CN103827145A - 相对于亲和性复合物的抗体 - Google Patents

相对于亲和性复合物的抗体 Download PDF

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Publication number
CN103827145A
CN103827145A CN201280045570.1A CN201280045570A CN103827145A CN 103827145 A CN103827145 A CN 103827145A CN 201280045570 A CN201280045570 A CN 201280045570A CN 103827145 A CN103827145 A CN 103827145A
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CN
China
Prior art keywords
antibody
affinity
vitamin
complex
affinity complex
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Pending
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CN201280045570.1A
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English (en)
Chinese (zh)
Inventor
小见和也
安藤豪
内田好昭
碁石胜利
冈麻子
白川贵志
佐久拓弥
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Fujirebio Inc
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Fujirebio Inc
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Publication of CN103827145A publication Critical patent/CN103827145A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201280045570.1A 2011-09-21 2012-07-04 相对于亲和性复合物的抗体 Pending CN103827145A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2011-206162 2011-09-21
JP2011206162 2011-09-21
JP2012-006359 2012-01-16
JP2012006359 2012-01-16
PCT/JP2012/067062 WO2013042426A1 (ja) 2011-09-21 2012-07-04 親和性複合体に対する抗体

Publications (1)

Publication Number Publication Date
CN103827145A true CN103827145A (zh) 2014-05-28

Family

ID=47914207

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280045570.1A Pending CN103827145A (zh) 2011-09-21 2012-07-04 相对于亲和性复合物的抗体

Country Status (13)

Country Link
US (1) US9599608B2 (https=)
EP (1) EP2759551B1 (https=)
JP (1) JP6156144B2 (https=)
KR (1) KR101720394B1 (https=)
CN (1) CN103827145A (https=)
AU (1) AU2012310880B2 (https=)
BR (1) BR112014006405A2 (https=)
CA (1) CA2849274C (https=)
IL (1) IL231404A0 (https=)
IN (1) IN2014CN02113A (https=)
RU (1) RU2014115676A (https=)
TW (1) TW201313743A (https=)
WO (1) WO2013042426A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2696075T3 (es) 2013-01-28 2019-01-14 Diasorin S P A Procedimiento y kit para detectar 1,25-dihidroxivitamina D y anticuerpos relacionados
US10983136B2 (en) 2013-01-28 2021-04-20 Diasorin S.P.A. Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker
US11261257B2 (en) 2013-01-28 2022-03-01 Diasorin S.P.A. Methods for detecting 1,25-dihydroxyvitamin D and related antibodies
KR101840525B1 (ko) 2013-02-06 2018-03-20 후지레비오 가부시키가이샤 비타민 d 의 측정 방법 및 측정용 키트
TW201536801A (zh) * 2014-02-25 2015-10-01 Fujirebio Kk 改質單體ＩｇＭ
CN108779169B (zh) 2015-12-21 2022-06-07 图尔库大学 针对包含蓝细菌环肽肝毒素的免疫复合物的抗体
WO2017127833A1 (en) 2016-01-22 2017-07-27 Affimedix, Inc. Device for detection of vitamin d metabolites
CN106244562B (zh) * 2016-05-20 2019-07-23 杭州奥泰生物技术股份有限公司 杂交瘤细胞株及其分泌的抗25羟基维生素d3单克隆抗体和应用
CN109863406B (zh) * 2016-07-29 2023-04-14 Diazyme研究室有限公司 用于测定维生素d的方法和成分
EP3624811A4 (en) * 2017-05-19 2021-03-10 The Regents of The University of California ANTIBODY-BASED CHEMICAL INDUCED DIMERIZER (ABCID) AS A MOLECULAR SWITCH FOR REGULATING CELL THERAPIES
EP3734271B1 (en) 2017-12-25 2026-04-15 Fujirebio Inc. Blood testing method for macrolide immunosuppressant
JP7434824B2 (ja) * 2019-11-20 2024-02-21 東ソー株式会社 抗イムノコンプレックス抗体を用いた測定方法
US20220349879A1 (en) * 2019-11-20 2022-11-03 Tosoh Corporation Measurement method using anti-immunocomplex antibody
JP7683188B2 (ja) * 2019-11-29 2025-05-27 東ソー株式会社 抗イムノコンプレックス抗体を用いた測定法
CN113125696B (zh) * 2019-12-31 2024-03-26 科美博阳诊断技术(上海)有限公司 一种雌二醇均相化学发光检测试剂盒及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001174460A (ja) * 1999-12-17 2001-06-29 Tosoh Corp 免疫測定方法および免疫測定試薬

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3364347D1 (en) * 1982-04-09 1986-08-07 Fujirebio Kk Anti immune complex antibody and preparation thereof
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8408193D0 (en) 1984-03-30 1984-05-10 Cambridge Patent Dev Antibodies
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5223441A (en) * 1986-10-09 1993-06-29 Syntex (U.S.A.) Inc. Receptors for immune complexes
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5187065A (en) * 1989-12-22 1993-02-16 Schutzer Steven E Method and materials for detecting lyme disease
EP1690934A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ATE300615T1 (de) 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
ATE182651T1 (de) 1992-06-09 1999-08-15 Hoppe Ag Riegel und türschloss
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
CA2219361C (en) 1995-04-27 2012-02-28 Abgenix, Inc. Human antibodies derived from immunized xenomice
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
EP1500329B1 (en) 1996-12-03 2012-03-21 Amgen Fremont Inc. Human antibodies that specifically bind human TNF alpha
JP4082740B2 (ja) 1997-02-28 2008-04-30 キリンファーマ株式会社 内因性遺伝子が破壊されている分化多能性保持細胞
TWI255853B (en) 1998-08-21 2006-06-01 Kirin Brewery Method for modifying chromosomes
US7122339B2 (en) 1998-10-09 2006-10-17 Medical Research Council Method for generating diversity
WO2000075300A2 (en) 1999-06-04 2000-12-14 Tranxenogen, Inc. Methods for manipulating the avian genome
JP2001231403A (ja) 2000-02-18 2001-08-28 Kirin Brewery Co Ltd 改変された外来染色体あるいはその断片を保持する非ヒト動物
DE60144305D1 (de) 2000-11-17 2011-05-05 Kyowa Hakko Kirin Co Ltd Expression von xenogenen (humanen) Immunglobulinen in klonierten, transgenen Huftieren
US7435871B2 (en) 2001-11-30 2008-10-14 Amgen Fremont Inc. Transgenic animals bearing human Igλ light chain genes
EA200401325A1 (ru) 2002-04-09 2005-04-28 Киова Хакко Когио Ко., Лтд. Клетки с модифицированным геномом
CN100379862C (zh) 2002-07-30 2008-04-09 独立行政法人理化学研究所 增强体细胞同源重组的方法和构建特异抗体的方法
FI20022048A0 (fi) * 2002-11-18 2002-11-18 Valtion Teknillinen Ei-kompetetiivinen immunomääritys pienille analyyteille
JP5319863B2 (ja) 2002-12-26 2013-10-16 独立行政法人理化学研究所 体細胞相同組換えの誘発方法
NZ550106A (en) 2004-04-22 2009-06-26 Kyowa Hakko Kirin Co Ltd Transgenic animals and uses thereof
US20080184380A1 (en) 2004-10-22 2008-07-31 Therapeutic Human Polyclonals Inc. Suppression of Endogenous Immunoglobulin Expression in Non-Human Transgenic Animals
JP4892717B2 (ja) * 2005-03-31 2012-03-07 国立大学法人広島大学 ニワトリキメラ抗体およびその利用
JP2009509992A (ja) * 2005-09-29 2009-03-12 エフ．ホフマン−ラ ロシュ アーゲー ２５−ヒドロキシビタミンｄに対する抗体
FI20075251A0 (fi) 2007-04-13 2007-04-13 Hytest Oy Immunomääritys epästabiilien antigeenien määrittämiseksi
JP2009082033A (ja) 2007-09-28 2009-04-23 Kaneka Corp 完全ヒト型抗体生産法
FI20085579A0 (fi) * 2008-06-12 2008-06-12 Valtion Teknillinen Kannabiskäytön toteaminen
US20110097733A1 (en) * 2009-10-27 2011-04-28 Michel Anciaux Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001174460A (ja) * 1999-12-17 2001-06-29 Tosoh Corp 免疫測定方法および免疫測定試薬

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
IHARA M等: "Open-sandwich enzyme immunoassay for one-step noncompetitive detection of corticosteroid 11-deoxycortisol", 《ANAL.CHEM》, vol. 81, no. 20, 31 December 2009 (2009-12-31), pages 8298 - 8304, XP055145692, DOI: 10.1021/ac900700a *
ROSSOTTI MA等: "Phage anti-immunocomplex assay for clomazone:two-site recognition increasing assay specificity and facilitating adaptation into an on-site format", 《ANAL.CHEM》, vol. 82, no. 21, 31 December 2010 (2010-12-31), pages 8838 - 8843, XP055145690, DOI: 10.1021/ac101476f *
张红等: "鸡免疫球蛋白基因结构与抗体多样性产生的分子机制", 《河南农业科学》, 15 February 2007 (2007-02-15), pages 102 - 105 *

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Publication number Publication date
CA2849274A1 (en) 2013-03-28
JPWO2013042426A1 (ja) 2015-03-26
EP2759551A4 (en) 2015-03-04
BR112014006405A2 (pt) 2017-04-04
US20150037813A1 (en) 2015-02-05
IL231404A0 (en) 2014-04-30
IN2014CN02113A (https=) 2015-05-29
TW201313743A (zh) 2013-04-01
AU2012310880B2 (en) 2015-12-03
KR20140044940A (ko) 2014-04-15
JP6156144B2 (ja) 2017-07-05
US9599608B2 (en) 2017-03-21
WO2013042426A1 (ja) 2013-03-28
RU2014115676A (ru) 2015-10-27
EP2759551B1 (en) 2019-05-22
CA2849274C (en) 2018-12-04
EP2759551A1 (en) 2014-07-30
AU2012310880A1 (en) 2014-04-10
KR101720394B1 (ko) 2017-03-27

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Application publication date: 20140528