TW200901987A - Triazole derivatives which are Smo antagonists - Google Patents
Triazole derivatives which are Smo antagonists Download PDFInfo
- Publication number
- TW200901987A TW200901987A TW097113665A TW97113665A TW200901987A TW 200901987 A TW200901987 A TW 200901987A TW 097113665 A TW097113665 A TW 097113665A TW 97113665 A TW97113665 A TW 97113665A TW 200901987 A TW200901987 A TW 200901987A
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- Prior art keywords
- cancer
- compound
- phenyl
- methyl
- bicyclo
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- A—HUMAN NECESSITIES
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
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| US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
| JP2011522773A (ja) * | 2007-12-27 | 2011-08-04 | インフィニティ ファーマスーティカルズ、インク． | 治療剤での癌の処置方法 |
| GB0813740D0 (en) * | 2008-07-28 | 2008-09-03 | Angeletti P Ist Richerche Biologica | Therapeutic compounds |
| JP5816087B2 (ja) * | 2008-08-29 | 2015-11-18 | エンメエッセディ・イタリア・エッセ・エッレ・エッレ | Ｓｍｏアンタゴニストとしての飽和二環式複素環誘導体 |
| CA2769795C (en) | 2009-08-05 | 2020-01-07 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
| EP2502078A1 (en) * | 2009-11-20 | 2012-09-26 | Infinity Pharmaceuticals, Inc. | Methods and compositions for treating hedgehog-associated cancers |
| US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| CN105492011A (zh) | 2013-04-08 | 2016-04-13 | 丹尼斯·M·布朗 | 不理想给药化学化合物的治疗增效 |
| CN104324039A (zh) * | 2014-10-20 | 2015-02-04 | 付茜 | 一种治疗人身体表面脂肪瘤的药剂及使用方法 |
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| JO2397B1 (en) * | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
| ATE476425T1 (de) | 2003-05-29 | 2010-08-15 | Merck Sharp & Dohme | Triazolderivate als inhibitoren von 11-beta- hydroxysteroid-dehydrogenase-1 |
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| JP4903133B2 (ja) | 2004-04-30 | 2012-03-28 | ジェネンテック，インコーポレイティド | ヘッジホッグシグナル伝達のキノキサリン阻害剤 |
| JP2008509146A (ja) | 2004-08-06 | 2008-03-27 | メルク エンド カムパニー インコーポレーテッド | １１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ−１の阻害剤としてのスルホニル化合物 |
| ES2578728T3 (es) | 2004-08-27 | 2016-07-29 | Infinity Pharmaceuticals, Inc. | Proceso para la preparación de compuestos análogos de ciclopamina |
| WO2006028958A2 (en) | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Pyridyl inhibitors of hedgehog signalling |
| RU2007119637A (ru) | 2004-10-28 | 2008-12-10 | Айрм Ллк (Bm) | Соединения и композиции в качестве модуляторов hedgehog-пути |
| CA2587489C (en) | 2004-11-03 | 2013-12-31 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| CN103724335A (zh) * | 2005-10-20 | 2014-04-16 | 默沙东公司 | 用作11β-羟基类固醇脱氢酶-1抑制剂的三唑衍生物 |
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| AU2008241527B2 (en) | 2014-02-13 |
| CA2683946C (en) | 2013-01-22 |
| US20080262051A1 (en) | 2008-10-23 |
| ATE555785T1 (de) | 2012-05-15 |
| AU2008241527A1 (en) | 2008-10-30 |
| CN101663033A (zh) | 2010-03-03 |
| AR066063A1 (es) | 2009-07-22 |
| CA2683946A1 (en) | 2008-10-30 |
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