TW200940709A - Oncolytic viruses as phenotyping agents for neoplasms - Google Patents
Oncolytic viruses as phenotyping agents for neoplasms Download PDFInfo
- Publication number
- TW200940709A TW200940709A TW098118162A TW98118162A TW200940709A TW 200940709 A TW200940709 A TW 200940709A TW 098118162 A TW098118162 A TW 098118162A TW 98118162 A TW98118162 A TW 98118162A TW 200940709 A TW200940709 A TW 200940709A
- Authority
- TW
- Taiwan
- Prior art keywords
- neoplasms
- oncolytic viruses
- tumors
- reovirus
- cells
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 7
- 244000309459 oncolytic virus Species 0.000 title abstract 3
- 241000702263 Reovirus sp. Species 0.000 abstract 3
- 230000002950 deficient Effects 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 2
- 230000037361 pathway Effects 0.000 abstract 2
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/14—Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39203102P | 2002-06-28 | 2002-06-28 | |
US44318803P | 2003-01-29 | 2003-01-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200940709A true TW200940709A (en) | 2009-10-01 |
TWI402345B TWI402345B (zh) | 2013-07-21 |
Family
ID=30003222
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW098118162A TWI402345B (zh) | 2002-06-28 | 2003-06-26 | 做為腫瘤表現型分類劑之溶瘤病毒 |
TW098135545A TWI334444B (en) | 2002-06-28 | 2003-06-26 | Oncolytic viruses as phenotyping agents for neoplasms |
TW092117377A TWI327167B (en) | 2002-06-28 | 2003-06-26 | Oncolytic viruses as phenotyping agents for neoplasms |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW098135545A TWI334444B (en) | 2002-06-28 | 2003-06-26 | Oncolytic viruses as phenotyping agents for neoplasms |
TW092117377A TWI327167B (en) | 2002-06-28 | 2003-06-26 | Oncolytic viruses as phenotyping agents for neoplasms |
Country Status (20)
Country | Link |
---|---|
US (3) | US7306902B2 (zh) |
EP (2) | EP1520175B1 (zh) |
JP (1) | JP2005531306A (zh) |
CN (1) | CN1666105B (zh) |
AR (1) | AR039768A1 (zh) |
AT (2) | ATE377754T1 (zh) |
AU (2) | AU2003245760B2 (zh) |
BR (1) | BR0311983A (zh) |
CA (1) | CA2487824C (zh) |
DE (1) | DE60317331T2 (zh) |
DK (2) | DK1520175T3 (zh) |
ES (2) | ES2385845T3 (zh) |
HK (2) | HK1069877A1 (zh) |
IL (2) | IL165498A0 (zh) |
MX (1) | MXPA04012414A (zh) |
NZ (1) | NZ537116A (zh) |
PT (1) | PT1890151E (zh) |
SI (1) | SI1890151T1 (zh) |
TW (3) | TWI402345B (zh) |
WO (1) | WO2004003562A2 (zh) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
US8491884B2 (en) | 2000-05-03 | 2013-07-23 | Oncolytics Biotech Inc. | Virus clearance of neoplastic cells from mixed cellular compositions |
US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
US20040115170A1 (en) * | 2001-11-30 | 2004-06-17 | Brown Earl Garnet | Oncolytic virus |
WO2004009763A2 (en) | 2002-07-24 | 2004-01-29 | Arizona Board Of Regents | Use of vaccinia virus deleted for the e3l gene as a vaccine vector |
AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
EP1648233A4 (en) * | 2003-07-08 | 2006-08-23 | Univ Arizona | VACCINE VACCINE MUTANTS INSTEAD OF ONCOLYTIC AGENTS |
WO2005111200A1 (en) * | 2004-05-17 | 2005-11-24 | Universite De Montreal | Novel strains of reoviruses and methods of uses thereof |
CA2617600A1 (en) | 2005-08-01 | 2007-09-07 | University Technologies International, Inc. | Attenuated reovirus |
US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
ATE516370T1 (de) * | 2005-12-22 | 2011-07-15 | Sloan Kettering Inst Cancer | Verfahren zur erfassung von krebszellen unter verwendung eines virus |
US20070190032A1 (en) * | 2006-02-13 | 2007-08-16 | Oncolytics Biotech Inc. | Use of Local Immune Suppression to Enhance Oncolytic Viral Therapy |
US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
US9241998B2 (en) * | 2007-05-21 | 2016-01-26 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oncolytic RSV activity |
WO2009143468A1 (en) * | 2008-05-22 | 2009-11-26 | Uti Limited Partnership | Tumor suppressor-based susceptibility of hyperproliferative cells to oncolytic viral therapy |
WO2009143611A1 (en) * | 2008-05-27 | 2009-12-03 | Oncolytics Biotech Inc. | Abrogating proinflammatory cytokine production during oncolytic reovirus therapy |
US20110086005A1 (en) * | 2008-05-27 | 2011-04-14 | Oncolytics Biotech Inc. | Modulating interstitial pressure and oncolytic viral delivery and distribution |
WO2010080909A1 (en) * | 2009-01-08 | 2010-07-15 | Yale University | Compositions and methods of use of an oncolytic vesicular stomatitis virus |
ES2385251B1 (es) | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | Adenovirus oncolíticos para el tratamiento del cáncer. |
EP2670426B1 (en) | 2011-01-31 | 2017-05-10 | The General Hospital Corporation | Multimodal trail molecules and uses in cellular therapies |
WO2013052915A2 (en) | 2011-10-05 | 2013-04-11 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
WO2013138522A2 (en) | 2012-03-16 | 2013-09-19 | Genelux Corporation | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
US20130280170A1 (en) | 2012-04-20 | 2013-10-24 | Aladar A. Szalay | Imaging methods for oncolytic virus therapy |
EP3473708B1 (en) | 2012-07-24 | 2021-01-27 | The General Hospital Corporation | Oncolytic virus therapy for resistant tumors |
WO2014035474A1 (en) | 2012-08-30 | 2014-03-06 | The General Hospital Corporation | Compositions and methods for treating cancer |
WO2014055960A1 (en) | 2012-10-05 | 2014-04-10 | Genelux Corporation | Energy absorbing-based diagnostic and therapeutic methods employing nucleic acid molecules encoding chromophore-producing enzymes |
EP3082834B1 (en) * | 2013-12-11 | 2020-03-11 | The General Hospital Corporation DBA Massachusetts | Stem cell delivered oncolytic herpes simplex virus and methods for treating brain tumors |
US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
PL3207130T3 (pl) | 2014-10-14 | 2020-02-28 | Halozyme, Inc. | Kompozycje deaminazy adenozyny 2 (ada2), jej warianty i sposoby ich zastosowania |
CN107735103B (zh) | 2015-02-25 | 2022-05-27 | 纪念斯隆-凯特琳癌症中心 | 使用灭活的非复制型的修饰的痘苗病毒安卡拉(mva)作为实体肿瘤的单一免疫疗法或与免疫检查点阻断剂的组合 |
CN116173193A (zh) | 2015-04-17 | 2023-05-30 | 纪念斯隆凯特琳癌症中心 | Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用 |
IL261321B2 (en) | 2016-02-25 | 2023-12-01 | Memorial Sloan Kettering Cancer Center | Recombinant MVA or MVADELE3L expressing human FLT3L and their use as immunotherapeutic agents against solid tumors |
AU2017222686B2 (en) | 2016-02-25 | 2021-12-23 | Memorial Sloan Kettering Cancer Center | Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human Flt3L or GM-CSF for cancer immunotherapy |
AU2017250358B2 (en) | 2016-04-15 | 2023-06-01 | Alpine Immune Sciences, Inc. | ICOS ligand variant immunomodulatory proteins and uses thereof |
IL310729A (en) | 2016-04-15 | 2024-04-01 | Alpine Immune Sciences Inc | Immunomodulatory proteins that are variants of CD80 and their uses |
WO2017205674A1 (en) | 2016-05-25 | 2017-11-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Oncolytic vaccinia virus mutants and using same for cancer treatment |
US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
CA3032120A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd155 variant immunomodulatory proteins and uses thereof |
US11834490B2 (en) | 2016-07-28 | 2023-12-05 | Alpine Immune Sciences, Inc. | CD112 variant immunomodulatory proteins and uses thereof |
MX2019003546A (es) * | 2016-09-27 | 2019-09-19 | Sator Therapeutics LLC | Virus oncoliticos optimizados y usos de los mismos. |
WO2018075978A1 (en) | 2016-10-20 | 2018-04-26 | Alpine Immune Sciences, Inc. | Secretable variant immunomodulatory proteins and engineered cell therapy |
CN110546265A (zh) | 2017-02-09 | 2019-12-06 | 因达普塔治疗公司 | 工程化自然杀伤(nk)细胞及其组合物和方法 |
PL3596116T3 (pl) | 2017-03-16 | 2024-05-13 | Alpine Immune Sciences, Inc. | Białka immunomodulujące wariant Pd-l1 i ich zastosowania |
WO2018170023A1 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Pd-l2 variant immunomodulatory proteins and uses thereof |
JP7386083B2 (ja) | 2017-03-16 | 2023-11-24 | アルパイン イミューン サイエンシズ インコーポレイテッド | Cd80バリアント免疫調節タンパク質及びその使用 |
WO2018209315A1 (en) | 2017-05-12 | 2018-11-15 | Memorial Sloan Kettering Cancer Center | Vaccinia virus mutants useful for cancer immunotherapy |
CA3078517A1 (en) | 2017-10-18 | 2019-04-25 | Alpine Immune Sciences, Inc. | Variant icos ligand immunomodulatory proteins and related compositions and methods |
CN112533621A (zh) | 2018-06-04 | 2021-03-19 | 卡利迪生物治疗有限公司 | 强化病毒疗法的基于细胞的媒介 |
US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
US20210363219A1 (en) | 2018-06-15 | 2021-11-25 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
WO2020047161A2 (en) | 2018-08-28 | 2020-03-05 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
AU2019377141B2 (en) | 2018-11-06 | 2024-06-06 | Calidi Biotherapeutics (Nevada), Inc. | Enhanced systems for cell-mediated oncolytic viral therapy |
KR20210123289A (ko) | 2018-11-21 | 2021-10-13 | 인답타 세라뷰틱스 인코포레이티드 | 자연 살해 세포 서브세트의 증식을 위한 방법 및 관련 조성물 및 방법 |
KR20210135987A (ko) | 2018-11-30 | 2021-11-16 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Cd86 변이체 면역조절 단백질 및 그의 용도 |
SG11202108459QA (en) | 2019-02-27 | 2021-09-29 | Actym Therapeutics Inc | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
AU2021258194A1 (en) | 2020-04-22 | 2022-11-24 | Indapta Therapeutics, Inc. | Natural killer (NK) cell compositions and methods for generating same |
WO2022147480A1 (en) | 2020-12-30 | 2022-07-07 | Ansun Biopharma, Inc. | Oncolytic virus encoding sialidase and multispecific immune cell engager |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5747469A (en) * | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
US5670330A (en) * | 1992-09-29 | 1997-09-23 | Mcgill University | Anti-tumor agent assay using PKR |
US5801029A (en) * | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
DK0931830T3 (da) | 1993-02-16 | 2001-06-11 | Onyx Pharma Inc | Cytopatiske vira til terapi og profylakse af neoplasi |
DE69432409T2 (de) | 1993-04-30 | 2003-12-24 | Wellstat Biologics Corp | Verwendung der NDV zur Herstellung eines Medikaments zur Krebsbehandlung |
JPH09506866A (ja) * | 1993-12-14 | 1997-07-08 | ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 医薬として活性のある物質の免疫療法のための放出制御 |
WO1995032300A1 (en) * | 1994-05-23 | 1995-11-30 | University Of Medicine & Dentistry Of New Jersey | Selective biological destruction of tumor cells |
US5585096A (en) * | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
US5840502A (en) * | 1994-08-31 | 1998-11-24 | Activated Cell Therapy, Inc. | Methods for enriching specific cell-types by density gradient centrifugation |
US6777177B1 (en) * | 1997-10-10 | 2004-08-17 | Vanderbilt University | Mammalian genes involved in viral infection and tumor suppression |
US6136307A (en) * | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
US6110461A (en) | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
CA2508238C (en) | 1997-08-13 | 2008-01-15 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
ES2292207T3 (es) * | 1997-10-09 | 2008-03-01 | Wellstat Biologics Corporation | Tratamiento de neoplasmas con virus clonales, sensibles al interferon. |
US6475481B2 (en) * | 1997-11-18 | 2002-11-05 | Canji Inc | Purging of stem cell products |
EP1061806A4 (en) | 1998-03-12 | 2001-09-12 | Univ Pennsylvania | PRODUCTIVE CELLS FOR REPLICATION-SELECTIVE VIRUSES FOR TREATING Vicious DISEASES |
WO2000012103A1 (en) * | 1998-08-31 | 2000-03-09 | Ambrus Julian L | Method for removal of hiv and other viruses from blood |
JP2003530301A (ja) | 1999-04-15 | 2003-10-14 | ウェルスタット バイオロジクス コーポレイション | ウイルスを用いた新生物の処置 |
DE19934788B4 (de) * | 1999-07-27 | 2004-05-27 | T-Mobile Deutschland Gmbh | Verfahren zur automatischen Anpassung von Daten an die Fähigkeiten einer Nutzer-Software |
WO2001019380A2 (en) | 1999-09-17 | 2001-03-22 | Pro-Virus, Inc. | Oncolytic virus |
EP1227828A1 (en) * | 1999-11-12 | 2002-08-07 | Oncolytics Biotech, Inc. | Viruses for the treatment of cellular proliferative disorders |
AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
AR028040A1 (es) | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de virus de celulas neoplasticas a partir de composiciones celulares mixtas |
AR028039A1 (es) * | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas |
ATE294858T1 (de) * | 2000-06-26 | 2005-05-15 | Wellstat Biologics Corp | Entfernung von zellen mit viren |
WO2002004596A2 (en) | 2000-07-07 | 2002-01-17 | President And Fellows Of Harvard College | Diagnosing and treating cancer cells using mutant viruses |
DK1332366T3 (da) | 2000-11-09 | 2010-08-02 | Oncolytics Biotech Inc | Fremgangsmåde til vurdering af cellulære proliferative forstyrrelser |
US20030138405A1 (en) * | 2001-04-17 | 2003-07-24 | Juan Fueyo | Conditionally replicative adenovirus to target the Rb and Rb-related pathways |
-
2003
- 2003-06-24 US US10/602,024 patent/US7306902B2/en not_active Expired - Lifetime
- 2003-06-25 PT PT07021569T patent/PT1890151E/pt unknown
- 2003-06-25 DK DK03737795T patent/DK1520175T3/da active
- 2003-06-25 ES ES07021569T patent/ES2385845T3/es not_active Expired - Lifetime
- 2003-06-25 SI SI200332164T patent/SI1890151T1/sl unknown
- 2003-06-25 AU AU2003245760A patent/AU2003245760B2/en not_active Expired
- 2003-06-25 MX MXPA04012414A patent/MXPA04012414A/es active IP Right Grant
- 2003-06-25 BR BR0311983-1A patent/BR0311983A/pt not_active IP Right Cessation
- 2003-06-25 ES ES03737795T patent/ES2292981T3/es not_active Expired - Lifetime
- 2003-06-25 CA CA2487824A patent/CA2487824C/en not_active Expired - Lifetime
- 2003-06-25 CN CN03815353.XA patent/CN1666105B/zh not_active Expired - Lifetime
- 2003-06-25 DK DK07021569.4T patent/DK1890151T3/da active
- 2003-06-25 AT AT03737795T patent/ATE377754T1/de not_active IP Right Cessation
- 2003-06-25 NZ NZ537116A patent/NZ537116A/en unknown
- 2003-06-25 AT AT07021569T patent/ATE555388T1/de active
- 2003-06-25 EP EP03737795A patent/EP1520175B1/en not_active Expired - Lifetime
- 2003-06-25 EP EP07021569A patent/EP1890151B1/en not_active Expired - Lifetime
- 2003-06-25 DE DE60317331T patent/DE60317331T2/de not_active Expired - Lifetime
- 2003-06-25 JP JP2004516379A patent/JP2005531306A/ja active Pending
- 2003-06-25 WO PCT/CA2003/000951 patent/WO2004003562A2/en active Application Filing
- 2003-06-26 TW TW098118162A patent/TWI402345B/zh not_active IP Right Cessation
- 2003-06-26 TW TW098135545A patent/TWI334444B/zh not_active IP Right Cessation
- 2003-06-26 TW TW092117377A patent/TWI327167B/zh not_active IP Right Cessation
- 2003-06-26 AR ARP030102317A patent/AR039768A1/es unknown
-
2004
- 2004-12-01 IL IL16549804A patent/IL165498A0/xx active IP Right Grant
-
2005
- 2005-04-18 HK HK05103306A patent/HK1069877A1/xx not_active IP Right Cessation
-
2007
- 2007-05-30 US US11/807,771 patent/US20080014577A1/en not_active Abandoned
-
2008
- 2008-06-26 HK HK08107121.9A patent/HK1112509A1/xx not_active IP Right Cessation
- 2008-08-28 AU AU2008207579A patent/AU2008207579B2/en not_active Expired
-
2010
- 2010-01-05 US US12/652,289 patent/US8222036B2/en not_active Expired - Lifetime
-
2012
- 2012-06-04 IL IL220139A patent/IL220139A/en active IP Right Grant
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW200940709A (en) | Oncolytic viruses as phenotyping agents for neoplasms | |
AU2002366641A1 (en) | Methods for inhibiting ocular processes | |
BRPI0607753A2 (pt) | método para prever um efeito clìnico em resposta a um tratamento de uma leucemia; método para prever um efeito clìnico de uma leucemia; método para selecionar um tratamento para um paciente com leucemia; método para o diagnóstico ou monitoramento de ocorrência, desenvolvimento, progressão ou tratamento de uma leucemia; arranjo para uso num método para prever um efeito clìnico para um paciente aml; arranjo para uso num método de diagnóstico de aml; meio legìvel por computador; kit para o prognóstico de aml | |
ATE424560T1 (de) | Marker für neuromyelitis optica | |
TW200707614A (en) | Testing method detecting localized failure on a semiconductor wafer | |
DE69931892D1 (de) | Test für antibiotikaresistenz | |
DE602007011566D1 (en) | Ankheit | |
WO2005079332A3 (en) | Display enhanced testing for concussions and mild traumatic brain injury | |
WO2005118878A3 (en) | Methods of screening for cell proliferation or neoplastic disorders | |
DK0939651T3 (da) | Materialer og metoder ved diagnose og behandling af præeclapsia | |
HK1143406A1 (zh) | 促認知藥的篩選方法 | |
DK1075277T4 (da) | Fremgangsmåder til detektion og inhibering af angiogenese | |
WO2007134028A3 (en) | Biomarkers for depression and methods using the same | |
WO2002000933A3 (en) | Screening assays for identifying modulators of the inflammatory or immune responses | |
WO2006110748A3 (en) | Response gene to complement 32 (rgc-32) in disease | |
BRPI0519060A2 (pt) | kit de teste rÁpido para a detecÇço e a localizaÇço de élceras nos eqÜinos e seu mÉtodo de produÇço | |
DE60043775D1 (de) | Verfahren zum identifizieren von präneoplastischen und neoplastischen stadien in säugern | |
Seager et al. | Effects of short‐term oxygen depletion on fish | |
Seisdedo et al. | Analysis of tools for trophic status assessment of water in Cienfuegos bay, Cuba | |
WO2006133027A3 (en) | Methods for immobilizing molecules on surfaces | |
DE502005011186D1 (de) | Stabiles, chromogenes Testreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests | |
AU2003293556A1 (en) | Methods of diagnosing and treating cancer | |
Black | Language dysfluency in the deaf inpatient population | |
MX2021009281A (es) | Metodos de deteccion de legionella. | |
RU2005108805A (ru) | Способ диагностики синдрома системной воспалительной реакции по основным системам жизнеобеспечения |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK4A | Expiration of patent term of an invention patent |