BR0311983A - Métodos para detectar células neoplásticas ativadas por ras em uma amostra biológica, para diagnosticar um neoplasma ativado por ras em um animal, para tratar ou melhorar um neoplasma ativado por ras em um animal, para diagnosticar a presença de um neoplasma em um mamìfero, para detectar células neoplásticas tendo um fenótipo particular em uma amostra biológica, para diagnosticar um neoplasma tendo um fenótipo particular em um animal, e tratar ou melhorar um neoplasma tendo um fenótipo particular em um animal - Google Patents
Métodos para detectar células neoplásticas ativadas por ras em uma amostra biológica, para diagnosticar um neoplasma ativado por ras em um animal, para tratar ou melhorar um neoplasma ativado por ras em um animal, para diagnosticar a presença de um neoplasma em um mamìfero, para detectar células neoplásticas tendo um fenótipo particular em uma amostra biológica, para diagnosticar um neoplasma tendo um fenótipo particular em um animal, e tratar ou melhorar um neoplasma tendo um fenótipo particular em um animalInfo
- Publication number
- BR0311983A BR0311983A BR0311983-1A BR0311983A BR0311983A BR 0311983 A BR0311983 A BR 0311983A BR 0311983 A BR0311983 A BR 0311983A BR 0311983 A BR0311983 A BR 0311983A
- Authority
- BR
- Brazil
- Prior art keywords
- neoplasm
- ras
- animal
- activated
- particular phenotype
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/14—Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
"MéTODOS PARA DETECTAR CéLULAS NEOPLáSTICAS ATIVADAS POR RAS EM UMA AMOSTRA BIOLóGICA, PARA DIAGNOSTICAR UM NEOPLASMA ATIVADO POR RAS EM UM ANIMAL, PARA TRATAR OU MELHORAR UM NEOPLASMA ATIVADO POR RAS EM UM ANIMAL, PARA DIAGNOSTICAR A PRESENçA DE UM NEOPLASMA EM UM MAMìFERO, PARA DETECTAR CéLULAS NEOPLáSTICAS TENDO UM FENóTIPO PARTICULAR EM UMA AMOSTRA BIOLóGICA, PARA DIAGNOSTICAR UM NEOPLASMA TENDO UM FENóTIPO PARTICULAR EM UM ANIMAL, E PARA TRATAR OU MELHORAR UM NEOPLASMA TENDO UM FENóTIPO PARTICULAR EM UM ANIMAL". A presente invenção prove um método de diagnosticar neoplasmas tendo um fenótipo particular, empregando vírus oncolíticos que se replicam seletivamente nos neoplasmas tendo o fenótipo particular. Por exemplo, o reovírus não se replica em células normais. Entretanto, o reovírus replica-se seletivamente em células com um trajeto de ras ativado, que conduz à morte destas células. Portanto, uma célula que torna-se neoplástica, devido a, pelo menos em parte, atividades elevadas de trajeto do ras, podem ser diagnosticadas por sua susceptibilidade à replicação do reovírus. Esta invenção pode ainda ser aplicada, usando-se outros vírus oncolíticos, ao diagnóstico e/ou tratamento de outros tumores, tais como tumores sensíveis a interferon, tumores deficientes em p53 e tumores deficientes em Rb. São também aqui providos kits úteis no diagnóstico ou tratamento descrito aqui.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39203102P | 2002-06-28 | 2002-06-28 | |
| US44318803P | 2003-01-29 | 2003-01-29 | |
| PCT/CA2003/000951 WO2004003562A2 (en) | 2002-06-28 | 2003-06-25 | Oncolytic viruses as phenotyping agents for neoplasms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0311983A true BR0311983A (pt) | 2005-04-26 |
Family
ID=30003222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0311983-1A BR0311983A (pt) | 2002-06-28 | 2003-06-25 | Métodos para detectar células neoplásticas ativadas por ras em uma amostra biológica, para diagnosticar um neoplasma ativado por ras em um animal, para tratar ou melhorar um neoplasma ativado por ras em um animal, para diagnosticar a presença de um neoplasma em um mamìfero, para detectar células neoplásticas tendo um fenótipo particular em uma amostra biológica, para diagnosticar um neoplasma tendo um fenótipo particular em um animal, e tratar ou melhorar um neoplasma tendo um fenótipo particular em um animal |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7306902B2 (pt) |
| EP (2) | EP1890151B1 (pt) |
| JP (1) | JP2005531306A (pt) |
| CN (1) | CN1666105B (pt) |
| AR (1) | AR039768A1 (pt) |
| AT (2) | ATE377754T1 (pt) |
| AU (2) | AU2003245760B2 (pt) |
| BR (1) | BR0311983A (pt) |
| CA (1) | CA2487824C (pt) |
| DE (1) | DE60317331T2 (pt) |
| DK (2) | DK1520175T3 (pt) |
| ES (2) | ES2292981T3 (pt) |
| HK (2) | HK1069877A1 (pt) |
| IL (2) | IL165498A0 (pt) |
| MX (1) | MXPA04012414A (pt) |
| NZ (1) | NZ537116A (pt) |
| PT (1) | PT1890151E (pt) |
| SI (1) | SI1890151T1 (pt) |
| TW (3) | TWI334444B (pt) |
| WO (1) | WO2004003562A2 (pt) |
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| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
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| US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
| US20040115170A1 (en) * | 2001-11-30 | 2004-06-17 | Brown Earl Garnet | Oncolytic virus |
| WO2004009763A2 (en) | 2002-07-24 | 2004-01-29 | Arizona Board Of Regents | Use of vaccinia virus deleted for the e3l gene as a vaccine vector |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| WO2005007824A2 (en) * | 2003-07-08 | 2005-01-27 | Arizona Board Of Regents | Mutants of vaccinia virus as oncolytic agents |
| WO2005111200A1 (en) * | 2004-05-17 | 2005-11-24 | Universite De Montreal | Novel strains of reoviruses and methods of uses thereof |
| US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
| CA2617600A1 (en) | 2005-08-01 | 2007-09-07 | University Technologies International, Inc. | Attenuated reovirus |
| WO2007075879A2 (en) * | 2005-12-22 | 2007-07-05 | Memorial Sloan-Kettering Cancer Center | Method for detection of cancer cells using virus |
| ES2551306T3 (es) * | 2006-02-13 | 2015-11-17 | Oncolytics Biotech Inc. | Uso de inmunosupresión local de baja dosis para potenciar una terapia viral oncolítica |
| US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
| WO2008144067A1 (en) * | 2007-05-21 | 2008-11-27 | Board Of Regents, University Of Texas System | Methods and compositions for treatment of cancer using oncolytic rsv activity |
| KR101585702B1 (ko) * | 2008-05-22 | 2016-01-15 | 제일약품주식회사 | 종양파괴 바이러스 요법에 대한 과다증식성 세포의 종양 억제인자-기초된 민감성 |
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| EP3473708B1 (en) | 2012-07-24 | 2021-01-27 | The General Hospital Corporation | Oncolytic virus therapy for resistant tumors |
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2003
- 2003-06-24 US US10/602,024 patent/US7306902B2/en not_active Expired - Lifetime
- 2003-06-25 AT AT03737795T patent/ATE377754T1/de not_active IP Right Cessation
- 2003-06-25 JP JP2004516379A patent/JP2005531306A/ja active Pending
- 2003-06-25 PT PT07021569T patent/PT1890151E/pt unknown
- 2003-06-25 DE DE60317331T patent/DE60317331T2/de not_active Expired - Lifetime
- 2003-06-25 CN CN03815353.XA patent/CN1666105B/zh not_active Expired - Lifetime
- 2003-06-25 AU AU2003245760A patent/AU2003245760B2/en not_active Expired
- 2003-06-25 EP EP07021569A patent/EP1890151B1/en not_active Expired - Lifetime
- 2003-06-25 SI SI200332164T patent/SI1890151T1/sl unknown
- 2003-06-25 ES ES03737795T patent/ES2292981T3/es not_active Expired - Lifetime
- 2003-06-25 AT AT07021569T patent/ATE555388T1/de active
- 2003-06-25 BR BR0311983-1A patent/BR0311983A/pt not_active IP Right Cessation
- 2003-06-25 DK DK03737795T patent/DK1520175T3/da active
- 2003-06-25 WO PCT/CA2003/000951 patent/WO2004003562A2/en active Application Filing
- 2003-06-25 DK DK07021569.4T patent/DK1890151T3/da active
- 2003-06-25 ES ES07021569T patent/ES2385845T3/es not_active Expired - Lifetime
- 2003-06-25 EP EP03737795A patent/EP1520175B1/en not_active Expired - Lifetime
- 2003-06-25 MX MXPA04012414A patent/MXPA04012414A/es active IP Right Grant
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