TW201034667A - N-[(6-azabicyclo[3.2.1]oct-1-yl)arylmethyl]benzamide derivatives, preparation and therapeutic use thereof - Google Patents

N-[(6-azabicyclo[3.2.1]oct-1-yl)arylmethyl]benzamide derivatives, preparation and therapeutic use thereof Download PDF

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Publication number
TW201034667A
TW201034667A TW099104006A TW99104006A TW201034667A TW 201034667 A TW201034667 A TW 201034667A TW 099104006 A TW099104006 A TW 099104006A TW 99104006 A TW99104006 A TW 99104006A TW 201034667 A TW201034667 A TW 201034667A
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TW
Taiwan
Prior art keywords
group
compound
azabicyclo
formula
trifluoromethyl
Prior art date
Application number
TW099104006A
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English (en)
Chinese (zh)
Inventor
Gihad Dargazanli
Genevieve Estenne-Bouhtou
Florence Medaisko
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of TW201034667A publication Critical patent/TW201034667A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
TW099104006A 2009-02-10 2010-02-09 N-[(6-azabicyclo[3.2.1]oct-1-yl)arylmethyl]benzamide derivatives, preparation and therapeutic use thereof TW201034667A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0900579A FR2941954B1 (fr) 2009-02-10 2009-02-10 Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
TW201034667A true TW201034667A (en) 2010-10-01

Family

ID=40935769

Family Applications (1)

Application Number Title Priority Date Filing Date
TW099104006A TW201034667A (en) 2009-02-10 2010-02-09 N-[(6-azabicyclo[3.2.1]oct-1-yl)arylmethyl]benzamide derivatives, preparation and therapeutic use thereof

Country Status (15)

Country Link
EP (1) EP2396335A1 (fr)
JP (1) JP2012517412A (fr)
KR (1) KR20110118813A (fr)
CN (1) CN102388050A (fr)
AR (1) AR075380A1 (fr)
AU (1) AU2010212703A1 (fr)
BR (1) BRPI1008544A2 (fr)
CA (1) CA2751866A1 (fr)
FR (1) FR2941954B1 (fr)
IL (1) IL214487A0 (fr)
MX (1) MX2011008459A (fr)
SG (1) SG173607A1 (fr)
TW (1) TW201034667A (fr)
UY (1) UY32429A (fr)
WO (1) WO2010092287A1 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861070B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
WO2005058317A1 (fr) * 2003-12-18 2005-06-30 Glaxo Group Limited Inhibiteurs du transporteur-1 de la glycine
WO2007053400A2 (fr) * 2005-10-28 2007-05-10 Merck & Co., Inc. Inhibiteurs de transporteurs de glycine de type pipéridine
AR064001A1 (es) * 2006-11-30 2009-03-04 Cenerx Bio Pharma Inc Esteres de dialquilaminoalquilo de pivagabina como medicamentos para el tratamiento de trastornos del sistema nervioso central, metodos para su preparacion y composiciones farmaceuticas que los comprenden.
WO2009013535A1 (fr) * 2007-07-23 2009-01-29 Astrazeneca Ab Dérivés de 2-azabicyclo(2,2,2)octane en tant que modulateurs du récepteur transporteur de type i de la glycine

Also Published As

Publication number Publication date
AU2010212703A1 (en) 2011-09-01
CN102388050A (zh) 2012-03-21
EP2396335A1 (fr) 2011-12-21
KR20110118813A (ko) 2011-11-01
SG173607A1 (en) 2011-09-29
AR075380A1 (es) 2011-03-30
UY32429A (es) 2010-09-30
JP2012517412A (ja) 2012-08-02
WO2010092287A1 (fr) 2010-08-19
MX2011008459A (es) 2011-12-16
CA2751866A1 (fr) 2010-08-19
IL214487A0 (en) 2011-09-27
BRPI1008544A2 (pt) 2016-03-15
FR2941954A1 (fr) 2010-08-13
FR2941954B1 (fr) 2011-04-08

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