於治療與apj受體活性相關的病狀的化合物及組成物 | |
EA038173B1 (ru) | Терапевтические соединения в качестве ингибиторов рецептора орексина-1 | |
RU2684635C1 (ru) | Производные тетрагидроимидазопиридина в качестве модуляторов активновти tnf | |
EA033679B1 (ru) | Пиридинондикарбоксамиды для применения в качестве ингибиторов бромодомена | |
TW202115054A (zh) | 經取代的雜芳族吡唑并-吡啶及其作為glun2b受體調節劑的用途 | |
WO2014146493A1 (en) | Acyclic cyanoethylpyrazolo pyridones as janus kinase inhibitors | |
JP2014159376A (ja) | アザスピロアルカン化合物 | |
WO2020046975A1 (en) | Methods of treating neurodegenerative diseases | |
CN111747954B (zh) | 吡嗪化合物和其用途 | |
CN112279837B (zh) | 吡嗪化合物和其用途 |