TW201130811A - Aryl benzylamine compounds - Google Patents

Aryl benzylamine compounds Download PDF

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Publication number
TW201130811A
TW201130811A TW100104005A TW100104005A TW201130811A TW 201130811 A TW201130811 A TW 201130811A TW 100104005 A TW100104005 A TW 100104005A TW 100104005 A TW100104005 A TW 100104005A TW 201130811 A TW201130811 A TW 201130811A
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TW
Taiwan
Prior art keywords
phenyl
methyl
gas
propylamino
carboxylic acid
Prior art date
Application number
TW100104005A
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English (en)
Chinese (zh)
Inventor
Daniela Angst
Birgit Bollbuck
Philipp Janser
Jean Quancard
Nikolaus Johannes Stiefl
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Novartis Ag
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Publication date
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Publication of TW201130811A publication Critical patent/TW201130811A/zh

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    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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TW100104005A 2010-02-02 2011-02-01 Aryl benzylamine compounds TW201130811A (en)

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US30060710P 2010-02-02 2010-02-02

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TW201130811A true TW201130811A (en) 2011-09-16

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US (1) US8791100B2 (https=)
EP (1) EP2531487B1 (https=)
JP (1) JP5876419B2 (https=)
CN (1) CN102741227B (https=)
AR (1) AR080102A1 (https=)
ES (1) ES2504090T3 (https=)
TW (1) TW201130811A (https=)
UY (1) UY33214A (https=)
WO (1) WO2011095452A1 (https=)

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CN106132928B (zh) * 2014-02-28 2019-03-29 橘生药品工业株式会社 苯胺衍生物、含有所述衍生物的药物组合物及其用途
CN111548257B (zh) * 2020-05-28 2022-11-15 安道麦马克西姆有限公司 一种（4-异丙氧基-2-甲基）苯基异丙基酮的制备方法

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
AU7686891A (en) 1990-04-05 1991-10-30 American National Red Cross, The A protein family related to immediate-early protein expressed by human endothelial cells during differentiation
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
US6060272A (en) 1997-05-07 2000-05-09 Human Genome Sciences, Inc. Human G-protein coupled receptors
US6310078B1 (en) * 1998-04-20 2001-10-30 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
AU5575299A (en) 1998-08-19 2000-03-14 Millennium Pharmaceuticals, Inc. 14274 receptor, a g-protein coupled receptor related to the edg receptor family
DE19846979A1 (de) 1998-09-11 2000-03-23 Max Delbrueck Centrum G-Protein gekoppelter Rezeptor EDG6 und seine Verwendung
CA2348688A1 (en) 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors
KR20080104062A (ko) 1998-11-20 2008-11-28 아레나 파마슈티칼스, 인크. 사람의 오르판 ｇ 단백질 커플링 수용체
US6323333B1 (en) 1999-04-05 2001-11-27 Smithkline Beecham Corporation Mouse EDG1
WO2001004139A2 (en) 1999-07-13 2001-01-18 Smithkline Beecham Corporation Human axor29 receptor
GB9923890D0 (en) 1999-10-08 1999-12-08 Pfizer Ltd Novel polypeptide
CA2401454A1 (en) 2000-03-03 2001-09-13 Incyte Genomics, Inc. G-protein coupled receptors
AU4251301A (en) 2000-03-24 2001-10-03 Bayer Aktiengesellschaft Regulation of human nerve growth factor-elated g protein-coupled receptor
WO2001073021A1 (fr) 2000-03-28 2001-10-04 Takeda Chemical Industries, Ltd. Nouvelle proteine receptrice couplee a une proteine g et adn associe
AU2001270489B2 (en) 2000-04-26 2007-03-15 Sanofi-Aventis Deutschland Gmbh EDG8 receptor, its preparation and use
DE10028901A1 (de) 2000-06-10 2001-12-20 Michael Brues Arminosäuresequenz
AU2001273541A1 (en) 2000-07-17 2002-01-30 Genaissance Pharmaceuticals, Inc. Haplotypes of the edg6 gene
AU2001288563A1 (en) 2000-08-31 2002-03-13 University Of Connecticut Regulation of angiogenesis via modulation of edg receptor mediated signal transduction comprising sphingosine-1-phosphate administration
AU2002221810B2 (en) 2000-11-07 2005-06-23 Novartis Ag Indolylmaleimide derivatives as protein kinase C inhibitors
US7521192B2 (en) * 2001-04-18 2009-04-21 Rigel Pharmaceuticals, Inc. EDG: modulators of lymphocyte activation and migration
MXPA04001287A (es) 2001-08-10 2004-05-27 Wyeth Corp Ensayo de receptor unido a proteina g.
US7479504B2 (en) 2002-01-18 2009-01-20 Merck & Co., Inc. Edg receptor agonists
WO2004078163A2 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
PE20040079A1 (es) 2002-04-03 2004-04-19 Novartis Ag Derivados de indolilmaleimida
US20030225288A1 (en) 2002-04-12 2003-12-04 Millennium Pharmaceuticals, Inc. Imidazolidine compounds
JP2005533852A (ja) 2002-07-18 2005-11-10 セレテック エルエルシー Ｅｄｇ−１受容体に関連した症状の治療方法
BR0314126A (pt) 2002-09-20 2005-06-28 Pfizer Prod Inc Ligandos de amida acìclica e sulfonamida para o receptor de estrogênio
WO2004035538A1 (en) 2002-10-15 2004-04-29 Merck & Co., Inc. Process for making azetidine-3-carboxylic acid
JP2006514021A (ja) 2002-12-09 2006-04-27 ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム Ｊａｎｕｓチロシンキナーゼ３（Ｊａｋ３）を選択的に阻害するための方法
BRPI0410439A (pt) 2003-05-19 2006-06-06 Irm Llc compostos e composições imunossupressoras
US7501538B2 (en) 2003-08-08 2009-03-10 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
CN1874991A (zh) * 2003-08-29 2006-12-06 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
EP1661881B1 (en) * 2003-08-29 2014-12-17 Ono Pharmaceutical Co., Ltd. Compound capable of binding s1p receptor and pharmaceutical use thereof
JPWO2005028667A1 (ja) 2003-09-19 2006-11-30 独立行政法人理化学研究所 ヒト肥満細胞で発現するｇ蛋白質共役型受容体を標的とした薬剤およびそのスクリーニング方法
EP1524265A1 (en) 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors
JP2007513082A (ja) * 2003-11-10 2007-05-24 シエーリング アクチエンゲゼルシャフト Ｃｃｒ−５アンタゴニストとして有用なベンジルエーテルアミン化合物
NZ546058A (en) 2004-01-12 2010-09-30 Ym Biosciences Australia Pty Benzimidazole and other fused ring derivatives as selective janus kinase inhibitors
US20060057559A1 (en) * 2004-06-23 2006-03-16 Rigel Pharmaceuticals, Inc. High-throughput cell migration screening assay
US7611851B2 (en) 2004-07-27 2009-11-03 Merck & Co., Inc. Canis sphingosine 1-phosphate receptor isoform 1
KR20140095109A (ko) 2004-11-29 2014-07-31 노파르티스 아게 Ｓ１ｐ 수용체 효능제의 투여 용법
CN101119714A (zh) * 2005-02-14 2008-02-06 弗吉尼亚大学专利基金会 含有由氨基和苯基取代的环烷基和5元杂环的1-磷酸鞘氨醇激动剂
US20090176776A1 (en) 2005-10-21 2009-07-09 University Of Alabama At Birmingham Small molecule inhibitors of hiv-1 capsid assembly
WO2007139946A2 (en) 2006-05-25 2007-12-06 University Of Tennessee Research Foundation Gpcr ligands identified by computational modeling
US7655396B1 (en) * 2006-09-29 2010-02-02 Allergan, Inc. Methods for detecting receptor modulator activity
US20080108077A1 (en) * 2006-11-07 2008-05-08 Stephanie Chissoe Genes associated with rheumatoid arthritis
JP2009007341A (ja) * 2007-06-01 2009-01-15 Mitsubishi Tanabe Pharma Corp 医薬組成物
ES2360929T3 (es) * 2007-09-20 2011-06-10 Amgen Inc. Derivados del ácido 1-(4-(4-bencilbenzamido)-bencil)azetidin-3-carboxílico y compuestos relacionados como moduladores del receptor s1p para el tratamiento de trastornos inmunitarios.
WO2009053481A1 (en) 2007-10-25 2009-04-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compositions and methods for modulating nk and t cell trafficking
GB0723794D0 (en) 2007-12-05 2008-01-16 Lectus Therapeutics Ltd Potassium ion channel modulators and uses thereof
UY31631A1 (es) 2008-02-06 2009-09-30 Nuevos derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino, sales de los mismos, procesos para su preparacion, composiciones farmacéuticas que los comprenden y aplicaciones
US20100324086A1 (en) 2008-02-19 2010-12-23 Novasaid Ab Compounds and methods
WO2009137081A2 (en) 2008-05-07 2009-11-12 Massachusetts Institute Of Technology Small molecule inhibitors of plasmodium falciparum dihydroorotate dehydrogenase
WO2010072712A1 (en) 2008-12-23 2010-07-01 Novartis Ag Biaryl benzylamine derivatives

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WO2011095452A1 (en) 2011-08-11
JP2013518846A (ja) 2013-05-23
US20110190258A1 (en) 2011-08-04
EP2531487B1 (en) 2014-06-18
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EP2531487A1 (en) 2012-12-12
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