MXPA04001287A - Ensayo de receptor unido a proteina g. - Google Patents

Ensayo de receptor unido a proteina g.

Info

Publication number
MXPA04001287A
MXPA04001287A MXPA04001287A MXPA04001287A MXPA04001287A MX PA04001287 A MXPA04001287 A MX PA04001287A MX PA04001287 A MXPA04001287 A MX PA04001287A MX PA04001287 A MXPA04001287 A MX PA04001287A MX PA04001287 A MXPA04001287 A MX PA04001287A
Authority
MX
Mexico
Prior art keywords
protein
gpcr
coupled receptor
methods
relates
Prior art date
Application number
MXPA04001287A
Other languages
English (en)
Inventor
Ho Guyu
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA04001287A publication Critical patent/MXPA04001287A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

La presente invencion se refiere a metodos y composiciones novedosas para el diagnostico, tratamiento y pronostico de los trastornos relacionados con el receptor unido a la proteina G (GPCR) por medio de la inhibicion de reguladores de las proteinas de senalizacion de la proteina G (RGS). La presente invencion se refiere a metodos de separacion por exclusion y evaluacion de los compuestos de prueba utiles en la intervencion y prevencion de los trastornos relacionados con GPCR incluyendo los trastornos neuropsiquiatricos y cardiopulmonares. La invencion se refiere ademas a metodos para identificar los inhibidores para la expresion o actividad de RGS los cuales son utiles en la modulacion de las rutas de senalizacion de GPCR.
MXPA04001287A 2001-08-10 2002-08-08 Ensayo de receptor unido a proteina g. MXPA04001287A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31168401P 2001-08-10 2001-08-10
PCT/US2002/025213 WO2003013551A1 (en) 2001-08-10 2002-08-08 G protein-coupled receptor assay

Publications (1)

Publication Number Publication Date
MXPA04001287A true MXPA04001287A (es) 2004-05-27

Family

ID=23207985

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04001287A MXPA04001287A (es) 2001-08-10 2002-08-08 Ensayo de receptor unido a proteina g.

Country Status (7)

Country Link
US (1) US20030119716A1 (es)
EP (1) EP1425023A1 (es)
CN (1) CN1592625A (es)
BR (1) BR0211835A (es)
CA (1) CA2455962A1 (es)
MX (1) MXPA04001287A (es)
WO (1) WO2003013551A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1594986B1 (de) * 2003-02-19 2011-07-13 Universität Duisburg-Essen Verwendung einer genveränderung im humanen gnas-gen zur vorhersage von erkrankungsrisiken, krankheitsverläufen und zur vorhersage des ansprechens auf krankheitstherapien
CA2554410A1 (en) * 2004-01-05 2005-08-11 Biotech Studio, Llc Biotherapeutics, diagnostics and research reagents
DE102004026330A1 (de) * 2004-05-26 2005-12-15 Universität Duisburg-Essen Verwendung einer Genveränderung im Humanen GNAQ-Gen zur Vorhersage von Erkrankungsrisiken, Krankheitsverläufen und zur Vorhersage des Ansprechens auf Krankheitstherapien
GB0421693D0 (en) 2004-09-30 2004-11-03 Amersham Biosciences Uk Ltd Method for measuring binding of a test compound to a G-protein coupled receptor
US20060157318A1 (en) * 2005-01-18 2006-07-20 Gao Guang R Money box
US8158588B2 (en) * 2005-12-05 2012-04-17 Simon Delagrave Loop-variant PDZ domains as biotherapeutics, diagnostics and research reagents
US20100021891A1 (en) * 2006-06-12 2010-01-28 Bernard Lerer Rgs2 genotypes associated with extrapyramidal symptoms induced by antipsychotic medication
US20110009475A1 (en) * 2007-07-13 2011-01-13 Massachusetts Institute Of Technology Methods for treating stress induced emotional disorders
WO2010058426A2 (en) * 2008-11-21 2010-05-27 Reliance Life Sciences Pvt. Ltd. Inhibition of vegf-a secretion, angiogenesis and/or neoangiogenesis by sina mediated knockdown of vegf-c and rhoa
NZ593294A (en) * 2009-01-29 2013-04-26 Commw Scient Ind Res Org Measuring g protein coupled receptor activation
ES2351492B2 (es) * 2009-05-28 2011-09-15 Universidad De Málaga Uso de la proteína rgs-14 para potenciar la memoria.
US8791100B2 (en) 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds
ES2374471B2 (es) * 2010-08-07 2012-09-13 Universidad De Málaga Uso de la proteína rgs-14 para fabricar un potenciador de la memoria.
ES2352931B1 (es) * 2010-12-02 2011-12-30 Universidad De Málaga Uso de la proteína rgs-14 para la prevención y/o tratamiento de un desorden cognitivo y/o un desorden de la memoria.
CN102839193A (zh) * 2012-08-22 2012-12-26 海狸（广州）生物科技有限公司 一种g蛋白偶联受体对化合物特异性的检测方法
CA2919980A1 (en) * 2013-08-20 2015-02-26 Meiji Seika Pharma Co., Ltd. Evaluation method and screening method for s1p1 receptor agonist
CN105126079B (zh) * 2015-09-29 2019-03-01 武汉大学 G蛋白信号转导调节蛋白14（rgs14）在治疗心肌肥厚中的功能及应用
CN105106936B (zh) * 2015-09-29 2018-05-15 武汉大学 G蛋白信号转导调节蛋白10（rgs10）在治疗心肌肥厚中的功能及应用
EP3327134A1 (en) * 2016-11-28 2018-05-30 Carsten Korth Method and biomarkers for in vitro diagnosis of mental disorders
EP3392656A1 (en) * 2017-04-20 2018-10-24 Euroimmun Medizinische Labordiagnostika AG Diagnosis of a neuroautoimmune disease
CN108241054B (zh) * 2017-12-26 2021-03-12 天津市中西医结合医院（天津市南开医院） 检测g蛋白偶联受体18的试剂在制备败血症诊断及病程监测和预后判断试剂中表达的应用

Also Published As

Publication number Publication date
CA2455962A1 (en) 2003-02-20
BR0211835A (pt) 2006-04-04
WO2003013551A1 (en) 2003-02-20
EP1425023A1 (en) 2004-06-09
CN1592625A (zh) 2005-03-09
US20030119716A1 (en) 2003-06-26

Similar Documents

Publication Publication Date Title
MXPA04001287A (es) Ensayo de receptor unido a proteina g.
WO2001077172A3 (en) Non-endogenous, constitutively activated known g protein-coupled receptors
AUPO755097A0 (en) Receptor agonist and antagonist
TR200100267T2 (tr) İkameli anilid bileşimleri ve yöntemler.
DK1100811T3 (da) Nucleinsyrer, som koder for en G-protein-koblet receptor involveret i sensorisk transduktion
TW200605864A (en) Methods and reagents for the treatment of immunoinflammatory disorders
ATE309543T1 (de) Natürlicher ligand von gpcr chemr23 und dessen verwendung
ATE526585T1 (de) Natürlicher ligand des g-protein-gekoppelten rezeptors rcc356 und verwendungen davon
IL174195A0 (en) Compositions, reagents and kits for and methods of diagnosing, monitoring and treating obesity and/or diabetes
MA45801A1 (fr) Protéines de liaison à l'antigène qui sont des antagonistes du récepteur de leptine
ATE356623T1 (de) 5-ht3-rezeptorantagonisten und verwendungsverfahren
CO5460266A1 (es) Novedosos analogos de la somatostatina
DE60033576D1 (de) Methoden zum screening knochenmorphogenetishemimetika
Von Buchholtz et al. RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells
ATE514778T1 (de) G-protein-gekoppelte rezeptor-antagonisten
DK1317564T3 (da) Screeningsfremgangsmåder til at identificere G-proteiner og andre forbindelser, som modulerer phosphodiesterase (PDE)-aktiviteten
SE9701010D0 (sv) Antibody
WO2005057223A3 (en) Methods for identifying modulators of active kit tyrosine kinase receptor
DE602004030899D1 (de) Neues screening-verfahren
WO2005055813A3 (en) Interaction of nmda receptor with the protein tyrosine phosphatase step in psychotic disorders
WO2004060282A3 (en) Uses of the snorf207 receptor
WO2004099419A3 (en) Methods and compositions for identifying modulators of g protein-coupled receptors
ATE380048T1 (de) Behandlung der männlichen sexuellen dysfunktion
TW200700727A (en) Screen
GB0221148D0 (en) Kinase inhibitor screening assay

Legal Events

Date Code Title Description
FA Abandonment or withdrawal