TW201313743A - 抗親和性複合體之抗體 - Google Patents
抗親和性複合體之抗體 Download PDFInfo
- Publication number
- TW201313743A TW201313743A TW101124860A TW101124860A TW201313743A TW 201313743 A TW201313743 A TW 201313743A TW 101124860 A TW101124860 A TW 101124860A TW 101124860 A TW101124860 A TW 101124860A TW 201313743 A TW201313743 A TW 201313743A
- Authority
- TW
- Taiwan
- Prior art keywords
- antibody
- affinity complex
- vitamin
- complex
- affinity
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011206162 | 2011-09-21 | ||
| JP2012006359 | 2012-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201313743A true TW201313743A (zh) | 2013-04-01 |
Family
ID=47914207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101124860A TW201313743A (zh) | 2011-09-21 | 2012-07-11 | 抗親和性複合體之抗體 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9599608B2 (https=) |
| EP (1) | EP2759551B1 (https=) |
| JP (1) | JP6156144B2 (https=) |
| KR (1) | KR101720394B1 (https=) |
| CN (1) | CN103827145A (https=) |
| AU (1) | AU2012310880B2 (https=) |
| BR (1) | BR112014006405A2 (https=) |
| CA (1) | CA2849274C (https=) |
| IL (1) | IL231404A0 (https=) |
| IN (1) | IN2014CN02113A (https=) |
| RU (1) | RU2014115676A (https=) |
| TW (1) | TW201313743A (https=) |
| WO (1) | WO2013042426A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2696075T3 (es) | 2013-01-28 | 2019-01-14 | Diasorin S P A | Procedimiento y kit para detectar 1,25-dihidroxivitamina D y anticuerpos relacionados |
| US10983136B2 (en) | 2013-01-28 | 2021-04-20 | Diasorin S.P.A. | Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker |
| US11261257B2 (en) | 2013-01-28 | 2022-03-01 | Diasorin S.P.A. | Methods for detecting 1,25-dihydroxyvitamin D and related antibodies |
| KR101840525B1 (ko) | 2013-02-06 | 2018-03-20 | 후지레비오 가부시키가이샤 | 비타민 d 의 측정 방법 및 측정용 키트 |
| TW201536801A (zh) * | 2014-02-25 | 2015-10-01 | Fujirebio Kk | 改質單體ＩｇＭ |
| CN108779169B (zh) | 2015-12-21 | 2022-06-07 | 图尔库大学 | 针对包含蓝细菌环肽肝毒素的免疫复合物的抗体 |
| WO2017127833A1 (en) | 2016-01-22 | 2017-07-27 | Affimedix, Inc. | Device for detection of vitamin d metabolites |
| CN106244562B (zh) * | 2016-05-20 | 2019-07-23 | 杭州奥泰生物技术股份有限公司 | 杂交瘤细胞株及其分泌的抗25羟基维生素d3单克隆抗体和应用 |
| CN109863406B (zh) * | 2016-07-29 | 2023-04-14 | Diazyme研究室有限公司 | 用于测定维生素d的方法和成分 |
| EP3624811A4 (en) * | 2017-05-19 | 2021-03-10 | The Regents of The University of California | ANTIBODY-BASED CHEMICAL INDUCED DIMERIZER (ABCID) AS A MOLECULAR SWITCH FOR REGULATING CELL THERAPIES |
| EP3734271B1 (en) | 2017-12-25 | 2026-04-15 | Fujirebio Inc. | Blood testing method for macrolide immunosuppressant |
| JP7434824B2 (ja) * | 2019-11-20 | 2024-02-21 | 東ソー株式会社 | 抗イムノコンプレックス抗体を用いた測定方法 |
| US20220349879A1 (en) * | 2019-11-20 | 2022-11-03 | Tosoh Corporation | Measurement method using anti-immunocomplex antibody |
| JP7683188B2 (ja) * | 2019-11-29 | 2025-05-27 | 東ソー株式会社 | 抗イムノコンプレックス抗体を用いた測定法 |
| CN113125696B (zh) * | 2019-12-31 | 2024-03-26 | 科美博阳诊断技术(上海)有限公司 | 一种雌二醇均相化学发光检测试剂盒及其应用 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3364347D1 (en) * | 1982-04-09 | 1986-08-07 | Fujirebio Kk | Anti immune complex antibody and preparation thereof |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8408193D0 (en) | 1984-03-30 | 1984-05-10 | Cambridge Patent Dev | Antibodies |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5223441A (en) * | 1986-10-09 | 1993-06-29 | Syntex (U.S.A.) Inc. | Receptors for immune complexes |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5187065A (en) * | 1989-12-22 | 1993-02-16 | Schutzer Steven E | Method and materials for detecting lyme disease |
| EP1690934A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| ATE182651T1 (de) | 1992-06-09 | 1999-08-15 | Hoppe Ag | Riegel und türschloss |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
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| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
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| TWI255853B (en) | 1998-08-21 | 2006-06-01 | Kirin Brewery | Method for modifying chromosomes |
| US7122339B2 (en) | 1998-10-09 | 2006-10-17 | Medical Research Council | Method for generating diversity |
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| JP2001231403A (ja) | 2000-02-18 | 2001-08-28 | Kirin Brewery Co Ltd | 改変された外来染色体あるいはその断片を保持する非ヒト動物 |
| DE60144305D1 (de) | 2000-11-17 | 2011-05-05 | Kyowa Hakko Kirin Co Ltd | Expression von xenogenen (humanen) Immunglobulinen in klonierten, transgenen Huftieren |
| US7435871B2 (en) | 2001-11-30 | 2008-10-14 | Amgen Fremont Inc. | Transgenic animals bearing human Igλ light chain genes |
| EA200401325A1 (ru) | 2002-04-09 | 2005-04-28 | Киова Хакко Когио Ко., Лтд. | Клетки с модифицированным геномом |
| CN100379862C (zh) | 2002-07-30 | 2008-04-09 | 独立行政法人理化学研究所 | 增强体细胞同源重组的方法和构建特异抗体的方法 |
| FI20022048A0 (fi) * | 2002-11-18 | 2002-11-18 | Valtion Teknillinen | Ei-kompetetiivinen immunomääritys pienille analyyteille |
| JP5319863B2 (ja) | 2002-12-26 | 2013-10-16 | 独立行政法人理化学研究所 | 体細胞相同組換えの誘発方法 |
| NZ550106A (en) | 2004-04-22 | 2009-06-26 | Kyowa Hakko Kirin Co Ltd | Transgenic animals and uses thereof |
| US20080184380A1 (en) | 2004-10-22 | 2008-07-31 | Therapeutic Human Polyclonals Inc. | Suppression of Endogenous Immunoglobulin Expression in Non-Human Transgenic Animals |
| JP4892717B2 (ja) * | 2005-03-31 | 2012-03-07 | 国立大学法人広島大学 | ニワトリキメラ抗体およびその利用 |
| JP2009509992A (ja) * | 2005-09-29 | 2009-03-12 | エフ．ホフマン−ラ ロシュ アーゲー | ２５−ヒドロキシビタミンｄに対する抗体 |
| FI20075251A0 (fi) | 2007-04-13 | 2007-04-13 | Hytest Oy | Immunomääritys epästabiilien antigeenien määrittämiseksi |
| JP2009082033A (ja) | 2007-09-28 | 2009-04-23 | Kaneka Corp | 完全ヒト型抗体生産法 |
| FI20085579A0 (fi) * | 2008-06-12 | 2008-06-12 | Valtion Teknillinen | Kannabiskäytön toteaminen |
| US20110097733A1 (en) * | 2009-10-27 | 2011-04-28 | Michel Anciaux | Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite |
-
2012
- 2012-07-04 EP EP12833103.0A patent/EP2759551B1/en active Active
- 2012-07-04 RU RU2014115676/10A patent/RU2014115676A/ru not_active Application Discontinuation
- 2012-07-04 BR BR112014006405A patent/BR112014006405A2/pt not_active IP Right Cessation
- 2012-07-04 CN CN201280045570.1A patent/CN103827145A/zh active Pending
- 2012-07-04 IN IN2113CHN2014 patent/IN2014CN02113A/en unknown
- 2012-07-04 AU AU2012310880A patent/AU2012310880B2/en not_active Ceased
- 2012-07-04 JP JP2013534624A patent/JP6156144B2/ja active Active
- 2012-07-04 WO PCT/JP2012/067062 patent/WO2013042426A1/ja not_active Ceased
- 2012-07-04 US US14/346,615 patent/US9599608B2/en active Active
- 2012-07-04 CA CA2849274A patent/CA2849274C/en active Active
- 2012-07-04 KR KR1020147006583A patent/KR101720394B1/ko not_active Expired - Fee Related
- 2012-07-11 TW TW101124860A patent/TW201313743A/zh unknown
-
2014
- 2014-03-06 IL IL231404A patent/IL231404A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2849274A1 (en) | 2013-03-28 |
| JPWO2013042426A1 (ja) | 2015-03-26 |
| EP2759551A4 (en) | 2015-03-04 |
| BR112014006405A2 (pt) | 2017-04-04 |
| US20150037813A1 (en) | 2015-02-05 |
| IL231404A0 (en) | 2014-04-30 |
| IN2014CN02113A (https=) | 2015-05-29 |
| CN103827145A (zh) | 2014-05-28 |
| AU2012310880B2 (en) | 2015-12-03 |
| KR20140044940A (ko) | 2014-04-15 |
| JP6156144B2 (ja) | 2017-07-05 |
| US9599608B2 (en) | 2017-03-21 |
| WO2013042426A1 (ja) | 2013-03-28 |
| RU2014115676A (ru) | 2015-10-27 |
| EP2759551B1 (en) | 2019-05-22 |
| CA2849274C (en) | 2018-12-04 |
| EP2759551A1 (en) | 2014-07-30 |
| AU2012310880A1 (en) | 2014-04-10 |
| KR101720394B1 (ko) | 2017-03-27 |
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