MX2011008459A - Derivados de n-[ (6-aza-biciclo [3.2.1] oct-1-il)abril-metil]-benz amida, su preparacion y su aplicacion en terapeutica. - Google Patents

Derivados de n-[ (6-aza-biciclo [3.2.1] oct-1-il)abril-metil]-benz amida, su preparacion y su aplicacion en terapeutica.

Info

Publication number
MX2011008459A
MX2011008459A MX2011008459A MX2011008459A MX2011008459A MX 2011008459 A MX2011008459 A MX 2011008459A MX 2011008459 A MX2011008459 A MX 2011008459A MX 2011008459 A MX2011008459 A MX 2011008459A MX 2011008459 A MX2011008459 A MX 2011008459A
Authority
MX
Mexico
Prior art keywords
alkyl
cycloalkyl
azabicyclo
oct
aryl
Prior art date
Application number
MX2011008459A
Other languages
English (en)
Inventor
Gihad Dargazanli
Florence Medaisko
Genevieve Estenne-Bouhtou
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2011008459A publication Critical patent/MX2011008459A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención se refiere a derivados de N-[(6-aza- biciclo[3.2.1]oct-1 -iI)-aril-metil]-benzamida de la fórmula (I). R representa un átomo de hidrógeno o un grupo alquilo(C1-C6), cicloalquilo-(C3-C7), opcionalmente sustituido por uno o varios de flúor, cicloalquilo-(C3-C7), alcenilo(C2-C4), fenilo, alcoxi(C1-C6), hidroxi; R1 representa un fenilo o naftilo, opcionalmente substituido por uno o varios de halógeno, alquilo(C1-C6), alcoxi(C1-C6), haloalquilo-(C1-C6), NR4R5, alquil-tio(C1-C6), alquil(C1-C6)-SO2, fenilo o heteroarilo; R2 representa uno o varios átomos de hidrógeno, de halógeno, haloalquilo-(C1-C6), alquilo(C1-C6), cicloalquilo(C3-C7), cicloalquil-(C3-C7)-alquilo(C1-C3); R3, R4 y R5 representan independientemente uno de otro un átomo de hidrógeno o un grupo alquilo(C1-C6); R6 representa un grupo alquilo(C1-C6); R4 y R5 pueden formar juntos un ciclo seleccionado entre los ciclos de azetidina, pirrolidina, piperidina, morfolina, tiomorfolina, piperazina, azepina, opcionalmente substituidos por un grupo alquilo(C1-C6). Utilización en terapéutica y método de síntesis.
MX2011008459A 2009-02-10 2010-02-09 Derivados de n-[ (6-aza-biciclo [3.2.1] oct-1-il)abril-metil]-benz amida, su preparacion y su aplicacion en terapeutica. MX2011008459A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0900579A FR2941954B1 (fr) 2009-02-10 2009-02-10 Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique
PCT/FR2010/050204 WO2010092287A1 (fr) 2009-02-10 2010-02-09 Derives de n-[(6-aza-bicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
MX2011008459A true MX2011008459A (es) 2011-12-16

Family

ID=40935769

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011008459A MX2011008459A (es) 2009-02-10 2010-02-09 Derivados de n-[ (6-aza-biciclo [3.2.1] oct-1-il)abril-metil]-benz amida, su preparacion y su aplicacion en terapeutica.

Country Status (15)

Country Link
EP (1) EP2396335A1 (es)
JP (1) JP2012517412A (es)
KR (1) KR20110118813A (es)
CN (1) CN102388050A (es)
AR (1) AR075380A1 (es)
AU (1) AU2010212703A1 (es)
BR (1) BRPI1008544A2 (es)
CA (1) CA2751866A1 (es)
FR (1) FR2941954B1 (es)
IL (1) IL214487A0 (es)
MX (1) MX2011008459A (es)
SG (1) SG173607A1 (es)
TW (1) TW201034667A (es)
UY (1) UY32429A (es)
WO (1) WO2010092287A1 (es)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861070B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
WO2005058317A1 (en) * 2003-12-18 2005-06-30 Glaxo Group Limited Glycine transporter-1 inhibirors
WO2007053400A2 (en) * 2005-10-28 2007-05-10 Merck & Co., Inc. Piperidine glycine transporter inhibitors
EP2101585A4 (en) * 2006-11-30 2011-06-15 Cenerx Biopharma Inc PIVAGABIN DIALKYLAMINOAL CYLTERS AS A MEDICAMENT FOR THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM
TW200911808A (en) * 2007-07-23 2009-03-16 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
AU2010212703A1 (en) 2011-09-01
CN102388050A (zh) 2012-03-21
UY32429A (es) 2010-09-30
SG173607A1 (en) 2011-09-29
FR2941954B1 (fr) 2011-04-08
WO2010092287A1 (fr) 2010-08-19
CA2751866A1 (fr) 2010-08-19
IL214487A0 (en) 2011-09-27
JP2012517412A (ja) 2012-08-02
TW201034667A (en) 2010-10-01
KR20110118813A (ko) 2011-11-01
FR2941954A1 (fr) 2010-08-13
AR075380A1 (es) 2011-03-30
EP2396335A1 (fr) 2011-12-21
BRPI1008544A2 (pt) 2016-03-15

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