ATE377754T1 - Onkolytische viren zur bestimmung des phänotypus von neoplasmen - Google Patents
Onkolytische viren zur bestimmung des phänotypus von neoplasmenInfo
- Publication number
- ATE377754T1 ATE377754T1 AT03737795T AT03737795T ATE377754T1 AT E377754 T1 ATE377754 T1 AT E377754T1 AT 03737795 T AT03737795 T AT 03737795T AT 03737795 T AT03737795 T AT 03737795T AT E377754 T1 ATE377754 T1 AT E377754T1
- Authority
- AT
- Austria
- Prior art keywords
- neoplasms
- phenotype
- determining
- oncolytic viruses
- oncolytic
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57575—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/14—Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39203102P | 2002-06-28 | 2002-06-28 | |
| US44318803P | 2003-01-29 | 2003-01-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE377754T1 true ATE377754T1 (de) | 2007-11-15 |
Family
ID=30003222
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07021569T ATE555388T1 (de) | 2002-06-28 | 2003-06-25 | Onkolytische viren zur bestimmung des phänotypus von neoplasmen |
| AT03737795T ATE377754T1 (de) | 2002-06-28 | 2003-06-25 | Onkolytische viren zur bestimmung des phänotypus von neoplasmen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07021569T ATE555388T1 (de) | 2002-06-28 | 2003-06-25 | Onkolytische viren zur bestimmung des phänotypus von neoplasmen |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7306902B2 (de) |
| EP (2) | EP1890151B1 (de) |
| JP (1) | JP2005531306A (de) |
| CN (1) | CN1666105B (de) |
| AR (1) | AR039768A1 (de) |
| AT (2) | ATE555388T1 (de) |
| AU (2) | AU2003245760B2 (de) |
| BR (1) | BR0311983A (de) |
| CA (1) | CA2487824C (de) |
| DE (1) | DE60317331T2 (de) |
| DK (2) | DK1890151T3 (de) |
| ES (2) | ES2292981T3 (de) |
| IL (2) | IL165498A0 (de) |
| MX (1) | MXPA04012414A (de) |
| NZ (1) | NZ537116A (de) |
| PT (1) | PT1890151E (de) |
| SI (1) | SI1890151T1 (de) |
| TW (3) | TWI402345B (de) |
| WO (1) | WO2004003562A2 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| US8491884B2 (en) * | 2000-05-03 | 2013-07-23 | Oncolytics Biotech Inc. | Virus clearance of neoplastic cells from mixed cellular compositions |
| US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
| US20040115170A1 (en) * | 2001-11-30 | 2004-06-17 | Brown Earl Garnet | Oncolytic virus |
| WO2004009763A2 (en) | 2002-07-24 | 2004-01-29 | Arizona Board Of Regents | Use of vaccinia virus deleted for the e3l gene as a vaccine vector |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| EP1648233A4 (de) * | 2003-07-08 | 2006-08-23 | Univ Arizona | Mutanten des vaccinia-virus als onkolytika |
| WO2005111200A1 (en) * | 2004-05-17 | 2005-11-24 | Universite De Montreal | Novel strains of reoviruses and methods of uses thereof |
| US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
| WO2007099401A2 (en) | 2005-08-01 | 2007-09-07 | University Technologies International, Inc. | Oncolytic attenuated reoviruses for treatment of proliferative disorders |
| WO2007075879A2 (en) * | 2005-12-22 | 2007-07-05 | Memorial Sloan-Kettering Cancer Center | Method for detection of cancer cells using virus |
| AU2007215328A1 (en) * | 2006-02-13 | 2007-08-23 | Oncolytics Biotech Inc. | Use of local immune suppression to enhance oncolytic viral therapy |
| US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
| US9241998B2 (en) * | 2007-05-21 | 2016-01-26 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oncolytic RSV activity |
| CN102124335B (zh) * | 2008-05-22 | 2014-07-30 | 第一药品株式会社 | 基于肿瘤抑制因子的过度增生细胞对溶瘤病毒疗法的敏感性 |
| TW200951143A (en) * | 2008-05-27 | 2009-12-16 | Oncolytics Biotech Inc | Modulating interstitial pressure and oncolytic viral delivery and distribution |
| US8470312B2 (en) * | 2008-05-27 | 2013-06-25 | Oncolytics Biotech, Inc. | Abrogating proinflammatory cytokine production during oncolytic reovirus therapy |
| WO2010080909A1 (en) * | 2009-01-08 | 2010-07-15 | Yale University | Compositions and methods of use of an oncolytic vesicular stomatitis virus |
| ES2385251B1 (es) | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | Adenovirus oncolíticos para el tratamiento del cáncer. |
| EP2670426B1 (de) | 2011-01-31 | 2017-05-10 | The General Hospital Corporation | Multimodale trail-moleküle und ihre verwendungen in zelltherapien |
| US8859256B2 (en) | 2011-10-05 | 2014-10-14 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
| WO2013138522A2 (en) | 2012-03-16 | 2013-09-19 | Genelux Corporation | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
| WO2013158265A1 (en) | 2012-04-20 | 2013-10-24 | Genelux Corporation | Imaging methods for oncolytic virus therapy |
| WO2014018113A1 (en) | 2012-07-24 | 2014-01-30 | The General Hospital Corporation | Oncolytic virus therapy for resistant tumors |
| WO2014035474A1 (en) | 2012-08-30 | 2014-03-06 | The General Hospital Corporation | Compositions and methods for treating cancer |
| US20140140959A1 (en) | 2012-10-05 | 2014-05-22 | Aladar A. Szalay | Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes |
| EP3082834B1 (de) * | 2013-12-11 | 2020-03-11 | The General Hospital Corporation DBA Massachusetts | Von stammzellen abgegebener onkolytischer herpes-simplex-virus und verfahren zur behandlung von hirntumoren |
| WO2015103438A2 (en) | 2014-01-02 | 2015-07-09 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| BR112017007765B1 (pt) | 2014-10-14 | 2023-10-03 | Halozyme, Inc | Composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo |
| WO2016144564A2 (en) | 2015-02-25 | 2016-09-15 | Memorial Sloan-Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
| CN107847534B (zh) | 2015-04-17 | 2022-10-04 | 纪念斯隆凯特琳癌症中心 | Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用 |
| US10512662B2 (en) | 2016-02-25 | 2019-12-24 | Memorial Sloan Kettering Cancer Center | Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human Flt3L or GM-CSF for cancer immunotherapy |
| US10736962B2 (en) | 2016-02-25 | 2020-08-11 | Memorial Sloan Kettering Cancer Center | Recombinant MVA or MVADELE3L expressing human FLT3L and use thereof as immuno-therapeutic agents against solid tumors |
| MX2018012472A (es) | 2016-04-15 | 2019-08-12 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras variantes de ligando icos y sus usos. |
| IL310729A (en) | 2016-04-15 | 2024-04-01 | Alpine Immune Sciences Inc | Immunomodulatory proteins that are variants of CD80 and their uses |
| US10842835B2 (en) | 2016-05-25 | 2020-11-24 | Arizona Board Of Regents On Behalf Of Arizona State University | Oncolytic vaccinia virus mutants and using same for cancer treatment |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| EP3491013A1 (de) | 2016-07-28 | 2019-06-05 | Alpine Immune Sciences, Inc. | Cd155-variante immunmodulatorische proteine und verwendungen davon |
| WO2018022945A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd112 variant immunomodulatory proteins and uses thereof |
| AU2017335673B2 (en) * | 2016-09-27 | 2024-11-14 | Sator Therapeutics LLC | Optimized oncolytic viruses and uses thereof |
| AU2017345764A1 (en) | 2016-10-20 | 2019-05-02 | Alpine Immune Sciences, Inc. | Secretable variant immunomodulatory proteins and engineered cell therapy |
| CA3052473A1 (en) | 2017-02-09 | 2018-08-16 | Indapta Therapeutics, Inc. | Engineered natural killer (nk) cells and compositions and methods thereof |
| IL320149A (en) | 2017-03-16 | 2025-06-01 | Alpine Immune Sciences Inc | Pd-l1 variant immunomodulatory proteins and uses thereof |
| JP2020511144A (ja) | 2017-03-16 | 2020-04-16 | アルパイン イミューン サイエンシズ インコーポレイテッド | Pd−l2バリアント免疫調節タンパク質及びその使用 |
| EP3596114A2 (de) | 2017-03-16 | 2020-01-22 | Alpine Immune Sciences, Inc. | Cd80-variante immunmodulatorische proteine und verwendungen davon |
| US11242509B2 (en) | 2017-05-12 | 2022-02-08 | Memorial Sloan Kettering Cancer Center | Vaccinia virus mutants useful for cancer immunotherapy |
| JP7282760B2 (ja) | 2017-10-18 | 2023-05-29 | アルパイン イミューン サイエンシズ インコーポレイテッド | バリアントicosリガンド免疫調節タンパク質ならびに関連する組成物および方法 |
| WO2019136179A1 (en) | 2018-01-03 | 2019-07-11 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| CA3177467A1 (en) | 2018-06-04 | 2019-12-12 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| US12065476B2 (en) | 2018-06-15 | 2024-08-20 | Alpine Immune Sciences, Inc. | PD-1 variant immunomodulatory proteins and uses thereof |
| US11242528B2 (en) | 2018-08-28 | 2022-02-08 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
| MX2021003013A (es) | 2018-09-15 | 2021-08-11 | Memorial Sloan Kettering Cancer Center | Poxvirus recombinantes para inmunoterapia contra cáncer. |
| CN113271955A (zh) | 2018-11-06 | 2021-08-17 | 卡利迪生物治疗有限公司 | 用于细胞介导的溶瘤病毒疗法的增强的系统 |
| US12410402B2 (en) | 2018-11-21 | 2025-09-09 | Indapta Therapeutics, Inc. | Methods for expansion of natural killer (NK) cell subset and related compositions and methods |
| JP7713886B2 (ja) | 2018-11-30 | 2025-07-28 | アルパイン イミューン サイエンシズ インコーポレイテッド | Cd86バリアント免疫調節タンパク質およびその使用 |
| CA3131017C (en) | 2019-02-27 | 2025-05-13 | Actym Therapeutics, Inc. | Immunostimulatory bacteria modified to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| AU2021258194A1 (en) | 2020-04-22 | 2022-11-24 | Indapta Therapeutics, Inc. | Natural killer (NK) cell compositions and methods for generating same |
| WO2022147481A1 (en) | 2020-12-30 | 2022-07-07 | Ansun Biopharma Inc. | Combination therapy of an oncolytic virus delivering a foreign antigen and an engineered immune cell expressing a chimeric receptor targeting the foreign antigen |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) * | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| US5670330A (en) * | 1992-09-29 | 1997-09-23 | Mcgill University | Anti-tumor agent assay using PKR |
| DK0931830T3 (da) * | 1993-02-16 | 2001-06-11 | Onyx Pharma Inc | Cytopatiske vira til terapi og profylakse af neoplasi |
| US5801029A (en) * | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| PT696326E (pt) | 1993-04-30 | 2003-08-29 | Wellstat Biologics Corp | Utilizacao de ndv no fabrico de um medicamento para tratamento do cancro |
| JPH09506866A (ja) * | 1993-12-14 | 1997-07-08 | ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 医薬として活性のある物質の免疫療法のための放出制御 |
| WO1995032300A1 (en) * | 1994-05-23 | 1995-11-30 | University Of Medicine & Dentistry Of New Jersey | Selective biological destruction of tumor cells |
| US5585096A (en) * | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
| US5840502A (en) * | 1994-08-31 | 1998-11-24 | Activated Cell Therapy, Inc. | Methods for enriching specific cell-types by density gradient centrifugation |
| US6777177B1 (en) * | 1997-10-10 | 2004-08-17 | Vanderbilt University | Mammalian genes involved in viral infection and tumor suppression |
| US6110461A (en) | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
| CA2508238C (en) | 1997-08-13 | 2008-01-15 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
| US6136307A (en) * | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
| US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| NZ503664A (en) * | 1997-10-09 | 2002-08-28 | Pro Virus Inc | A method for purifying an RNA virus comprising generating a clonal virus and purifying the clonal virus by ultracentrifugation without pelleting |
| US6475481B2 (en) * | 1997-11-18 | 2002-11-05 | Canji Inc | Purging of stem cell products |
| WO1999045783A1 (en) | 1998-03-12 | 1999-09-16 | The Trustees Of The University Of Pennsylvania | Producer cells for replication selective viruses in the treatment of malignancy |
| EP1109564B1 (de) * | 1998-08-31 | 2006-02-22 | Julian L. Ambrus | Verfahren zur entfernung von hiv und anderen viren aus blut |
| NZ550861A (en) | 1999-04-15 | 2009-03-31 | Wellstat Biologics Corp | Treatment of neoplasms with viruses |
| DE19934788B4 (de) * | 1999-07-27 | 2004-05-27 | T-Mobile Deutschland Gmbh | Verfahren zur automatischen Anpassung von Daten an die Fähigkeiten einer Nutzer-Software |
| DE60041210D1 (de) | 1999-09-17 | 2009-02-05 | Wellstat Biologics Corp | Onkolytisches Virus |
| CA2720361A1 (en) | 1999-11-12 | 2001-05-25 | Oncolytics Biotech, Inc. | Viruses for the treatment of cellular proliferative disorders |
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
| AR028040A1 (es) * | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de virus de celulas neoplasticas a partir de composiciones celulares mixtas |
| AR028039A1 (es) * | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas |
| CN1250711C (zh) * | 2000-06-26 | 2006-04-12 | 威尔斯达特生物制剂公司 | 用病毒清除细胞 |
| WO2002004596A2 (en) | 2000-07-07 | 2002-01-17 | President And Fellows Of Harvard College | Diagnosing and treating cancer cells using mutant viruses |
| DK2189162T3 (da) | 2000-11-09 | 2014-02-03 | Oncolytics Biotech Inc | Fremgangsmåder til behandling af cellulære proliferative forstyrrelser |
| US20030138405A1 (en) * | 2001-04-17 | 2003-07-24 | Juan Fueyo | Conditionally replicative adenovirus to target the Rb and Rb-related pathways |
-
2003
- 2003-06-24 US US10/602,024 patent/US7306902B2/en not_active Expired - Lifetime
- 2003-06-25 PT PT07021569T patent/PT1890151E/pt unknown
- 2003-06-25 NZ NZ537116A patent/NZ537116A/en unknown
- 2003-06-25 DE DE60317331T patent/DE60317331T2/de not_active Expired - Lifetime
- 2003-06-25 DK DK07021569.4T patent/DK1890151T3/da active
- 2003-06-25 CA CA2487824A patent/CA2487824C/en not_active Expired - Lifetime
- 2003-06-25 EP EP07021569A patent/EP1890151B1/de not_active Expired - Lifetime
- 2003-06-25 DK DK03737795T patent/DK1520175T3/da active
- 2003-06-25 EP EP03737795A patent/EP1520175B1/de not_active Expired - Lifetime
- 2003-06-25 AU AU2003245760A patent/AU2003245760B2/en not_active Expired
- 2003-06-25 CN CN03815353.XA patent/CN1666105B/zh not_active Expired - Lifetime
- 2003-06-25 JP JP2004516379A patent/JP2005531306A/ja active Pending
- 2003-06-25 ES ES03737795T patent/ES2292981T3/es not_active Expired - Lifetime
- 2003-06-25 AT AT07021569T patent/ATE555388T1/de active
- 2003-06-25 BR BR0311983-1A patent/BR0311983A/pt not_active IP Right Cessation
- 2003-06-25 MX MXPA04012414A patent/MXPA04012414A/es active IP Right Grant
- 2003-06-25 ES ES07021569T patent/ES2385845T3/es not_active Expired - Lifetime
- 2003-06-25 SI SI200332164T patent/SI1890151T1/sl unknown
- 2003-06-25 WO PCT/CA2003/000951 patent/WO2004003562A2/en not_active Ceased
- 2003-06-25 AT AT03737795T patent/ATE377754T1/de not_active IP Right Cessation
- 2003-06-26 AR ARP030102317A patent/AR039768A1/es unknown
- 2003-06-26 TW TW098118162A patent/TWI402345B/zh not_active IP Right Cessation
- 2003-06-26 TW TW098135545A patent/TWI334444B/zh not_active IP Right Cessation
- 2003-06-26 TW TW092117377A patent/TWI327167B/zh not_active IP Right Cessation
-
2004
- 2004-12-01 IL IL16549804A patent/IL165498A0/xx active IP Right Grant
-
2007
- 2007-05-30 US US11/807,771 patent/US20080014577A1/en not_active Abandoned
-
2008
- 2008-08-28 AU AU2008207579A patent/AU2008207579B2/en not_active Expired
-
2010
- 2010-01-05 US US12/652,289 patent/US8222036B2/en not_active Expired - Fee Related
-
2012
- 2012-06-04 IL IL220139A patent/IL220139A/en active IP Right Grant
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