IN2014CN02113A - - Google Patents

Info

Publication number
IN2014CN02113A
IN2014CN02113A IN2113CHN2014A IN2014CN02113A IN 2014CN02113 A IN2014CN02113 A IN 2014CN02113A IN 2113CHN2014 A IN2113CHN2014 A IN 2113CHN2014A IN 2014CN02113 A IN2014CN02113 A IN 2014CN02113A
Authority
IN
India
Prior art keywords
antibody
affinity complex
specifically
region
measuring
Prior art date
Application number
Inventor
Kazuya Omi
Tsuyoshi Ando
Yoshiaki Uchida
Katsutoshi Goishi
Asako Oka
Takashi Shirakawa
Takuya Sakyu
Original Assignee
Fujirebio Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujirebio Kk filed Critical Fujirebio Kk
Publication of IN2014CN02113A publication Critical patent/IN2014CN02113A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

The present invention provides a method and a means for highly sensitively and specifically measuring a substance such as a low molecular weight substance by means of a sandwich method. Specifically the present invention provides a method that is for measuring an affinity complex and that includes measuring an affinity complex using an antibody that can specifically bond to the affinity complex and an antibody that can specifically bond to the affinity complex. The antibody may be a full length antibody. The antibody also may have a region (e.g. a complementarity determining region a framework region or a variable region) derived from the immunoglobulin of an animal having gene conversion ability. As at least one of the factors constituting the affinity complex for example a low molecular weight substance or a protein (e.g. an antibody) can be cited.
IN2113CHN2014 2011-09-21 2012-07-04 IN2014CN02113A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011206162 2011-09-21
JP2012006359 2012-01-16
PCT/JP2012/067062 WO2013042426A1 (en) 2011-09-21 2012-07-04 Antibody against affinity complex

Publications (1)

Publication Number Publication Date
IN2014CN02113A true IN2014CN02113A (en) 2015-05-29

Family

ID=47914207

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2113CHN2014 IN2014CN02113A (en) 2011-09-21 2012-07-04

Country Status (13)

Country Link
US (1) US9599608B2 (en)
EP (1) EP2759551B1 (en)
JP (1) JP6156144B2 (en)
KR (1) KR101720394B1 (en)
CN (1) CN103827145A (en)
AU (1) AU2012310880B2 (en)
BR (1) BR112014006405A2 (en)
CA (1) CA2849274C (en)
IL (1) IL231404A0 (en)
IN (1) IN2014CN02113A (en)
RU (1) RU2014115676A (en)
TW (1) TW201313743A (en)
WO (1) WO2013042426A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11261257B2 (en) 2013-01-28 2022-03-01 Diasorin S.P.A. Methods for detecting 1,25-dihydroxyvitamin D and related antibodies
US10983136B2 (en) 2013-01-28 2021-04-20 Diasorin S.P.A. Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker
EP2759550B1 (en) 2013-01-28 2018-08-15 DiaSorin S.p.A. Method and kit for detecting 1,25-dihydroxyvitamin D and related antibodies
WO2014122972A1 (en) 2013-02-06 2014-08-14 富士レビオ株式会社 Vitamin d measurement method and measurement kit
WO2015129651A1 (en) * 2014-02-25 2015-09-03 富士レビオ株式会社 Modified monomeric igm
EP3394097A1 (en) 2015-12-21 2018-10-31 Turun Yliopisto Antibodies against immunocomplexes comprising cyanobacterial cyclic peptide hepatotoxins
JP2019507890A (en) * 2016-01-22 2019-03-22 アフィメディックス， インコーポレイテッド Device for detection of vitamin D metabolites
CN106244562B (en) * 2016-05-20 2019-07-23 杭州奥泰生物技术股份有限公司 Hybridoma cell strain and its 3 monoclonal antibody of anti-25(OH)VD and application of secretion
EP3491392B1 (en) * 2016-07-29 2021-03-31 Diazyme Laboratories, Inc. Methods and compositions for assaying vitamin d
US11939379B2 (en) 2017-05-19 2024-03-26 The Regents Of The University Of California Antibody chemically induced dimerizer (AbCID) as molecular switches for regulating cellular therapies
CN111512154B (en) 2017-12-25 2022-05-27 富士瑞必欧株式会社 Blood detection method aiming at macrolide immunosuppressant
JP7434824B2 (en) 2019-11-20 2024-02-21 東ソー株式会社 Measurement method using anti-immunocomplex antibody
US20220349879A1 (en) * 2019-11-20 2022-11-03 Tosoh Corporation Measurement method using anti-immunocomplex antibody
CN113125696B (en) * 2019-12-31 2024-03-26 科美博阳诊断技术(上海)有限公司 Estradiol homogeneous chemiluminescence detection kit and application thereof

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091760B1 (en) * 1982-04-09 1986-07-02 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Anti immune complex antibody and preparation thereof
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8408193D0 (en) * 1984-03-30 1984-05-10 Cambridge Patent Dev Antibodies
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5223441A (en) 1986-10-09 1993-06-29 Syntex (U.S.A.) Inc. Receptors for immune complexes
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5187065A (en) * 1989-12-22 1993-02-16 Schutzer Steven E Method and materials for detecting lyme disease
CA2050918A1 (en) 1990-01-12 1991-07-13 Raju Kucherlapati Generation of xenogeneic antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ES2108048T3 (en) 1990-08-29 1997-12-16 Genpharm Int PRODUCTION AND USE OF LOWER TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGICAL ANTIBODIES.
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
ES2136092T3 (en) 1991-09-23 1999-11-16 Medical Res Council PROCEDURES FOR THE PRODUCTION OF HUMANIZED ANTIBODIES.
WO1993011236A1 (en) 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
EP0598877B1 (en) 1992-06-09 1999-07-28 Hoppe Ag Latch and lockset system
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
KR100654645B1 (en) 1995-04-27 2007-04-04 아브게닉스, 인크. Human Antibodies from Immunized Genomous
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc Human antibodies derived from immunized xenomice
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
ATE549918T1 (en) 1996-12-03 2012-04-15 Amgen Fremont Inc HUMAN ANTIBODIES THAT EXPRESSLY BIND HUMAN TNF ALPHA
JP4082740B2 (en) 1997-02-28 2008-04-30 キリンファーマ株式会社 Pluripotent retaining cells with disrupted endogenous genes
TWI255853B (en) 1998-08-21 2006-06-01 Kirin Brewery Method for modifying chromosomes
US7122339B2 (en) 1998-10-09 2006-10-17 Medical Research Council Method for generating diversity
NZ516173A (en) 1999-06-04 2004-02-27 Tranxenogen Inc Methods for manipulating the avian genome
JP4228095B2 (en) * 1999-12-17 2009-02-25 東ソー株式会社 Immunoassay method and immunoassay reagent
JP2001231403A (en) 2000-02-18 2001-08-28 Kirin Brewery Co Ltd Nonhuman animal retaining varied alien chromosome or its fragment
KR100882030B1 (en) 2000-11-17 2009-02-09 교와 핫꼬 기린 가부시키가이샤 Expression of Xenogenous (Human) Immunoglobulins in Cloned, Transgenic Ungulates
JP2005510253A (en) 2001-11-30 2005-04-21 アブジェニックス インコーポレイテッド Transgenic animal carrying human Igλ light chain gene
WO2003085107A1 (en) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Cells with modified genome
EP1536004B1 (en) * 2002-07-30 2010-12-01 Riken Method of promoting homologous recombination of somatic cells and method of constructing specific antibody
FI20022048A0 (en) * 2002-11-18 2002-11-18 Valtion Teknillinen Non-competitive immunoassay for small assays
JP5319863B2 (en) 2002-12-26 2013-10-16 独立行政法人理化学研究所 Induction method of somatic cell homologous recombination
WO2005104835A2 (en) 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
US20080184380A1 (en) 2004-10-22 2008-07-31 Therapeutic Human Polyclonals Inc. Suppression of Endogenous Immunoglobulin Expression in Non-Human Transgenic Animals
JP4892717B2 (en) * 2005-03-31 2012-03-07 国立大学法人広島大学 Chicken chimeric antibody and use thereof
CA2624124A1 (en) * 2005-09-29 2007-04-12 F. Hoffmann-La Roche Ag Antibodies against 25-hydroxyvitamin d
FI20075251A0 (en) 2007-04-13 2007-04-13 Hytest Oy Immunoassay for the detection of unstable antigens
JP2009082033A (en) 2007-09-28 2009-04-23 Kaneka Corp Method for producing completely human antibody
FI20085579A0 (en) * 2008-06-12 2008-06-12 Valtion Teknillinen Detection of cannabis use
US20110097733A1 (en) * 2009-10-27 2011-04-28 Michel Anciaux Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite

Also Published As

Publication number Publication date
KR101720394B1 (en) 2017-03-27
US20150037813A1 (en) 2015-02-05
CN103827145A (en) 2014-05-28
TW201313743A (en) 2013-04-01
EP2759551B1 (en) 2019-05-22
BR112014006405A2 (en) 2017-04-04
KR20140044940A (en) 2014-04-15
AU2012310880A1 (en) 2014-04-10
RU2014115676A (en) 2015-10-27
CA2849274C (en) 2018-12-04
CA2849274A1 (en) 2013-03-28
EP2759551A4 (en) 2015-03-04
IL231404A0 (en) 2014-04-30
JPWO2013042426A1 (en) 2015-03-26
AU2012310880B2 (en) 2015-12-03
WO2013042426A1 (en) 2013-03-28
EP2759551A1 (en) 2014-07-30
US9599608B2 (en) 2017-03-21
JP6156144B2 (en) 2017-07-05

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